公开(公告)号：EP2861961A4

公开(公告)日：2016-03-02

申请号：EP13807484

申请日：2013-06-18

Applicant: ABLE INSPECTORS INC D B A FARSHOT

Inventor： CABANISS JOHN

IPC: G01N21/25 ,  G01J3/02 ,  G01J3/12 ,  G01J3/36

CPC classification number: G01J3/0237 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/12 ,  G01J3/36 ,  G01J3/42

公开(公告)号：EP2953215A1

公开(公告)日：2015-12-09

申请号：EP14192304.5

申请日：2014-11-07

Applicant: Ludwig-Maximilians-Universität München

Inventor： Huber, Robert Alexander ,  Karpf, Sebastian ,  Eibl, Matthias

IPC: H01S3/10 ,  H01S3/30 ,  H01S3/094

CPC classification number: G01N21/6456 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/06146 ,  G01N2201/0635 ,  G01N2201/105 ,  G01N2201/11 ,  G01N2201/12 ,  H01S3/06712 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/10015 ,  H01S3/1618 ,  H01S3/2316 ,  H01S3/302 ,  H01S2301/02

Abstract: Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

Abstract translation: 描述了用于诱导和检测多光子过程，特别是样品中的多光子荧光或更高次谐波产生的系统。 该系统包括动态可控光源，所述动态可控光源包括第一子光源，所述第一子光源是电可控制的，以便产生具有第一波长的光的可控时间依赖强度图案， 和至少一个光放大器，从而允许对多光子激发的产生的主动时间控制。 该系统还包括用于将由所述动态可控光源产生的光传送到采样点的光束传送单元，以及用于检测指示所述多光子过程，特别是多光子荧光信号的信号的检测器单元或检测器组件， 高次谐波信号。

公开(公告)号：EP2950708A2

公开(公告)日：2015-12-09

申请号：EP14707449.6

申请日：2014-01-22

Applicant: Koninklijke Philips N.V.

Inventor： HENDRIKS, Bernardus Hendrikus Wilhelmus ,  SCHLEIPEN, Johannes Joseph Hubertina Barbara ,  REICH, Christian ,  LUCASSEN, Gerhardus Wilhelmus ,  MÜLLER, Manfred ,  PULLY, Vishnu Vardhan

IPC: A61B5/00 ,  G01J3/28 ,  G06T11/00

CPC classification number: A61B5/0077 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/1455 ,  A61B5/742 ,  A61B8/12 ,  A61B2560/0223 ,  A61B2576/00 ,  G01J3/0218 ,  G01J3/2823 ,  G06T7/70 ,  G06T2207/10064 ,  G06T2207/30096

Abstract: A medical imaging system for identifying a target structure (TS), e.g. a tumor, in a biological tissue. A hyperspectral camera system is used for imaging a surface area (A1) of the tissue (BT), e.g. with a limited spectral resolution, but enough to allow identification of suspicious areas where the target structure (TS) may be, e.g. such areas can be visually indicated on a display to the operator. A probe (PR), e.g. an optical surface probe, is used to provide probe measurement of a smaller surface area (A2) of the tissue, but with more information indicative of the target structure. The probe is selected to provide a higher specificity with respect to identification of the target structure than the hyperspectral camera (HSC). The hyperspectral processing algorithm (PP) is then calibrated based on probe measurement data performed within the suspicious areas, thus providing a calibrated hyperspectral processing algorithm resulting in images with an enhanced sensitivity to identify the target structure. Only few probe measurements are required to significantly improve the resulting image, thereby providing a reliable and fast target structure (TS) identification.

Abstract translation: 用于识别目标结构（TS）的医学成像系统，例如， 在生物组织中的肿瘤。 高光谱相机系统用于对组织（BT）的表面积（A1）进行成像，例如， 具有有限的光谱分辨率，但足以允许识别目标结构（TS）可能的可疑区域，例如， 这样的区域可以在显示器上被视觉地指示给操作者。 探针（PR），例如 光学表面探针用于提供组织的较小表面积（A2）的探针测量，但具有指示靶结构的更多信息。 选择探针以提供比高光谱相机（HSC）更高的针对目标结构的识别的特异性。 然后，基于在可疑区域内执行的探测测量数据校准高光谱处理算法（PP），从而提供校准的高光谱处理算法，从而产生具有增强灵敏度的图像以识别目标结构。 只需要很少的探头测量来显着改善所得到的图像，从而提供可靠和快速的目标结构（TS）识别。

