公开(公告)号：EP3127148A1

公开(公告)日：2017-02-08

申请号：EP15773019.3

申请日：2015-03-30

申请人： Multerra Bio, Inc.

发明人： MILANINIA, Kaveh, M.

IPC分类号： H01L23/02

CPC分类号： H01L23/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L9/527 ,  B01L2300/0645 ,  B01L2300/0816 ,  H01L21/50 ,  H01L21/52 ,  H01L21/565 ,  H01L2924/0002 ,  H01L2924/00

摘要： The present disclosure provides methods for packaging a chip and packaged chips in which the chip and packaging are co-planar and gap-less. In certain instances, the packaged chip has electrodes or fluidics integrated with the chip.

摘要翻译： 本公开提供了用于封装芯片和封装芯片的方法，其中芯片和封装是共面的且无间隙的。 在某些情况下，封装芯片具有与芯片集成的电极或流体。

公开(公告)号：EP3126813A2

公开(公告)日：2017-02-08

申请号：EP15712964.4

申请日：2015-03-31

申请人： Fluidion

发明人： ANGELESCU, Dan ,  HAUSOT, Andreas

IPC分类号： G01N1/10 ,  A61B10/00 ,  A61B5/00 ,  A61M31/00 ,  B01L3/00 ,  E21B49/08 ,  G01T7/02 ,  A61B5/06 ,  A61J1/00 ,  G01N33/18 ,  E21B41/00 ,  G01N1/16

CPC分类号： G01N1/10 ,  A61B5/061 ,  A61B10/0035 ,  A61B10/0045 ,  A61B2010/008 ,  A61M31/002 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/0683 ,  E21B49/081 ,  G01N1/16 ,  G01N2001/1031 ,  G01N2001/1056 ,  G01V1/02

摘要： An electrically passive device and method for in-situ acoustic emission, and/or releasing, sampling and/or measuring of a fluid or various material(s) is provided. The device may provide a robust timing mechanism to release, sample and/or perform measurements on a predefined schedule, and, in various embodiments, emits an acoustic signal sequence(s) that may be used for triangulation of the device position within, for example, a hydrocarbon reservoir or a living body.

公开(公告)号：EP3124118A1

公开(公告)日：2017-02-01

申请号：EP16170761.7

申请日：2016-05-23

申请人： Panasonic Intellectual Property Management Co., Ltd.

发明人： Hishida, Mitsuoki

IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/68

CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2400/0655 ,  C12P19/34 ,  C12Q1/686 ,  C12Q2547/101

摘要： A method for performing a polymerase chain reaction (PCR) process on a treatment target liquid using a microchannel chip and a heating/cooling control apparatus is provided. The microchannel chip includes: a first substrate layer that has an introducing channel and a discharging channel; and a second substrate layer that is disposed on the first substrate layer and has a second substrate layer body and a metal film, the second substrate layer body having a microchannel connected to the two channels, the metal film structuring an upper surface of the microchannel. The heating/cooling control apparatus includes: a temperature regulator; a power source that supplies voltage to the temperature regulator; and a heating/cooling controller that controls heating or cooling of the temperature regulator by controlling the voltage. The heating/cooling controller controls the voltage to change the temperature of the temperature regulator. The heat of the temperature regulator is conducted to the liquid in the microchannel via the metal film, thereby achieving the PCR process.

摘要翻译： 提供了使用微通道芯片和加热/冷却控制装置对处理目标液体进行聚合酶链式反应（PCR）方法的方法。 微通道芯片包括：具有引入通道和放电通道的第一衬底层; 以及第二基板层，其设置在所述第一基板层上并具有第二基板层主体和金属膜，所述第二基板层主体具有连接到所述两个通道的微通道，所述金属膜构成所述微通道的上表面。 加热/冷却控制装置包括：温度调节器; 将电压提供给温度调节器的电源; 以及通过控制电压来控制温度调节器的加热或冷却的加热/冷却控制器。 加热/冷却控制器控制电压来改变温度调节器的温度。 温度调节器的热量通过金属膜传导到微通道中的液体，从而实现PCR过程。

公开(公告)号：EP3117897A1

公开(公告)日：2017-01-18

申请号：EP15762221.8

申请日：2015-03-11

申请人： Toppan Printing Co., Ltd. ,  Tokyo Institute of Technology

发明人： TAKINOUE Masahiro ,  MORITA Masamune ,  YAMASHITA Hitoyoshi

IPC分类号： B01J13/04 ,  C07K1/02

CPC分类号： B01L3/502784 ,  B01J13/04 ,  B01J19/0093 ,  B01J2219/00797 ,  B01J2219/00891 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2300/0832 ,  B01L2400/0409

摘要： A droplet producing device (1) includes an outer tube (2); and an inner tube (3) that is arranged inside the outer tube (2) and feeds a droplet raw material, in which an inner tube discharge port (3b) opens to an inner tube tip portion (3a) formed on a downstream in a fluid feed direction, an outer tube discharge port (2b) opens to an outer tube tip portion (2a) formed on the downstream in the fluid feed direction, and in which a gap (2c) is formed between the outer tube (2) and the inner tube (3). It is preferable that the inner tube discharge port (3b) be provided inside the outer tube on an upstream of the outer tube discharge port (2b) in the fluid feed direction.

