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    AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS
    8.
    发明公开
    AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS 失效
    AMINOVERBINDUNGEN UND ANGIOTENSIN IV REZEPTOR AGONISTEN

    公开(公告)号：EP0882699A1

    公开(公告)日：1998-12-09

    申请号：EP97933908.2

    申请日：1997-08-05

    申请人： TAISHO PHARMACEUTICAL CO. LTD ,  SAGAMI CHEMICAL RESEARCH CENTER

    发明人： KOBORI, Takeo ,  GODA, Kenichi ,  SUGIMOTO, Kikuo ,  OTA, Tomomi, Taisho Pharmaceutical Co., Ltd. ,  TOMISAWA, Kazuyuki, Taisho Pharmaceutical Co. Ltd.

    IPC分类号： C07C211/13 ,  C07C211/18 ,  C07C211/22 ,  C07C211/25 ,  C07C211/27 ,  C07C211/28 ,  C07C215/52 ,  C07K5/06 ,  C07K5/08 ,  A61K31/165 ,  A61K31/24

    CPC分类号： C07D213/40 ,  C07C237/20 ,  C07D215/12

    摘要： The present invention provides an amino compound represented by Formula:
    wherein X is CH 2 NH or CONH, Y is CH 2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R 4 )R 5 , CH 2 CH(R 4 )R 5 or an alkoxycarbonyl group, R 1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R 2 and R 3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R 4 and R 5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.

    摘要翻译： 本发明提供由式：表示的氨基化合物，其中X为CH 2 NH或CONH，Y为CH 2 NH或CONH，条件是X和Y不同时为CONH; Z是CH = C（R 4）R 5，CH 2 CH（R 4）R 5或烷氧基羰基，R 1是氢原子; 低级烷基，环烷基，环烷基取代的烷基，芳烷基或芳基，其各自为取代或未取代的，R 2和R 3各自独立地为低级烷基或 每个基团为取代或未取代的芳烷基，R 4和R 5各自独立地为氢原子; 其各自为取代或未取代的烷基，芳烷基，芳基或杂芳基，或其药学上可接受的盐; 包含式（1）的氨基化合物或其药学上可接受的盐的药物; 和含有与有效成分相同的血管紧张素IV受体激动剂，其特别可用作血管紧张素IV参与的各种疾病的治疗药物（拮抗剂或激动剂），例如加速肾血流量，脑血管舒张 ，抑制细胞增殖和高血症。