公开(公告)号：EP1696915A1

公开(公告)日：2006-09-06

申请号：EP04801352.8

申请日：2004-12-06

Applicant: Pfizer, Inc.

Inventor： EDWARDS, Martin, P., Agouron Pharmaceuticals, Inc ,  JOHNSON, Theodore O., Agouron Pharmaceutica, Inc. ,  NAIR, Sajiv K., Agouron Pharmaceuticals, Inc. ,  SIU, Michael, Agouron Pharmaceuticals, Inc. ,  TAYLOR, Wendy, D., Agouron Pharmaceuticals, Inc. ,  CRIPPS, Stephan J., Agouron Pharmaceuticals, Inc. ,  WANG, Yong, Agouron Pharmaceuticals, Inc. ,  CHENG, Hengmiao, Agouron Pharmaceuticals, Inc. ,  SMITH, Christopher, Agouron Pharmaceuticals Inc.

IPC: A61K31/44 ,  A61K31/4436 ,  C07D213/76 ,  C07D409/12 ,  C07D401/12 ,  C07D417/12 ,  C07C311/37 ,  C07C311/36 ,  A61P3/10 ,  A61P3/04

CPC classification number: C07D209/08 ,  C07D213/76 ,  C07D215/38 ,  C07D235/06 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D513/04

Abstract: The present invention relates to compounds with the formula (I), or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of (C1-C6)alkyl, -(CR3R4)t(C3-C12)cycloalkyl, -(CR3R4)t(C6-C12)aryl, and -(CR3R4)t(4-10)-membered heterocyclyl; b and k are each independently selected from 1 and 2; j is selected from the group consisting of 0, 1, and 2; t, u, p, q, and v are each independently selected from the group consisting of 0, 1, 2, 3, 4, and 5; T is a (6-10)-membered heterocyclyl containing at least one nitrogen atom; R2 is selected from the group consisting of H, (C1-C6)alkyl, -(CR3R4)t(C3-C12)cycloalkyl, -(CR3R4)t(C6-C12)aryl, and -(CR3R4)t(4-10)-membered heterocyclyl; each R3 and R4 is independently selected from H and (C1-C6)alkyl, the carbon atoms of T, R1, R2, R3 and R4 may each be optionally, substituted by I to 5 R5 groups; R5 is defined in the claims; The compounds of the present invention are 11 ß-hsd-1 inhibitors, and are therefore believed to be useful in the treatment of diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, depression, hypertension, and metabolic diseases.

公开(公告)号：EP1443041A4

公开(公告)日：2006-06-07

申请号：EP02777984

申请日：2002-10-29

Applicant: KISSEI PHARMACEUTICAL

Inventor： UCHIDA MASAHIKO ,  KOBAYASHI HIROAKI ,  KAI YUICHIRO ,  YOKOYAMA KENJI ,  TERAO YOSHIHIRO ,  MURANAKA HIDEYUKI

IPC: A61K31/18 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P25/28 ,  A61P31/16 ,  C07C311/29 ,  C07D207/00 ,  C07D207/16 ,  C07D207/26 ,  C07D207/273 ,  C07D211/42 ,  C07D211/60 ,  C07D213/42 ,  C07D213/82 ,  C07D231/12 ,  C07D233/02 ,  C07D261/08 ,  C07D263/38 ,  C07D271/10 ,  C07D271/113 ,  C07D277/28 ,  C07D277/44 ,  C07D277/46 ,  C07D295/088 ,  C07D295/13 ,  C07D295/185 ,  C07D295/192 ,  C07D317/62 ,  C07D333/20 ,  C07C311/37 ,  A61K31/00 ,  C07D211/62 ,  C07D213/00 ,  C07D233/36 ,  C07D241/04 ,  C07D263/20 ,  C07D271/00 ,  C07D295/00 ,  C07D333/00

CPC classification number: C07D207/273 ,  A61K31/18 ,  C07C311/29 ,  C07D207/00 ,  C07D207/16 ,  C07D211/42 ,  C07D211/60 ,  C07D213/42 ,  C07D213/82 ,  C07D231/12 ,  C07D233/02 ,  C07D261/08 ,  C07D263/38 ,  C07D271/113 ,  C07D277/28 ,  C07D277/46 ,  C07D295/088 ,  C07D295/13 ,  C07D295/185 ,  C07D295/192 ,  C07D317/62 ,  C07D333/20