摘要翻译： 液滴产生装置（1）包括外管（2）; 和内管（3），其设置在所述外管（2）的内部，并且供给内筒排出口（3b）向形成在所述外管（2）的下游侧的内管末端部（3a）开口的液滴原料 流体供给方向，外管排出口（2b）通向形成在流体供给方向下游的外管末端部分（2a），并且在外管（2）和 内管（3）。 内管排出口（3b）优选在外管排出口（2b）的流体供给方向的上游设置在外管内。

公开(公告)号：EP3117206A1

公开(公告)日：2017-01-18

申请号：EP15761784.6

申请日：2015-03-12

申请人： MC10, INC.

发明人： GHAFFARI, Roozbeh ,  ARANYOSI, Alexander ,  LEE, Stephen

IPC分类号： G01N27/02

CPC分类号： G01N21/272 ,  B01L3/502715 ,  B01L3/5055 ,  B01L2200/025 ,  B01L2300/023 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  G01N35/00871 ,  G01N2021/7783 ,  G01N2035/00881

摘要： The present invention relates to portable devices for point-of-care diagnostics that can perform measurements on a sample (e.g., blood, serum, saliva, or urine) and relay data to an external device for, e.g., data analysis. The device can comprise a paper-based diagnostic substrate and a base substrate that include electronic circuitry and electronic elements necessary for performing the measurements. The device can also comprise an antenna for near field communication with an external device. Another aspect of the invention relates to methods of using these devices.

摘要翻译： 本发明涉及可以对样本（例如血液，血清，唾液或尿液）进行测量并将数据中继到外部设备的数据分析的点护理诊断的便携式设备。 该装置可以包括基于纸的诊断基板和基底，其包括执行测量所需的电子电路和电子元件。 该设备还可以包括用于与外部设备进行近场通信的天线。 本发明的另一方面涉及使用这些装置的方法。

公开(公告)号：EP3114454A1

公开(公告)日：2017-01-11

申请号：EP15758609.0

申请日：2015-03-04

申请人： National Research Council of Canada

发明人： VERES, Teodor ,  BRASSARD, Daniel ,  CLIME, Liviu

IPC分类号： G01N1/28 ,  C12M1/34 ,  C12M1/36

CPC分类号： B01L3/502746 ,  B01F9/0003 ,  B01F13/0059 ,  B01F13/0222 ,  B01F13/0277 ,  B01F15/00357 ,  B01F15/0261 ,  B01F2215/0037 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N35/00029 ,  G01N2035/00158 ,  G01N2035/0439 ,  G01N2035/0449 ,  G05D7/0635

摘要： A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.

摘要翻译： 提供了一种将气动控制结合在离心微流体中的技术。 该技术涉及提供具有用于将控制器的一个或多个加压室与微流体芯片的端口联接的加压流体供应管线的芯片控制器。 芯片控制器的至少一部分安装到离心机上以与芯片一起旋转。 在每个供应管线中设置流量控制装置，用于选择性地控制加压流体供应，并且被电控制。 证明了气泡混合，片上和片外阀门和切换。

公开(公告)号：EP2925442B1

公开(公告)日：2017-01-11

申请号：EP13794898.0

申请日：2013-11-21

申请人： Robert Bosch GmbH

发明人： HOEHL, Melanie ,  DANNENBERG, Arne ,  STEIGERT, Juergen

IPC分类号： B01L3/00

CPC分类号： B01L3/50825 ,  B01L3/5021 ,  B01L3/502715 ,  B01L3/50851 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/06 ,  B01L2300/0609 ,  B01L2300/0645 ,  B01L2300/0841 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0409 ,  B01L2400/0644

公开(公告)号：EP3110553A1

公开(公告)日：2017-01-04

申请号：EP16716937.4

申请日：2016-04-07

申请人： Cell ID Pte Ltd

发明人： SIM, Lye Hock

IPC分类号： B01L3/00 ,  B01L7/00 ,  B81B7/00

CPC分类号： H05B3/34 ,  B01J2219/00495 ,  B01J2219/00533 ,  B01L3/502715 ,  B01L3/502784 ,  B01L3/505 ,  B01L3/50825 ,  B01L3/50851 ,  B01L3/50855 ,  B01L7/52 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1827 ,  B81B7/0083 ,  B81B2201/058 ,  H05B3/267 ,  H05B2203/002 ,  H05B2203/003

摘要： A dc heater comprising: a discrete heating area made of a heat conductive material disposed on a surface that is electrically non-conductive; and at least one conductive trace configured to be connected to a dc voltage source and to heat the discrete heating area to a uniform temperature when connected to the dc voltage source, the at least one conductive trace disposed in an undulating configuration on the surface at least partially around the discrete heating area.

