公开(公告)号：EP1184074A3

公开(公告)日：2002-04-10

申请号：EP01116411.8

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  Mcfarland, Eric

IPC: B01J19/00 ,  B01F13/08

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: Apparatus for parallel processing of reaction mixtures comprising a reactor block having a series of wells therein extending from an exterior surface of the block, a removable plate removably secured to the reactor block face-to-face with said exterior surface, the removable plate having openings therein in registry with the wells in the reactor block, removable liners in the wells for containing the reaction mixtures, a temperature control system for regulating the temperature of the reaction mixtures, and a stirring system attached to the removable plate and removable with the removable plate for agitating the reaction mixtures, the stirring system comprising spindles extending into respective wells, each of the spindles having a first end and a second end, stirring blade attached to the first end of each of the spindles, a drive mechanism located external to the vessels that is adapted to rotate the spindles, and magnetic feed through devices for magnetically coupling the drive mechanism to the second end of each of the spindles.

公开(公告)号：EP1174183A3

公开(公告)日：2002-04-10

申请号：EP01116442.3

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A. M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  B01F15/00 ,  B01F7/16 ,  F28F27/00 ,  G01K13/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A parallel reactor for simultaneously processing a plurality of reaction mixtures, the reactor comprising: vessels for containing the reaction mixtures, and multi-piece spindles for stirring the reaction mixtures in the vessels, each multi-piece spindle comprising a metal upper spindle portion, a plastic stirrer, and a coupling for releasably coupling the plastic stirrer to the metal upper spindle portion in a position wherein the stirrer extends down into a respective vessel, the plastic stirrer being removable from the coupling after a mixing operation to permit replacement of the stirrer.

Abstract translation: 用于同时处理多种反应混合物的平行反应器，反应器包括：用于容纳反应混合物的容器，以及用于搅拌容器中的反应混合物的多件式锭子，每个多件式锭子包括金属上锭部分， 塑料搅拌器和用于将塑料搅拌器可释放地连接到金属上心轴部分上的联接器，其中搅拌器向下延伸到相应的容器中，在混合操作之后塑料搅拌器可从联接器移除以允许更换搅拌器。

公开(公告)号：EP1184073A2

公开(公告)日：2002-03-06

申请号：EP01116401.9

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES

Inventor： Turner, Howard ,  Dales, G. Cameron ,  Van Erden, Lynn ,  Van Beek, Johannes A.M. ,  Hajduk, Damian A. ,  Nielsen, Ralph B. ,  Mansky, Paul ,  Matsiev, Leonid ,  Wang, Pei ,  McFarland, Eric

IPC: B01J19/00 ,  B01F15/00 ,  F28F27/00 ,  G01K13/00

CPC classification number: B01L3/50851 ,  B01F15/00207 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00056 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N21/253

Abstract: A reactor control system which monitors sensors providing measured values relating to a plurality of reactor vessels of a combinatorial reactor when used in a combinatorial chemical reaction, said system comprising: (a) a receiver for receiving the measured value associated with the contents of each of the plurality of reactor vessels during the course of the combinatorial chemical reaction; and (b) a display for simultaneously displaying during the course of the combinatorial chemical reaction the received measured values, said display comprising a tabular array corresponding to the plurality of reactor vessels.

公开(公告)号：EP1153005A1

公开(公告)日：2001-11-14

申请号：EP00914659.8

申请日：2000-02-22

Applicant: SYMYX TECHNOLOGIES

Inventor： LIU, Yumin

IPC: C07C5/48 ,  B01J23/755 ,  B01J23/76 ,  C01G53/04

CPC classification number: C07C45/34 ,  B01J23/76 ,  B01J23/80 ,  B01J23/83 ,  B01J23/8474 ,  B01J23/8476 ,  C07C5/48 ,  C07C45/33 ,  C07C45/35 ,  C07C51/25 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2523/06 ,  C07C2523/10 ,  C07C2523/20 ,  C07C2523/30 ,  C07C2523/75 ,  C07C2523/755 ,  C07C11/02 ,  C07C47/22 ,  C07C49/08 ,  C07C49/10 ,  C07C47/21 ,  C07C49/205 ,  C07C53/08

Abstract: Catalysts and methods for alkane oxydehydrogenation are disclosed. The catalysts of the invention generally comprise (i) nickel or a nickel-containing compound and (ii) at least one or more of titanium (Ti), tantalum (Ta), niobium (Nb), cobalt (Co), hafnium (Hf), tungsten (W), yttrium (Y), zinc (Zn), zirconium (Zr), or aluminum (Al), or a compound containing one or more of such element(s). In preferred embodiments, the catalyst is a supported catalyst, the alkane is selected from the group consisting of ethane, propane, isopropane, isobutane, n-butane and ethyl chloride, molecular oxygen is co-fed with the alkane to a reaction zone maintained at a temperature ranging from about 250 °C to about 350 °C, and the ethane is oxidatively dehydrogenated to form the corresponding the alkene with an alkane conversion of at least about 10 % and an alkene selectivity of at least about 70 %.

