公开(公告)号：WO2007066206A1

公开(公告)日：2007-06-14

申请号：PCT/IB2006/003489

申请日：2006-12-06

Applicant: ATHELAS SA ,  BENGHEZAL, Mohammed ,  ADAM, Eric ,  BRAILLARD, Stephanie ,  BURN, Christine ,  LUCAS, Aurore ,  PACCAUD, Jean-Pierre ,  VALENTINO, Emilio ,  COSSON, Pierre

Inventor： BENGHEZAL, Mohammed ,  ADAM, Eric ,  BRAILLARD, Stephanie ,  BURN, Christine ,  LUCAS, Aurore ,  PACCAUD, Jean-Pierre ,  VALENTINO, Emilio ,  COSSON, Pierre

IPC: C12Q1/18

CPC classification number: C12Q1/18 ,  C12Q1/04 ,  G01N2333/44

Abstract: The present invention relates to a method for identifying and/or quantifying an anti-infective compound. Furthermore it relates to a method for identifying and/or quantifying a mutation in a virulence factor of a pathogen of a host organism that reduces the virulence of the pathogen to a unicellular test organism.

Abstract translation: 本发明涉及用于鉴定和/或定量抗感染化合物的方法。 此外，它涉及用于鉴定和/或定量宿主生物体病原体的毒力因子中的突变的方法，其将病原体的毒力降低到单细胞测试生物。

公开(公告)号：WO2008017840A1

公开(公告)日：2008-02-14

申请号：PCT/GB2007/003017

申请日：2007-08-08

Applicant: MERLION PHARMACEUTICALS SA ,  MERLION PHARMACEUTICALS PTE LTD ,  ORCHARD, Michael Glen ,  BENGHEZAL, Mohammed ,  BRAILLARD, Stéphanie ,  BURN, Christine ,  DEUSCHEL, Christine ,  LUCAS, Aurore ,  VALENTINO, Emilio ,  JANSSEN, Christian ,  BOYCE, Rustum S.

Inventor： ORCHARD, Michael Glen ,  BENGHEZAL, Mohammed ,  BRAILLARD, Stéphanie ,  BURN, Christine ,  DEUSCHEL, Christine ,  LUCAS, Aurore ,  VALENTINO, Emilio ,  JANSSEN, Christian ,  BOYCE, Rustum S.

IPC: C07C229/46 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C233/63 ,  C07C255/60 ,  C07C311/46 ,  C07D235/16 ,  C07D277/82 ,  C07D295/182 ,  A61K31/192 ,  A61K31/196 ,  A61K31/165 ,  A61K31/428 ,  A61K31/4453

CPC classification number: C07C233/60 ,  C07B2200/07 ,  C07C229/46 ,  C07C233/58 ,  C07C233/59 ,  C07C233/63 ,  C07C255/60 ,  C07C311/46 ,  C07C2601/08 ,  C07D235/16 ,  C07D235/30 ,  C07D277/82 ,  C07D295/182

Abstract: The invention relates to cyclopentanecarboxylic acid derivatives and related compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as described in the specification, processes for the preparation thereof, pharmaceutical compositions containing the same, the use thereof optionally in combination with one or more other pharmaceutically active compounds as anti-bacterial agents for the therapy of infective diseases, and a method for the treatment of such diseases. The compounds of formula (I) are reducing selectively the pathogenicity of bacteria within the host, but without affecting the bacteria outside the host environment.

Abstract translation: 本发明涉及环戊烷羧酸衍生物及其相应的式（I）化合物，其中R 1，R 2，R 3，R 3， 4，R 5和R 6如说明书中所述，其制备方法，含有它们的药物组合物，其用途可任选地在 与一种或多种其它药学活性化合物的组合作为用于治疗感染性疾病的抗细菌剂，以及治疗这些疾病的方法。 式（I）化合物选择性地降低宿主细菌的致病性，但不影响宿主环境外的细菌。

公开(公告)号：WO2007017114A1

公开(公告)日：2007-02-15

申请号：PCT/EP2006/007373

申请日：2006-07-26

Applicant: ATHELAS S.A. ,  ORCHARD, Michael, Glen ,  BENGHEZAL, Mohammed ,  BRAILLARD, Stéphanie ,  BURN, Christine ,  COSSON, Pierre ,  DEUSCHEL, Christine ,  LUCAS, Aurore ,  PACCAUD, Jean-Pierre ,  VALENTINO, Emilio

Inventor： ORCHARD, Michael, Glen ,  BENGHEZAL, Mohammed ,  BRAILLARD, Stéphanie ,  BURN, Christine ,  COSSON, Pierre ,  DEUSCHEL, Christine ,  LUCAS, Aurore ,  PACCAUD, Jean-Pierre ,  VALENTINO, Emilio

IPC: C07D253/075 ,  C07D409/04 ,  C07D401/06 ,  C07D239/56 ,  C07D401/04 ,  A61K31/505 ,  A61K31/53 ,  A61P31/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/04 ,  C07D417/12

CPC classification number: C07D253/075 ,  C07D239/56 ,  C07D401/04 ,  C07D401/06 ,  C07D409/04

Abstract: The invention relates to substituted azathymidines and related compounds of formula (I), wherein X is N or CH, and R 1 , R 2 and R 3 are as described in the specification, processes for the preparation thereof, pharmaceutical compositions containing the same, the use thereof optionally in combination with one or more other pharmaceutically active compounds as antibacterial agents for the therapy of infective diseases, and a method for the treatment of such diseases. The compounds of formula (I) are reducing selectively the pathogenicity of bacteria within the host, but without affecting the bacteria outside the host environment.

Abstract translation: 本发明涉及取代的azathymidines和相关的式（I）化合物，其中X是N或CH，R 1，R 2和R 3， SUP>如说明书中所述，其制备方法，含有它们的药物组合物，其任选与一种或多种其它药学活性化合物组合的用途作为用于治疗感染性疾病的抗菌剂，以及用于治疗感染性疾病的方法 治疗这些疾病。 式（I）化合物选择性地降低宿主细菌的致病性，但不影响宿主环境外的细菌。