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1.发明申请FUSED BICYCLIC SULFAMOYL DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开熔化的双相磺酰胺衍生物及其作为治疗乙型肝炎的药物的用途
公开(公告)号：WO2014033167A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067814
申请日：2013-08-28
申请人： JANSSEN R&D IRELAND
IPC分类号： C07D231/56 , C07D261/20 , A61K31/416 , A61K31/42
CPC分类号： C07D471/04 , A61K31/416 , A61K31/423 , A61K31/437 , A61K45/06 , C07D231/56 , C07D261/20 , C07D405/12
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein A-E, R 1 , R 2 , R 3 and R 5 , have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 含有立体化学异构形式的式（I）的HBV复制抑制剂及其盐，水合物，溶剂合物，其中A-E，R 1，R 2，R 3和R 5具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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2.发明申请SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开磺酰吡咯烷酮衍生物及其作为治疗乙型肝炎的药物的用途
公开(公告)号：WO2014184350A1
公开(公告)日：2014-11-20
申请号：PCT/EP2014/060102
申请日：2014-05-16
申请人： JANSSEN R&D IRELAND
发明人： VANDYCK, Koen , HACHÉ, Geerwin, Yvonne, Paul , LAST, Stefaan, Julien , MC GOWAN, David, Craig , ROMBOUTS, Geert , VERSCHUEREN, Wim, Gaston , RABOISSON, Pierre, Jean-Marie, Bernard
IPC分类号： C07D207/40 , A61K31/401 , A61P31/00
CPC分类号： C07D207/36 , A61K31/401 , A61K45/06 , C07D207/40 , C07D403/12 , C07D405/12 , A61K2300/00
摘要： Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R a to R d and R 4 to R 6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 包括立体化学异构形式的式（ID）的HBV复制抑制剂及其盐，水合物，溶剂化物，其中X，Ra至Rd和R4至R6具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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3.发明申请GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开GLYOXAMIDE取代的吡咯烷衍生物及其作为治疗乙型肝炎的药物的用途
公开(公告)号：WO2015011281A1
公开(公告)日：2015-01-29
申请号：PCT/EP2014/066093
申请日：2014-07-25
申请人： JANSSEN R&D IRELAND
发明人： VANDYCK, Koen , KESTELEYN, Bart, Rudolf, Romanie , PIETERS, Serge, Maria, Aloysius , ROMBOUTS, Geert , VERSCHUEREN, Wim, Gaston , RABOISSON, Pierre, Jean-Marie, Bernard
IPC分类号： C07D207/34 , A61K31/40 , A61P31/00
CPC分类号： C07D207/34 , A61K31/40 , A61K31/4025 , A61K31/454 , A61P31/00 , C07D401/12 , C07D405/12
摘要： Inhibitors of HBV replication of Formula (IA), including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R 1 to R 6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 式（IA）的HBV复制抑制剂，包括立体化学异构形式，以及其盐，水合物，溶剂合物，其中X和R 1至R 6具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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公开(公告)号：WO2013098313A1
公开(公告)日：2013-07-04
申请号：PCT/EP2012/076934
申请日：2012-12-27
申请人： JANSSEN R&D IRELAND
IPC分类号： C07D401/14 , C07D403/14 , C07D491/10 , A61K31/4412 , A61K31/506 , A61K31/513 , A61K31/527 , A61P31/14
CPC分类号： C07D401/14 , A61K31/4412 , A61K31/4709 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/527 , A61K31/549 , A61K45/06 , C07D403/14 , C07D417/14 , C07D491/10 , C07D491/107 , C07D491/113
摘要： Inhibitors of HCV replication of formula I, including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R and R' have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
摘要翻译： 式I的HCV复制抑制剂，包括立体化学异构形式，以及其盐，水合物，溶剂合物，其中R和R'具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HCV治疗中单独或与其它HCV抑制剂组合的用途。
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5.发明申请SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开磺酰亚胺及其作为治疗乙型肝炎的药物的用途
公开(公告)号：WO2014033176A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067829
申请日：2013-08-28
申请人： JANSSEN R&D IRELAND
发明人： LAST, Stefaan, Julien , RABOISSON, Pierre, Jean-Marie, Bernard , ROMBOUTS, Geert , VANDYCK, Koen , VERSCHUEREN, Wim, Gaston
IPC分类号： A61K31/18 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/4164 , A61K31/426 , A61K31/44 , A61K31/4453 , A61K31/4468 , A61P31/20 , C07D309/14 , C07D233/42 , C07C311/16 , C07C311/20 , C07C311/51 , C07D277/16
CPC分类号： C07C311/37 , A61K31/18 , A61K31/337 , A61K31/34 , A61K31/341 , A61K31/351 , A61K31/397 , A61K31/401 , A61K31/4164 , A61K31/426 , A61K31/44 , A61K31/4453 , A61K31/4468 , A61K31/495 , A61K31/5375 , A61K31/55 , A61K45/06 , C07C311/14 , C07C311/16 , C07C311/20 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/14 , C07D207/273 , C07D207/36 , C07D211/28 , C07D211/56 , C07D211/76 , C07D211/96 , C07D213/42 , C07D213/81 , C07D213/82 , C07D223/06 , C07D233/84 , C07D233/90 , C07D277/56 , C07D295/13 , C07D295/26 , C07D305/08 , C07D307/22 , C07D307/60 , C07D307/68 , C07D309/14 , C07D333/38 , C07D333/48 , C07D491/107 , C07D493/08
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R 1 , R 2 and R 4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 含有立体化学异构形式的式（I）的HBV复制抑制剂及其盐，水合物，溶剂合物，其中B，R 1，R 2和R 4具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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