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    PERCUTANEOUS TRANSMYOCARDIAL REVASCULARIZATION (PTMR) SYSTEM
    2.
    发明申请
    PERCUTANEOUS TRANSMYOCARDIAL REVASCULARIZATION (PTMR) SYSTEM 审中-公开
    PERCUTANEOUS TRANSMYOCARALAL REVASCULARATIONATION（PTMR）系统

    公开(公告)号：WO0110287A8

    公开(公告)日：2001-12-06

    申请号：PCT/US0021341

    申请日：2000-08-04

    申请人： HOUSER RUSSELL A

    发明人： HOUSER RUSSELL A

    IPC分类号： A61B17/00 ,  A61B18/14 ,  A61B18/18

    CPC分类号： A61B18/1492 ,  A61B17/32 ,  A61B18/1815 ,  A61B2017/00247 ,  A61B2018/00011 ,  A61B2018/00285 ,  A61B2018/00357 ,  A61B2018/00392 ,  A61B2018/00607 ,  A61B2018/00613 ,  A61B2018/144 ,  A61B2218/002

    摘要： Percutaneous transmyocardial revascularization (PMR) systems are disclosed for creating thin, linear incisions through the endocardium and partially into the myocardium. The systems position a catheter body (10) lengthwise along the endocardial surface and incorporate a cutting mechanism (14) movable radially relative to the catheter body to create one or more thin, linear incisions along one or more windows (16) through the catheter body. Flexible support strands (12) are used to urge each window into intimate contact with the endocardial surface. Each cutting element is adapted to protrude radially outward from the catheter body to contact tissue adjacent each window. The cutting mechanism incorporates a mechanical cutting element or an electrode designed to transmit direct current or RF energy into tissue to simultaneously cut and coagulate tissue. The catheter also can infuse a therapeutic agent directly into the incisions to encourage angiogenesis. The catheter also cuts thin, linear incisions capable of ablating arrhythmia substrates by disrupting electrical propagation through the affected myocardium.

    摘要翻译： 公开了经皮心肌血运重建（PMR）系统，用于通过心内膜产生薄而线性的切口并部分进入心肌。 系统沿着心内膜表面纵向定位导管主体（10）并且包括相对于导管主体径向移动的切割机构（14），以沿着穿过导管主体的一个或多个窗口（16）创建一个或多个薄的线性切口 。 柔性支撑股（12）用于促使每个窗口与心内膜表面紧密接触。 每个切割元件适于从导管主体径向向外突出以接触每个窗口附近的组织。 切割机构包括机械切割元件或设计成将直流电或RF能量传输到组织中以同时切割和凝固组织的电极。 导管还可以将治疗剂直接注入切口以促进血管生成。 导管还切割能够通过破坏通过受影响的心肌的电传播来消融心律失常底物的薄的线性切口。

    RADIALLY EXPANDING PROSTHESES AND SYSTEMS FOR THEIR DEPLOYMENT
    5.
    发明申请
    RADIALLY EXPANDING PROSTHESES AND SYSTEMS FOR THEIR DEPLOYMENT 审中-公开
    放射性地扩展其部署的前景和系统

    公开(公告)号：WO1998011847A1

    公开(公告)日：1998-03-26

    申请号：PCT/US1997016737

    申请日：1997-09-19

    申请人： HOUSER, Russell, A. ,  WHAYNE, James, G. ,  FLEISCHMAN, Sid, D.

    IPC分类号： A61F02/06

    CPC分类号： A61F2/07 ,  A61F2/2412 ,  A61F2/3094 ,  A61F2/88 ,  A61F2/90 ,  A61F2/92 ,  A61F2/945 ,  A61F2/954 ,  A61F2/962 ,  A61F2/966 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/30011 ,  A61F2002/30098 ,  A61F2002/30448 ,  A61F2002/30583 ,  A61F2002/30677 ,  A61F2002/9511 ,  A61F2002/9528 ,  A61F2210/0033 ,  A61F2210/0076 ,  A61F2210/0085 ,  A61F2220/0008 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2240/001 ,  A61F2250/0003 ,  A61F2250/0023 ,  A61F2250/0067

    摘要： A resilient graft construction incorporates a structural layer (38) formed of a resilient body compatible metal or polymer, and a fluid impervious layer of graft material (40) secured to the structural layer. The structural layer includes an elongate longitudinal primary section (42), and secondary sections (46) extended transversely from opposie sides of the primary section (42). The secondary sections (46) can be arranged in opposed pairs, or staggered. The secondary sections (46) further can be tapered in width, thickness or both. The grafts can be constructed by stamping or otherwise severing structural layer patterns from a flat sheet of structural material, then thermally setting the structural layers when they are wrapped about a mandril to determine a relaxed state curvature. Opposed longitudinal edges either can overlap one another or be spaced apart from one another in the relaxed state. According to one alternative, the structural layer (38) alone functions as a stent. Other alternatives include circumferentially closed graft structures, one of which consists of a resilient graft material.

