公开(公告)号：EP0721464A1

公开(公告)日：1996-07-17

申请号：EP94928025.0

申请日：1994-08-31

申请人： START TECHNOLOGY PARTNERSHIP

发明人： CUNNINGHAM, Timothy, J. ,  HAUN, Forest ,  EAGLESON, Katie, L. ,  LEVITT, Pat, R. ,  KENNEDY, Sarah, E.

IPC分类号： C12N15 ,  A61K9 ,  A61K38 ,  A61K39 ,  A61P25 ,  A61P43 ,  C07K4 ,  C07K14 ,  C07K16 ,  C12P21 ,  C12R1

CPC分类号： C07K14/475 ,  A61K38/00

摘要： A neuron regulatory factor (NRF), derived from cells of the central nervous system, is provided. NRF comprises a large polypeptide or complex of polypeptides that is antigenically distinct from several other known neurotrophic or neuron regulatory factors, and is capable of promoting survival and neurite outgrowth of cultured neurons in vitro, and preventing neuron degeneration and promoting neuron survival in vivo. NRF exerts a neurotrophic effect in a concentration-dependent manner on a variety of distinct neuron populations, and is administered as a pharmaceutical preparation to patients suffering from neuron damage or neurodegenerative disease in an amount effective to facilitate survival and recovery of damaged neurons.

公开(公告)号：EP0711431A1

公开(公告)日：1996-05-15

申请号：EP94925376.0

申请日：1994-07-21

申请人： EUROPEAN ATOMIC ENERGY COMMUNITY (EURATOM)

发明人： HEMMERICH, Johann, Ludwig ,  MILVERTON, Paul ,  SERIO, Luigi

IPC分类号： G05D23 ,  G01K17 ,  G01N25

CPC分类号： G01K17/00 ,  G01N25/4826 ,  G01N25/4833

摘要： A temperature derivative sensing and regulating device and method is described which facilitates the maintainance of a very stable isothermal environment for an item, apparatus or facility or a constant rate of temperature change. The device comprises a block (6) of material having no internal heat sources, a thermal conductivity greater than 100 Wm K and a specific heat capacity greater than 400JK kg . The block (6) is surrounded by means for measuring the heat flow to and from the block (6) and the device is further provided with means for generating a signal proportional to said heat flow and means for interfacing with the controller of a heating or cooling means associated with the item, apparatus or facility.

公开(公告)号：EP0701608A1

公开(公告)日：1996-03-20

申请号：EP94919157.0

申请日：1994-05-16

申请人： BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION

发明人： WHEELER, Matthew B.

IPC分类号： C12N15 ,  A01K67 ,  C12N5

CPC分类号： A01K67/0275 ,  A01K67/0271 ,  A01K2217/05 ,  A01K2227/101 ,  A01K2227/102 ,  A01K2227/103 ,  A01K2227/108 ,  A01K2267/02 ,  C12N5/0606 ,  C12N15/873 ,  C12N2502/14 ,  C12N2510/00

摘要： Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric ungulates which have germ cells comprising the exogenous genetic material. The chimeric ungulates are bred to provide transgenic ungulates. The transgenic animals of the invention may show improved qualities and can be used to provide human proteins or peptide hormones or can be used as xenograft donors.

公开(公告)号：EP0667790A1

公开(公告)日：1995-08-23

申请号：EP93918635.0

申请日：1993-08-05

申请人： Bristol-Myers Squibb Company ,  McMASTER UNIVERSITY

发明人： SHOYAB, Mohammed ,  BROWN, Thomas Joseph ,  RICHARDS, Carl D. ,  GAULDIE, Jack

IPC分类号： A61K38 ,  C07K14

CPC分类号： C07K14/52 ,  A61K38/1841 ,  A61K38/204 ,  A61K38/2093 ,  A61K2300/00

摘要： A method for decreasing metalloproteinase activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion construct thereof. Also, a method for increasing TIMP activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion construct thereof. In addition a method for inhibiting or treating progression of a tumor in a patient that comprises the step of administering to said patient a therapeutic composition comprising oncostatin-M, or a biologically active fragment, mutant, analog, or fusion construct thereof, said method being effective to inhibit invasion by a tumor cell through an extracellular space, extracellular matrix, basement membrane, interstitial tissue or connective tissue. Also methods effective to treat inflammatory or degenerative disease, methods effective to stimulate erythropoiesis, and methods effective to regulate tissue remodeling and to promote healing of injury.