Abstract: 5-Amidino-2-hydroxybenzenesulfonamide derivatives represented by the following general formula [I] exhibiting a potent and selective inhibitory activity on activated blood coagulation factor X and thus being useful as preventives or remedies for diseases in the onset of which activated blood coagulation factor X participates: [I] wherein R1 represents optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted alkenyl, cycloalkyl, lower acyl, etc.; Q represents hydrogen or optionally substituted lower alkyl; and Z represents hydrogen, hydroxy, etc.; pharmacologically acceptable salts thereof, medicinal compositions containing the same and intermediates in the production thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer’s diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.

公开(公告)号：EP1077928B1

公开(公告)日：2005-12-07

申请号：EP99918037.5

申请日：1999-05-10

Applicant: Les Laboratoires Servier

Inventor： LESIEUR, Daniel ,  KLUPSCH, Frédérique ,  GUILLAUMET, Gérald ,  VIAUD, Marie-Claude ,  LANGLOIS, Michel ,  BENNEJEAN, Caroline ,  RENARD, Pierre ,  DELAGRANGE, Philippe

IPC: C07C233/43 ,  C07C233/62 ,  C07C237/48 ,  C07C271/30 ,  C07C275/24 ,  C07C311/37 ,  C07D307/81 ,  C07D307/85 ,  C07D311/58 ,  C07D319/18 ,  C07D333/58 ,  C07D471/04 ,  A61K31/165

CPC classification number: C07D207/27 ,  C04B35/632 ,  C07C233/43 ,  C07C233/62 ,  C07C233/65 ,  C07C237/48 ,  C07C271/20 ,  C07C275/24 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/14 ,  C07D209/20 ,  C07D209/60 ,  C07D213/70 ,  C07D221/10 ,  C07D231/12 ,  C07D233/42 ,  C07D233/56 ,  C07D233/84 ,  C07D235/06 ,  C07D249/08 ,  C07D261/20 ,  C07D307/81 ,  C07D307/92 ,  C07D311/58 ,  C07D311/60 ,  C07D319/18 ,  C07D319/20 ,  C07D333/20 ,  C07D333/38 ,  C07D333/58 ,  C07D333/74 ,  C07D335/06 ,  C07D335/08 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14

公开(公告)号：EP1472260A2

公开(公告)日：2004-11-03

申请号：EP03715930.8

申请日：2003-01-14

Applicant: PHARMACIA & UPJOHN COMPANY

Inventor： LARSEN, Scott, D. ,  MAY, Paul, D. ,  ROMINES, Karen ,  SCHNUTE, Mark, E. ,  TANIS, Steven, P. ,  NIEMAN, James, A. ,  ANDERSON, David, John ,  KIM, Euibong, J. ,  TURNER, Steven, Ronald

IPC: C07D495/04 ,  C07D213/89 ,  C07D231/12 ,  C07D233/54 ,  C07D241/12 ,  C07D265/36 ,  C07D277/28 ,  C07D295/12 ,  C07C215/34 ,  C07C233/43 ,  C07C311/37 ,  C07C317/32 ,  A61K31/4365 ,  A61P31/22

CPC classification number: C07D495/04

Abstract: The invention provides a compound of formula I: (F) wherein G, R2, R3, and R4 have any of the values defined in specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpesvirus infection using such compounds or salts.

公开(公告)号：EP0882707B1

公开(公告)日：2003-10-08

申请号：EP96942564.4

申请日：1996-12-18

Applicant: Asahi Kasei Kabushiki Kaisha

Inventor： MIYOSHI, Shiro ,  OGAWA, Kohei

IPC: C07C311/37 ,  C07C311/08 ,  C07C311/13 ,  C07C307/10 ,  C07D209/88 ,  C07D307/91 ,  C07D333/76 ,  A61K31/40 ,  A61K31/34 ,  A61K31/38 ,  A61K31/135

CPC classification number: C07D307/91 ,  C07C307/10 ,  C07C311/08 ,  C07C311/37 ,  C07C2603/18 ,  C07D209/88 ,  C07D333/76

