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35 条记录 (耗时 0.032 秒)

    Modified coagulation factors with enhanced stability and their derivatives
    25.
    发明公开
    Modified coagulation factors with enhanced stability and their derivatives 审中-公开
    Modifizierte Gerinnungsfaktoren miterhöhterStabilitätund deren Derivate

    公开(公告)号：EP1598367A1

    公开(公告)日：2005-11-23

    申请号：EP04011736.8

    申请日：2004-05-18

    申请人： ZLB Behring GmbH

    发明人： Weimer, Thomas, Dr. ,  Schulte, Stefan, Dr. ,  Hofmann, Kay, Dr. ,  Hauser, Hans-Peter, Dr.

    IPC分类号： C07K14/745 ,  C07K14/755 ,  C12N15/12

    CPC分类号： C07K14/811 ,  C07K14/755 ,  C12N9/0091 ,  C12Y116/03001

    摘要： The present invention relates to modified nucleic acid sequences coding for coagulation Factors, in particular human FV and human Factor VIII and their derivatives with improved stability, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises modified DNA sequences.

    摘要翻译： 本发明涉及编码凝血因子的修饰的核酸序列，特别是人FV和人因子VIII及其衍生物具有改善的稳定性，含有此类核酸序列的重组表达载体，用这种重组表达载体转化的宿主细胞，重组多肽和 确实具有未修饰的野生型蛋白质的生物活性但具有改进的稳定性的生物活性衍生物和用于制备这些重组蛋白质及其衍生物的方法。 本发明还涵盖用于人基因治疗的转移载体，其包含修饰的DNA序列。

    CERULOPLASMIN AND AN ANTIOXIDANT COMPOSITION COMPRISING THE SAME AND THEIR USES AS NEUROPROTECTIVE AGENT
    27.
    发明公开
    CERULOPLASMIN AND AN ANTIOXIDANT COMPOSITION COMPRISING THE SAME AND THEIR USES AS NEUROPROTECTIVE AGENT 审中-公开
    铜蓝蛋白和抗氧化剂成分含相同，及其作为神经保护产品

    公开(公告)号：EP1176977A2

    公开(公告)日：2002-02-06

    申请号：EP00926611.5

    申请日：2000-05-05

    申请人： Gestilab Inc.

    发明人： PAQUIN, Joanne ,  MATEESCU, Mircea-Alexandru ,  DE GRANDPR , ric

    IPC分类号： A61K38/57 ,  A61K38/43

    CPC分类号： C12Y116/03001 ,  A61K38/44 ,  A61K2300/00

    摘要： A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a therapeutically effective amount of ceruloplasmin or a functional derivative thereof. The neuroprotective composition is characterized in that it protects neuronal cells from reactive oxygen species such as •O2- and •OH. In a preferred embodiment, the neuroprotective composition further comprises an antioxidant consisting of catalase or of an amphiphilic physiological antioxidative solution comprising a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

    FRATAXIN MUTANTS
    30.
    发明授权
    FRATAXIN MUTANTS 有权
    突变体FRAAXIN的

    公开(公告)号：EP2598525B1

    公开(公告)日：2015-08-19

    申请号：EP11788225.8

    申请日：2011-07-27

    申请人： Testi, Roberto

    发明人： Testi, Roberto

    IPC分类号： C07K14/47

    CPC分类号： C12N9/0091 ,  A61K38/44 ,  C07K14/47 ,  C12Y116/03001

    摘要： Described herein are compositions and methods for treating Friedreich's Ataxia (FRDA). In some aspects, mutant forms of frataxin which are resistant to ubiquitination are provided. In some aspects, pharmaceutical compositions comprising mutant frataxin are provided. In further aspects, methods of using mutant frataxin are provided.