公开(公告)号：WO2016113387A1

公开(公告)日：2016-07-21

申请号：PCT/EP2016/050762

申请日：2016-01-15

Applicant: DSM IP ASSETS B.V.

Inventor： CHEN, Shuen Ei ,  CHUNG, Thau Kiong ,  RAEDERSTORFF, Daniel ,  SCHALCH, Wolfgang

IPC: A23L33/105 ,  A23L33/155 ,  A23L33/15 ,  A23L33/16 ,  A23K20/10 ,  A23K20/174 ,  A61K31/593 ,  A23K50/75 ,  A61P9/04 ,  A61P3/10

CPC classification number: A23L33/16 ,  A23D7/0053 ,  A23K20/158 ,  A23K20/174 ,  A23K20/30 ,  A23K50/75 ,  A23L33/105 ,  A23L33/15 ,  A23L33/155 ,  A23V2002/00 ,  A61K31/045 ,  A61K31/047 ,  A61K31/05 ,  A61K31/065 ,  A61K31/122 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/455 ,  A61K31/519 ,  A61K31/592 ,  A61K31/593 ,  A61K33/04 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K45/06 ,  A23V2200/02 ,  A23V2250/156 ,  A23V2250/211 ,  A23V2250/704 ,  A23V2250/708 ,  A23V2250/71 ,  A23V2250/712 ,  A61K2300/00

Abstract: This invention relates to the use of the combination of 25-hydroxyvitamin D3 ("25-OH D3") and antioxidants/anti-inflammatories (ascorbic acid, vitamin E and at least one carotenoid) to make a pharmaceutical, nutraceutical or food supplement which can ameliorate various problems observed in humans connected with polycystic ovarian 5 syndrome and cardiovascular diseases. Pharmaceuticals, nutraceuticals and food supplements containing the 25-OH D3 and antioxidants/anti-inflammatories and premixes are also provided.

Abstract translation: 本发明涉及使用25-羟基维生素D3（“25-OH D3”）与抗氧化剂/抗炎剂（抗坏血酸，维生素E和至少一种类胡萝卜素）的组合来制备药物，营养食品或食品补充剂，其中 可以改善与多囊卵巢综合征和心血管疾病相关的人类观察到的各种问题。 还提供含有25-OH D3和抗氧化剂/抗炎剂和预混剂的药物，营养保健品和食品补充剂。

公开(公告)号：WO2009103754A2

公开(公告)日：2009-08-27

申请号：PCT/EP2009/051958

申请日：2009-02-19

Applicant: DSM IP Assets B.V. ,  HUG, Hubert ,  MUSSELR, Bernd ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying

Inventor： HUG, Hubert ,  MUSSELR, Bernd ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying

IPC: A23L1/30 ,  A61K31/404 ,  A23L2/52 ,  A61P43/00 ,  A61P17/00

CPC classification number: A61K31/404 ,  A23L33/10 ,  A23L33/105

Abstract: The present invention relates to a novel use of 3,3'-diindolylmethane (CAS1968-05-4) and/or its derivatives in the form of a pharmaceutical and/or nutritional composition to retard or delay typical signs of aging and/or age-related pathological changes.

Abstract translation: 本发明涉及药物和/或营养组合物形式的3,3'-二吲哚基甲烷（CAS1968-05-4）和/或其衍生物的新用途，以延缓或延缓 典型的老化迹象和/或年龄相关的病理变化。

公开(公告)号：WO2008128703A1

公开(公告)日：2008-10-30

申请号：PCT/EP2008/003088

申请日：2008-04-17

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

Inventor： RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

IPC: A23L1/30 ,  A61K31/05 ,  A61K31/7048 ,  A23L2/52

CPC classification number: A61K36/63 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/2131 ,  A61K31/05 ,  A61K31/7048 ,  A23V2200/302 ,  A23V2250/2132 ,  A23V2250/708 ,  A23V2250/032 ,  A23V2250/5072 ,  A23V2250/211

Abstract: The present invention is directed to the use of (a composition comprising) hydroxytyrosol as life prolonging agent. The composition, to which the present invention is also directed, does essentially not comprise resveratrol and is preferably administered orally to animals. The present invention is further directed to a life prolonging method. "Life prolonging" meaning in the context of the present invention: reducing the risk to die at a certain age compared to untreated; increasing the chance to live longer (longevity), i.e. increasing the average life expectancy compared to untreated; and/or extending the lifetime independent of medical care.

