公开(公告)号：WO2019213550A1

公开(公告)日：2019-11-07

申请号：PCT/US2019/030643

申请日：2019-05-03

Applicant: DUKE UNIVERSITY ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： HE, You-Wen ,  SUN, Heqiang ,  AUGUST, Thomas ,  LIU, Jun ,  WEI, Yadong

IPC: A61K39/21 ,  A61P31/12 ,  A61K39/12

Abstract: Vaccine design, polycistronic vaccine constructs, compositions, and methods comprising nucleic acids (DNA, RNA), peptides, proteins and derivatives thereof, including cells and cell-lines, for enhanced antigen-specific vaccination.

公开(公告)号：WO2021067405A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053486

申请日：2020-09-30

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted, M. ,  DAWSON, Valina, L. ,  LIU, Jun ,  PARK, Hyejin ,  KAM, Tae-In ,  PENG, Hanjing ,  AYINAMPUDI, Venkata, Subbarao

IPC: C07D498/04 ,  C07D498/14 ,  C07F9/32

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

公开(公告)号：WO2017136731A8

公开(公告)日：2017-08-10

申请号：PCT/US2017/016516

申请日：2017-02-03

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： LIU, Jun ,  WANG, Jingxin ,  GUO, Zufeng

IPC: A61K31/713 ,  A61K31/436 ,  A61K9/16

Abstract: Compounds with the following structures and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

公开(公告)号：WO2018045250A1

公开(公告)日：2018-03-08

申请号：PCT/US2017/049778

申请日：2017-08-31

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted M. ,  DAWSON, Valina L. ,  WANG, Yingfei ,  PARK, Hyejin ,  LIU, Jun ,  PENG, Hanjing

IPC: A61P25/00 ,  A61P25/28 ,  A61K38/17

Abstract: Provided herein are methods of treating a disease, such as Parkinson's disease, that is due to increased poly [ADP-ribose] polymerase 1 (PARP-1) activation, by inhibiting macrophage migration inhibitory factor (MIF) nuclease activity.

Abstract translation: 本文提供了治疗由于增加的聚[ADP-核糖]聚合酶1（PARP-1）激活，通过抑制巨噬细胞迁移抑制因子（MIF）引起的疾病（例如帕金森氏病）的方法 ）核酸酶活性。

公开(公告)号：WO2017136717A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/016494

申请日：2017-02-03

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： LIU, Jun ,  WANG, Jingxin ,  SUN, Zhaoli ,  HONG, Sam

IPC: A61K47/48 ,  A61K31/454

CPC classification number: C07D519/00 ,  C07D498/18

Abstract: A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Abstract translation: 提供式（I）的化合物及其类似物。 包括式I的组合物可用于抑制人平衡核苷转运蛋白1，增加腺苷信号传导并产生包括增加抗病毒活性，增加抗寄生虫活性，增加酒精耐受性，减少对局部缺血以及许多其他病症的保护作用的疼痛的效果。 p>

公开(公告)号：WO2017136708A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/016481

申请日：2017-02-03

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： LIU, Jun ,  WANG, Jingxin ,  GUO, Zufeng ,  HONG, Sam ,  LIU, Wukun ,  PENG, Hanjing ,  DAS, Manisha

IPC: C07K17/08 ,  G01N33/566

CPC classification number: C07K17/08 ,  B82Y5/00 ,  C07K1/047 ,  G01N33/574 ,  G01N2500/00 ,  G01N2800/24

Abstract: A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Abstract translation: 提供含有通式结构（A）和（E）的化合物的拉帕福星文库以及这些化合物的合成。

公开(公告)号：WO2021067439A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053549

申请日：2020-09-30

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  RAPAFUSYN RESEARCH AND DEVELOPMENT, INC.

Inventor： HONG, Sam ,  ULLMAN, Brett, R. ,  SEMPLE, Joseph, E. ,  YAMAMOTO, Kana ,  KUMAR, Puneet ,  SADAGOPAN, Magesh ,  SCHMITT, Jennifer, C. ,  LIU, Jun

IPC: A61K38/04 ,  A61K38/12 ,  A61P13/12 ,  C01N33/566

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

公开(公告)号：WO2020072830A1

公开(公告)日：2020-04-09

申请号：PCT/US2019/054583

申请日：2019-10-03

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： LIU, Jun ,  LI, Yingjun ,  PASUNOOTI, Kalyan, Kumar ,  LIU, Wukun ,  SHI, Wei ,  LI, Ruojing ,  HEAD, Sarah

IPC: A61K31/496 ,  A61K31/506 ,  C07D405/14

Abstract: Itraconazole, a widely used antifungal drug, has been found to possess potent anti-angiogenic and anti-hedgehog activities, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of cancer, however, has been limited by its potent inhibition of the drug metabolic enzyme CYP3A4 which causes drug-drug interactions. In an effort to eliminate the CYP3A4 inhibition of itraconazole while retaining its anti-angiogenic activity, we synthesized a series of itraconazole derivatives. The newly synthesized analogs of itraconazole were evaluated for their cytotoxicity against human umbilical vein endothelial cells (HUVEC) and their inhibitory activity against CYP3A4 enzyme.

公开(公告)号：WO2008124132A1

公开(公告)日：2008-10-16

申请号：PCT/US2008/004513

申请日：2008-04-07

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  LIU, Jun ,  CHONG, Curtis, Robert ,  XU, Jing ,  LU, Jun ,  BHAT, Shridhar

Inventor： LIU, Jun ,  CHONG, Curtis, Robert ,  XU, Jing ,  LU, Jun ,  BHAT, Shridhar

IPC: A61K31/497 ,  A61K31/415

CPC classification number: A61K31/415 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/497 ,  C12Q1/25 ,  G01N2500/00

Abstract: Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.

Abstract translation: 本文描述了抑制血管发生，治疗或预防与血管生成相关的疾病或病症（或其症状）的方法，其中向受试者施用抗血管生成化合物。

公开(公告)号：WO2007024971A3

公开(公告)日：2007-03-01

申请号：PCT/US2006/032952

申请日：2006-08-22

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  BEACHY, Philip, Arden ,  LIU, Jun

Inventor： BEACHY, Philip, Arden ,  LIU, Jun

IPC: A61K31/497 ,  A61K31/44 ,  A61K31/415

Abstract: Compounds, compositions, kits and methods for modulating hedgehog pathway activity, and treating conditions related to abnormal or aberrant hedgehog pathway activity, are disclosed.