UNSATURATED HYDROCARBON OLIGOMERIZATION METHOD

    公开(公告)号:WO2023057928A1

    公开(公告)日:2023-04-13

    申请号:PCT/IB2022/059516

    申请日:2022-10-05

    Abstract: An oligomerization method of unsaturated hydrocarbons having double bonds, proceeding in a liquid phase, in an organic medium, in a mixture of substrates mutually exhibiting a double bond system of the [2+2], [4+2] or [2+4] type, using a reaction initiating agent, according to the invention, characterized in that at least one of the substrates has an ionization potential lower than 9.33 eV or a redox potential lower than 2.0 V, at least one of the substrates has at least one double bond involved in the reaction that is not part of an aromatic ring, wherein the other substrate can react via a double bond system of the aromatic ring, as long as it has an electron delocalization energy in the aromatic ring lower than 18 kj/mol per aromatic carbon atom in the structure of that compound, and a solid silver(ll) salt is used as the initiating agent, which leads to the formation of a radical cation from a substrate of a lower ionization energy, which then reacts with another substrate molecule without a deprotonation step for that radical cation, and then transforming the resulting adduct into a neutral molecule with the formation of another radical cation from a substrate of a lower ionization energy, which radical cation further reacts in solution according to the same mechanism, wherein the process is carried out at 270-350 K, preferably at room temperature, in an apparatus made of a material which is chemically inert and inert with respect to silver(ll) salts, preferably in an apparatus with an inner surface made of glass, quartz, fluoropolymers or stainless steel, into which are introduced substrates and an anhydrous organic solvent, which is chemically inert, also with respect to the silver(ll) salt, and then the silver(ll) salt is introduced as an initiating agent, after which the apparatus is closed and the reaction is carried out for at least 24 hours, preferably for at least 72 hours, and then the solid silver compounds are recovered from the post-reaction mixture and subjected to regeneration, and the liquid phase is separated into a light fraction of dimeric cycloaddition products and heavier fractions of oligomeric linear addition products, from which pure products or mixtures of isomeric products are isolated, for example by chromatographic methods. The invention provides an unsaturated hydrocarbon oligomerization method, including the cycloaddition of unsaturated hydrocarbons, which makes it possible to carry out, under ordinary pressure and temperature conditions, reactions between reactants commonly regarded as inert.

    METHOD FOR TREATMENT OF TOOLS AND TOOLS USED FOR ISOLATION OF MICROVESICLES, NANOVESICLES OR EXSOMES
    3.
    发明申请
    METHOD FOR TREATMENT OF TOOLS AND TOOLS USED FOR ISOLATION OF MICROVESICLES, NANOVESICLES OR EXSOMES 审中-公开
    用于分离用于分离微胶囊,纳米颗粒或异物的工具和工具的方法

    公开(公告)号:WO2016030358A1

    公开(公告)日:2016-03-03

    申请号:PCT/EP2015/069420

    申请日:2015-08-25

    CPC classification number: A61L29/14 A61L33/0094 A61L2400/18

    Abstract: According to the present invention a method which prevents excessive adsorption of microvesicles on the surfaces of tools used for sampling, storing and handling body flu- ids containing microvesicles is provided. The method comprises the steps of: selecting said a tool from the a list plurality of tools including but not limited to needles, blood tubing, blood bags, catheters, Eppendorf tubes, pipettes or the like, providing said tool from said plurality of tools, providing a source of positively and negatively charged particles of high density, selecting a source assuring for formation of positively and negatively charged particles of high density and treating a surface of said tool by applying short pulses of said source of particles next to or on the said surface of said tool to assure surface modification of said surface by reacting said positively and negatively charged particles of high density on said surface. The method according to the present invention ensures contacting of tools with short pulses of highly ionized gas comprising both positively and negatively charged particles, the pulses being essentially short enough to avoid excessive heating of materials used for collecting, sampling, storage, transport and isolation of micro vesicles and the density of both positively and negatively charged particles which is essentially high enough to cause roughening of said tools on sub-micrometer or nanometer scale. Especially tools treated according to the present inventive method prevents excessive adsorption of microvesicles on the surfaces of said tools used for collecting, sampling, storing, transporting and isolating of microvesicles or the like. The method according to the present invention enables higher yields and lower frag- mentation of microvesicles for instance by preventing adsorption of this valuable diag- nostic material on the surface of different tools used for isolation and detection. Accordingly, the present invention also provides increasing the roughness of a material by the method according to the present invention. In particular the material which is used to produce diagnostic or medical tools or devices. (Fig. 1)

