公开(公告)号：WO2008132247A2

公开(公告)日：2008-11-06

申请号：PCT/EP2008/058302

申请日：2008-06-27

Applicant: RUCKSTUHL, Thomas ,  SEEGER, Stefan

Inventor： RUCKSTUHL, Thomas ,  SEEGER, Stefan

CPC classification number: G01N21/0303 ,  B01L3/5027 ,  B01L3/5082 ,  B01L3/5085 ,  B01L2300/0654 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2201/0642 ,  G02B2207/113

Abstract: Die Erfindung betrifft einen Flüssigkeitsbehälter, umfassend einen Boden und Seitenwände zum Halten einer Flüssigkeit, wobei der Boden umfasst: eine ebene Sensoroberfläche, die bei Befüllung mit der Flüssigkeit in Kontakt steht; eine Lichteintrittsfläche unterhalb der Sensoroberfläche, die geeignet ist, Licht auf die Sensoroberfläche zu fokussieren; eine Lichtaustrittsfläche; und eine Mantelfläche, die geeignet ist, Licht von der Sensoroberfläche zu reflektieren, so dass es durch die Lichtaustrittsfläche austreten kann. Weiterhin betrifft die Erfindung ein Verfahren zur qualitativen oder quantitativen Analytbestimmung in einem derartigen Flüssigkeitsbehälter wobei Anregungslicht über die Lichteintrittsfläche auf die Sensoroberfläche fokussiert wird, hierdurch ein den Analyten kennzeichnender Lumineszenzmarker angeregt wird, und dann die so entstehende Lumineszenz an der Manteloberfläche reflektiert und nach Austritt durch die Lichtaustrittsfläche detektiert wird. Die Erfindung betrifft auch eine Analysevorrichtung, umfassend eine Halterung für einen Flüssigkeitsbehälter; eine Lichtquelle, die derart angeordnet ist, dass ihr Licht über die Lichteintrittsfläche auf die Sensoroberfläche des Flüssigkeitsbehälters fokussiert werden kann; sowie einen Detektor, der derart angeordnet ist, dass er das aus der Lichtaustrittsfläche des Flüssigkeitsbehälters austretende Licht detektieren kann.

Abstract translation: 本发明涉及一种包括用于容纳液体，所述基部包括底部和侧壁的液体容器：平坦的传感器表面，其与接触所述液体填充; 传感器表面，其适于将光聚焦到所述传感器表面下方的光入射表面上; 光出射表面; 并且其适于横向表面，以反射从所述传感器表面的光，以便它可以通过光出射面出射。 此外，本发明涉及用于定性或定量测定在这样的液体容器，其中，所述激发光经由光输入表面聚焦在传感器表面上的分析物的方法，由此特性，分析物发光标记物被激发，然后反映了如此得到的覆盖表面，并通过退出后的发光 被检测光发射表面。 本发明还涉及一种包括用于液体容器的保持器的分析装置; 其被布置为使得它们的光可以聚焦通过所述光入射面的液体容器的传感器表面上的光源; 并且被布置为使得它可以检测排出的液体容器的光的光出射面的光的检测器。

公开(公告)号：WO1998005680A1

公开(公告)日：1998-02-12

申请号：PCT/EP1997004195

申请日：1997-08-01

Applicant: SEEGER, Stefan

IPC: C07K01/22

CPC classification number: C07K1/22 ,  B01D15/00

Abstract: The invention concerns a process and a device for preparing molecules. Generally, the preparation of molecules is subject to statistical variations in the number of molecules to be prepared. According to the invention, this problem is overcome in that the molecules to be prepared are applied with a high degree of dilution to a surface such that their number can be determined precisely and they can be handled in a specific manner.

Abstract translation: 本发明描述的方法和分子的制备装置。 分子通常要经过在分子的数目统计波动的制备来制备。 根据本发明，这个问题被解决在要制备的分子在一个大的稀释被施加到表面上，从而使它们的数量必须被确定，并且它们可以特异性来处理。

公开(公告)号：WO2008132247A3

公开(公告)日：2010-03-11

申请号：PCT/EP2008058302

申请日：2008-06-27

Applicant: RUCKSTUHL THOMAS ,  SEEGER STEFAN

Inventor： RUCKSTUHL THOMAS ,  SEEGER STEFAN

IPC: G01N21/03 ,  B01L3/00 ,  B01L3/14 ,  G01N21/64 ,  G01N33/551 ,  G02B19/00

CPC classification number: G01N21/0303 ,  B01L3/5027 ,  B01L3/5082 ,  B01L3/5085 ,  B01L2300/0654 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2201/0642 ,  G02B2207/113