    摘要翻译： 弹性移植物结构包括由弹性体相容的金属或聚合物形成的结构层（38）和固定到结构层的移植材料（40）的流体不可渗透层。 结构层包括细长纵向初级部分（42），并且从初级部分（42）的相对侧横向延伸的次级部分（46）。 次级部分46可以相对设置或交错布置。 次级部分（46）还可以在宽度，厚度或两者上锥形化。 移植物可以通过冲压或以其他方式从平板结构材料切断结构层图案，然后在将结构层缠绕在心轴周围热定形以确定松弛状态曲率时构造。 相对的纵向边缘可以在松弛状态下彼此重叠或彼此间隔开。 根据一个替代方案，结构层（38）单独用作支架。 其它替代方案包括周向封闭的移植物结构，其中一个由弹性移植材料组成。

    ATHERECTOMY CATHETER AND RF CUTTING METHOD
    6.
    发明申请
    ATHERECTOMY CATHETER AND RF CUTTING METHOD 审中-公开
    ATHERECTOMY导管和RF切割方法

    公开(公告)号：WO1996022737A1

    公开(公告)日：1996-08-01

    申请号：PCT/US1996001010

    申请日：1996-01-23

    申请人： HOUSER, Russell, A.

    IPC分类号： A61B17/20

    CPC分类号： A61B18/1492 ,  A61B2018/00601 ,  A61B2018/1861 ,  A61B2218/007

    摘要： An atherectomy device includes a catheter (20) with a window (28) at its distal tip for admitting tissue into a catheter compartment. A cylindrical cartridge (32) in the compartment has a cutting edge that supports an electrically conductive cutting element, e.g. a band or wire. The cutting element and adjacent tissue can be heated to a selected temperature by generating an electrical current through the cutting element. The catheter is maneuverable to position its distal end near a lesion in an artery. The catheter incorporates a dilatation balloon or other feature to urge the catheter against the lesion, so that at least part of the lesion enters the compartment through the window. Then, the cartridge (32) is manipulated from the catheter's proximal end to move the cutting edge across the window (28), severing the acquired tissue. According to alternative embodiments, the cartridge is either rotated or moved axially relative to the catheter, in either event closing the catheter window when the cut is complete.

    摘要翻译： 粥样斑块切除装置包括在其远侧末端具有窗口（28）的导管（20），用于将组织导入导管室。 隔室中的圆柱形盒（32）具有支撑导电切割元件的切割边缘，例如， 乐队或电线。 通过产生通过切割元件的电流，切割元件和相邻的组织可被加热到选定的温度。 导管是可操纵的，以将其远端定位在动脉附近的病变附近。 该导管结合有扩张球囊或其它特征以推动导管抵靠病变，使得损伤的至少一部分通过窗口进入隔室。 然后，从导管的近端操作药筒（32），以移动切割边缘穿过窗口（28），切断所获取的组织。 根据替代实施例，当切割完成时，在任何情况下关闭导管窗口，盒都相对于导管旋转或轴向移动。

    RAPID EXCHANGE CATHETER WITH STENT DEPLOYMENT, THERAPEUTIC INFUSION, AND LESION SAMPLING FEATURES
    9.
    发明申请
    RAPID EXCHANGE CATHETER WITH STENT DEPLOYMENT, THERAPEUTIC INFUSION, AND LESION SAMPLING FEATURES 审中-公开
    快速交换导管的支架部署，治疗性输注和病变采样功能

    公开(公告)号：WO03039626A8

    公开(公告)日：2003-08-21

    申请号：PCT/US0235830

    申请日：2002-11-08

    申请人： HOUSER RUSSELL A ,  HARE WILLIAM D

    发明人： HOUSER RUSSELL A ,  HARE WILLIAM D

    IPC分类号： A61F2/82 ,  A61M20060101 ,  A61M29/00 ,  A61M29/02 ,  A61M31/00 ,  A61M

    CPC分类号： A61M25/104 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/821 ,  A61F2250/0098 ,  A61M2025/0183 ,  A61M2025/1047 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1072 ,  A61M2025/1095