    Abstract translation: 根据本发明,提供了防止微泡在用于取样,储存和处理含有微泡的体液的工具的表面上过度吸附的方法。 该方法包括以下步骤:从列表中选择多个工具的工具,包括但不限于针,血管,血袋,导管,Eppendorf管,移液管等,从所述多个工具提供所述工具, 提供具有高密度的正带负电粒子源,选择源确保形成具有高密度的带正电荷和带负电荷的颗粒并通过施加所述工具的表面的所述短脉冲来施加所述工具的表面的所述短脉冲, 所述工具的表面以通过在所述表面上反应所述带正电荷和带负电荷的高密度颗粒来确保所述表面的表面改性。 根据本发明的方法确保工具与包括正带电荷和带负电粒子的短电离气体的短脉冲接触,所述脉冲基本足够短以避免过度加热用于收集,取样,储存,运输和分离的材料 微泡和正和负带电粒子的密度,其基本上足够高以在亚微米或纳米级上引起所述工具的粗糙化。 特别是根据本发明方法处理的工具防止微囊在用于收集,取样,储存,运输和分离微泡等的所述工具的表面上过度吸附。 根据本发明的方法,通过防止这种有价值的诊断材料在用于分离和检测的不同工具的表面上的吸附,能够实现更高的产率和更低的微泡分解。 因此,本发明还通过根据本发明的方法提高材料的粗糙度。 特别是用于生产诊断或医疗工具或设备的材料。 (图。1)

    HYBRID SOL-GEL COMPOSITIONS AND CORROSION-RESISTANT COATINGS BASED UPON SAME
    4.
    发明申请
    HYBRID SOL-GEL COMPOSITIONS AND CORROSION-RESISTANT COATINGS BASED UPON SAME 审中-公开
    混合溶胶凝胶组合物和耐腐蚀涂料

    公开(公告)号:WO2015001461A1

    公开(公告)日:2015-01-08

    申请号:PCT/IB2014/062687

    申请日:2014-06-27

    CPC classification number: C08G77/56 C08G77/58 C09D5/08 C09D183/14

    Abstract: A curable hybrid sol-gel composition includes the combination of: (a) a first sol comprising the combination of (i) a hydrolysable silicon alkoxide and (ii) a silicon alkoxide having a least one non-hydrolysable substituent bonded to the silicon atom; and (b) a second sol comprising the combination of (i) a hydrolysable metal oxide in which the central metal atom is selected from the group consisting of Ti, Zr, Al, B, Sn, and V, and (ii) a (meth)acrylic acid-functional component. The cured composition is useful in a variety of compositions, e.g., as an anti-corrosion coating for metal substrates.

    Abstract translation: 可固化的混合溶胶 - 凝胶组合物包括以下组合:(a)包含(i)可水解的硅醇盐和(ii)具有至少一个与硅原子键合的不可水解取代基的硅醇盐的组合的第一溶胶; 和(b)第二溶胶,其包含以下组合:(i)其中所述中心金属原子选自Ti,Zr,Al,B,Sn和V的可水解金属氧化物,和(ii)( 甲基)丙烯酸功能组分。 固化的组合物可用于各种组合物,例如用作金属基材的防腐涂层。

    USE OF QUASI-ONE-DIMENSIONAL POLYMERS BASED ON THE METAL-CHALCOGEN-HALOGEN SYSTEM
    6.
    发明申请
    USE OF QUASI-ONE-DIMENSIONAL POLYMERS BASED ON THE METAL-CHALCOGEN-HALOGEN SYSTEM 审中-公开
    基于金属 - 卤代烃系统的四分之一聚合物的使用

    公开(公告)号:WO2007051481A2

    公开(公告)日:2007-05-10

    申请号:PCT/EP2005/011711

    申请日:2005-11-02

    CPC classification number: C30B29/62

    Abstract: The present invention relates to the use of a quasi-one-dimensional material with sub-micron cross-section described by the formula M 6 C y H Z , wherein M = transition metal, C = chalcogen, H = halogen, and wherein y and z are real numbers such that 8≤(y+z) ≤ 12, preferably 8≤ (y+z) ≤ 11. Said materials may be synthesized in a single-step procedure at temperatures above 1000 °C and used in electronic, chemical, optical or mechanical applications.

