公开(公告)号：EP2922954A1

公开(公告)日：2015-09-30

申请号：EP13857215.1

申请日：2013-11-13

申请人： BASF SE

发明人： ZELDER, Oskar ,  HOFF, Birgit ,  SCHRöDER, Hartwig ,  MOLT, Andrea ,  HARTMANN, Holger ,  DITRICH, Klaus ,  BREUER, Michael ,  REINGRUBER, Rüdiger ,  WEBER, Jakob

IPC分类号： C12N15/11 ,  C12N15/63 ,  C12N15/67 ,  A01N37/00 ,  C07D307/77

CPC分类号： C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：EP3080290A1

公开(公告)日：2016-10-19

申请号：EP14835475.6

申请日：2014-12-04

申请人： BASF SE

发明人： HOFF, Birgit ,  MOLT, Andrea ,  HAEFNER, Stefan ,  ZELDER, Oskar

IPC分类号： C12P25/00

CPC分类号： C12P25/00 ,  C12N15/80

摘要： The present invention relates to a method of producing riboflavin in a genetically modified organism of the genus Eremothecium, wherein said genetic modification is linked to the fatty acid uptake and/or beta-oxidation pathway of said organism, comprising growing said organisms in a culture medium and isolating riboflavin from the culture medium. The invention further relates to a method of providing a riboflavin accumulating organism belonging to the genus Eremothecium by genetically modifying said organism, to organisms obtained by such a method, as well as the use of such genetically modified organisms for increasing the accumulation of riboflavin.

公开(公告)号：EP2888351A2

公开(公告)日：2015-07-01

申请号：EP13831449.7

申请日：2013-08-13

申请人： BASF SE ,  Evolva SA

发明人： NAESBY, Michael ,  FOLLY, Christophe ,  NIELSEN, Curt Aimé Friis ,  HATSCH, Anaelle ,  SCHWAB, Markus ,  ZELDER, Oskar ,  HAEFNER, Stefan ,  SCHRÖDER, Hartwig ,  HOFF, Birgit ,  MOLT, Andrea ,  DITRICH, Klaus ,  BREUER, Michael ,  HARTMANN, Holger ,  KÖRBER, Karsten

IPC分类号： C12N1/21 ,  C12N1/15 ,  C12N1/16 ,  C12N15/80 ,  C12N15/81 ,  C12N15/31 ,  C12N15/52 ,  C12P1/00 ,  C12P17/10 ,  C07K14/195 ,  C07K14/37 ,  A61K31/48 ,  C07K16/00

CPC分类号： C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.