    摘要： A catheter is insertable into a vessel within a mammalian body. The catheter includes a tubular body, at least one channel extending along the tubular body; and a central lumen. The tubular body includes an exterior surface, a first end and a second end, and defines a length between the first end and the second end. The channel passes between a first opening and a second opening and includes a slot in the tubular body between the channel and the exterior surface of the tubular body such that a tubular member can be passed between the channel and the exterior surface. The slot extends from the the first opening to the second opening and includes a pair of edges. The central lumen extends along the tubular body at least for a portion of the length of the tubular body. The catheter can be used as a rapid exchange catheter, for stent deployment, for drug delivery or therapeutic infusion with or without electoporation, to provide localized heat, to provide ultrasonic visualization and ablation, and to examine for vulnerable plaque. The catheter may have multiple balloons.

    摘要翻译： 导管可插入哺乳动物体内的血管内。 导管包括管状体，至少一个通道沿着管状体延伸; 和一个中央腔。 管状体包括外表面，第一端和第二端，并限定第一端和第二端之间的长度。 通道在第一开口和第二开口之间通过，并且在通道和管状体的外表面之间的管状体中包括狭槽，使得管状构件可以在通道和外表面之间通过。 狭槽从第一开口延伸到第二开口并且包括一对边缘。 中心内腔至少在管状体的一部分长度上沿着管状体延伸。 导管可用作快速交换导管，用于支架展开，药物输送或有或无电穿孔的治疗性输注，提供局部热量，提供超声波可视化和消融，并检查易损斑块。 导管可以具有多个气球。

    PERCUTANEOUS TRANSMYOCARDIAL REVASCULARIZATION (PTMR) SYSTEM
    10.
    发明申请
    PERCUTANEOUS TRANSMYOCARDIAL REVASCULARIZATION (PTMR) SYSTEM 审中-公开
    经皮心肌转复（PTMR）系统

    公开(公告)号：WO0110287A2

    公开(公告)日：2001-02-15

    申请号：PCT/US0021341

    申请日：2000-08-04

    申请人： HOUSER RUSSELL A

    发明人： HOUSER RUSSELL A

    IPC分类号： A61B17/00 ,  A61B18/14 ,  A61B

    CPC分类号： A61B18/1492 ,  A61B17/32 ,  A61B18/1815 ,  A61B2017/00247 ,  A61B2018/00011 ,  A61B2018/00285 ,  A61B2018/00357 ,  A61B2018/00392 ,  A61B2018/00607 ,  A61B2018/00613 ,  A61B2018/144 ,  A61B2218/002

    摘要： Percutaneous transmyocardial revascularization (PMR) systems are disclosed for creating thin, linear incisions through the endocardium and partially into the myocardium. The systems position a catheter body (10) lengthwise along the endocardial surface and incorporate a cutting mechanism (14) movable radially relative to the catheter body to create one or more thin, linear incisions along one or more windows (16) through the catheter body. Flexible support strands (12) are used to urge each window into intimate contact with the endocardial surface. Each cutting element is adapted to protrude radially outward from the catheter body to contact tissue adjacent each window. The cutting mechanism incorporates a mechanical cutting element or an electrode designed to transmit direct current or RF energy into tissue to simultaneously cut and coagulate tissue. The catheter also can infuse a therapeutic agent directly into the incisions to encourage angiogenesis. The catheter also cuts thin, linear incisions capable of ablating arrhythmia substrates by disrupting electrical propagation through the affected myocardium.

    摘要翻译： 公开了经皮心肌血运重建（PMR）系统，用于通过心内膜创建细的线性切口并且部分地进入心肌。 系统沿着心内膜表面纵向定位导管主体（10），并且包括相对于导管主体径向移动的切割机构（14），以沿着穿过导管主体的一个或多个窗口（16）形成一个或多个薄的线性切口 。 柔性支撑股线（12）用于促使每个窗口与心内膜表面紧密接触。 每个切割元件适于从导管主体径向向外突出以接触每个窗口附近的组织。 切割机构包含机械切割元件或电极，其被设计成将直流电或RF能量传输到组织中以同时切割和凝结组织。 导管还可以将治疗剂直接注入切口以促进血管生成。 导管还切割薄而线性的切口，能够通过破坏通过受影响的心肌的电传播来消融心律失常底物。