公开(公告)号：EP2293031A3

公开(公告)日：2015-11-18

申请号：EP10182394.6

申请日：2004-09-08

Applicant: The General Hospital Corporation

Inventor： Yun, Seok Hyun, Ph. D. ,  Bouma, Brett Eugene, Ph. D. ,  Tearney, Guillermo J., MD, Ph. D. ,  Boer, Johannes Fitzgerald de, Ph. D

IPC: G01J3/18 ,  H01S3/10 ,  G01J3/02 ,  G01J3/10 ,  G01N21/47 ,  A61B5/00 ,  G02B27/48 ,  G01B9/02

CPC classification number: H01S5/5045 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02004 ,  G01B9/02043 ,  G01B9/02075 ,  G01B9/02081 ,  G01B9/02083 ,  G01B9/02084 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/453 ,  G01J9/0215 ,  G01N21/4795 ,  G02B6/3604 ,  G02B26/12 ,  G02B27/48 ,  G02F1/093 ,  G02F1/11 ,  H01S3/0071 ,  H01S3/0078 ,  H01S3/08009 ,  H01S3/08063 ,  H01S3/105 ,  H01S3/1068 ,  H01S5/0071 ,  H01S5/0078 ,  H01S5/1025 ,  H01S5/14 ,  H01S5/141 ,  H01S5/146

Abstract: An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.

公开(公告)号：EP2904359A1

公开(公告)日：2015-08-12

申请号：EP13783730.8

申请日：2013-10-08

Applicant: SI-Ware Systems ,  Sabry, Yasser, M. ,  Khalil, Diaa, A.m. ,  Saadany, Bassam, A.

Inventor： SABRY, Yasser, M. ,  KHALIL, Diaa, A. M. ,  SAADANY, Bassam, A.

IPC: G01J3/02 ,  G01J3/26 ,  G01J3/453

CPC classification number: G01J3/45 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/26 ,  G01J3/4535 ,  G01J2003/4538

Abstract: A spectrometer with improved resolution includes a spectral domain modulator having a periodic response in the spectral domain to modulate a wideband source spectrum and cause one or more shifted bursts in the interferogram.

公开(公告)号：EP2887050A1

公开(公告)日：2015-06-24

申请号：EP13199357.8

申请日：2013-12-23

Applicant: Hochschule Reutlingen

Inventor： Kessler, Rudolf W. ,  Ostertag, Edwin ,  Ritz, Rainer ,  Bartsch, Jörg-Walter

IPC: G01N21/31 ,  A61B5/00

CPC classification number: G01N21/31 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/1459 ,  A61B5/415 ,  A61B5/7264 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/06 ,  G01J3/1256 ,  G01J3/14 ,  G01J3/18 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/44 ,  G01J3/443 ,  G01J3/45 ,  G01J2003/2826

Abstract: The invention relates to a method for a marker-free demarcation of distinct areas of a tissue in vitro, comprising the steps of recording at least two different spectra and/or spectral images of the tissue, analyzing the recorded spectra and/or spectral images by a multivariate data analysis to segment the tissues into distinct areas of similar spectral signature, and classifying each area as physiological, pathological or dead according to its spectral signature.

Abstract translation: 本发明涉及一种用于在体外对组织的不同区域进行无标记分界的方法，包括以下步骤：记录组织的至少两个不同的光谱和/或光谱图像，通过以下步骤分析所记录的光谱和/或光谱图像： 多元数据分析，将组织分成不同区域的相似光谱特征，并根据其光谱特征将每个区域分类为生理，病理或死亡。

公开(公告)号：EP2877692A1

公开(公告)日：2015-06-03

申请号：EP13766748.1

申请日：2013-09-05

Applicant: Halliburton Energy Services, Inc.

Inventor： SAMSON, Etienne, M. ,  MAIDA, John, L.

IPC: E21B47/06 ,  E21B47/10 ,  E21B47/12

CPC classification number: G02F1/0115 ,  E21B41/00 ,  E21B47/06 ,  E21B47/10 ,  E21B47/123 ,  G01J3/00 ,  G01J3/0218 ,  G01J3/10 ,  G01N2021/855 ,  G01V8/24 ,  G02F1/365 ,  G02F2001/3528

Abstract: A disclosed remote work system (100) includes a light source (102) and a nonlinear converter (108A-N) optically coupled to and remote from the light source. The nonlinear light converter converts a narrowband light pulse received from the light source to a converted spectrum light pulse. The system also includes a work element (110A-N) coupled to the nonlinear light converter. The work element performs a work operation using the converted spectrum light pulse. A related remote work method includes generating a narrowband light pulse and conveying the narrowband light pulse to a remote location (114). The method also includes converting the narrowband light pulse to a converted spectrum light pulse at the remote location. The method also includes performing a sense operation or work operation at the remote location using the converted spectrum light pulse.

