公开(公告)号：WO2015024111A1

公开(公告)日：2015-02-26

申请号：PCT/CA2014050728

申请日：2014-08-01

Applicant: UNIV LAVAL

Inventor： POIRIER DONALD ,  MALTAIS RENÉ

IPC: C07D405/14 ,  A61K31/472 ,  A61K31/4725 ,  A61P5/00 ,  A61P5/30 ,  A61P5/32 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/14

CPC classification number: C07D409/14 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D217/04 ,  C07D217/06 ,  C07D217/08 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14

Abstract: Provided are compounds of general formula A and A', wherein X1 and X2 are each C, CH or N; R3 and R4 are each H, optionally substituted C1-C30 saturated or unsaturated chemical group, or together form an optionally substituted C5-C8 cycle; Z1; Z2 and Z3 are each N or CH; V is C=0, C=S or CH2; n is from 1 to 12; W1 and W2 are each H, CH2, O or S; and R1 and R2 are each H, Cr1C6 alkyl, C1C6 aryl, C1C12 alkylaryl, optionally substituted phenyl, C1C6 alkoxy, C1C6 thioalkoxy, F, CI, Br or I. These compounds inhibit steroid sulfatase (STS), act as selective estrogen receptor modulators (SERMs), increase alkaline phosphatase (ALP) activity, and are useful in the treatment of medical conditions involving hormones such as breast cancer, prostate cancer, endometriosis, osteoporosis, benign prostatic hyperplasia and endometrial cancer.

Abstract translation: 提供通式A和A'的化合物，其中X 1和X 2各自为C，CH或N; R 3和R 4各自为H，任选取代的C 1 -C 30饱和或不饱和化学基团，或一起形成任选取代的C 5 -C 8周期; Z1; Z2和Z3各自为N或CH; V为C = O，C = S或CH 2; n为1〜12; W1和W2分别为H，CH2，O或S; 并且R 1和R 2各自为H，C 1 -C 6烷基，C 1 -C 6芳基，C 1 -C 12烷基芳基，任选取代的苯基，C 1 -C 6烷氧基，C 1 -C 6硫代烷氧基，F，Cl，Br或I.这些化合物抑制类固醇硫酸酯酶（STS），作为选择性雌激素受体调节剂 （SERMs），增加碱性磷酸酶（ALP）活性，并且可用于治疗涉及激素如乳腺癌，前列腺癌，子宫内膜异位，骨质疏松症，良性前列腺增生和子宫内膜癌的医学病症。

公开(公告)号：WO2004106544A3

公开(公告)日：2005-04-21

申请号：PCT/CA2004000824

申请日：2004-06-03

Applicant: INFECTIO DIAGNOSTIC INC ,  UNIV LAVAL ,  LECLERC MARIO ,  HO HOANG-ANH ,  BOISSINOT MAURICE

Inventor： LECLERC MARIO ,  HO HOANG-ANH ,  BOISSINOT MAURICE

IPC: C12Q1/68 ,  C07D333/32 ,  C12N15/11

CPC classification number: C12Q1/6876 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q2563/173 ,  C12Q2563/107 ,  C12Q2537/101 ,  C12Q2525/205

Abstract: An optical sensor for detecting a target comprising a singlestranded aptamer complementary to said target, and a water-soluble cationic polythiophene derivative of the following formula (I) wherein "n" is an integer ranging from 6 to 100, is disclosed. The optical sensor allows for the detection of targets selected from the group consisting of potassium ions, small organic molecules, amino acids, proteins, whole cells and nucleotides. The detection is based on the formation of hybrid anionic aptamer/cationic polythiophene complexes.

