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    OBJECT MOVING DEVICE
    23.
    发明公开
    OBJECT MOVING DEVICE 审中-公开
    对象移动设备

    公开(公告)号：EP3159396A1

    公开(公告)日：2017-04-26

    申请号：EP14895075.1

    申请日：2014-06-17

    申请人： Yamaha Hatsudoki Kabushiki Kaisha

    发明人： ITO, Saburo ,  OSADA, Yukimasa ,  IZUME, Yohei

    IPC分类号： C12M1/26

    CPC分类号： G01N35/026 ,  C12M31/02 ,  C12M33/06 ,  G01N21/59 ,  G01N35/0099 ,  G01N35/1002 ,  G01N35/1074 ,  G01N35/109 ,  G01N2015/0065 ,  G01N2015/149 ,  G01N2035/0434 ,  G01N2035/1034 ,  G01N2201/062

    摘要： An object moving device includes: a first drive mechanism configured to move a head unit in a first direction and in a second direction that is orthogonal to the first direction in a horizontal direction; a second drive mechanism configured to move an illumination unit in the first direction; a third drive mechanism configured to move a camera unit in the first direction; and a control unit configured to control operations of the first, second, and third drive mechanisms. The control unit controls the first drive mechanism to move the head unit on a first path along a movement line. The control unit controls the second and third drive mechanisms to move the illumination unit and the camera unit on the first path between the first container and the second container. When the head unit and the illumination unit interfere with each other on the first path, the control unit implements control such that the head unit moves in the second direction and the head units moves in the first direction on a second path parallel to the first path.

    摘要翻译： 物体移动装置包括：第一驱动机构，该第一驱动机构构造成使头单元沿第一方向和与第一方向正交的第二方向在水平方向上移动; 第二驱动机构，所述第二驱动机构被构造成沿第一方向移动照明单元; 第三驱动机构，所述第三驱动机构构造成沿第一方向移动相机单元; 以及控制单元，被配置为控制第一，第二和第三驱动机构的操作。 控制单元控制第一驱动机构沿着运动线在第一路径上移动头单元。 控制单元控制第二和第三驱动机构以在第一容器和第二容器之间的第一路径上移动照明单元和相机单元。 当头单元和照明单元在第一路径上彼此干涉时，控制单元执行控制，使得头单元在第二方向上移动并且头单元在平行于第一路径的第二路径上在第一方向上移动 。

    METHOD AND APPARATUS FOR SORTING CELLS
    25.
    发明公开
    METHOD AND APPARATUS FOR SORTING CELLS 审中-公开
    VERFAHREN UND VORRICHTUNG ZUR ZELLSORTIERUNG

    公开(公告)号：EP3109616A1

    公开(公告)日：2016-12-28

    申请号：EP16182851.2

    申请日：2006-02-01

    申请人： Premium Genetics (UK) Limited

    发明人： MUETH, Daniel ,  ANDERSON, Amy, L. ,  KNUTSON, Christopher, R. ,  PLEWA, Joseph

    IPC分类号： G01N15/14

    CPC分类号： G01N21/6428 ,  C12M47/04 ,  G01N15/1404 ,  G01N15/1459 ,  G01N2015/1409 ,  G01N2015/1411 ,  G01N2015/149

    摘要： Apparatus for sorting and orienting sperm cells has a pair or walls (314, 316) in confronting relationship forming a flow chamber (312) having an inlet, a downstream outlet, and intermediate detector region (338). The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid (328) containing the cells (330) to be sorted. The first and second streams have respective flow rates relative to the third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells (330) are oriented parallel to the walls (314, 316). A detector (340) detects desired cells (330) and a sorter (356) downstream of the detector (340) sorts the desired cells (330) from the stream.

    摘要翻译： 用于分选和定向精子细胞的装置具有面对关系的一对或多个壁（314,316），形成具有入口，下游出口和中间检测器区域（338）的流动室（312）。 入口接收第一和第二间隔开的输入流体流和包含要分选的单元（330）的第三流体样品流体（328）。 第一和第二流具有相对于第三流的相应流速，使得第三流收缩形成相对窄的样品流，使得电池（330）平行于壁（314,316）取向。 检测器（340）检测期望的单元（330）并且检测器（340）下游的分选器（356）从流中对期望的单元（330）进行分类。

    A METHOD FOR ANALYSING MARKERS ON THE SURFACE OF VESICLES
    26.
    发明公开
    A METHOD FOR ANALYSING MARKERS ON THE SURFACE OF VESICLES 审中-公开
    VERFAHREN ZUR ANALYZE VON MARKERN AUF DEROBERFLÄCHEVON VESIKELN

