Technologies for adaptive processing of multiple buffers is disclosed. A compute device may establish a buffer queue to which applications can submit buffers to be processed, such as by hashing the submitted buffers. The compute device monitors the buffer queue and determines an efficient way of processing the buffer queue based on the number of buffers present. The compute device may process the buffers serially with a single processor core of the compute device or may process the buffers in parallel with single-instruction, multiple data (SIMD) instructions. The compute device may determine which method to use based on a comparison of the throughput of serially processing the buffers as compared to parallel processing the buffers, which may depend on the number of buffers in the buffer queue.