Abstract: The invention relates to a liquid receptacle (22) comprising a bottom (1) and sidewalls for holding a liquid. The bottom (1) encompasses a flat sensor surface (3) that is in contact with the liquid when the receptacle is filled, a light-incident area (2) that is located below the sensor surface (3) and is suitable for focusing light (13) onto the sensor surface (3), a light emergence area (5), and a cover area (4) that is suitable for reflecting light from the sensor surface (3) such that the light can emerge through the light emergence area (5). The invention further relates to a method for qualitatively or quantitatively determining an analyte in such a liquid receptacle (22). In said method, excitation light (13) is focused onto the sensor surface (3) via the light-incident area (2) such that a luminescent marker which characterizes the analyte is excited, and the generated luminescence is then reflected onto the cover surface (4) and is detected after emerging through the light emergence area (5). The invention also relates to an analysis device comprising a holder for a liquid receptacle, a light source (10) that is disposed such that the light (13) thereof can be focused onto the sensor surface (3) of the liquid receptacle (22) via the light-incident area (2), and a detector (17) which is arranged in such a way as to be able to detect the light (9) emerging from the light emergence area (5) of the liquid receptacle (22).

Abstract translation: 本发明涉及一种液体容器（22）包括一个底部（1）和侧壁用于容纳液体，所述基座（1），包括：平坦的传感器表面（3），其与接触所述液体填充; 光入射面（2）的传感器表面（3）所示的适合于将光聚焦（13）的传感器表面（3）上; 光出射表面（5）; 因此，它可以退出和外侧表面（4），其适于通过所述光出射面以反射来自所述传感器表面（3）的光（5）。 此外，本发明涉及用于定性或定量测定分析物的方法，在这样一个液体容器（22）的激发光（13）聚焦在传感器表面（3）上的光入射面（2）上，从而特性的分析物发光标记物被激发，然后将 被反射地幔表面（4），从而产生的发光和新兴通过光出射面（5）之后检测到。 本发明还涉及一种包括用于液体容器的保持器的分析装置; 一个光源（10），其被布置成使得它的光（13）在所述光入射面（2）的传感器表面（3）上的液体容器（22）的可聚焦， - 和一个检测器（17），它是设置 它可以从液体容器的出射表面（5）检测所述光（22）射出的光（9）。

公开(公告)号：WO2008132247A8

公开(公告)日：2010-01-07

申请号：PCT/EP2008058302

申请日：2008-06-27

Applicant: RUCKSTUHL THOMAS ,  SEEGER STEFAN

Inventor： RUCKSTUHL THOMAS ,  SEEGER STEFAN

CPC classification number: G01N21/0303 ,  B01L3/5027 ,  B01L3/5082 ,  B01L3/5085 ,  B01L2300/0654 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2201/0642 ,  G02B2207/113

Abstract: The invention relates to a liquid receptacle comprising a bottom and sidewalls for holding a liquid. The bottom encompasses a flat sensor surface that is in contact with the liquid when the receptacle is filled, a light-incident area that is located below the sensor surface and is suitable for focusing light onto the sensor surface, a light emergence area, and a cover area that is suitable for reflecting light from the sensor surface such that the light can emerge through the light emergence area. The invention further relates to a method for qualitatively or quantitatively determining an analyte in such a liquid receptacle. In said method, excitation light is focused onto the sensor surface via the light-incident area such that a luminescent marker which characterizes the analyte is excited, and the generated luminescence is then reflected onto the cover surface and is detected after emerging through the light emergence area. The invention also relates to an analysis device comprising a holder for a liquid receptacle, a light source that is disposed such that the light thereof can be focused onto the sensor surface of the liquid receptacle via the light-incident area, and a detector which is arranged in such a way as to be able to detect the light emerging from the light emergence area of the liquid receptacle.

Abstract translation: 本发明涉及一种包括用于容纳液体，所述基部包括底部和侧壁的液体容器：平坦的传感器表面，其与接触所述液体填充; 传感器表面，其适于将光聚焦到所述传感器表面下方的光入射表面上; 光出射表面; 并且其适于横向表面，以反射从所述传感器表面的光，以便它可以通过光出射面出射。 此外，本发明涉及用于定性或定量测定在这样的液体容器，其中，所述激发光经由光输入表面聚焦在传感器表面上的分析物的方法，由此特性，分析物发光标记物被激发，然后反映了如此得到的覆盖表面，并通过退出后的发光 被检测光发射表面。 本发明还涉及一种包括用于液体容器的保持器的分析装置; 其被布置为使得它们的光可以聚焦通过所述光入射面的液体容器的传感器表面上的光源; 并且被布置为使得它可以检测排出的液体容器的光的光出射面的光的检测器。

公开(公告)号：WO2004113456A2

公开(公告)日：2004-12-29

申请号：PCT/CH2004/000383

申请日：2004-06-23

Applicant: UNIVERSITY OF ZURICH ,  ZIMMERMANN, Jan ,  SEEGER, Stefan ,  ARTUS, Georg ,  JUNG, Stefan

