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1.发明公开
公开(公告)号：EP3644992A1
公开(公告)日：2020-05-06
申请号：EP18825469.2
申请日：2018-06-22
发明人： ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , NA, Meng , RUDD, Michael T. , SELYUTIN, Oleg B. , TELLERS, David M. , TONG, Ling , ZHANG, Fengqi
IPC分类号： A61K31/4155 , C07D231/10
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2.发明公开
公开(公告)号：EP3644991A1
公开(公告)日：2020-05-06
申请号：EP18824389.3
申请日：2018-06-22
发明人： ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , HENDERSON, Timothy, J. , KNOWLES, Sandra, L. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , NA, Meng , SELYUTIN, Oleg, B. , SUZUKI, Takao , ZHANG, Fengqi
IPC分类号： A61K31/4155 , C07D231/10 , C07D471/04
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公开(公告)号：EP3883576A1
公开(公告)日：2021-09-29
申请号：EP19887235.0
申请日：2019-11-15
发明人： BRILL, Zachary, G. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GALLO-ETIENNE, Gioconda, V. , GRAHAM, Thomas, H. , KUANG, Rongze , LARSEN, Matthew, A. , LIM, Yeon-Hee , LIU, Kun , MANSOOR, Umar Faruk , MORENO, Jesus , VARA, Brandon, A. , WANG, Huijun , ZHANG, Yonglian
IPC分类号： A61K31/519 , A61K31/4985 , C07D487/04
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4.发明公开HETEROBICYCLO-SUBSTITUTED-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES 有权HETEROBCYCLOSUBSTITUIERTE [1,2,4]三唑并[1,5-C]喹唑啉-5-胺化合物A2A拮抗性能
公开(公告)号：EP2945632A1
公开(公告)日：2015-11-25
申请号：EP13866588.0
申请日：2013-12-20
发明人： ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , HUANG, Xianhai , HENDERSON, Timothy, J. , KIM, Jae-Hun , BOYCE, Christopher , TING, Pauline , ZHENG, Junying , METZGER, Edward , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda, V. , WON, Walter , WU, Heping , DENG, Qiaolin
IPC分类号： A61K31/4985 , A61K31/519 , C07D487/04 , A61P25/16
CPC分类号： C07D519/00 , C07D487/04
摘要： Disclosed are compounds of Formula Gl (structurally represented): where "RG3" "Rd1" to "Rd4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
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公开(公告)号：EP3887377A1
公开(公告)日：2021-10-06
申请号：EP19888675.6
申请日：2019-11-26
发明人： ZHANG, Yonglian , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , HENNESSY, Elisabeth , LARSEN, Matthew, A. , LIU, Kun , LIU, Ping , MANSOOR, Umar Faruk , PAN, Jianping , PLUMMER, Christopher, W. , SATHER, Aaron , SWAMINATHAN, Uma , WANG, Huijun
IPC分类号： C07D487/04 , C07D487/08 , C07D487/18
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公开(公告)号：EP3886988A1
公开(公告)日：2021-10-06
申请号：EP19827893.9
申请日：2019-11-26
发明人： LARSEN, Matthew, A. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , HENNESSY, Elisabeth , HOOVER, Andrew, J. , LIU, Ping , LIU, Kun , MANSOOR, Umar Faruk , PAN, Jianping , PLUMMER, Christopher, W. , SATHER, Aaron , SWAMINATHAN, Uma , WANG, Huijun , ZHANG, Yonglian
IPC分类号： A61P35/00 , C07D487/04 , A61K31/519
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公开(公告)号：EP3700550A1
公开(公告)日：2020-09-02
申请号：EP18858623.4
申请日：2018-09-21
发明人： PALANI, Anandan , DENG, Qiaolin , HUANG, Chunhui , ZHU, Yuping , BIANCHI, Elisabetta , ORVIETO, Federica
IPC分类号： A61K38/28 , A61K38/26 , C07K14/605
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公开(公告)号：EP3209682A1
公开(公告)日：2017-08-30
申请号：EP15790398.0
申请日：2015-10-22
发明人： CARRINGTON, Paul, E. , DENG, Qiaolin , NARGUND, Ravi , PALANI, Anandan , TUCKER, Thomas Joseph , WU, Chengwei , BIANCHI, Elisabetta , ORVIETO, Federica , PESSI, Antonello
IPC分类号： C07K14/605 , A61K38/26 , A61K38/28
CPC分类号： A61K38/28 , A61K38/26 , C07K14/605 , A61K2300/00
摘要： Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity
摘要翻译： 描述了胰高血糖素的肽类似物，其已经被修饰以抵抗二肽基肽酶IV（DPP-IV）的切割和失活并且增加肽类似物的体内半衰期，同时使肽类似物具有相对平衡的激动剂活性 对胰高血糖素样肽1（GLP-1）受体和胰高血糖素（GCG）受体的应用，以及此类GLP-1受体/ GCG受体共激动剂用于治疗代谢病症例如糖尿病，非酒精性脂肪肝 疾病（NAFLD），非酒精性脂肪性肝炎（NASH）和肥胖。
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公开(公告)号：EP1737811B1
公开(公告)日：2016-08-10
申请号：EP05736159.4
申请日：2005-04-08
发明人： ALI, Amjad , BOHN, Joann , DENG, Qiaolin , LU, Zhijian , SINCLAIR, Peter, J. , TAYLOR, Gayle, E. , THOMPSON, Christopher, F. , QURAISHI, Nazia
IPC分类号： C07C271/16 , C07C205/00 , C07C229/00 , C07D213/64 , A61P9/10 , A61K31/44
CPC分类号： C07C271/20 , C07C233/18 , C07C271/16 , C07C271/22 , C07C279/08 , C07C311/04 , C07C311/08 , C07C317/32 , C07D209/08 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/89 , C07D215/12 , C07D215/26 , C07D217/02 , C07D217/14 , C07D261/08 , C07D271/06 , C07D307/52 , C07D307/79 , C07D333/20 , C07D333/22 , C07D333/28
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公开(公告)号：EP3883575A1
公开(公告)日：2021-09-29
申请号：EP19886307.8
申请日：2019-11-15
发明人： BRILL, Zachary, G. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GRAHAM, Thomas, H. , KUANG, Rongze , LIM, Yeon-Hee , PLUMMER, Christopher, W. , RICO DUQUE, Jenny Lorena , WANG, Huijun , ZHANG, Yonglian , ZHAO, Kake
IPC分类号： A61K31/519 , A61P35/00 , C07D487/04
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