摘要翻译： 一种直流加热器，包括：由导电材料制成的分立加热区域，其设置在不导电的表面上; 以及至少一个导电迹线，被配置为连接到直流电压源并且当连接到直流电压源时将分立加热区域加热到均匀的温度，所述至少一个导电迹线至少布置在表面上的起伏构型中 部分围绕离散加热区域。

公开(公告)号：EP2384432B1

公开(公告)日：2016-12-28

申请号：EP08771651.0

申请日：2008-06-20

申请人： GEN-PROBE INCORPORATED

发明人： NELSON, Norman C. ,  ROMA, Gianluca

IPC分类号： G01N21/63 ,  G01N1/28 ,  G01N35/00

CPC分类号： B01F11/00 ,  B01F3/1271 ,  B01F11/0045 ,  B01F11/0071 ,  B01F13/0059 ,  B01F15/00214 ,  B01F2215/0037 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/0621 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0677 ,  C12N15/1006 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N1/44 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N35/0098 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2035/00544 ,  G01N2201/0627 ,  Y10T137/0391 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/255

摘要： A detector for detecting an optical signal from a sample that may be indicative of the presence, amount, or state of one or more analytes in the sample, the detector comprising: one or more excitation channels, each disposed within one of the conduits of the housing and adapted to direct an excitation signal of a prescribed excitation wavelength or range of excitation wavelengths toward the sample, and each excitation channel comprising: a light emitting element adapted to emit excitation light; and excitation optical elements defining an excitation optical path having an excitation optic axis, the excitation optical elements comprising a lens and an excitation filter constructed and arranged to transmit only light emitted by the light emitting element having the prescribed excitation wavelength or range of excitation wavelengths toward the sample, one or more emissions channels, each disposed within one of the conduits of the housing and adapted to receive an emission signal from the sample and detect an emission signal having a prescribed emission wavelength or range of emission wavelengths, and each emission channel comprising: emission optical elements defining an emission optical path having an emission optic axis, the emission optical elements comprising a lens and an emission filter constructed and arranged to transmit only light emitted by the sample having the prescribed emission wavelength or range of emission wavelengths; and a light-detecting element adapted to detect light transmitted by the emission optical elements and to convert the detected light to an electronic signal indicative of at least one of the presence and strength of the detected light, a housing, wherein each of the excitation and emission channels is disposed within a different conduit defined within the housing; wherein the excitation and emission optic axes are parallel to one another throughout their extents; and an optic lens constructed and arranged with respect to the excitation and emission channels to (1) direct excitation light transmitted by each excitation channel and impinging on a different portion of the optic lens at a prescribed location and (2) receive emission signals emitted by the sample at the prescribed location and to direct at least a portion of the received emission signals into each emission channel.

公开(公告)号：EP3013223A4

公开(公告)日：2016-12-21

申请号：EP14817669

申请日：2014-06-26

申请人： UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

发明人： SNIADECKI NATHAN J ,  WHITE NATHAN J ,  TING LUCAS H ,  KARCHIN ARI

IPC分类号： A61B5/026 ,  B01L3/00 ,  C12M1/00 ,  G01N33/48 ,  G01N33/86

CPC分类号： G01N33/86 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2300/025 ,  B01L2300/027 ,  B01L2300/0627 ,  B01L2300/0663 ,  B01L2300/0819 ,  B01L2300/0832 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N2800/224

摘要： The present technology relates generally to fluidics devices for measuring platelet coagulation and associated systems and methods. In some embodiments, a fluidics device includes an array of microstructures including pairs of generally rigid blocks and generally flexible posts. The fluidics device further includes at least one fluid channel configured to accept the array. The fluidics device can further include a measuring element configured to measure a degree of deflection of one or more of the flexible posts in the array. In some embodiments, the fluidics device comprises a handheld device and usable for point of care testing of platelet forces and coagulation.

摘要翻译： 本技术一般涉及用于测量血小板凝结的流体装置及其相关系统和方法。 在一些实施例中，流体装置包括一组微结构，包括一对通常刚性的块和通常柔性的柱。 流体装置还包括配置成接受阵列的至少一个流体通道。 流体装置还可以包括测量元件，其被配置成测量阵列中的一个或多个柔性柱的偏转程度。 在一些实施例中，流体装置包括手持装置，并且可用于血小板力和凝血的护理点测试。