Inventor： ZIMMERMANN, Jan ,  SEEGER, Stefan ,  ARTUS, Georg ,  JUNG, Stefan

IPC: C09D4/00

CPC classification number: C09D4/00 ,  Y10T428/2438 ,  Y10T428/24421 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/2924 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2962 ,  Y10T428/2964 ,  Y10T428/31612 ,  Y10T428/31663 ,  Y10T442/218 ,  C08G77/04

Abstract: A composition for coating comprising at least one compound of formula (I): R a Si(R 1 ) n (X 1 ) 3-n , and optionally at least one compound of formula (II): R b Si(R 2 ) m (X 2 ) 3-m , wherein R a is a straight-chain or branched C (1-24) alkyl group, R b is an aromatic group, such as an optionally substituted carbocyclic and heterocyclic group comprising five-, six- or ten-membered ring systems, which is linked by a single covalent bond or a spacer unit, such as a straight-chain or branched alkyl residue having 1 to 8 carbon atoms, to the Si- atom, R 1 and R 2 are independently of each other a lower alkyl group, such as a straight chain and branched hydrocarbon radical having 1 to 6 carbon atoms, X 1 and X 2 are independently of each other a hydrolysable group, such as a halogen or an alkoxy group and n, m are independently of each other 0 or 1, with the proviso that if n and m are independently of each other 0 or 1, X may represent the same or different groups.

Abstract translation: 包含至少一种式（I）化合物：R a Si（R 1）n（X 1）3-n和任选至少一种式（II）的化合物的涂料组合物：R Si（R 2）m（X 2）3-m，其中R a是直链或支链C（1-24）烷基，R b是芳基 ，例如通过单个共价键或间隔单元连接的任选取代的碳环和杂环基，其包含五，六或十元环系，例如具有1至8个直链或支链烷基的直链或支链烷基 碳原子相对于Si原子，R 1和R 2彼此独立地是低级烷基，例如具有1至6个碳原子的直链和支链烃基，X 1和X <2>彼此独立地是可水解基团，例如卤素或烷氧基，n，m彼此独立地为0或1，条件是如果n和m彼此独立地为0或1， X可以表示相同或不同的组。

公开(公告)号：WO1995008770A1

公开(公告)日：1995-03-30

申请号：PCT/EP1994003137

申请日：1994-09-20

Applicant: SEEGER, Stefan ,  HARTMANN, Andreas

IPC: G01N33/543

CPC classification number: C12N11/06 ,  G01N33/54353 ,  G01N33/54393

Abstract: A process is disclosed that uses the Langmuir-Blodgett technique to produce ultra-thin monolayers that contain receptor or biological molecules. Cross-linkable, non-amphiphilic matrix molecules are used, with which receptor and/or biological molecules are intercalated or covalently coupled. A new process, a modified Lemieux reaction, is disclosed for that purpose.

Abstract translation: 现在叙述其使用朗缪尔 - 布罗杰特技术生产超薄单层含有受体分子或生物分子的方法。 此处可交联的非两亲性基质分子的使用，可以存储在所述受体分子和/或生物分子，或它们被共价偶联到基质分子。 为了这个目的，一种新颖的方法，改性勒米厄反应说明。

公开(公告)号：WO0075657A3

公开(公告)日：2001-09-27

申请号：PCT/EP0004948

申请日：2000-05-30

Applicant: MOLECULAR MACHINES & IND GMBH ,  ANSELL RICHARD ,  SEEGER STEFAN

Inventor： ANSELL RICHARD ,  SEEGER STEFAN

IPC: G01N21/64 ,  C40B30/04 ,  G01N33/52 ,  G01N33/566 ,  G01N33/68

CPC classification number: C40B30/04 ,  G01N33/52 ,  G01N33/6845 ,  G01N2500/20

Abstract: The invention relates to a method for screening target-ligand interactions while using a chemical library of ligands, to the chemical library of ligands as such, to a method for producing the chemical library, as well as to the use of the chemical library for developing active agents and for developing molecular sensors. The screening method comprises the following steps: (a) measuring at least one fluorescence property of a locally addressable chemical library of ligands that is immobilized on a solid phase, whereby a molecular fluorescence sensor is bound to each ligand; (b) adding the target, and; (c) measuring the same fluorescence property/properties of the chemical library as described in step (a). The locally addressable chemical library of ligands that is immobilized on a solid phase is characterized in that each ligand is bound to a molecular fluorescence sensor in a preferable manner in which the molecular fluorescence sensor is bound between the ligand and the solid phase and/or to the end of the ligand situated opposite the solid phase.