Abstract translation: 本发明涉及（含有羟基酪醇的组合物）作为延长剂的用途。 本发明也涉及的组合物基本上不包含白藜芦醇，并且优选口服给予动物。 本发明还涉及寿命延长方法。 本发明背景下的“延续寿命”意义：降低与未经治疗相比在一定年龄死亡的风险; 增加延长寿命（延长寿命）的机会，即增加与未治疗相比的平均预期寿命; 和/或延长终身独立于医疗保健的寿命。

公开(公告)号：WO2008031572A1

公开(公告)日：2008-03-20

申请号：PCT/EP2007/007925

申请日：2007-09-12

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel ,  SCHUELER, Goede ,  SCHWÄGER, Joseph

Inventor： RAEDERSTORFF, Daniel ,  SCHUELER, Goede ,  SCHWÄGER, Joseph

IPC: A61K31/352 ,  A61P19/02

CPC classification number: A61K31/352

Abstract: The invention relates to novel nutraceutical and pharmaceutical compositions comprising at least a compound of the general formula (I), wherein R 1 and R 2 are independently from each other C 1-8 -alk(en)yl and R 3 and R 4 are independently from each other hydroxy or C 1-8 -alkyloxy, as well as to the use of these compositions for the treatment, co-treatment or prevention of joint disorders.

Abstract translation: 本发明涉及至少包含通式（I）化合物的新型营养药物和药物组合物，其中R 1和R 2彼此独立地为C _{1-8烷基（烯）基，R 3和R 4彼此独立地为羟基或C 1-8烷基， 以及这些组合物用于治疗，共同治疗或预防关节疾病的用途。}

公开(公告)号：WO2006136429A1

公开(公告)日：2006-12-28

申请号：PCT/EP2006/006049

申请日：2006-06-23

Applicant: DSM IP ASSETS B.V. ,  D'ORAZIO, Daniel ,  DE SAIZIEU, Antoine ,  RAEDERSTORFF, Daniel ,  SCHUELER, Göde ,  WANG-SCHMIDT, Ying ,  WEHRLI, Christof ,  WERTZ, Karin ,  WOLFRAM, Swen

Inventor： D'ORAZIO, Daniel ,  DE SAIZIEU, Antoine ,  RAEDERSTORFF, Daniel ,  SCHUELER, Göde ,  WANG-SCHMIDT, Ying ,  WEHRLI, Christof ,  WERTZ, Karin ,  WOLFRAM, Swen

IPC: C07H15/04

CPC classification number: C07H15/04 ,  C07C49/796 ,  C07C49/835 ,  C07C49/84 ,  C07C69/618 ,  C07C69/78 ,  C07C233/33 ,  C07D317/64

Abstract: The present invention relates to compounds of the formula (I); wherein R 1 Js H, CH 3 or OCH 3 ; R 3 = H, OH, CH 3 , OCH 3 , O-glucose or benzoyloxy; R 4 = H; R 5 = H or OH; R 6 = H or OCH 3 ; R 7 = H, CH 3 , OCH 3 , cinnamoyloxy or (3,4,5-trimethoxy)-benzoyloxy; R 8 = H, OH, CH 3 or OCH3; or R 7 and R 8 form together a group 0-CH 2 -O; R 9 = H or OCH 3 ; R 10 = H or N-acetyl, N-methyl-2-aminoethyl; to their use as medicament for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X, to dietary and pharmaceutical compositions containing them and to a method for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X in animals including humans, said method comprising the step of administering an effective dose of a compound of the formula (I) to animals including humans which are in need thereof.

Abstract translation: 本发明涉及式（I）的化合物; 其中R 1，H 3，CH 3或OCH 3; R 3 = H，OH，CH 3，OCH 3，O-葡萄糖或苯甲酰氧基; R 4 = H; R 5 = H或OH; R 6 = H或OCH 3; CH 3，H 3，CH 3，OCH 3，肉桂酰氧基或（3,4,5-三甲氧基） - 苯甲酰氧基; R 8 = H，OH，CH 3或OCH 3; 或R 7和R 8一起形成0-CH 2 -O-O基团; R 9 = H或OCH 3; R 10 = H或N-乙酰基，N-甲基-2-氨基乙基; 用于治疗非自身免疫性2型糖尿病和/或综合征X的药物用于含有它们的膳食和药物组合物以及用于治疗非自身免疫性2型糖尿病和/或症状X的综合征的方法 包括人的动物，所述方法包括向有需要的动物（包括人）施用有效剂量的式（I）化合物的步骤。

公开(公告)号：WO2010118789A1

公开(公告)日：2010-10-21

申请号：PCT/EP2009/063492

申请日：2009-10-15

Applicant: DSM IP Assets B.V. ,  FOWLER, Ann ,  FRIEDEL, Angelika ,  KNUTTI, Darko ,  KURATLI, Karin ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

Inventor： FOWLER, Ann ,  FRIEDEL, Angelika ,  KNUTTI, Darko ,  KURATLI, Karin ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

IPC: A23L1/00 ,  A23L1/29 ,  A61K31/05 ,  A61K31/197 ,  A61K31/205 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/522 ,  A61K31/525 ,  A61K31/714 ,  A61K45/06 ,  A61K36/63 ,  A61K36/254

