INTRALUMINAL SCAFFOLD SYSTEM AND USE THEREOF
    2.
    发明申请
    INTRALUMINAL SCAFFOLD SYSTEM AND USE THEREOF 审中-公开
    内部SCAFFOLD系统及其使用

    公开(公告)号:WO2012097311A3

    公开(公告)日:2012-10-04

    申请号:PCT/US2012021335

    申请日:2012-01-13

    Abstract: Intraluminal scaffold assembly implantable in a body lumen of a patient to manipulate a valve of the lumen is provided. The intraluminal scaffold assembly includes an intraluminal scaffold (1100), an elongated core member (1200) coupled with the intraluminal scaffold having a length sufficient to traverse a valve in a body lumen with the intraluminal scaffold positioned proximate the valve. The intraluminal scaffold assembly can further include one or more additional intraluminal scaffolds, a weighted element (1201) or an active element that is coupled with the elongated core member. A system including a delivery system and the intraluminal scaffold assembly, as well as methods of delivering the intraluminal scaffold assembly and using the intraluminal scaffold assembly to manipulate a valve in a body lumen, is also provided.

    Abstract translation: 提供可植入患者的体腔中以操纵管腔的瓣膜的腔内支架组件。 管腔内支架组件包括管腔内支架(1100),与管腔内支架联接的细长芯构件(1200),其长度足以穿过体腔内的瓣膜,腔内支架位于瓣膜附近。 管腔内支架组件还可以包括一个或多个附加的管腔内支架,加权元件(1201)或与细长芯构件联接的有源元件。 还提供了包括递送系统和管腔内支架组件的系统,以及递送管腔内支架组件和使用管腔内支架组件来操纵体腔中的瓣膜的方法。

    EXPANDABLE MEMBER FORMED OF A FIBROUS MATRIX FOR INTRALUMINAL DRUG DELIVERY
    3.
    发明申请
    EXPANDABLE MEMBER FORMED OF A FIBROUS MATRIX FOR INTRALUMINAL DRUG DELIVERY 审中-公开
    用于腹腔内药物输送的纤维基质的可膨胀成员

    公开(公告)号:WO2010036697A1

    公开(公告)日:2010-04-01

    申请号:PCT/US2009/058012

    申请日:2009-09-23

    Abstract: An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.

    Abstract translation: 一种管腔内导管装置,其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。 治疗剂可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置,所述可扩张构件具有分散在其中的治疗剂,并且将导管装置推进到期望的治​​疗部位。 一旦在所需的治疗部位,将流体引入充气腔,以将可膨胀构件从第一轮廓扩张到第二轮廓,并将治疗剂递送到所需的治疗部位。

    AUTOMATED EXTRACTION AND PURIFICATION OF SAMPLES USING OPTICAL TWEEZERS
    5.
    发明申请
    AUTOMATED EXTRACTION AND PURIFICATION OF SAMPLES USING OPTICAL TWEEZERS 审中-公开
    使用光学自动提取和纯化样品

    公开(公告)号:WO2006063335A3

    公开(公告)日:2009-04-16

    申请号:PCT/US2005044880

    申请日:2005-12-12

    Abstract: An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; and an output through which unselected particles of the sample are removed. At least one buffer input channel is provided. The input channel may allow sedimentation of the sample into the chamber by gravity. In another arrangement, the system includes an optical trapping system; a first channel through which the sample is introduced; a second channel through which buffer is introduced; wherein the optical tweezers are used to move selected particles of the sample from the first channel to the second channel. The selected particles may be sperm. The optical tweezers preferably utilize holographic optical trapping.

    Abstract translation: 使用自动提取和净化系统来净化法医样品的装置和方法包括光学镊子; 导入样品的输入通道; 从输入通道接收样品的室; 取出样品的所选粒子的收集通道; 以及去除样品的未选择的颗粒的输出。 提供至少一个缓冲器输入通道。 输入通道可以允许样品通过重力沉降到室中。 在另一种布置中,该系统包括光学捕获系统; 引入样品的第一通道; 引入缓冲液的第二通道; 其中所述光学镊子用于将所述样品的选定颗粒从所述第一通道移动到所述第二通道。 所选择的颗粒可能是精子。 光学镊子优选利用全息光学捕获。

    FLEXIBLE INTRALUMINAL SCAFFOLD
    6.
    发明申请
    FLEXIBLE INTRALUMINAL SCAFFOLD 审中-公开
    灵活的内窥镜SCAFFOLD

    公开(公告)号:WO2012097308A1

    公开(公告)日:2012-07-19

    申请号:PCT/US2012/021329

    申请日:2012-01-13

    Abstract: Expandable intraluminal scaffold defining a longitudinal axis is provided, wherein the scaffold includes at least two filaments (110) extending from a head portion (120) disposed along the longitudinal axis at a first longitudinal end, each of the at least two filaments including a free end portion at a second longitudinal end opposite the head portion. The at least two filaments converge toward each other at a juncture (140) disposed proximate the longitudinal axis between the first longitudinal end and the second longitudinal end. A system including a delivery system and the intraluminal scaffold, as well as a method of delivering the scaffold, is also provided.

    Abstract translation: 提供了限定纵向轴线的可扩展的管腔内支架,其中所述支架包括从在第一纵向端部处沿着所述纵向轴线设置的头部部分(120)延伸的至少两根细丝(110),所述至少两根细丝中的每一个包括自由 在与头部相对的第二纵向端部处的端部。 至少两根细丝在第一纵向端和第二纵向端之间的纵向轴线附近设置的接合部处朝向彼此会聚。 还提供了包括递送系统和管腔内支架的系统以及递送支架的方法。

    INTRALUMINAL SCAFFOLD SYSTEM AND USE THEREOF
    10.
    发明申请
    INTRALUMINAL SCAFFOLD SYSTEM AND USE THEREOF 审中-公开
    内部SCAFFOLD系统及其使用

    公开(公告)号:WO2012097311A2

    公开(公告)日:2012-07-19

    申请号:PCT/US2012/021335

    申请日:2012-01-13

    Abstract: Intraluminal scaffold assembly implantable in a body lumen of a patient to manipulate a valve of the lumen is provided. The intraluminal scaffold assembly includes an intraluminal scaffold, an elongated core member coupled with the intraluminal scaffold having a length sufficient to traverse a valve in a body lumen with the intraluminal scaffold positioned proximate the valve. The intraluminal scaffold assembly can further include one or more additional intraluminal scaffolds, a weighted element or an active element that is coupled with the elongated core member. A system including a delivery system and the intraluminal scaffold assembly, as well as methods of delivering the intraluminal scaffold assembly and using the intraluminal scaffold assembly to manipulate a valve in a body lumen, is also provided.

    Abstract translation: 提供可植入患者的体腔中以操纵管腔的瓣膜的腔内支架组件。 管腔内支架组件包括管腔内支架,与管腔内支架连接的细长芯构件,其长度足以穿过体腔内的瓣膜,腔内支架位于靠近瓣膜的位置。 管腔内支架组件还可以包括一个或多个额外的管腔内支架,加权元件或与细长芯构件联接的有源元件。 还提供了包括递送系统和管腔内支架组件的系统,以及递送管腔内支架组件和使用管腔内支架组件来操纵体腔中的瓣膜的方法。

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