Abstract translation: 本发明涉及一种方法，用于筛选使用的配体的化学文库的配体作为这样的化学文库靶 - 配体相互作用，用于制备化学文库和用于药物发现中的用途的化学库的和分子的传感器的发展过程 ， 该筛选方法包括以下步骤：（a）测量的固定化在固相上的至少一个荧光特性，ortsadressierbaren配体其中，在每个配位体的分子荧光传感器附着的化学文库，（b）加入的目标，以及（c）测量所述 如在步骤中描述的化学文库的相同的荧光特性（一个或多个）（a）中。 固定化在固相上，ortsadressierbare配体的化学文库，其特征在于每个配体结合到一个分子荧光传感器，优选地使得所述配体和固相和/或分子之间的荧光传感器结合到所述固相上的相对的配体的端 是。

公开(公告)号：WO2010057523A1

公开(公告)日：2010-05-27

申请号：PCT/EP2008/065776

申请日：2008-11-18

Applicant: PIRELLI TYRE S.P.A. ,  MUEHLHAUSE, Christof ,  MEURET, Jochen ,  MICHEL, Thomas ,  SEEGER, Stefan ,  MUHN, Roland

Inventor： MUEHLHAUSE, Christof ,  MEURET, Jochen ,  MICHEL, Thomas ,  SEEGER, Stefan ,  MUHN, Roland

IPC: B60C15/06 ,  B60C17/00

CPC classification number: B60C17/0036 ,  B60C1/00 ,  B60C9/0007 ,  B60C9/02 ,  B60C9/18 ,  B60C11/00 ,  B60C13/00 ,  B60C15/0027 ,  B60C15/0036 ,  B60C15/0045 ,  B60C15/0603 ,  B60C17/0009 ,  B60C2001/005 ,  B60C2015/061 ,  B60C2015/0614 ,  B60C2015/0639

Abstract: A pneumatic vehicle tire comprises a carcass (11) extending between two bead cores (15). A belt structure (18) is provided between the carcass (11) and a tread strip (19) which is connected with a pair of sidewalls (20). A runflat reinforcement (17) is arranged at the inner side of each sidewall (20). A reinforcer (13) is arranged within each bead portion of the tire. A bead filler (14) extends from the bead ring (15) along the reinforcer (13). To improve the runflat performance, handling and comfort properties of such a runflat tire the reinforcer (13) is arranged at the inner side of the bead filler (14). The reinforcer (13) comprises metal cords. The bead filler (14) which extends beyond an end (13a) of the reinforcer (13) is made of a soft rubber compound with an IHRD hardness lower than (80), e.g. between (75) and (79).

Abstract translation: 气动车辆轮胎包括在两个胎圈芯（15）之间延伸的胎体（11）。 带状结构（18）设置在胎体（11）和与一对侧壁（20）连接的胎面条（19）之间。 在每个侧壁（20）的内侧设有漏气补强筋（17）。 在轮胎的每个胎圈部分内布置有加强件（13）。 珠填料（14）沿着加强件（13）从胎圈环（15）延伸。 为了改善这种漏气保用轮胎的漏气保护性能，处理和舒适性，加强件（13）布置在胎圈填料（14）的内侧。 加强件（13）包括金属帘线。 延伸超过加强件（13）的端部（13a）的胎圈填料（14）由IHRD硬度低于（80）的软橡胶化合物制成，例如， （75）和（79）之间。

公开(公告)号：WO2004113456A3

公开(公告)日：2004-12-29

申请号：PCT/CH2004/000383

申请日：2004-06-23

Applicant: UNIVERSITY OF ZURICH ,  ZIMMERMANN, Jan ,  SEEGER, Stefan ,  ARTUS, Georg ,  JUNG, Stefan

Inventor： ZIMMERMANN, Jan ,  SEEGER, Stefan ,  ARTUS, Georg ,  JUNG, Stefan

IPC: C09D4/00

Abstract: A composition for coating comprising at least one compound of formula (I): R a Si(R 1 ) n (X 1 ) 3-n , and optionally at least one compound of formula (II): R b Si(R 2 ) m (X 2 ) 3-m , wherein R a is a straight-chain or branched C (1-24) alkyl group, R b is an aromatic group, such as an optionally substituted carbocyclic and heterocyclic group comprising five-, six- or ten-membered ring systems, which is linked by a single covalent bond or a spacer unit, such as a straight-chain or branched alkyl residue having 1 to 8 carbon atoms, to the Si- atom, R 1 and R 2 are independently of each other a lower alkyl group, such as a straight chain and branched hydrocarbon radical having 1 to 6 carbon atoms, X 1 and X 2 are independently of each other a hydrolysable group, such as a halogen or an alkoxy group and n, m are independently of each other 0 or 1, with the proviso that if n and m are independently of each other 0 or 1, X may represent the same or different groups.