公开(公告)号：EP2831565A4

公开(公告)日：2015-04-15

申请号：EP13768319

申请日：2013-03-26

Applicant: INNOVATIVE SCIENCE TOOLS INC

Inventor： MICHEELS RONALD H ,  LEE DON J

IPC: G01N21/3563 ,  G01J3/02 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/85 ,  G01N21/95 ,  G02B6/42

CPC classification number: G01N21/255 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/18 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/8507 ,  G01N21/9508 ,  G01N2021/475 ,  G01N2021/4759 ,  G01N2201/0627 ,  G01N2201/0631 ,  G02B6/4298

Abstract: A device and method for identifying solid and powdered materials use near-infrared reflection spectroscopy combined with multivariate calibration methods for analysis of the spectral data. Near-infrared reflection spectroscopy is employed within either the 700-1100 nm or the 900-1700 nm wavelength range to identify solid or powdered materials and determine whether they match specific known materials. Uses include identifying solid and powdered materials with a fast measurement cycle time of about 2 to 15 seconds and with a method that requires no sample preparation, as well as quantitative analysis to determine the concentration of one or more chemical components in a solid or powdered sample that consists of a mixture of components. A primary application involving identification analysis verification of the identify and purity of powdered materials used for fabricating drug tablets and capsules for quality control purposes.

Abstract translation: 用于识别固体和粉末材料的装置和方法使用近红外反射光谱结合多变量校准方法来分析光谱数据。 在700-1100nm或900-1700nm波长范围内采用近红外反射光谱法来鉴定固体或粉末材料，并确定它们是否与特定的已知材料相匹配。 用途包括以大约2至15秒的快速测量周期时间确定固体和粉末材料，并采用不需要样品制备的方法，以及定量分析来确定固体或粉末样品中一种或多种化学成分的浓度 它由组分的混合物组成。 涉及用于制造药物片剂和胶囊用于质量控制目的的粉末材料的鉴定和纯度的识别分析验证的主要应用。

公开(公告)号：EP2309923A4

公开(公告)日：2015-03-18

申请号：EP09798660

申请日：2009-07-14

Applicant: GEN HOSPITAL CORP

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT EUGENE ,  YELIN DVIR ,  KANG DONGKYUN

IPC: A61B5/05 ,  A61B5/07 ,  G01J3/02 ,  G01J3/18 ,  G02B23/24 ,  G05F1/00

CPC classification number: A61B1/00172 ,  A61B1/04 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G01N21/4795 ,  G02B23/2423 ,  G02B23/2469

公开(公告)号：EP2829855A1

公开(公告)日：2015-01-28

申请号：EP14165535.7

申请日：2014-04-23

Applicant: Canon Kabushiki Kaisha ,  The University of Tokyo

Inventor： Sukegawa, Takashi ,  Kobayashi, Yohei ,  Ozawa, Akira ,  Endo, Mamoru ,  Gonokami, Makoto

IPC: G01J3/02 ,  G01J3/18 ,  G01J3/22 ,  G01J1/04

CPC classification number: G02B27/1086 ,  G01J1/0411 ,  G01J1/0414 ,  G01J1/0425 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/1804 ,  G01J3/22 ,  G01J3/2823 ,  G01J2003/1861 ,  G01N21/75 ,  G02B5/18 ,  G02B2005/1804

Abstract: The present invention provides a spectral apparatus for spectrally separating light including a predetermined wavelength, including a slit that the light enters, a first optical system configured to collimate the light from the slit, a transmissive type diffraction element configured to diffract the light from the first optical system, and a second optical system including a first mirror configured to reflect the light diffracted by the transmissive type diffraction element, and a second mirror configured to reflect the light reflected by the first mirror and diffracted by the transmissive type diffraction element, and configured to make the light reciprocally travel between the first mirror and the second mirror via the transmissive type diffraction element.

Abstract translation: 本发明提供了一种用于光谱分离包括光入射的狭缝的预定波长的光的光谱装置，被配置为准直来自狭缝的光的第一光学系统，被配置为衍射来自第一 光学系统，以及第二光学系统，包括被配置为反射由透射型衍射元件衍射的光的第一反射镜，以及被配置为反射由第一反射镜反射并被透射型衍射元件衍射的光的第二反射镜， 以使光通过透射型衍射元件在第一反射镜和第二反射镜之间往复行进。