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    CIS-DIHYDROXYCYCLOHEXADIENES AND THEIR PREPARATION
    3.
    发明申请
    CIS-DIHYDROXYCYCLOHEXADIENES AND THEIR PREPARATION 审中-公开
    独联体二羟基胆碱酯酶及其制备

    公开(公告)号：WO1995007253A1

    公开(公告)日：1995-03-16

    申请号：PCT/GB1994001940

    申请日：1994-09-07

    Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  UNIVERSITY OF WARWICK ,  BOYD, Derek, Raymond ,  DALTON, Howard

    Inventor： THE QUEEN'S UNIVERSITY OF BELFAST ,  UNIVERSITY OF WARWICK

    IPC: C07C29/58

    CPC classification number: C07C35/48 ,  C07C35/18 ,  C07C205/18 ,  C12P7/02

    Abstract: This application relates to 3-substituted and 4-substituted cis-diols. Specifically, there are provided 3-substituted diols of formula (II) and 4-substituted cis-diols having (1S, 2R) and (1R, 2S) absolute configurations of formulae (III) and (IV). Also provided are processes for making such 3- and 4-substituted cis-diols using a reductive fission reaction. The compounds described herein are useful as synthons for the preparation of various compounds including therapeutics, agricultural, polymers and other classes of compounds. In formulae (II, III and IV), R is halogen, CN, aryl, alkyl, alkenyl, alkynyl, O-alkyl, CF3 or NO2.

    Abstract translation: 本申请涉及3-取代和4-取代的顺式二醇。 具体地，提供式（II）的3-取代二醇和具有式（III）和（IV）的（1S，2R）和（1R，2S）绝对构型的4-取代的顺式二醇。 还提供了使用还原裂变反应制备这种3-和4-取代的顺式二醇的方法。 本文所述的化合物可用作制备包括治疗剂，农业，聚合物和其它类别化合物在内的各种化合物的合成子。 在式（II，III和IV）中，R是卤素，CN，芳基，烷基，烯基，炔基，O-烷基，CF 3或NO 2。

    ４－ヒドロキシメチル－２，３，５，６－テトラフルオロトルエンの製造方法
    4.
    发明申请
    ４－ヒドロキシメチル－２，３，５，６－テトラフルオロトルエンの製造方法 审中-公开
    生产4-羟基甲基-2,3,5,6-四氢叶酸的方法

    公开(公告)号：WO2013069810A1

    公开(公告)日：2013-05-16

    申请号：PCT/JP2012/079581

    申请日：2012-11-08

    Applicant: 住友化学株式会社

    Inventor： 三浦　正哉 ,  北浦　武明

    IPC: C07C29/58 ,  C07C33/46 ,  C07B61/00

    CPC classification number: C07C29/58 ,  C07C33/46

    Abstract: 炭素数１～３のアルコール溶媒とパラジウム炭素との存在下で４－ヒドロキシメチル－２，３，５，６－テトラフルオロベンジルハライドと水素とを接触させて４－ヒドロキシメチル－２，３，５，６－テトラフルオロトルエンを製造する製造方法であり、４－ヒドロキシメチル－２，３，５，６－テトラフルオロベンジルハライドと水素との接触開始までの間、炭素数１～３のアルコール溶媒とパラジウム炭素とを含む混合物の温度を１５℃以下に保持する製造方法。

    Abstract translation: 通过使4-羟甲基-2,3,5,6-四氟苄基卤与C1-3醇溶剂和钯碳存在下与氢接触来制备4-羟甲基-2,3,5,6-四氟甲苯的方法 其中包括C 1-3醇溶剂和钯碳的​​混合物的温度保持在15℃或更低，直到4-羟甲基-2,3,5,6-四氟苄基卤化物与氢气开始接触。

    PROCESS FOR PRODUCING 1,2-PROPANEDIOL
    6.
    发明申请
    PROCESS FOR PRODUCING 1,2-PROPANEDIOL 审中-公开
    生产1,2-丙二醇的方法

    公开(公告)号：WO98052893A1

    公开(公告)日：1998-11-26

    申请号：PCT/JP1998/002166

    申请日：1998-05-18

    IPC: C07C29/58 ,  C07C31/20

    CPC classification number: C07C29/58 ,  C07B2200/07 ,  C07C31/205

    Abstract: A process for producing 1,2-propanediol or optically active isomers thereof from a readily available starting material in high yields at a low cost. The process comprises catalytically hydrogenating a 3-halogeno-1,2-propanediol of general formula (I) in a C2 or higher alcoholic solvent in the presence of an at least equivalent of a base to give 1,2-propanediol of formula (II). In formula (I), X represents a halogen atom.

