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    CRYSTALLINE FORMS OF ERAVACYCLINE
    3.
    发明申请
    CRYSTALLINE FORMS OF ERAVACYCLINE 审中-公开
    ERAVACYCLINE的结晶形式

    公开(公告)号：WO2018075767A1

    公开(公告)日：2018-04-26

    申请号：PCT/US2017/057385

    申请日：2017-10-19

    Applicant: TETRAPHASE PHARMACEUTICALS, INC. ,  LAFRANCE, Danny ,  HOGAN, Philip, C. ,  LIU, Yansheng ,  HE, Minsheng ,  CHEN, Chi-Li ,  NIU, John

    Inventor： LAFRANCE, Danny ,  HOGAN, Philip, C. ,  LIU, Yansheng ,  HE, Minsheng ,  CHEN, Chi-Li ,  NIU, John

    IPC: C07D295/15 ,  A61K31/65 ,  A61P31/00 ,  A61P35/00 ,  A61P1/00

    Abstract: The invention relates to crystalline forms of the bis-HCI salt of a compound represented by Structural Formula 1, and pharmaceutical compositions comprising crystalline forms of the bis-HCL salt of a compound represented by Structural Formula 1 described herein. The crystalline forms of the bis-HCI salt of a compound of Structural Formula 1 and compositions comprising the crystalline forms of the compound of Structural Formula 1 provided herein, in particular, crystalline Form I, crystalline Form J, crystalline Form A, and crystalline Form B, or mixtures thereof, can be incorporated into pharmaceutical compositions, which can be used to treat various disorders. Also described herein are methods for preparing the crystalline forms (e.g., Forms I, J, B and A) of the bis-HCI salt of a compound represented by Structural Formula 1.

    Abstract translation: 本发明涉及由结构式1表示的化合物的双-HCl盐的结晶形式，以及包含由所述结构式1表示的化合物的双-HCL盐的结晶形式的药物组合物 于此。 结构式1的化合物的双-HCl盐的结晶形式和包含本文提供的结构式1的化合物的结晶形式的组合物，特别是结晶形式I，结晶形式J，结晶形式A和结晶形式 B或其混合物可以掺入可用于治疗各种病症的药物组合物中。 本文还描述了制备由结构式1表示的化合物的双-HCl盐的结晶形式（例如，形式I，J，B和A）的方法。

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