Abstract:
The present invention relates to the field of (bio-)medicine, and more particularly to the treatment of copper-related diseases. Novel means and methods for depleting (excess) copper from organs and/or the circulation are provided. Agents with a high copper binding affinity and stabilized forms thereof are provided, as well as a novel treatment regimen. The means and methods of the present invention are particularly useful for treatment of Wilson Disease, but also for treatment of other conditions.
Abstract:
The interaction between multiple intense ultrashort laser pulses and solids typically produces a regular nanoscale surface corrugation. A coupled mechanism has been identified that operates in a specific range of fluences in GaAs that exhibits transient loss of the imaginary part of the dielectric function and X2, which produces a unique corrugation known as high spatial frequency laser induced periodic surface structures (HSFL). This mechanism is unique in that the corrugation does not involve melting or ablation.
Abstract:
Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical actives and new chemical entities, are provided. The organic compound may be present at ≥ about 99 mass % in the one or more discrete regions and may be crystalline or amorphous. The deposited organic compound may be deposited as a film having high surface area. The deposited organic compound exhibits enhanced solubility and bioavailability, by way of non-limiting example. Methods of organic vapor jet printing deposition method of such a low molecular weight organic compound in an inert gas stream are also provided.
Abstract:
An interactive projection system for outputting illuminated indicia upon a projection surface. A detection system is operable to detect both stationary and movable features. A control system is operable to determine the position of the stationary and movable features. A reflective device reflects light from a light source (natural and/or artificial) upon the projection surface as the illuminated indicia. A drive system moves the reflective device, thereby moving the illuminated indicia across the projection surface in response to control system thereby simulating the stationary feature on the projection surface as a physical boundary to the illuminated indicia and simulating the movable feature contacting the illuminated indicia.
Abstract:
The present invention is directed to claudin-1 -specific peptide reagents, methods for detecting pre-cancer (dysplasia), early cancer and/or cancer using the peptide reagents, and methods for targeting pre-cancerous (dysplastic) cells, and/or cancer cells using the peptide reagents.
Abstract:
Techniques are presented for fabricating transducers and other types of microstructures having high aspect ratios. To achieve high aspect ratios, wafers are etched from both sides for example using deep reactive ion etching. The three-dimensional structure is designed to have an overall footprint less than four hundred micrometers with a thickness on the order of 0.5-2 millimeters as compared to conventional planar devices.
Abstract:
Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
Abstract:
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.
Abstract:
A method of closing a urogenital hiatus in which a pubovisceral muscle (PVM) is damaged, and an implant for use in the method are disclosed. The implant includes two suspension arms that are generally flexible in bending but stiff in tension and form muscle-equivalent tensile load-bearing elements. An upper end of each suspension arm can be affixed on or near the pubic bone or rectus fascia near the origins of the PVM. A lower end of each suspension arm is configured to be operatively coupled to and/or support the perineal body so as to support the perineal body from the rectus fascia or pubic bone and close the urogenital hiatus. The lower ends of the suspensions arms can be directly secured to the perineal body, or the lower ends of the suspension arms may be connected to a support hammock that directly supports the perineal body.
Abstract:
There is disclosed a method of preparing a photovoltaic device. In particular, the method comprises integrating epitaxial lift-off solar cells with mini-parabolic concentrator arrays via a printing method. Thus, there is disclosed a method comprising providing a growth substrate; depositing at least one protection layer on the growth substrate; depositing at least one sacrificial layer on the protection layer; depositing at least one photoactive cell on the sacrificial layer; etching a pattern of at least two parallel trenches that extend from the at least one photoactive cell to the sacrificial layer; depositing a metal on the at least one photoactive cell; bonding said metal to a host substrate; and removing the sacrificial layer with one or more etch steps. The host substrate can be a siloxane, which when rolled, can form a stamp used to integrate solar cells into concentrator arrays. There are also disclosed a method of making a growth substrate and the growth substrate made therefrom.