CPC classification number: A61K31/05 ,  A23K20/111 ,  A23K20/121 ,  A23K20/147 ,  A23K20/174 ,  A23L2/52 ,  A23L33/10 ,  A23L33/105 ,  A23L33/11 ,  A23L33/15 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/122 ,  A61K31/145 ,  A61K31/19 ,  A61K31/195 ,  A61K31/197 ,  A61K31/205 ,  A61K31/34 ,  A61K31/352 ,  A61K31/4188 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/522 ,  A61K31/525 ,  A61K31/714 ,  A61K36/63 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/33 ,  A23V2250/2108 ,  A23V2250/7042 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/705 ,  A23V2250/706 ,  A23V2250/72

Abstract: Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

Abstract translation: 含有羟基酪醇的羟基酪醇或橄榄油与选自肌酸，辅酶Q10，白藜芦醇，咖啡因，肉碱，B族维生素（B1，B2，B3，B5，B6和/或B12）中的至少一种化合物组合 ）和人参（优选：根）提取物可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

公开(公告)号：WO2008128629A1

公开(公告)日：2008-10-30

申请号：PCT/EP2008/002674

申请日：2008-04-03

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel ,  SCHWAGER, Joseph ,  WERTZ, Karin

Inventor： RAEDERSTORFF, Daniel ,  SCHWAGER, Joseph ,  WERTZ, Karin

IPC: A61K31/05 ,  A61P19/02

CPC classification number: A61K31/05 ,  A61K31/202 ,  A61K31/7004 ,  A61K31/737 ,  A61K2300/00

Abstract: The invention relates to the use of hydroxytyrosol for inducing or enhancing cartilage repair or cartilage regeneration. Furthermore, the invention relates to nutraceutical and pharmaceutical compositions comprising hydroxytyrosol for regeneration and repair of cartilage injuries in joints, in particular of traumatic cartilage injuries.

Abstract translation: 本发明涉及羟基酪醇诱导或增强软骨修复或软骨再生的用途。 此外，本发明涉及包含羟基酪醇的营养药物和药物组合物，用于再生和修复关节软骨损伤，特别是创伤性软骨损伤。

公开(公告)号：WO2007096078A1

公开(公告)日：2007-08-30

申请号：PCT/EP2007/001256

申请日：2007-02-14

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel ,  SCHEHLMANN, Volker ,  WANG-SCHMIDT, Ying ,  WEBER, Gilbert

Inventor： RAEDERSTORFF, Daniel ,  SCHEHLMANN, Volker ,  WANG-SCHMIDT, Ying ,  WEBER, Gilbert

IPC: A61K31/05 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P37/00 ,  A61P39/00

CPC classification number: A61K31/05

Abstract: The invention relates to the use of resveratrol, a derivative, metabolite or analogue thereof for promoting the wellness state of a mammal or for changing gene expression profiles in older adult mammals towards conformity with expression profiles found in younger adult mammals as well as to their use for the manufacture of corresponding nutraceutical compositions.

Abstract translation: 本发明涉及白藜芦醇，其衍生物，代谢物或类似物用于促进哺乳动物的健康状态或改变老年成年哺乳动物中的基因表达谱以符合年轻成年哺乳动物中发现的表达谱以及其使用 用于制造相应的营养组合物。

公开(公告)号：WO2007093387A1

公开(公告)日：2007-08-23

申请号：PCT/EP2007/001241

申请日：2007-02-13

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel

Inventor： RAEDERSTORFF, Daniel

IPC: C07C65/28 ,  C07C43/295 ,  C07D311/58 ,  A61K31/192 ,  A61P29/02

CPC classification number: C07C43/23 ,  C07C65/28 ,  C07D311/58

Abstract: The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.

Abstract translation: 本发明涉及新的甲氧基化芳族化合物。 它还涉及包含甲氧基化芳族化合物的新型组合物以及这些组合物作为药物，特别是作为治疗，共同治疗或预防炎症性疾病的药物的用途。

公开(公告)号：WO2007042272A3

公开(公告)日：2007-04-19

申请号：PCT/EP2006/009815

申请日：2006-10-11

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WOLFRAM, Swen

Inventor： RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WOLFRAM, Swen

IPC: A61K31/05 ,  A61K31/353 ,  A23L1/30 ,  A61P43/00 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00

Abstract: The use of resveratrol, a derivative, metabolite or analogue thereof, in combination with at least one additional component selected from EGCG, coenzyme Q-IO, genistein, lycopene, hydroxytyrosol and polyunsaturated fatty acids in the manufacture of a nutraceutical composition for delaying aging and/or for the treatment or prevention of age-related diseases in animals, in particular in mammals including humans.