公开(公告)号：EP1936359A3

公开(公告)日：2008-08-20

申请号：EP07123123.7

申请日：2007-12-13

Applicant: Palo Alto Research Center Incorporated

Inventor： Krivacic, Robert T. ,  Hsieh, H Ben ,  Curry, Douglas N. ,  Bruce, Richard H.

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  A61B5/0059 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833

Abstract: A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source frequency than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.

公开(公告)号：EP1936359A2

公开(公告)日：2008-06-25

申请号：EP07123123

申请日：2007-12-13

Applicant: PALO ALTO RES CT INC

Inventor： KRIVACIC ROBERT T ,  HSIEH H BEN ,  CURRY DOUGLAS N ,  BRUCE RICHARD H

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  A61B5/0059 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833

Abstract: A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source frequency than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.

Abstract translation: 的系统和方法许可证自发荧光的来自信号分离通过将单个样品至样品，令人兴奋的具有单个波长光源的样品，从而发射光从所述光源的距离。 所发射的光被分裂，和分割的光被收集到两个或更多个不同的信道。 所述不同的信道的第一信道的位置比不同的信道的第二信道不同的更靠近所述光源的频率，并且所述第二信道更靠近单个样品的发射频率是比所述第一信道。 在所述第一通道和第二通道中收集的光收集的光进行了研究，并基于该调查产生输出信号。

公开(公告)号：EP1902306A1

公开(公告)日：2008-03-26

申请号：EP06739501.2

申请日：2006-03-24

Applicant: 3M Innovative Properties Company

Inventor： BEDINGHAM, William ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

IPC: G01N21/64 ,  G01N35/00

CPC classification number: F16K99/003 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/004 ,  F16K2099/0084 ,  G01N21/0332 ,  G01N21/07 ,  G01N21/359 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/00069 ,  G01N35/1097 ,  G01N2021/0325 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/00267 ,  G01N2035/00415 ,  G01N2035/0474 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0833 ,  Y10T436/11 ,  Y10T436/111666

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

公开(公告)号：EP1830174A3

公开(公告)日：2007-09-12

申请号：EP07011773.4

申请日：2006-01-03

Applicant: Samsung Electronics Co., Ltd

Inventor： Ok, Gyeong-sik ,  Kim, Su-hyeon ,  Kim, Jin-tae ,  Oh, Kwang-wook

IPC: G01N21/64 ,  G01N21/05 ,  G01J3/44 ,  C12M1/34 ,  C12Q1/68

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source (60a-d); an integrator (70) for giving the light irradiated from the light source a uniform intensity distribution; a sample holder (80) having a plurality of sample channels on which the samples (m) are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter (75) between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles (85a-d) and photodiodes (89a-d), the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

公开(公告)号：EP1791983A2

公开(公告)日：2007-06-06

申请号：EP05810419.1

申请日：2005-07-22

Applicant: Applera Corporation

Inventor： VANN, Charles, S.

IPC: C12Q1/68

CPC classification number: G01N21/7703 ,  B01J19/0046 ,  B01J2219/00326 ,  B01J2219/0043 ,  B01J2219/00495 ,  B01J2219/00515 ,  B01J2219/00524 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00657 ,  B01J2219/00675 ,  B01J2219/00702 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01L3/5023 ,  B01L3/5085 ,  B82Y30/00 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14 ,  G01N21/6452 ,  G01N21/648 ,  G01N2201/0833

Abstract: The system includes a bundle of elongate optical fibers, multiple probes, a well, a light source and a detector. The optical fibers each have a first end remote from a second end, Each of the multiple probes is attached to one of the optical fibers within a predetermined section between each of the optical fiber’s first and second ends. The well is configured to hold a solution comprising a target and to receive at least the predetermined section of each of the optical fibers. The light source is configured to direct light into the first end of each of the optical fibers. Finally, the detector is configured to detect light emitted by the binding of the target to at least one of the multiple probes. In some embodiments, there are multiple bundles and multiple wells.

公开(公告)号：EP1431750A3

公开(公告)日：2004-09-08

申请号：EP03078526.5

申请日：2001-12-18

Applicant: Packard Instrument Company, Inc.

Inventor： Rushbrooke, John Gordon ,  Hooper, Claire Elizabeth

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fibre optic epi-fluorescence imaging system in which the optical fibres are rearranged so that the system can be used for measuring luminescence samples.