Abstract translation: 一种用于检测包含与所述靶互补的单链适配体的靶的光学传感器和下式（I）的水溶性阳离子聚噻吩衍生物，其中“n”为6至100的整数。 光学传感器允许检测从由钾离子，小有机分子，氨基酸，蛋白质，全细胞和核苷酸组成的组中选择的靶标。 检测是基于杂交阴性适体/阳离子聚噻吩复合物的形成。

公开(公告)号：WO03043769A2

公开(公告)日：2003-05-30

申请号：PCT/CA0201787

申请日：2002-11-19

Applicant: UNIV LAVAL ,  CURODEAU ALAIN ,  GUIDOIN MARIE-FRANCE

Inventor： CURODEAU ALAIN ,  GUIDOIN MARIE-FRANCE

IPC: B23H1/04 ,  B23H1/06 ,  B23H1/08 ,  C04B35/52 ,  B23H

CPC classification number: B23H1/04 ,  B23H1/06 ,  B23H1/08 ,  B82Y30/00

Abstract: A method for electric discharge machining (EDM) with a ductile carbonaceous electrode, to automate roughing, finishing, polishing and texturing operations on a electrically conductive material. The EDM method comprises using a ductile electrically conductive electrode made of carbon-polymer composite material. Prior to electric discharge machining, the electrode is made by heating uniformly a prescribed volume of said ductile electrode material, at a temperature close to the melting point temperature of the polymer matrix. The composite material is then molded into the desired electrode shape by pressing the soft material against a template, a mold model, a replicate of the workpiece or part of the workpiece. The formed electrode is then used to machine the desired shape and surface finish on the said workpiece using proper electric discharge machining techniques. When the dimensions and surface of the electrode are altered by wear, the same electrode can be rectified quickly and repetitively, by following the initial procedure of softening and pressing until the workpiece is complete.

Abstract translation: 一种用延展性碳质电极进行放电加工（EDM）的方法，以使导电材料上的粗加工，精加工，抛光和纹理化操作自动化。 EDM方法包括使用由碳 - 聚合物复合材料制成的延性导电电极。 在放电加工之前，电极通过在接近聚合物基体的熔点温度的温度下均匀加热规定体积的所述可延展电极材料而制成。 然后通过将软材料压向模板，模具模型，工件或部分工件的复制品，将复合材料模制成期望的电极形状。 然后使用合适的放电加工技术，将形成的电极用于在所述工件上加工所需的形状和表面光洁度。 当电极的尺寸和表面由于磨损而改变时，通过遵循软化和压制的初始程序直到工件完成，可以快速且重复地对同一电极进行矫正。

公开(公告)号：WO03012076A3

公开(公告)日：2003-05-30

申请号：PCT/CA0201216

申请日：2002-08-02

Applicant: UNIV LAVAL ,  TREMBLAY JACQUES P

Inventor： TREMBLAY JACQUES P

IPC: C12N5/077 ,  C12N5/00 ,  A61K35/34 ,  C12N5/06

CPC classification number: C12N5/0658 ,  C12N2500/32 ,  C12N2501/115

Abstract: The present invention relates to a novel culture medium composition to improve the percentage of myoblasts in a primary culture made from a muscle biopsy, which in turn permits a more successful treatment of myopathies and cardiopathies. The present invention also relates to a method to increase the preparation of myoblasts in a primary culture of mixed cells and in particular from a muscle biopsy. The invention also relates to such enriched myoblast cultures to treat myopathies and cardiopathies. In addition, the invention relates to a nutrient medium which increases the proportion of myoblasts with respect to other cell types. The present invention also relates to a myoblast basal growth medium comprising all nutrients required for growth and expansion of myoblasts wherein at least a portion of the amino acid L-valine is replaced with D-valine.