公开(公告)号：EP1131283A1

公开(公告)日：2001-09-12

申请号：EP99974013.7

申请日：1999-09-10

Applicant: SYMYX TECHNOLOGIES

Inventor： GURAM, Anil, S. ,  LUND, Cheryl ,  TURNER, Howard, W. ,  UNO, Tetsuo

IPC: C07C251/24 ,  C07C211/55 ,  C07C223/06 ,  C07D317/28

CPC classification number: C07C211/55 ,  B01J2219/00315 ,  B01J2219/00659 ,  B01J2219/00738 ,  C07C223/06 ,  C07C251/24 ,  C40B60/14

Abstract: New ligands that include a benzene ring in the backbone can be combined with a metal or metal precursor compound or formed into a metal-ligand complex catalyze a number of different chemical transformations, including olefin polymerization reactions. The ligands, complexes formed with the ligands and compositions including the ligands are useful catalysts, depending on the reaction.

公开(公告)号：EP1019947A2

公开(公告)日：2000-07-19

申请号：EP97910017.9

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES

Inventor： WEINBERG, W., Henry ,  MCFARLAND, Eric, W. ,  CONG, Peijun ,  GUAN, Shenheng

IPC: H01J49/00

CPC classification number: G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering and/or optimizing new materials with specific desired properties. According to one aspect, a scanning mass spectrometer is used which includes an ionization chamber and a collector that outputs an electrical signal responsive to the quantity of gas ions contacting the collector surface. A conduit system selectively withdraws samples from the array of materials, passing the samples into the ionization chamber. In a specific embodiment, reactants are passed through the conduit system to the selected regions of interest on the substrate. Means are provided to selectively heat regions on the substrate.

Abstract translation: 提供了用于筛选各种材料阵列的方法和设备。 具体而言，提供了用于快速表征材料的组合阵列中的化合物的技术，以发现和/或优化具有特定期望性质的新材料。 根据一个方面，使用扫描质谱仪，其包括电离室和收集器，该收集器响应于接触收集器表面的气体离子的量输出电信号。 导管系统选择性地从材料阵列中取出样品，使样品进入电离室。 在具体的实施方式中，反应物通过导管系统到达基板上的选定感兴趣区域。 提供手段来选择性地加热衬底上的区域。

公开(公告)号：EP0985678A3

公开(公告)日：2000-07-05

申请号：EP99203630.1

申请日：1997-07-22

Applicant: Symyx Technologies (US/US)

Inventor： Weinberg, Henry W. ,  McFarland, Eric ,  Goldwasser, Isy ,  Boussie, Thomas ,  Turner, Howard ,  van Beek, Johannes A. M. ,  Murphy, Vince ,  Powers, Timothy

IPC: C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C07F19/00 ,  C08F10/00 ,  G01N21/64

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.

Abstract translation: 有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法学，包括组合合成，筛选和表征负载和未负载的有机金属化合物和催化剂（例如均相催化剂）文库。 该方法可用于大量有机金属化合物的制备和筛选，其不仅可以用作催化剂（例如均相催化剂），还可以用作添加剂和治疗剂。

公开(公告)号：EP0983983A3

公开(公告)日：2000-07-05

申请号：EP99203631.9

申请日：1997-07-22

Applicant: Symyx Technologies (US/US)

Inventor： Weinberg, Henry W. ,  McFarland, Eric ,  Goldwasser, Isy ,  Boussie, Thomas ,  Turner, Howard ,  Van Beek, Johannes A. M. ,  Murphy, Vince ,  Powers, Timothy

IPC: C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C07F19/00 ,  C08F10/00 ,  G01N21/64

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：EP0978499A3

公开(公告)日：2000-07-05

申请号：EP99203632.7

申请日：1997-07-22

Applicant: Symyx Technologies (US/US)

Inventor： Weinberg, Henry W. ,  McFarland, Eric ,  Goldwasser, Isy ,  Boussie, Thomas ,  Turner, Howard ,  Van Beek, Johannes A M ,  Murphy, Vince ,  Powers, Timothy

IPC: C07B61/00 ,  C07F19/00 ,  C07F15/00 ,  C07F15/04 ,  C08F10/00 ,  G01N21/64

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：EP0950114A1

公开(公告)日：1999-10-20

申请号：EP98934381.0

申请日：1998-07-10

Applicant: SYMYX TECHNOLOGIES

Inventor： BOUSSIE, Thomas ,  MURPHY, Vince ,  VAN BEEK, Johannes, A., M. ,  DEVENNEY, Martin ,  TURNER, Howard, W. ,  POWERS, Timothy

IPC: B01J19 ,  C07B61 ,  C12Q1 ,  G01N33

CPC classification number: B01J19/00 ,  C07B61/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/543

Abstract: The present invention discloses methods and materials for constructing combinatorial libraries composed of organometallic compounds immobilized on solid supports and encoded with detectable tags. The encoded library of organometallic compound is especially useful for rapidly screening large numbers of member compounds for catalytic performance. These immobilized catalysts can be pooled in a single reactor where they are screened for a predefined property, such as catalytic activity and selectivity.