    公开(公告)号：EP3093664A1

    公开(公告)日：2016-11-16

    申请号：EP15167673.1

    申请日：2015-05-13

    申请人： Miltenyi Biotec GmbH

    发明人： Bosio, Andreas ,  Wild, Stefan ,  Koliha, Nina

    IPC分类号： G01N33/543

    CPC分类号： G01N33/56972 ,  G01N15/14 ,  G01N33/5076 ,  G01N33/5308 ,  G01N33/5432 ,  G01N33/56966 ,  G01N33/581 ,  G01N33/582 ,  G01N33/588 ,  G01N33/60 ,  G01N2015/0065 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/149

    摘要： The present invention provides a method for analysing levels of markers of subpopulations of vesicles in a sample comprising a heterogeneous population of said vesicles, the method comprising a) contacting said sample with a set of at least two capture agents, marker of said vesicles; thereby capturing at least two subpopulations of said vesicles, b) contacting the captured at least two subpopulations of vesicles with at least two different detection agents, thereby labeling at least two markers of said at least two subpopulations of said vesicles inversely with said at least two capture agents and at least two detection agents, thereby generating an at least 2x2 matrix of signal intensities, and c) determining the levels of said at least two markers of said at least two subpopulations of said vesicles, wherein said levels of said at least two markers of subpopulations of said vesicles are determined relative to each other.

    摘要翻译： 本发明提供了一种用于分析包含所述囊泡的异质群体的样品中囊泡亚群的标记水平的方法，所述方法包括a）使所述样品与一组至少两种捕获剂，所述囊泡的标记接触; 从而捕获所述囊泡的至少两个亚群，b）使捕获的至少两个囊泡子群与至少两种不同的检测剂接触，由此将所述囊泡的所述至少两个亚群的至少两个标记与所述至少两个 捕获剂和至少两种检测剂，从而产生信号强度的至少2×2矩阵，以及c）确定所述囊泡的所述至少两个亚群的所述至少两个标记的水平，其中所述至少两个 确定所述泡囊的亚群的标记物相对于彼此。

    ANALOGS OF SHK TOXIN AND THEIR USES IN SELECTIVE INHIBITION OF KV1.3 POTASSIUM CHANNELS
    28.
    发明公开
    ANALOGS OF SHK TOXIN AND THEIR USES IN SELECTIVE INHIBITION OF KV1.3 POTASSIUM CHANNELS 审中-公开
    ANALOGA VON SHK-TOXIN UND IHRE VERWENDUNG ALS SELEKTIVE INHIBITOREN VON KV1.3-KALIUMKANÄLEN

    公开(公告)号：EP3090753A1

    公开(公告)日：2016-11-09

    申请号：EP16157419.9

    申请日：2005-10-07

    申请人： The Regents of the University of California ,  Bachem Biosciences, Inc

    发明人： CHANDY, K., George ,  BEETON, Christine ,  PENNINGTON, Michael, William

    IPC分类号： A61K38/00

    CPC分类号： A61K38/1767 ,  A61K47/48038 ,  A61K47/48261 ,  A61K47/542 ,  A61K47/6415 ,  G01N33/68 ,  G01N2015/149

    摘要： Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety, etc.) that has an anionic charge. In some embodiments the chemical entity attached to the ShK toxin may comprise an amino acid residue. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or to otherwise treat diseases or disorders. In some embodiments, the chemical entity to which the ShK toxin is attached may be chosen to provide selective inhibition of certain potassium channels (e.g., Kv1.3 channels) over other potassium channels (e.g., Kv1.1 channels). In come embodiments, the chemical entity to which the ShK toxin is attached may include a fluorophore, thereby providing a fluorophore tagged ShK analog. Such fluorophore tagged ShK analogs may be used in flow cytometry alone, or in conjunction with class II tetramers that can detect autoreactive cells.

    摘要翻译： ShK毒素的类似物和使用这种ShK类似物的方法。 ShK类似物通常包含与具有阴离子电荷的化学实体（例如原子，分子，基团，残基，化合物，部分等）连接的ShK毒素。 在一些实施方案中，连接至ShK毒素的化学实体可以包含氨基酸残基。 可以向人类或非人类动物受试者施用ShK类似物以引起钾通道的抑制或以其它方式治疗疾病或病症。 在一些实施方案中，可以选择与其连接的ShK毒素的化学实体以提供对其它钾通道（例如，Kv1.1通道）的某些钾通道（例如，Kv1.3通道）的选择性抑制。 在实施方案中，ShK毒素所连接的化学实体可以包括荧光团，从而提供荧光标记的ShK类似物。 这种荧光标记的ShK类似物可以单独用于流式细胞术，或与可检测自身反应性细胞的II类四聚体结合使用。