Abstract translation: 本发明涉及一种新的培养基组合物，用于提高由肌肉活组织检查制成的原代培养物中成肌细胞的百分比，进而允许更成功地治疗肌病和心脏病。 本发明还涉及增加混合细胞的原代培养物中，特别是肌肉活组织检查中制备成肌细胞的方法。 本发明还涉及这种富含成肌细胞培养物以治疗肌病和心脏病。 此外，本发明涉及增加成肌细胞相对于其他细胞类型的比例的营养培养基。 本发明还涉及包含成肌细胞生长和扩增所需的全部营养素的成肌细胞基础生长培养基，其中至少一部分氨基酸L-缬氨酸被D-缬氨酸替代。

公开(公告)号：WO0220729A3

公开(公告)日：2002-10-03

申请号：PCT/CA0101276

申请日：2001-09-05

Applicant: UNIV LAVAL ,  GERMAIN LUCIE ,  AUGER FRANCOIS A ,  ROCHON MARIE-HELENE ,  BLACK ANNIE F

Inventor： GERMAIN LUCIE ,  AUGER FRANCOIS A ,  ROCHON MARIE-HELENE ,  BLACK ANNIE F

IPC: A61L27/38 ,  C12N5/071 ,  C12N5/08 ,  G01N33/50

CPC classification number: A61L27/3813 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/3804 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2502/28 ,  C12N2502/30 ,  C12N2503/04 ,  C12N2503/06

Abstract: The present invention relates to a tridimensional living tissue construct free of exogenous extracellular matrix material, and in which angiogenesis occurs. Network of capillaries formed into the living tissue construct allows to provide blood vessels for replacement or repair in human and animals, and is also useful in screening compounds or agents potentially having capability of modulating the angiogenesis in vitro or in vivo .

Abstract translation: 本发明涉及不含外源细胞外基质材料的三维生物体组织结构，其中发生血管生成。 形成活组织结构的毛细管网络允许提供血管用于人和动物的置换或修复，并且还可用于筛选潜在地具有调节体外或体内血管发生能力的化合物或试剂。

公开(公告)号：WO0159521A3

公开(公告)日：2002-03-14

申请号：PCT/CA0100163

申请日：2001-02-14

Applicant: UNIV LAVAL

Inventor： GALSTIAN TIGRAN ,  TORK AMIR

IPC: G03F7/00 ,  G03F7/032 ,  G03H1/02 ,  C09K19/54 ,  G02B5/32 ,  G03F7/031

CPC classification number: G03F7/001 ,  G03F7/032 ,  G03H1/02 ,  G03H2260/12 ,  G03H2260/33 ,  G03H2270/53

Abstract: The invention is concerned with a photopolymerizable composition sensitive to light in a green to infrared region of the optical spectrum, comprising (a) a photopolymerizable monomer or oligomer, or a mixture thereof, capable of forming a polymer having predetermined optical properties; (b) a photoinitiator sensitive to light in the aforesaid region; (c) an additive for increasing the refractive index and decreasing the viscosity of the composition; and (d) a filler having optical properties selected to contrast with the optical properties of the polymer. The composition of the invention is particularly useful for producing holographic polymer dispersed liquid crystal materials and reversible dye doped polymer materials having improved electrical and optical switching characteristics.

Abstract translation: 本发明涉及一种对光谱的绿色至红外区域中的光敏感的可光聚合组合物，其包含（a）能够形成具有预定光学性质的聚合物的可光聚合单体或低聚物或其混合物; （b）在上述区域中对光敏感的光引发剂; （c）用于提高折射率并降低组合物粘度的添加剂; 和（d）具有选择的光学性质以与聚合物的光学性质形成对比的填料。 本发明的组合物对于制造全息聚合物分散液晶材料和具有改进的电学和光学开关特性的可逆染料掺杂聚合物材料特别有用。

公开(公告)号：WO2012040834A1

公开(公告)日：2012-04-05

申请号：PCT/CA2011001107

申请日：2011-09-30

Applicant: UNIV LAVAL ,  DUMAS GUY ,  KINSEY THOMAS ,  LEMAY JEAN ,  JEAN YVES ,  PLOURDE-CAMPAGNA MARC-ANDRE ,  LALANDE GUILLAUME

Inventor： DUMAS GUY ,  KINSEY THOMAS ,  LEMAY JEAN ,  JEAN YVES ,  PLOURDE-CAMPAGNA MARC-ANDRE ,  LALANDE GUILLAUME

IPC: F03B17/06 ,  F01D23/00 ,  F03B13/12 ,  F03D5/06

CPC classification number: F01D7/00 ,  F01D17/06 ,  F05D2250/184 ,  F05D2250/42 ,  Y02E10/28