Abstract: Compounds represented by general formula (I) or salts thereof, a process for producing the same, and intermediates therefor, wherein R represents hydrogen or methyl; R1 represents hydrogen, halogeno, hydroxy, benzyloxy, amino, or hydroxymethyl; R2 represents hydrogen, hydroxymethyl, NHR3, SO2NR4R4, or nitro; R6 represents hydrogen or lower alkyl; and X represents nitrogen, oxygen, sulfur, or methylene, provided that when X represents nitrogen, oxygen, or sulfur, then R9 represents hydrogen, one of R?7 and R8¿ represents hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy, and when X represents methylene, then R?7 and R8¿ each represents hydrogen and R9 represents hydrogen, amino, etc. They have a β-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc.

公开(公告)号：EP1157002A1

公开(公告)日：2001-11-28

申请号：EP00901861.5

申请日：2000-02-18

Applicant: Pfizer Limited ,  PFIZER INC.

Inventor： MIDDLETON, Donald Stuart ,  STOBIE, Alan

IPC: C07C237/20 ,  C07C237/48 ,  C07C311/37 ,  C07D249/06 ,  C07C229/50

CPC classification number: C07D213/64 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/15 ,  A61K31/343 ,  A61K31/451 ,  A61K31/4525 ,  C07B2200/07 ,  C07C211/42 ,  C07C211/60 ,  C07C215/42 ,  C07C215/64 ,  C07C229/46 ,  C07C229/50 ,  C07C233/43 ,  C07C235/20 ,  C07C237/20 ,  C07C237/48 ,  C07C255/58 ,  C07C259/18 ,  C07C275/24 ,  C07C307/06 ,  C07C311/08 ,  C07C311/13 ,  C07C311/35 ,  C07C311/37 ,  C07C317/28 ,  C07C317/32 ,  C07C323/29 ,  C07C323/38 ,  C07C2601/02 ,  C07C2602/10 ,  C07D213/73 ,  C07D231/12 ,  C07D231/38 ,  C07D239/26 ,  C07D239/42 ,  C07D239/48 ,  C07D239/54 ,  C07D249/06 ,  C07D249/08 ,  C07D271/06 ,  C07D295/088 ,  C07D295/145 ,  C07D295/185 ,  C07D295/192 ,  C07D295/26 ,  C07F5/025

Abstract: The invention provides compounds of formula (I), wherein R?1 and R2¿ independently represent H or C¿1-6? alkyl; R?3¿ represents phenyl substituted by at least one group selected form halo, CF¿3?, OCF3, CN, OH, C1-6 alkyl and C1-6 alkoxy; and R?4, R5 and R11¿ independently represent H or -(CH¿2?)n-A, wherein n represents 0, 1 or 2, provided that at least one of R?4, R5 and R11¿ is other than H; A represents CONR6R7 or SO¿2NR?6R7, wherein R?6 and R7¿ independently represent H, C¿3-6? cycloalkyl or C1-6 alkyl, the C?1-6¿ alkyl group being optionally substituted, in addition, R?6 and R7¿ may, together with the N atom to which they are attached, represent a ring which is optionally substituted; CO¿2R?8, wherein R8 represents H or C¿1-6? alkyl; NR?9R10¿, wherein R?9 and R10¿ independently represent H, C¿1-6? alkyl (optionally substituted), (C1-6 alkyl)SO2-, (C1-6 alkyl)CO-, H2NSO2- or H2NCO-; a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, which is optionally substituted; S(O)x(C1-6 alkyl), wherein x represents 0, 1 or 2; OH; CN, NO2; or C1-6 alkoxy which is optionally substituted; provided that when NR?1R2¿ represents N(H) methyl, R4 represents H and R3 represents 4- chlorophenyl, then R5 does not represent methoxy; and pharmaceutically acceptable salts thereof. The compounds of the invention are useful in the treatment or prevention of a variety of disorders, including those in which the regulation of monoamine transporter function is implicated.

