公开(公告)号：EP0764265A4

公开(公告)日：1998-05-20

申请号：EP95923727

申请日：1995-06-05

申请人： UNIV BOSTON

发明人： MADANSHETTY SAMEER I

IPC分类号： G01N29/02 ,  G01N15/06 ,  G21C17/00

CPC分类号： G01N15/06

摘要： A method of detecting (40) particles in ultra-clean liquids in a tube (10) using acoustic scattering and cavitation (30) comprises inducing gas caps to form on the particles. The gas caps are then separated from the particles to form bubbles in the liquid. An acoustic signature received as an echo from the bubbles is detected. The detection of the acoustic signature indicates the presence of particles in the liquid.

公开(公告)号：EP0763009A4

公开(公告)日：1998-05-06

申请号：EP95921230

申请日：1995-05-11

申请人： UNIV BOSTON

发明人： ROTHSCHILD KENNETH J ,  SONAR SANJAY M ,  OLEJNIK JERZY

IPC分类号： A61K38/00 ,  A61K41/00 ,  C07C205/45 ,  C07C205/57 ,  C07D207/40 ,  C07D207/404 ,  C07D311/16 ,  C07D405/12 ,  C07D495/04 ,  C07H19/04 ,  C07H21/00 ,  C07K1/107 ,  C07K1/13 ,  C12P21/00 ,  G01N33/532 ,  C07C205/00 ,  C07C205/06 ,  C07C205/07 ,  C07D235/02 ,  C07H1/06 ,  C07H1/08

CPC分类号： C12Q1/6876 ,  A61K38/00 ,  A61K41/0042 ,  C07C205/45 ,  C07C205/57 ,  C07D207/404 ,  C07D311/16 ,  C07D405/12 ,  C07D495/04 ,  C07H19/04 ,  C07H21/00 ,  C07K1/1077 ,  C07K1/13 ,  C12P21/00 ,  G01N33/532

摘要： The present invention relates to a bioreactive agent comprising a detectable moiety linked to a photo-reactive moiety, wherein said photoreactive moiety comprises at least one group covalently bound to a substrate to form a conjugate that can be selectively photocleaved to release said substrate, wherein said substrate is selected from proteins, peptides, amino acids, lipids, cells, virus particles, fatty acids, nucleic acids, nucleotides, nucleosides, oligonucleotides, polysaccharides and inorganic molecules.

公开(公告)号：EP0744958A4

公开(公告)日：1997-07-30

申请号：EP95909384

申请日：1995-01-27

申请人： UNIV BOSTON

发明人： SHARON JACQUELINE

IPC分类号： A61K38/00 ,  A61K47/48 ,  C07K16/00 ,  C07K16/30 ,  C12N1/21 ,  C12N15/10 ,  C12P21/04 ,  C12P21/08 ,  C40B40/02 ,  A61K51/00 ,  C07K1/00 ,  C12N15/00 ,  C12P21/06

CPC分类号： C40B40/02 ,  A61K38/00 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/55 ,  C12N15/1037

公开(公告)号：EP0649474A4

公开(公告)日：1996-04-03

申请号：EP93916630

申请日：1993-06-18

申请人： UNIV BOSTON

发明人： SIMONS ELIZABETH R ,  DAVIES THERESA A

IPC分类号： G01N33/50 ,  G01N33/68 ,  C12Q1/44 ,  G01N21/00

CPC分类号： G01N33/6896 ,  G01N33/5091 ,  G01N2800/2821

摘要： A method of assaying for non-familial Alzheimer's disease in a live patient, by preparing washed platelets from the blood of the patient; inserting a pH probe in the platelets in the form of a fluorescent dye such as 2',7'-bis (carboxyethyl)- 5(6)-carboxyfluorescein; inhibiting alkalinization of platelet response by blocking Na+/H+ transfer across the platelet membranes with dimethyl amiloride; stimulating the platelets with (alpha)-thrombin so that the cytoplasm of the stimulated platelets shows a characteristic acidification response or change in cytoplasmic pH; measuring the cytoplasmic pH of the platelets following stimulation; and comparing the measured pH with the corresponding stimulated cytoplasmic pH in platelets from normal individuals.

公开(公告)号：EP0576566A4

公开(公告)日：1995-03-15

申请号：EP92908776

申请日：1992-03-18

申请人： UNIV BOSTON

发明人： MOUSTAKAS THEODORE D

IPC分类号： C30B23/08 ,  C30B23/02 ,  C30B29/38 ,  H01L21/203 ,  H01L21/205 ,  H01L21/314 ,  H01L21/318 ,  H01L33/00 ,  H01L33/32 ,  H01S5/323

CPC分类号： H01L33/32 ,  C30B23/02 ,  C30B29/403 ,  C30B29/406 ,  H01L21/0237 ,  H01L21/02381 ,  H01L21/0242 ,  H01L21/02433 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/0262 ,  H01L21/02631 ,  H01L33/007 ,  H01L33/0075 ,  Y10S148/113

摘要： This invention relates to a method of preparing highly insulating GaN single crystal films in a molecular beam epitaxial growth chamber. A single crystal substrate is provided with the appropriate lattice match for the desired crystal structure of GaN. A molecular beam source of Ga and source of activated atomic and ionic nitrogen are provided within the growth chamber. The desired film is deposited by exposing the substrate to Ga and nitrogen sources in a two step growth process using a low temperature nucleation step and a high temperature growth step. The low temperature process is carried out at 100 DEG -400 DEG C. and the high temperature process is carried out at 600 DEG -900 DEG C. The preferred source of activated nitrogen is an electron cyclotron resonance microwave plasma.