Abstract: System and method for converting kinetic energy from a fluid flow into mechanical energy, the method comprising the steps of: a) providing a turbine including first and second hydrofoils, each of the hydrofoils being able to move linearly in a heaving motion, and being able to oscillate about a spanwise axis in a pitching motion, said heaving and pitching motions being quasi-sinusoidal, b) coupling the heaving motions of the first and second hydrofoils to the pitching motions of the second and first hydrofoils respectively, with the pitch-heave motion phase being substantially equal to the inter-hydrofoil phase, the heaving motion of one of the hydrofoils thereby driving the pitching motion of the other hydrofoil; and c) transforming the heaving motions of the hydrofoils into a rotational movement of a rotatable shaft, with linear-to-rotary transmission means.

Abstract translation: 用于将动能从流体流转换成机械能的系统和方法，所述方法包括以下步骤：a）提供包括第一和第二水翼的涡轮机，每个水翼能够以沉降运动线性移动，并且能够 以俯仰运动绕翼展轴线摆动，所述起伏和俯仰运动是准正弦波，b）分别将第一和第二水翼的起伏运动与第二和第一水翼的俯仰运动耦合， 运动相位基本上等于水翼相位，其中一个水翼从而驱动另一个水翼的俯仰运动; 以及c）利用线性到旋转传动装置将水翼的沉降运动变换成可旋转轴的旋转运动。

公开(公告)号：WO2009009900A8

公开(公告)日：2009-09-24

申请号：PCT/CA2008001315

申请日：2008-07-17

Applicant: UNIV LAVAL ,  BERGERON MICHEL G ,  FRENETTE JOHANNE ,  BOISSINOT MAURICE ,  LEBLANC ERIC ,  BOIVIN GUY ,  DIONNE NATASHA

Inventor： BERGERON MICHEL G ,  FRENETTE JOHANNE ,  BOISSINOT MAURICE ,  LEBLANC ERIC ,  BOIVIN GUY ,  DIONNE NATASHA

IPC: C07H21/04 ,  C07H21/00 ,  C12N15/41 ,  C12N15/44 ,  C12N15/45 ,  C12N15/50 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/70 ,  C40B40/06

CPC classification number: C40B40/06 ,  C07B2200/11 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2760/16122 ,  C12N2760/16222 ,  C12N2760/18322 ,  C12N2760/18522 ,  C12N2760/18622 ,  C12N2760/18722 ,  C12N2770/20022 ,  C12N2770/32322 ,  C12N2770/32722 ,  C12Q1/701 ,  C40B30/04

Abstract: The present invention relates to methods of detection, as well as assays, reagents and kits for the specific detection of 15 clinically important respiratory viruses including influenza A and B viruses, human respiratory syncytial viruses, human metapneumoviruses, human enteroviruses, all serotypes of rhinoviruses, 7 serotypes of adenoviruses, parainfluenza viruses types 1, 2, 3, and 4, as well as coronaviruses NL, 229E, OC43, and SARS-CoV. The present invention allows for the detection of each of these respiratory viruses in a single assay.

Abstract translation: 本发明涉及检测方法，以及用于特异性检测15种临床重要呼吸道病毒（包括甲型和乙型流感病毒），人呼吸道合胞病毒，人类偏肺病毒，人肠道病毒，所有鼻病毒血清型的试剂和试剂盒， 7型血清型腺病毒，副流感病毒1,2,3型和4型，以及冠状病毒NL，229E，OC43和SARS-CoV。 本发明允许在单次测定中检测这些呼吸道病毒中的每一种。

