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11.发明公开
公开(公告)号：EP1443913A2
公开(公告)日：2004-08-11
申请号：EP02807153.8
申请日：2002-07-03
申请人： Curagen Corporation
发明人： LI, Li , SHENOY, Suresh, G. , PATTURAJAN, Meera , ELLERMAN, Karen , GORMAN, Linda , ZHONG, Mei , CATTERTON, Elina , SPYTEK, Kimberly, A. , MILLER, Charles, E. , EDINGER, Shlomit, R. , HJALT, Tord , GERLACH, Valerie, L. , SHIMKETS, Richard, A. , TAUPIER, Raymond, J., Jr. , ANDERSON, David, W. , GUO, Xiaojia , BAUMGARTNER, Jason, C. , PADIGARU, Muralidhara , PEYMAN, John, A. , SMITHSON, Glennda , CASMAN, Stacie J. , VOSS, Edward Z. , BOLDOG, Ferenc L. , PENA, Carol E.A. , CHAPOVAL, Andrei , RASTELLI, Luca , KEKUDA, Ramesh , VERNET, Corine A.M.
IPC分类号： A61K31/00
摘要： The present invention relates to novel polypeptides, and the nucleic acids encoding them, having properties related to stimulation of biochemical or physiological responses in a cell, a tissue, an organ or an organism. More particularly, the novel polypeptides are gene products of novel genes, or are specified biologically active fragments or derivatives thereof. Methods of use encompass diagnostic and prognostic assay procedures as well as methods of treating diverse pathological conditions.
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12.发明公开NOVEL ANTIBODIES THAT BIND TO ANTIGENIC POLYPEPTIDES, NUCLEIC ACIDS AND ENCODINGTHE ANTIGENS, AND METHODS OF USE. 审中-公开新抗原多肽结合的抗体ANTI编码基因NUCLEIC和使用方法
公开(公告)号：EP1430110A2
公开(公告)日：2004-06-23
申请号：EP02736496.7
申请日：2002-03-08
申请人： Curagen Corporation
发明人： RASTELLI, Luca , MEZES, Peter, S. , SMITHSON, Glennda , GUO, Xiaojia , GERLACH, Valerie , CASMAN, Stacie, J. , BOLDOG, Ferenc L. , LI, Li , ZERHUSEN, Bryan, D. , TCHERNEV, Velizar, T. , GANGOLLI, Esha, A. , VERNET, Corine, A., M. , PENA, Carol, E.A. , BURGESS, Catherine, E. , LIU, Xiaohong , SPYTEK, Kimberly, A. , RIEGER, Daniel, K.A. , GORMAN, Linda , SPADERNA, Steven, K. , VOSS, Edward, Z. , ANDERSON, David, W. , PATTURAJAN, Meera , MILLER, Charles, E. , TAUPIER, Raymond J. jr. , PADIGARU, Muralidhara , SHENOY, Suresh G. , KEKUDA, Ramesh , GUSEV, Vladimir Y. , POCHART, Pascale, F.-J. , ZHONG, Mei , MISHRA, Vishnu , ALSOBROOK, John, P. II , LEPLEY, Denise, M. , MALYANKAR, Uriel, M.
摘要： Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
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公开(公告)号：EP1427749A2
公开(公告)日：2004-06-16
申请号：EP02713788.4
申请日：2002-03-08
申请人： Curagen Corporation
发明人： PADIGARU, Muralidhara , SPYTEK, Kimberly,A , SHENOY, Suresh,G , TAUPIER, Raymond, J , PENA, Carol,E, A , LI, Li , ZERHUSEN, Bryan,D , GUSEV, Vladimir , JI, Weizhen , GORMAN, Linda , MILLER, Charles, E , KEKUDA, Ramesh , PATTURAJAN, Meera , GANGOLLI, Esha , VERNET,Corine, A.M , GUO,Xiaojia , TCHERNEV, Velizar , FERNANDES, Elma, R , CASMAN, Stacie, J , GERLACH, Valerie , LIU, Yi , ANDERSON, David , SPANDERNA, Steven,K , CATTERTON, Elina , BURGESS, Catherine , LEITE, Mario , ZHONG, Haihong , ALSOBROOK, John,P.II , LEPLEY, Denise, M , RIEGER, Daniel,K , MALYANKAR, Uriel M.
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
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公开(公告)号：EP1409681A2
公开(公告)日：2004-04-21
申请号：EP02784815.9
申请日：2002-01-31
申请人： Curagen Corporation
发明人： TCHERNEV, Velizar, T. , SPYTEK, Kimberly, A. , ZERHUSEN, Bryan, D. , PATTURAJAN, Meera , SHIMKETS, Richard, A. , LI, Li , GANGOLLI, Esha, A. , PADIGARU, Muralidhara , ANDERSON, David, W. , RASTELLI, Luca , MILLER, Charles, E. , GERLACH, Valerie, L. , TAUPIER, Raymond, J., Jr. , GUSEV, Vladimir, Y. , COLMAN, Steven, D. , WOLENC, Adam, R.c/o CuraGen Corporation , PENA, Carol, E., A.c/o CuraGen Corporation , FURTAK, Katarzyna , GROSSE, William, M. , ALSOBROOK, John, P., II , LEPLEY, Denise, M. , RIEGER, Daniel, K. , BURGESS, Catherine, E.
