利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

34 条记录 (耗时 0.022 秒)

    MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF SUCCINATE
    11.
    发明公开
    MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF SUCCINATE 审中-公开

    公开(公告)号：EP3502241A1

    公开(公告)日：2019-06-26

    申请号：EP17209645.5

    申请日：2017-12-21

    申请人： BASF SE

    发明人： HOFF, Birgit ,  BOEHMER, Nico ,  HAEFNER, Stefan ,  SCHROEDER, Hartwig ,  ZELDER, Oskar ,  WITTMANN, Christoph ,  SCHROER, Anna Christine

    IPC分类号： C12N9/02 ,  C12P7/46

    摘要： The present invention relates to a process of producing an organic compound, the process comprising
    I) cultivating a genetically modified microorganism in a culture medium comprising at least one assimilable carbon source to allow the genetically modified microorganism to produce the organic compound,
    II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises
    A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the udhA -gene, compared to the original microorganism that has not been genetically modified,

    and wherein the original microorganism belongs to the family Pasteurellaceae.
    The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from at least one assimilable carbon source.

    METHOD OF REMOVING DNA FROM BIOTECHNOLOGICAL PRODUCTS
    12.
    发明公开
    METHOD OF REMOVING DNA FROM BIOTECHNOLOGICAL PRODUCTS 审中-公开
    从生物技术产品中去除DNA的方法

    公开(公告)号：EP3230435A1

    公开(公告)日：2017-10-18

    申请号：EP15817104.1

    申请日：2015-12-09

    申请人： BASF SE

    发明人： HOFF, Birgit ,  HAEFNER, Stefan ,  JEONG, Weol Kyu ,  SCHOLTEN, Edzard

    IPC分类号： C12N1/08 ,  C12N1/06 ,  C12P25/00

    CPC分类号： C12N1/06 ,  C12N1/08 ,  C12N2510/00 ,  C12N2523/00 ,  C12P19/34 ,  C12P25/00

    摘要： The present invention relates to a method for degrading DNA in a sample obtained by microbial fermentation or bio-transformation, comprising treating the sample with a combination of increased temperature and low pH. It also relates to a method for releasing DNA from a microbial cell, comprising incubating the microbial cell at a temperature of 45° C. to 55° C. for two to ten hours. Finally, the present invention provides a method for producing a product, comprising a step of releasing DNA from a microbial cell and degrading said DNA.

    摘要翻译： 本发明涉及降解通过微生物发酵或生物转化获得的样品中的DNA的方法，包括用升高的温度和低pH值的组合处理样品。 本发明还涉及从微生物细胞中释放DNA的方法，包括在45℃至55℃的温度下孵育微生物细胞2至10小时。 最后，本发明提供了一种生产产品的方法，包括从微生物细胞释放DNA并降解所述DNA的步骤。

    THE USE OF GLYCEROL WITH LIMITED FEED OF CARBOHYDRATES FOR FERMENTATION
    13.
    发明公开
    THE USE OF GLYCEROL WITH LIMITED FEED OF CARBOHYDRATES FOR FERMENTATION 审中-公开
    佛罗伦萨VERBENRENZTERZUFÜHRUNGVON KOHLENHYDRATEN ZUR FERMENTIERUNG

    公开(公告)号：EP3119898A1

    公开(公告)日：2017-01-25

    申请号：EP15711141.0

    申请日：2015-03-18

    申请人： BASF SE

    发明人： DANTAS COSTA, Esther ,  ZELDER, Oskar ,  SCHRÖDER, Hartwig ,  HAEFNER, Stefan ,  KRAWCZYK, Joanna Martyna ,  VON ABENDROTH, Gregory ,  RIEDELE, Christian ,  RENZ, Torsten

    IPC分类号： C12P7/46 ,  C12N9/04 ,  C12N9/10 ,  C07K14/285

    CPC分类号： C12N9/0006 ,  C07K14/285 ,  C12N9/1029 ,  C12P7/46 ,  C12Y101/01027 ,  C12Y203/01054

    摘要： The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).