公开(公告)号：WO2005110490A8

公开(公告)日：2007-02-08

申请号：PCT/CA2005000738

申请日：2005-05-13

Applicant: UNIV LAVAL ,  COULL JEFFREY A M ,  DE KONINCK YVES

Inventor： COULL JEFFREY A M ,  DE KONINCK YVES

IPC: A61K48/00 ,  A61K31/132 ,  A61K31/265 ,  A61K31/4015 ,  A61K31/661 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/7105 ,  A61K39/395 ,  A61P25/02 ,  A61P29/02 ,  C07K16/40 ,  C12N15/113 ,  C12Q1/02 ,  C12Q1/44 ,  G01N33/50

CPC classification number: C12N15/1137 ,  A61K31/132 ,  A61K31/265 ,  A61K31/4015 ,  A61K31/661 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/7105 ,  A61K2039/505 ,  C07K16/40 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q1/44 ,  C12Y301/04003 ,  G01N33/5023 ,  G01N2333/916 ,  G01N2500/04

Abstract: The present invention provides methods of preventing and treating pain, by modulating, e.g. inhibiting, the activity, function and/or expression of a PLC ? in a subject. The invention further relates to methods of identifying agents capable of modulating the activity and/or expression of a PLC ? , or capable of modulating binding of a ligand or binding partner to a PLC ? , and their use thereof for the prevention and/or treatment of pain. In a further aspect, the invention provides methods for the diagnosis and prognostication of pain by determining whether there is modulation of activity and/or expression of a PLC ? , relative to a corresponding control.

Abstract translation: 本发明提供了预防和治疗疼痛的方法。 抑制，受试者中的PLC的活性，功能和/或表达。 本发明还涉及鉴定能够调节PLC的活性和/或表达或能够调节配体或结合配偶体与PLC结合的试剂的方法 以及它们用于预防和/或治疗疼痛的用途。 在另一方面，本发明提供了通过确定相对于相应对照是否存在对PLC的活性和/或表达的调节来诊断和预测疼痛的方法。

公开(公告)号：WO03043149B1

公开(公告)日：2003-09-12

申请号：PCT/CA0201751

申请日：2002-11-15

Applicant: UNIV LAVAL ,  DUGUAY MICHEL A ,  LAROCHELLE SOPHIE ,  GRONDIN ETIENNE ,  DELTEL GEOFFROY

Inventor： DUGUAY MICHEL A ,  LAROCHELLE SOPHIE ,  GRONDIN ETIENNE ,  DELTEL GEOFFROY

IPC: H01S3/067 ,  H01S3/098 ,  H01S5/065 ,  H01S5/10 ,  H01S5/14 ,  H01S5/50

CPC classification number: H01S5/146 ,  H01S3/0675 ,  H01S3/06791 ,  H01S3/08086 ,  H01S3/10046 ,  H01S3/107 ,  H01S3/1109 ,  H01S5/0657

Abstract: A laser cavity for generating a train of laser pulses at a selected wavelength comprises a gain medium (100); an input pulse generator for gating on an effective gain of the cavity, the generator generating pairs of pulses with a time tsel between the pulses and a time T between the pairs of pulses; a first and a second set of distributed wavelength selective reflectors (101,102) on each side of the gain medium (100), each of the reflections being spaced apart in time; the second (102) set being paired with the first set (101) wherein the pairing ensures that a total cavity round-trip delay of T is equal for all wavelengths; a delay modifier for adjusting the time tsel between the pulses and selecting a wavelength; and an output; whereby the output repetition rate of the train of laser pulses can be equal for all wavelengths reflected by the first and second sets.

Abstract translation: 用于产生选定波长的激光脉冲序列的激光腔包括增益介质（100）; 输入脉冲发生器，用于门控空腔的有效增益，发生器产生脉冲对之间的时间tsel和脉冲对之间的时间T; 在增益介质（100）的每一侧上的第一和第二组分布式波长选择反射器（101,102），每个反射在时间上间隔开; 所述第二组（102）与所述第一组（101）配对，其中所述配对确保T的总谐振往返延迟对所有波长相等; 延迟修改器，用于调整脉冲之间的时间tsel并选择波长; 和输出; 由此对于由第一组和第二组反射的所有波长，激光脉冲串的输出重复率可以相等。