公开(公告)号：EP0365615A4

公开(公告)日：1990-06-27

申请号：EP89903398

申请日：1989-02-27

申请人： UNIV BOSTON

发明人： LICHTIN NORMAN N ,  DIMAURO THOMAS M ,  SVRLUGA RICHARD C

IPC分类号： B01J21/06 ,  B01J21/20 ,  B01J35/02 ,  C02F1/28 ,  C02F1/30 ,  C02F1/32 ,  C02F1/72 ,  C02F1/78

CPC分类号： B01J21/063 ,  B01J21/20 ,  C02F1/283 ,  C02F1/32 ,  C02F1/722 ,  C02F1/725 ,  C02F1/78 ,  C02F2305/10 ,  Y02W10/37 ,  Y10S210/908 ,  Y10S502/518

公开(公告)号：EP2999940A4

公开(公告)日：2017-11-15

申请号：EP14800348

申请日：2014-05-22

申请人： NEURALA INC ,  UNIV BOSTON

发明人： GORSHECHNIKOV ANATOLY ,  VERSACE MASSIMILIANO ,  BARNES TIM

IPC分类号： G06N3/00

CPC分类号： B25J9/1694 ,  B25J9/1664 ,  B25J9/1697 ,  G06F17/30241 ,  G06F17/30321 ,  G06K9/4619 ,  G06K9/4671 ,  G06N3/008 ,  G06N3/02 ,  G06N5/02 ,  Y10S901/01 ,  Y10S901/09 ,  Y10S901/46 ,  Y10S901/47

摘要： The systems and methods disclosed herein include a path integration system that calculates optic flow, infers angular velocity from the flow field, and incorporates this velocity estimate into heading calculations. The resulting system fuses heading estimates from accelerometers, gyroscopes, engine torques, and optic flow to determine self-localization. The system also includes a motivational system that implements a reward drive, both positive and negative, into the system. In some implementations, the drives can include: a) a curiosity drive that encourages exploration of new areas, b) a resource drive that attracts the agent towards the recharging base when the battery is low, and c) a mineral reward drive that attracts the agent towards previously explored scientific targets.

公开(公告)号：EP3087402A4

公开(公告)日：2017-09-27

申请号：EP14877490

申请日：2014-12-31

申请人： UNIV BOSTON

发明人： ÜNLÜ M SELIM ,  GOLDBERG BENNETT B ,  LEBLEBICI YUSUF

IPC分类号： G01R31/26 ,  G01R31/28 ,  G01R31/308 ,  G01R31/311 ,  H01L21/66

CPC分类号： G01R31/311 ,  G01R31/2856 ,  H01L22/12 ,  H01L22/14

公开(公告)号：EP3077551A4

公开(公告)日：2017-05-31

申请号：EP14868654

申请日：2014-12-05

申请人： HARVARD COLLEGE ,  UNIV BOSTON

发明人： PARDEE KEITH ,  COLLINS JAMES J

IPC分类号： C12Q1/68 ,  A61K9/14

CPC分类号： C12Q1/6897 ,  C12Q1/6806 ,  C12Q2521/119 ,  C12Q2527/125

摘要： Disclosed herein are shelf-stable compositions based on synthetic gene networks and/or cell-free systems that are lyophilized on a solid support. The compositions can be easily transported and stored for a period of time, and activation can be done by simply adding water. Methods of use are also disclosed herein, including, but are not limited to, sensing and a variety of logic functions. The invention permits straightforward, sterile and abiotic distribution of synthetic biology-based technology to clinical settings, food processing and industry, the military and consumer products.

摘要翻译： 本文公开了基于冻干在固体支持物上的合成基因网络和/或无细胞系统的货架稳定的组合物。 该组合物可以容易地运输和储存一段时间，并且可以通过简单地添加水来进行活化。 本文还公开了使用方法，包括但不限于感测和各种逻辑功能。 本发明允许基于合成生物学的技术直接，无菌和非生物分布到临床环境，食品加工和工业，军事和消费品。

公开(公告)号：EP3044588A4

公开(公告)日：2017-04-12

申请号：EP14843631

申请日：2014-09-15

申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND ,  UNIV BOSTON

发明人： KHISMATULLIN DAMIR ,  HOLT RAY

IPC分类号： G01N33/483 ,  G01N33/49

CPC分类号： G01N33/4905 ,  G01N11/02