IPC分类号： C12N15/12 , C12N1/21 , C07K14/47 , C07K14/705 , C07K16/18
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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15.发明公开
公开(公告)号：EP1399537A2
公开(公告)日：2004-03-24
申请号：EP02726701.2
申请日：2002-04-03
申请人： Curagen Corporation
发明人： LI, Li , GERLACH, Valerie , LIU, Xiaohong , MILLER, Charles, E. , SPYTEK, Kimberly, A. , ZERHUSEN, Bryan, D. , PENA, Carol, E., A. , SHENOY, Suresh, G. , ZHONG, Haihong , SMITHSON, Glennda , CASMAN, Stacie, J. , BOLDOG, Ferenc, L. , VOSS, Edward, Z. , VERNET, Corine, A., M. , MACDOUGALL, John, R. , RASTELLI, Luca , ANDERSON, David, W. , ZHONG, Mei , MEZES, Peter, S. , FURTAK, Katarzyna , PATTURAJAN, Meera , BURGESS, Catherine E. , MALYANKAR, Uriel M. , SHIMKETS, Richard A. , TAUPIER, Raymond J., Jr. , EDINGER, Shlomit R. , MAZUR, Ann
IPC分类号： C12N1/00
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1354042A2
公开(公告)日：2003-10-22
申请号：EP01999178.5
申请日：2001-12-31
申请人： Curagen Corporation
发明人： SPYTEK, Kimberly, A. , LI, Li , WOLENC, Adam, R. , VERNET, Corine, A., M. , EISEN, Andrew , LIU, Xiaohong , MALYANKAR, Uriel , SHIMKETS, Richard, A. , TCHERNEV, Velizar, T. , SPADERNA, Steven, K. , GORMAN, Linda , KEKUDA, Ramesh , PATTURAJAN, Meera , GUSEV, Vladimir , GANGOLLI, Esha, A. , GUO, Xiaojia , SHENOY, Suresh , RASTELLI, Luca , CASMAN, Stacie, J. , BOLDOG, Ferenc , BURGESS, Catherine E. , EDINGER, Shlomit , ELLERMAN, Karen , GUNTHER, Erik , SMITHSON, Glennda , MILLET, Isabelle , MACDOUGALL, John R.
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00
摘要： Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recobinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
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公开(公告)号：EP1274844A2
公开(公告)日：2003-01-15
申请号：EP01930432.8
申请日：2001-03-30
申请人： Curagen Corporation
发明人： MAJUMDER, Kumud , VERNET, Corine, A., M. , CASMAN, Stacie, J. , WOLENC, Adam R. , SPADERNA, Steven, K. , PADIGARU, Muralidhara , MISHNU, Vishnu, S. , TCHERNEV, Velizar T. , SPYTEK, Kimberly, A. , LI, Li , BAUMGARTNER, Jason, C. , GUSEV, Vladimir, Y.
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1263955A2
公开(公告)日：2002-12-11
申请号：EP01916558.8
申请日：2001-03-12
申请人： Curagen Corporation
发明人： PADIGARU, Muralidhara , VERNET, Corine, A., M. , FERNANDES, Elma , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , MAJUMDER, Kumud , LI, Li
IPC分类号： C12N15/12 , C12N15/10 , C12N15/66 , C07K14/47 , C07K16/18 , G01N33/53 , G01N33/68 , C12Q1/68 , A61K38/17 , A61K39/395 , A61K31/70
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505
摘要： The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
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公开(公告)号：EP1259612A2
公开(公告)日：2002-11-27
申请号：EP01916415.1
申请日：2001-03-05
申请人： Curagen Corporation
发明人： PADIGARU, Muralidhara , BURGESS, Catherine, E. , MAJUMDER, Kumud , MISHRA, Vishnu, S. , LI, Li , BAUMGARTNER, Jason, C. , SPYTEK, Kimberly, A. , TCHERNEV, Velizar, T.
IPC分类号： C12N15/12 , C07K14/705 , C07K16/28 , C12N1/21 , C12N5/10 , G01N33/68 , C12Q1/68 , A61K38/17 , A61K31/70 , A61K39/395
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , C07K2317/21 , C07K2317/622
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecificlly-bind o the polypeptide, as well as derivatives, variants, mutants, or fragments or the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1578905A2
公开(公告)日：2005-09-28
申请号：EP02765778.2
申请日：2002-06-04
申请人： Curagen Corporation
发明人： AGEE, Michele L. , ANDERSON, David W. , BERGHS, Constance , CASMAN, Stacie J. , CATTERTON, Elina , DIPIPPO, Vincent A. , EDINGER, Shlomit R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha A. , GERLACH, Valerie L. , GORMAN, Linda , GUO, Xiaojia , HERRMANN, John L. , HJALT, Tord , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai V. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel M. , MILLER, Charles E. , MILLET, Isabelle , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol E.A. , RASTELLI, Luca , RIEGER, Daniel K. , ROTHENBERG, Mark E. , SHENOY, Suresh G. , SHIMKETS, Richard A. , SMITHSON, Glennda , SPADERNA, Steven K. , SPYTEK, Kimberly A. , STONE, David J. , VERNET, Corine A.M. , ZHONG, Haihong , ZHONG, Mei , ALSOBROOK, John P.,II , BURGESS, Catherine E. , LEPLEY, Denise M.
IPC分类号： C12N1/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
摘要翻译： 本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。 公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。
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