    Abstract translation: 从容易获得的原料以低成本高收率生产1,2-丙二醇或其光学活性异构体的方法。 该方法包括在至少相当于碱的存在下，在C2或更高级醇溶剂中催化氢化通式（I）的3-卤代-1,2-丙二醇，得到式（II）的1,2-丙二醇 ）。 在式（I）中，X表示卤素原子。

    METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL
    7.
    发明申请
    METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL 审中-公开
    合成二羟基庚酸等取代己二酸的方法

    公开(公告)号：WO2012024368A2

    公开(公告)日：2012-02-23

    申请号：PCT/US2011/048032

    申请日：2011-08-17

    Applicant: DEL MAR PHARMACEUTICALS ,  BROWN, Dennis, M.

    Inventor： BROWN, Dennis, M.

    IPC: C07C29/58

    CPC classification number: C07D301/26 ,  C07D301/32 ,  C07D303/14

    Abstract: The present invention provides an efficient method of synthesizing and purifying dianhydrohexitols such as dianhydrogalactitol. In general, as applied to dianhydrogalactitol, the method comprises: (1) reacting dulcitol with a concentrated solution of hydrobromic acid at a temperature of about 80° C to produce dibromogalactitol; (2) reacting the dibromogalactitol with potassium carbonate in t- butanol to produce dianhydrogalactitol; and (3) purifying the dianhydrogalactitol using a slurry of ethyl ether to produce purified dianhydrogalactitol.

    Abstract translation: 本发明提供了合成和纯化二脱水己糖醇如二脱水半乳糖醇的有效方法。 通常，当应用于二脱水半乳糖醇时，该方法包括：（1）在约80℃的温度下使半胱氨酸与浓氢溴酸溶液反应; C生成二溴半乳糖醇; （2）使二溴半乳糖醇与碳酸钾在叔丁醇中反应以生成二脱水半乳糖醇; 和（3）使用乙醚浆液纯化二脱水半乳糖醇以产生纯化的二脱水半乳糖醇。

    Production of racemic 2-(6-methoxy-2-naphthyl)propionic acid or precursors thereof
    10.
    发明申请
    Production of racemic 2-(6-methoxy-2-naphthyl)propionic acid or precursors thereof 审中-公开
    制备外消旋的2-（6-甲氧基-2-萘基）丙酸或其前体

    公开(公告)号：WO9830528A3

    公开(公告)日：1998-08-13

    申请号：PCT/US9724024

    申请日：1997-12-29

    Applicant: ALBEMARLE CORP

    Inventor： SABAHI MAHMOOD ,  THERIOT KEVIN J ,  BECNEL BRIAN F

    IPC: B01J31/34 ,  C07B61/00 ,  C07C29/58 ,  C07C37/00 ,  C07C39/38 ,  C07C41/09 ,  C07C41/16 ,  C07C41/30 ,  C07C41/40 ,  C07C41/42 ,  C07C43/215 ,  C07C43/225 ,  C07C51/09 ,  C07C51/14 ,  C07C59/64 ,  C07C59/72 ,  C07C67/343 ,  C07C69/734 ,  C07F3/02 ,  C07F3/06 ,  C07F1/02 ,  C07F3/00

    CPC classification number: C07C41/16 ,  C07C29/58 ,  C07C59/64 ,  C07C43/225 ,  C07C43/215

    Abstract: In producing (±)-2-(6-methoxy-2-naphthyl)propionic acid or precursor thereof from 2-bromo-6-methoxynaphthalene, use is made of 2-bromo-6-methoxynaphthalene formed by (a) methylating 6-bromo-2-naphthol with methyl chloride in a solvent comprising one or more compounds, RZ, where R is a hydrogen atom or an alkyl group, and Z is -OH or -CN provided that if Z is -CN, R is alkyl, and in the presence of a strong base; and (b) recovering and purifying 2-bromo-6-methoxynaphthalene so formed. Preferably, the 6-bromo-2-naphthol is formed by (1) reacting 1,6-dibromo-2-naphthol with hydrogen, in a solvent comprising (a) organic halide in which the halogen has an atomic number of 35 or less or (b) a mixture of water and such organic halide, and in the presence of catalytically effective amounts of (i) a tungsten carbide-based catalyst, and (ii) phase transfer catalyst; and (2) separating 6-bromo-2-naphthol from the organic halide solvent so that the 6-bromo-2-naphthol is substantially free of halogen-containing impurities before use in the above methylation reaction. This technology makes possible reductions in quantities of co-products formed, eliminates need for use of excess iron and/or dimethyl sulfate as reaction components, and makes possible improvements in plant operating efficiency. Precursors of (±)-2-(6-methoxy-2-naphthyl)propionic acid formed from such 2-bromo-6-methoxynaphthalene are Grignard reagent of 2-bromo-6-methoxynaphthalene, bis(6-methoxy-2-naphthyl)zinc, 6-methoxy-2-naphthylzinc halide, 6-methoxy-2-naphthyllithium, 6-methoxy-2-naphthylcopper (I), bis(6-methoxy-2-naphthyl)cadmium, 6-methoxy-2-naphthylcadmium halide, and 6-methoxy-2-vinylnaphthalene.

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