Abstract translation: 本发明提供式（I）化合物，其中R 1和R 2独立地表示H或C 1-6烷基; R 3表示被至少一个选自卤素，CF 3，OCF 3，CN，OH，C 1-6烷基和C 1-6烷氧基的基团取代的苯基; 和R 4，R 5和R 11独立地表示H或 - （CH 2）n A，其中n表示0,1或2，条件是R 4，R 5和 R 11不是H; A表示CONR 6 R 7或SO 2 NR 6 R 7，其中R 6和R 7独立地表示H，C 3-6环烷基或C 1-6烷基，C 1-6 >烷基任选被取代，此外，R 6和R 7可以与它们所连接的N原子一起代表任选被取代的环; CO 2 R 8，其中R 8表示H或C 1-6烷基; NR 9 R 10，其中R 9和R 10独立地表示H，C 1-6烷基（任选取代的），（C 1-6烷基）SO 2 - ，（C 1-6烷基）CO-， H2NSO2-或H2NCO-; 含有1,2或3个选自N，S和O的杂原子的5-或6-元杂环，其被任选取代; S（O）x（C 1-6烷基），其中x表示0,1或2; 哦; CN，NO2; 或任选取代的C 1-6烷氧基; 条件是当NR 1 R 2表示N（H）甲基时，R 4表示H且R 3表示4-氯苯基，则R 5不表示甲氧基; 及其药学上可接受的盐。 本发明的化合物可用于治疗或预防各种疾病，包括涉及单胺转运蛋白功能调节的疾病。

公开(公告)号：EP1077928A1

公开(公告)日：2001-02-28

申请号：EP99918037.5

申请日：1999-05-10

Applicant: ADIR ET COMPAGNIE

Inventor： LESIEUR, Daniel ,  KLUPSCH, Frédérique ,  GUILLAUMET, Gérald ,  VIAUD, Marie-Claude ,  LANGLOIS, Michel ,  BENNEJEAN, Caroline ,  RENARD, Pierre ,  DELAGRANGE, Philippe

IPC: C07C233/43 ,  C07C233/62 ,  C07C237/48 ,  C07C271/30 ,  C07C275/24 ,  C07C311/37 ,  C07D307/81 ,  C07D307/85 ,  C07D311/58 ,  C07D319/18 ,  C07D333/58 ,  C07D471/04 ,  A61K31/165

CPC classification number: C07D207/27 ,  C04B35/632 ,  C07C233/43 ,  C07C233/62 ,  C07C233/65 ,  C07C237/48 ,  C07C271/20 ,  C07C275/24 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/14 ,  C07D209/20 ,  C07D209/60 ,  C07D213/70 ,  C07D221/10 ,  C07D231/12 ,  C07D233/42 ,  C07D233/56 ,  C07D233/84 ,  C07D235/06 ,  C07D249/08 ,  C07D261/20 ,  C07D307/81 ,  C07D307/92 ,  C07D311/58 ,  C07D311/60 ,  C07D319/18 ,  C07D319/20 ,  C07D333/20 ,  C07D333/38 ,  C07D333/58 ,  C07D333/74 ,  C07D335/06 ,  C07D335/08 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14

Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R?1, R2, R3¿, v and R4 are as defined in the description; R' represents a -(CH¿2)t-R?5 group wherein t and R5 are as defined in the description.

Abstract translation: 本发明涉及式（I）化合物：R-A-R“worin：A是如说明书中所定义; R 2表示，其中E，Q，R <1>，R <2>，R <3>，V和R <4>如定义的基团（V），（VI），（VII）或（VIII）， 在说明书; R“darstellt一个 - （CH 2）T-R <5>组worin T和R <5>如说明书中所定义，以及药物含有相同。

公开(公告)号：EP1053224A1

公开(公告)日：2000-11-22

申请号：EP99913138.6

申请日：1999-02-04

Applicant: Aventis Pharma Deutschland GmbH

Inventor： KLEEMANN, Heinz-Werner ,  LANG, Hans-Jochen ,  SCHWARK, Jan-Robert ,  WEICHERT, Andreas ,  FABER, Sabine ,  JANSEN, Hans-Willi ,  PETRY, Stefan

IPC: C07C311/46 ,  C07C311/37 ,  C07D333/24 ,  C07D333/60 ,  C07D209/18 ,  A61K31/18

CPC classification number: C07C311/47 ,  C07C311/37 ,  C07C311/46 ,  C07C317/44 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10

Abstract: The invention relates to compounds of formula (I) in which the symbols have the meanings given in the description. The compounds have excellent antiarrhythmic properties and comprise a cardioprotective component. The inventive compounds can preventively inhibit or strongly reduce the pathophysiological processes when ischaemic induced damages arise, especially during the onset of ischaemic induced cardiac arrhythmias. In addition, the inventive compounds have a strong inhibiting effect on the proliferation of cells.

