利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

197 条记录 (耗时 0.042 秒)

    CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE
    43.
    发明公开
    CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE 审中-公开
    细胞内神经毒素融合蛋白，融合蛋白，其表达及使用

    公开(公告)号：EP3230457A1

    公开(公告)日：2017-10-18

    申请号：EP15867414.3

    申请日：2015-12-09

    申请人： New York University

    发明人： ICHTCHENKO, Konstantin ,  VAZQUEZ-CINTRON, Edwin ,  BANK, Philip, A. ,  CARDOZO, Timothy

    IPC分类号： C12N15/63 ,  C12N15/70

    CPC分类号： C07K14/33 ,  A61K2039/505 ,  C07K16/1282 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/41 ,  C07K2319/50

    摘要： The present invention is directed to a fusion protein comprising a light chain region of a Clostridial neurotoxin and a heavy chain region of a Clostridial neurotoxin, where the light and heavy chain regions are linked by a disulfide bond. The fusion protein also has a single chain antibody positioned upstream of the light chain region, where the single chain antibody possesses antigen-binding activity. Also disclosed are therapeutic agents, treatment methods, propeptide fusions, isolated nucleic acid molecules, expression systems, host cells, and methods of expressing fusion proteins.

    摘要翻译： 本发明涉及包含梭菌神经毒素的轻链区和梭菌神经毒素的重链区的融合蛋白，其中轻链和重链区通过二硫键连接。 融合蛋白还具有位于轻链区上游的单链抗体，其中单链抗体具有抗原结合活性。 还公开了治疗剂，治疗方法，前肽融合物，分离的核酸分子，表达系统，宿主细胞和表达融合蛋白的方法。

    SPIDER SILK FUSION PROTEIN STRUCTURES FOR BINDING TO AN ORGANIC TARGET
    44.
    发明公开
    SPIDER SILK FUSION PROTEIN STRUCTURES FOR BINDING TO AN ORGANIC TARGET 审中-公开
    旋转蛋白质组织蛋白

    公开(公告)号：EP3178843A1

    公开(公告)日：2017-06-14

    申请号：EP16198836.5

    申请日：2011-10-25

    申请人： Spiber Technologies AB

    发明人： JOHANSSON, Jan ,  RISING, Anna ,  NYGREN, Per-Åke ,  HEDHAMMAR, My

    IPC分类号： C07K14/435 ,  C07K16/06 ,  B01D15/38

    CPC分类号： C07K14/43518 ,  B01D15/20 ,  B01D15/3804 ,  B01D15/3809 ,  B01D15/3823 ,  B01J20/281 ,  C07D495/04 ,  C07K14/31 ,  C07K14/76 ,  C07K16/065 ,  C07K2319/01 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/70 ,  C07K2319/705 ,  C12N5/0068 ,  C12N2533/50 ,  Y10S210/905

    摘要： A protein structure capable of selective interaction with an organic target is provided. The protein structure is a polymer comprising as a repeating structural unit a recombinant fusion protein that is capable of selective interaction with the organic target. The fusion protein is comprising the moieties B, REP and CT, and optionally NT. B is a non-spidroin moiety of more than 30 amino acid residues, which provides the capacity of selective interaction with the organic target. REP is a moiety of from 70 to 300 amino acid residues and is derived from the repetitive fragment of a spider silk protein. CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein. NT is an optional moiety of from 100 to 160 amino acid residues and is derived from the N-terminal fragment of a spider silk protein. The fusion protein and protein structure thereof is useful as an affinity medium and a cell scaffold material.

    摘要翻译： 提供了能够与有机靶相互选择性的蛋白质结构。 蛋白质结构是包含能够与有机靶选择性相互作用的重组融合蛋白作为重复结构单元的聚合物。 融合蛋白包含部分B，REP和CT，以及任选的NT。 B是超过30个氨基酸残基的非宿主部分，其提供与有机靶的选择性相互作用的能力。 REP是70至300个氨基酸残基的部分，并衍生自蜘蛛丝蛋白的重复片段。 CT是70至120个氨基酸残基的部分，衍生自蜘蛛丝蛋白的C末端片段。 NT是100至160个氨基酸残基的任选部分，并衍生自蜘蛛丝蛋白的N-末端片段。 其融合蛋白质和蛋白质结构可用作亲和介质和细胞支架材料。

    FUSION MOLECULES
    46.
    发明公开
    FUSION MOLECULES 审中-公开
    FUSIONSMOLEKÜLE

    公开(公告)号：EP3115371A1

    公开(公告)日：2017-01-11

    申请号：EP15306106.4

    申请日：2015-07-07

    申请人： SANOFI

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C07K14/47

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/30 ,  C07K2319/50 ,  C07K2319/70

    摘要： The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

    摘要翻译： 本发明涉及对于pydudine I型，II型和Py和Pyochelin具有结合特异性的融合分子，可用于各种应用，包括诊断和/或治疗应用，例如抑制或减少铜绿假单胞菌的生长和 /或预防或治疗铜绿假单胞菌生物膜感染以及与铜绿假单胞菌生物膜感染相关的疾病或病症。 本发明还涉及生产本文所述的融合分子的方法以及包含这种融合分子的组合物和试剂盒。 本发明还涉及编码本文所述的融合分子的核酸分子。