    Abstract translation: 本发明涉及具有亚微米横截面的准一维材料的用途,所述亚微米横截面由式M 6 C H Z 其中M =过渡金属,C =硫族元素,H =卤素,并且其中y和z是实数,使得8 =(y + z)= 12,优选8 =(y + z)= 11。 材料可以在高于1000℃的温度下以单步程序合成并用于电子,化学,光学或机械应用。

    AN APPARATUS FOR ANODIC OXIDATION OF VERY SMALL METAL GRIDS

    公开(公告)号:WO2022194832A1

    公开(公告)日:2022-09-22

    申请号:PCT/EP2022/056634

    申请日:2022-03-15

    Abstract: The present invention belongs to the field of nanotechnology, more precisely to the field of nanostructures formed by manipulation of individual atoms, molecules, and to manufacturing processes for providing said nanostructures. The invention relates to an apparatus for anodic oxidation of small metal grids, which comprises: − a housing comprising a bottom part and a top part arranged to receive a metal grid, wherein - each part is provided with an opening for allowing contact with an electrolyte, - one of the said parts is provided with a slot for receiving an electrical contact, said slot is arranged around the said opening, - at least one, preferably at least one, preferably both parts are provided with a slot for installation of a seal, preferably rubber seal, around the said opening, - each part having assembly means to assemble both housing parts together, − the electrical contact shaped as an elongated flat element with a circular head having a hole to receive the metal grid, said hole being slightly smaller than the metal grid to be anodized, wherein the elongated flat element is arranged to be connected to electricity, preferably using an alligator clip, and − preferably the metal grid, typically a TEM grid usually having a diameter or length up to 5 mm.

    CARDAN JOINT
    8.
    发明申请
    CARDAN JOINT 审中-公开

    公开(公告)号:WO2018197439A1

    公开(公告)日:2018-11-01

    申请号:PCT/EP2018/060387

    申请日:2018-04-23

    Inventor: KOVAC, Dr Igor

    Abstract: A cardan joint and a multi-axis positioning containing the same. The cardan joint comprising: a first yoke; and a second yoke. Wherein the first yoke and the second yoke are connected via a linkage. The cardan joint further comprising: a backlash adjusting mechanism, the backlash adjusting mechanism configured to reduce or increase an amount of backlash between the linkage and either the first yoke or the second yoke.

    POLYMER DISPERSED LIQUID CRYSTAL ELASTOMERS (PDLCE)
    10.
    发明申请
    POLYMER DISPERSED LIQUID CRYSTAL ELASTOMERS (PDLCE) 审中-公开
    聚合物分散液晶弹性体(PDLCE)

    公开(公告)号:WO2015140149A1

    公开(公告)日:2015-09-24

    申请号:PCT/EP2015/055527

    申请日:2015-03-17

    Abstract: The present invention relates to a method of producing liquid crystal elastomer (LCE) based components. The method comprises the steps of (i) providing or creating micro- sized or nano-sized LCE particles, (ii) dispersing the particles in an uncured liquid polymer, (iii) aligning the nematic directors of the particles and, (iv) shaping and curing the matrix/particles mixture. The composite material formed by this method is a polymer dispersed liquid crystal elastomer (PDLCE) with custom-tailored properties which can be shaped into arbitrary forms.

    Abstract translation: 本发明涉及一种生产基于液晶弹性体(LCE)的组分的方法。 该方法包括以下步骤:(i)提供或产生微尺寸或纳米尺寸的LCE颗粒,(ii)将颗粒分散在未固化的液体聚合物中,(iii)使颗粒的向列引线对准,和(iv)成形 并固化基质/颗粒混合物。 通过该方法形成的复合材料是具有定制特性的聚合物分散液晶弹性体(PDLCE),其可以成形为任意形式。

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