    摘要翻译： 本发明涉及通过发酵生产有机酸的方法，包括以下工艺步骤：I）在作为可同化碳源进料的培养基中培养微生物甘油和另外的碳质化合物，以使微生物 产生有机酸，从而得到包含有机酸的发酵液; II）从方法步骤I）中获得的发酵液中回收有机酸或其盐; 其中，至少在处理步骤I）中的一段时间内，进一步的碳质化合物（CRc.c;以g / l / h）的消耗速率低于进一步的碳质化合物的最大理论消耗速率 （CRc.c.max;以g每升/小时计）。

    SYNTHETIC PHYTASE VARIANTS
    15.
    发明公开
    SYNTHETIC PHYTASE VARIANTS 有权
    合成植酸酶变体

    公开(公告)号：EP2699674A1

    公开(公告)日：2014-02-26

    申请号：EP12773585.0

    申请日：2012-04-18

    申请人： BASF SE

    发明人： HAEFNER, Stefan ,  WELZEL, Annegret ,  THUMMER, Robert

    IPC分类号： C12N9/16 ,  C07K14/00

    CPC分类号： C12N9/16 ,  A23K20/189 ,  C07K2319/21

    摘要： The invention relates to a synthetic phytase with elevated thermostability, elevated stability to acids at p H 2, elevated stability to pepsin and with a broadened active p H range, and to an isolated nucleic acid sequence coding for a synthetic phytase and to the use of the phytase in an animal feed for reducing the phosphate content in the slurry and to animal feed additives and animal feeds comprising the synthetic phytase.

    摘要翻译： 本发明涉及具有提高的热稳定性，提高的对p H 2的酸稳定性，提高的对胃蛋白酶的稳定性并具有扩大的活性p H范围的合成肌醇六磷酸酶，以及编码合成植酸酶的分离的核酸序列以及涉及 用于降低浆液中磷酸盐含量的动物饲料中的植酸酶以及包含合成植酸酶的动物饲料添加剂和动物饲料。

    GENETICALLY MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS ON SUCROSE
    18.
    发明公开
    GENETICALLY MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS ON SUCROSE 审中-公开
    自由之家MIKROORGANISMUS ZUR VERBESSERTEN HERSTELLUNG VON FEINCHEMIKALIEN AUF SUCROSE

    公开(公告)号：EP3140412A1

    公开(公告)日：2017-03-15

    申请号：EP15735633.8

    申请日：2015-05-07

    申请人： BASF SE

    发明人： KRAWCZYK, Joanna Martyna ,  HAEFNER, Stefan ,  SCHROEDER, Hartwig ,  ZELDER, Oskar

    IPC分类号： C12P7/46 ,  C12R1/01 ,  C12N9/12

    CPC分类号： C12N15/102 ,  C07K14/195 ,  C12N15/74 ,  C12N2510/02 ,  C12P7/46 ,  C12Y207/11

    摘要： The present invention relates to a modified microorganism having, compared to its wildtype,—a reduced activity of an enzyme encoded by the ptsA-gene,—a reduced activity of an enzyme encoded by the ptsH-gene or—a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.

    摘要翻译： 本发明涉及一种经修饰的微生物，其与野生型相比具有降低的由ptsA基因编码的酶的活性， - 由ptsH基因编码的酶的活性降低或酶活性降低 由ptsA基因编码并且由ptsH基因编码的酶的活性降低，其中已经衍生了经修饰的微生物的野生型属于巴氏杆菌科。 本发明还涉及生产琥珀酸的方法和使用改性微生物。

    SYNTHETISCHE PHYTASEVARIANTEN
    20.
    发明公开
    SYNTHETISCHE PHYTASEVARIANTEN 有权
    合成植酸酶

    公开(公告)号：EP2491120A2

    公开(公告)日：2012-08-29

    申请号：EP10773880.9

    申请日：2010-10-18

    申请人： BASF SE

    发明人： HAEFNER, Stefan ,  SERWE, Annegret ,  STOSIK, Beata

    IPC分类号： C12N9/16

    CPC分类号： C12N9/16 ,  A23K20/189

    摘要： The invention relates to a synthetic phytase having increased thermal stability, and an isolated nucleic acid sequence coding for a synthetic phytase, and the use of the phytase in an animal feed for reducing phosphate content in the manure, and to animal feed additives and animal feeds comprising the synthetic phytase.