公开(公告)号：EP0981734A1

公开(公告)日：2000-03-01

申请号：EP98922205.4

申请日：1998-05-12

Applicant: Colvin, Arthur E., Jr.

Inventor： Colvin, Arthur E., Jr.

IPC: G01N21/64 ,  G01N21/77

CPC classification number: G01N21/6454 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2021/6484 ,  G01N2201/0833

Abstract: A fluorescence sensing device for determining the presence or concentration of an analyte in a liquid or gaseous medium is constructed of a fiber optic plate (12) comprising optical fibers having relatively small numerical apertures. The fiber optic plate is positioned on a photodetector and has a layer of analyte-permeable fluorescent matrix (22) or coated waveguide material on its top surface. The fluorescent matrix or waveguide coating contains indicator molecules whose fluorescence is affected by the local presence of analyte. A light source emits light into the fluorescent matrix in a direction generally parallel to the top surface of the fiber optic plate. Upon absorbing light from the light source, indicator molecules in the fluorescent matrix emit fluorescent light which is transmitted through the fiber optic plate to the photodetector.

公开(公告)号：EP0910790A1

公开(公告)日：1999-04-28

申请号：EP97930637.0

申请日：1997-07-04

Applicant: Cambridge Imaging Limited

Inventor： RUSHBROOKE, John, Gordon ,  HOOPER, Claire, Elizabeth ,  NEALE, William, Wray

IPC: G01N21

CPC classification number: G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fibre optic coupling plate (24) has a sample viewing face for receiving light from a sample (12), an output window (18) for conveying sample originating (emitted) light to an imaging detector and an additional window through which excitation radiation can be projected. A primary light is provided through the plate made up of optical fibres which will convey light entering the viewing face, directly and with minimal loss, to the output window, and a secondary light path separate from the primary light path, by which excitation radiation entering the additional window is conveyed to the viewing face for irradiating the sample.

公开(公告)号：EP0864856A1

公开(公告)日：1998-09-16

申请号：EP97301575.3

申请日：1997-03-10

Applicant: Dia-Stron Limited

Inventor： Gale, Desmond Roy ,  Winsey, Nigel John Peter ,  Bucknell, Steven Paul

IPC: G01N21/47

CPC classification number: G01N21/474 ,  G01N2021/4747 ,  G01N2021/4773 ,  G01N2201/062 ,  G01N2201/0833 ,  G01N2201/0846

Abstract: The translucency of a material is determined by illuminating the material and detecting the intensity of radiation leaving the material as a function of distance from the radiation source. The resulting measurements may be used to determine a translucency gradient for the material. In the case of materials in sheet form or having a defined thickness, the translucency can be measured in transmission mode or back scattering mode to measure through translucency or surface translucency .

Abstract translation: 通过照射材料并检测离开材料的辐射强度作为与辐射源距离的函数来确定材料的半透明度。 所得到的测量结果可以用于确定材料的半透明梯度。 在材料为片状或具有限定厚度的情况下，可以透射模式或背散射模式测量半透明度以通过半透明度或表面半透明度来测量。

公开(公告)号：EP0647858A1

公开(公告)日：1995-04-12

申请号：EP94307438.5

申请日：1994-10-11

Applicant: WALLAC OY

Inventor： Harju, Raimo

IPC: G01T1/20 ,  G01N21/76

CPC classification number: G01T1/2942 ,  G01N21/76 ,  G01N2201/0438 ,  G01N2201/0833 ,  G01T1/2921

Abstract: A method for counting the number and measuring the intensity of light pulses produced in a scintillator by the chemiluminescence labels or radioisotopes used in biochemical applications in plane-like samples (13) so that in addition to the intensity of the light pulses, also the position of each light pulse is determined. An image detector (20) is used in measuring so that the light-sensitive surface of the image detector and the sample (13) are brought as close to each other as possible.

Abstract translation: 通过在平面样品（13）中的生化应用中使用的化学发光标记或放射性同位素来测量闪烁体中产生的光脉冲强度的方法，使得除了光脉冲的强度之外， 确定每个光脉冲。 图像检测器（20）用于测量，使得图像检测器和样品（13）的感光表面尽可能接近。