公开(公告)号：EP1020434A4

公开(公告)日：2000-11-15

申请号：EP98938906

申请日：1998-08-20

Applicant: KISSEI PHARMACEUTICAL

Inventor： AKAHANE SATOSHI ,  UCHIDA MASAHIKO ,  ISAWA HIDEOTOSHI ,  KIKUCHI NORIHIKO ,  OZAWA TOMONAGA ,  KOBAYASHI HIROAKI ,  KAI YUICHIRO ,  AKAHANE KENJI

IPC: C07C255/58 ,  C07C257/18 ,  C07C311/37 ,  C07C317/32 ,  C07D211/26 ,  C07D211/46 ,  C07D233/54 ,  C07D233/64 ,  C07D295/195 ,  C07D295/24 ,  C07D401/12 ,  A61K31/165 ,  A61K31/245 ,  A61K31/415 ,  A61K31/445 ,  A61K31/505 ,  C07C271/44 ,  C07C307/10 ,  C07C311/08

CPC classification number: C07D233/64 ,  C07C255/58 ,  C07C257/18 ,  C07C311/37 ,  C07C317/32 ,  C07C2601/02 ,  C07D211/26 ,  C07D211/46 ,  C07D295/195 ,  C07D295/24 ,  C07D401/12

Abstract: 3-Amidinoaniline derivatives represented by general formula (I) which have potent and selective activity of inhibiting activated blood coagulation factor X and are useful as activated blood coagulation factor X inhibitors, or pharmacologically acceptable salts thereof and intermediates in producing the same, wherein R represents hydrogen, lower alkyl, lower alkenyl, etc; R1 represents hydrogen, hydroxy, lower alkyl, etc.; Y represents a single bond or oxygen; and R2 represents lower alkyl or a group represented by (a) wherein n is 1 or 2; and T is hydrogen or -C(=NH)-W (wherein W is lower alkyl).

Abstract translation: 本发明涉及由以下通式表示的三脒基苯胺衍生物： worinřdarstellt氢原子，低级烷基，低级链烯基等; [R <1> darstellt氢原子，羟基，低级烷基等; Y表示单键或氧原子; 且R <2> darstellt低级烷基或由通式表示的基团： worinÑdarstellt 1或2; 和T表示氢原子或由下述通式表示的基团：-C（= NH）-W worinW¯¯darstellt低级烷基; 或其药学上可接受的盐，其具有有效的和选择性的活化血液凝固因子X抑制活性，并以中间的制造两者。

公开(公告)号：EP0904262A4

公开(公告)日：2000-10-04

申请号：EP97903805

申请日：1997-01-13

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： BILLER SCOTT A ,  DICKSON JOHN K ,  LAWRENCE R MICHAEL ,  MAGNIN DAVID R ,  POSS MICHAEL A ,  ROBL JEFFREY A ,  SLUSARCHYK WILLIAM A ,  SULSKY RICHARD B ,  TINO JOSEPH A

