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62 条记录 (耗时 0.012 秒)

    NON-DESTRUCTIVE FIRMNESS MEASURING DEVICE
    42.
    发明公开
    NON-DESTRUCTIVE FIRMNESS MEASURING DEVICE 失效
    破坏性阻力测量装置

    公开(公告)号：EP0722370A4

    公开(公告)日：1998-03-18

    申请号：EP94928583

    申请日：1994-09-09

    申请人： UNIV GEORGIA RES FOUND

    发明人： PRUSSIA STANLEY E ,  ASTLEFORD JOHN J ,  HEWLETT BOB ,  HUNG YEN-CON

    IPC分类号： A61B3/16 ,  G01N3/00 ,  G01N3/06 ,  G01N3/40 ,  G01N33/02 ,  B07C5/02 ,  G01N3/48

    CPC分类号： G01N33/025 ,  A61B3/165 ,  G01N3/40 ,  G01N2203/0082 ,  G01N2203/0641 ,  G01N2203/0682

    摘要： A firmness measuring device (10) for non-destructive testing of compliant or soft objects, such as fruit, with rough surfaces is disclosed. The device comprises the following components: a fluid supply means (25) with pressure regulating means (30) that define an impulsive air-jet generating unit (20); a means, including accumulator (35), solenoid valve (40) and nozzle (45) to generate an impulsive jet of a fluid, such as air, aimed at the exposed surface of the object (150) under test; a laser (65) to generate a beam of coherent light (75) aimed at the area (155) on the surface of the object (150) under test when impacted by the fluid jet (not shown); a surface-deformation measuring unit (60) having an optical displacement detector (70) to sense the light (80) reflected off of the surface of the object from the incident laser beam (75); an analyzer unit (120) with means to determine the amount of deformation of the surface caused by the fluid jet, as based on the change of input light signal reaching the detector (70); and a controller unit (100) to coordinate the timed release of the impulsive fluid jet with a triggered active functioning of analyzer means near the moment of maximum surface deformation on object (150).

    ANTIMICROBIAL PEPTIDES.
    44.
    发明公开
    ANTIMICROBIAL PEPTIDES. 失效
    抗微生物多肽。

    公开(公告)号：EP0665754A4

    公开(公告)日：1996-06-12

    申请号：EP93923208

    申请日：1993-10-01

    申请人： UNIV EMORY ,  UNIV GEORGIA RES FOUND

    发明人： SHAFER WILLIAM ,  POHL JAN

    IPC分类号： A61K38/00 ,  A01N37/46 ,  A61P1/02 ,  A61P31/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C12N9/64 ,  C12N9/76 ,  C07K14/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C12N9/64 ,  C12N9/6424 ,  C12N9/6427

    摘要： Peptides which exhibit antimicrobial activity comparable to certain known antibiotics are provided. These peptides are related in sequence to amino acid sequences within Cathepsin G. A broad spectrum bactericidal peptide disclosed herein is RPGTLCTVAGWGRVSMRRGT (SEQ ID NO:22). It is active against Pseudomonas aeruginosa, Neisseria gonorrhoeae and Staphylococcus aureus. RRENTQQHITARRAIRHPQY (SEQ ID NO:19) and GKSSGVPPEVFTRFVSSFLPWIRTTMR (SEQ ID NO:26) also exhibited potent activity against P. aeruginosa strains, including clinical isolates. IIGGR (SEQ ID NO:1) and IVGGR (SEQ ID NO:2) act against both gram-negative and gram-positive bacterial strains. HPQYNQR (SEQ ID NO:3) and certain related peptides are also active against both gram-negative and gram-positive bacteria, including, but not limited to, strains of Escherichia coli, Neisseria gonorrhoeae, Staphylococcus aureus, Capnocytophage sputigena and Pseudomonas aeruginosa. The peptides of the present invention will be useful in pharmaceutical compositions useful in the treatment of prophylaxis of infections.

    ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS.
    47.
    发明公开
    ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS. 失效
    ANTAGONISMUS VON HEILMITTELN DES ZENTRALNERVENSYSTEMS DURCH VERABREICHEN DES 4-AMINOPYRIDINS ALLEIN ODER IN ZUSAMMENHANG MIT SONSTIGEN HEILMITTELN。

    公开(公告)号：EP0105361A4

    公开(公告)日：1984-07-24

    申请号：EP83901675

    申请日：1983-04-13

    申请人： UNIV GEORGIA RES FOUND

    发明人： BOOTH NICHOLAS H ,  HATCH ROGER C ,  CRAWFORD LESTER M

    IPC分类号： C07D489/00 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/475 ,  A61K31/485 ,  C07D213/00 ,  C07D459/00

    CPC分类号： A61K31/445 ,  A61K31/44 ,  A61K31/475 ,  A61K31/485 ,  A61K2300/00

    摘要： The use of 4-aminopyridine and congeners or derivatives thereof to antagonize drugs which act at or upon central nervous system receptors, especially dopamine receptors, such as butyrophenones and congeners or derivatives thereof. 4-aminopyridine is used above or in combination with other drugs such as naloxone hydrochloride or yohimbine hydrochloride. The use of 4-aminopyridine overcomes the problems of drug overdoses of drugs which act at or upon central nervous system receptors, especially dopamine receptors by reversing the effects of toxic amounts or toxic dosages.

    摘要翻译： 4-氨基吡啶及其同系物或其衍生物用于拮抗在中枢神经系统受体处或其上作用的药物，特别是多巴胺受体如丁酰苯类和同类物或其衍生物的药物的用途。 4-氨基吡啶在上面或与其他药物如盐酸纳洛酮或盐酸育亨宾联合使用。 4-氨基吡啶的使用克服了药物药物过量的问题，所述药物通过逆转毒性量或毒性剂量的作用而作用于中枢神经系统受体，尤其是多巴胺受体。