IPC: A61K31/00 ,  A61K31/191 ,  A61K31/34 ,  A61K31/341 ,  A61K31/365 ,  A61K31/366 ,  A61K31/38 ,  A61K31/381 ,  A61K31/382 ,  A61K31/39 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/505 ,  A61K31/52 ,  A61K31/535 ,  C07C17/093 ,  C07C33/34 ,  C07C47/453 ,  C07C49/225 ,  C07C49/252 ,  C07C49/563 ,  C07C49/567 ,  C07C49/573 ,  C07C69/00 ,  C07C205/11 ,  C07C205/43 ,  C07C205/55 ,  C07C233/57 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C233/62 ,  C07C233/63 ,  C07C233/78 ,  C07C235/40 ,  C07C235/56 ,  C07C237/22 ,  C07C237/24 ,  C07C255/41 ,  C07C259/08 ,  C07C271/22 ,  C07C291/04 ,  C07C311/19 ,  C07C311/21 ,  C07C311/37 ,  C07C311/42 ,  C07C311/46 ,  C07C317/12 ,  C07C321/22 ,  C07C323/60 ,  C07D207/32 ,  C07D207/335 ,  C07D207/38 ,  C07D209/08 ,  C07D209/16 ,  C07D209/34 ,  C07D209/38 ,  C07D209/46 ,  C07D209/48 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/64 ,  C07D213/74 ,  C07D213/75 ,  C07D213/80 ,  C07D213/89 ,  C07D221/16 ,  C07D231/56 ,  C07D233/24 ,  C07D233/54 ,  C07D233/78 ,  C07D233/84 ,  C07D233/88 ,  C07D233/90 ,  C07D235/06 ,  C07D235/08 ,  C07D235/16 ,  C07D235/24 ,  C07D235/26 ,  C07D235/28 ,  C07D235/30 ,  C07D239/38 ,  C07D239/42 ,  C07D239/46 ,  C07D249/12 ,  C07D249/14 ,  C07D249/18 ,  C07D253/06 ,  C07D253/07 ,  C07D263/38 ,  C07D263/46 ,  C07D263/58 ,  C07D271/06 ,  C07D271/07 ,  C07D277/20 ,  C07D277/36 ,  C07D277/56 ,  C07D277/74 ,  C07D285/08 ,  C07D285/12 ,  C07D285/125 ,  C07D295/108 ,  C07D295/155 ,  C07D295/185 ,  C07D307/14 ,  C07D307/52 ,  C07D311/84 ,  C07D317/30 ,  C07D317/58 ,  C07D319/06 ,  C07D327/06 ,  C07D333/20 ,  C07D335/14 ,  C07D335/20 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07F7/18 ,  C07F9/40 ,  C07F9/58 ,  C07F9/59 ,  C07F9/6506 ,  C07F9/6533 ,  C07F9/655 ,  C07C217/04 ,  A61K31/24 ,  A61K31/47 ,  C07D401/08 ,  C07D403/08 ,  C07D471/10

CPC classification number: C07F7/1856 ,  A61K31/191 ,  A61K31/366 ,  A61K31/404 ,  A61K31/4468 ,  C07C17/093 ,  C07C47/453 ,  C07C49/563 ,  C07C49/567 ,  C07C49/573 ,  C07C69/00 ,  C07C205/11 ,  C07C205/43 ,  C07C205/55 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C233/62 ,  C07C233/63 ,  C07C233/78 ,  C07C235/40 ,  C07C235/56 ,  C07C237/22 ,  C07C237/24 ,  C07C255/41 ,  C07C259/08 ,  C07C271/22 ,  C07C291/04 ,  C07C311/19 ,  C07C311/21 ,  C07C311/37 ,  C07C311/42 ,  C07C311/46 ,  C07C317/12 ,  C07C321/22 ,  C07C323/60 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/00 ,  C07C2603/18 ,  C07C2603/32 ,  C07C2603/74 ,  C07D207/335 ,  C07D207/38 ,  C07D209/08 ,  C07D209/16 ,  C07D209/34 ,  C07D209/38 ,  C07D209/46 ,  C07D209/48 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/64 ,  C07D213/74 ,  C07D213/75 ,  C07D213/80 ,  C07D213/89 ,  C07D221/16 ,  C07D231/56 ,  C07D233/24 ,  C07D233/64 ,  C07D233/84 ,  C07D233/88 ,  C07D233/90 ,  C07D235/06 ,  C07D235/08 ,  C07D235/16 ,  C07D235/24 ,  C07D235/26 ,  C07D235/28 ,  C07D235/30 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D249/12 ,  C07D249/14 ,  C07D249/18 ,  C07D253/07 ,  C07D263/38 ,  C07D263/46 ,  C07D263/58 ,  C07D271/07 ,  C07D277/36 ,  C07D277/56 ,  C07D277/74 ,  C07D285/08 ,  C07D285/125 ,  C07D295/108 ,  C07D295/155 ,  C07D295/185 ,  C07D307/14 ,  C07D311/84 ,  C07D317/30 ,  C07D317/58 ,  C07D319/06 ,  C07D327/06 ,  C07D333/20 ,  C07D335/14 ,  C07D401/12 ,  C07D403/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07C25/22