公开(公告)号：EP0952821A1

公开(公告)日：1999-11-03

申请号：EP97953453.0

申请日：1997-12-29

申请人： Inhale Therapeutic Systems, Inc.

发明人： GORDON, Marc, S.

IPC分类号： A61K9 ,  A61K31 ,  A61K38 ,  A61K45 ,  A61K47 ,  B01D1 ,  B01J2

CPC分类号： A61K9/0075 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1694 ,  A61K31/353 ,  A61K31/355 ,  A61K31/557 ,  A61K31/56 ,  A61K31/573 ,  A61K31/59 ,  A61K31/7012 ,  A61K31/715 ,  B01D1/18 ,  B01J2/04 ,  Y10S514/938 ,  Y10S514/951 ,  Y10S514/958 ,  Y10S977/775 ,  Y10S977/783 ,  Y10S977/829 ,  Y10S977/884 ,  Y10S977/89 ,  Y10S977/906 ,  Y10S977/915 ,  Y10S977/926

摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. The hydrophilic component is dissolved in an aqueous solution and the hydrophobic component suspended therein. The method provides dry powders having relatively uniform characteristics.

公开(公告)号：EP0952773A1

公开(公告)日：1999-11-03

申请号：EP96935833.0

申请日：1996-09-13

申请人： Gerding, Dale N.

发明人： Gerding, Dale N.

IPC分类号： A61K35 ,  G01N33

CPC分类号： G01N33/56911 ,  A61K35/742 ,  G01N2333/33

摘要： This invention provides methods and compositions for preventing and treating Clostridium difficile-associated disease in a subject, wherein the subject is either a human or non-human animal. The method comprises administering to the subject an effective amount of a non-toxigenic strain of C. difficile or a combination of strains. A suitable non-toxigenic strain is selected from the M, T, C, P, S and AP group as defined by restriction endonuclease analysis. Also provided are pharmaceutical compositions and unit dosage forms comprising a single strain or a combination of strains selected from a non-toxigenic C. difficile group and a method for selecting non-toxigenic C. difficile strains.

公开(公告)号：EP0950184A1

公开(公告)日：1999-10-20

申请号：EP97931456.0

申请日：1997-06-26

申请人： CELLSTAT TECHNOLOGIES, INC.

发明人： MALIN, Patricia, J. ,  WADA, Kenneth, R. ,  DEHLINGER, Peter, J.

IPC分类号： B01J19 ,  B01L3 ,  G01N33 ,  C40B60

CPC分类号： G01N33/5008 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00713 ,  B01L3/5085 ,  C40B60/14 ,  G01N33/502

摘要： High-throughput screening method and apparatus are described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about 100/cm2, with the number of cells in each well being less than about 1000, and where the cells in each well have been exposed to a selected agent. The change in conductance in each well is determined by applying a low-voltage, AC signal across a pair of electrodes placed in that well, and synchronously measuring the conductance across the electrodes, to monitor the level of growth or metabolic activity of cells contained in each well. Also disclosed is an apparatus for carrying out the screening method.

公开(公告)号：EP0941239A1

公开(公告)日：1999-09-15

申请号：EP97952926.0

申请日：1997-12-03

申请人： JANSSEN PHARMACEUTICA N.V.

发明人： PLATTEEUW, Christ, Jules ,  BUESA ARJOL, Carlos, Manuel ,  DERAEYMAEKER, Marc ,  VERHASSELT, Peter ,  PUJOL, Nathalie, Jeanne, Raymonde ,  MAERTENS, Luc, Jacques, Simon ,  LUYTEN, Walter ,  GEERTS, Hugo ,  VANDEKERCKHOVE, Joel, Stefaan ,  GEYSEN, Johan ,  BOGAERT, Thierry, André, Olivier, Eddy

IPC分类号： C12N15 ,  A61K38 ,  A61K45 ,  A61K48 ,  A61P25 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1 ,  C12R1

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Vertebrate protein homologues of UNC-53 protein of C. elegans and nucleic acid sequences coding for said homologues or functional equivalents thereof are identified. The nucleic acid sequences in an appropriate vector are used to transfect or transform cells, tissues or organisms useful in identifying inhibitors or enhancers of the vertebrate homologue, or further proteins involved in the signal transduction pathway of which said vertebrate homologue is a component. Any of said inhibitors or enhancers identified can be included in a pharmaceutical composition or in the preparation of a medicament for treating conditions such as neurological diseases, acute traumatic injuries and to promote neuronal regeneration and inhibit metastasis or loss of contact inhibition.

公开(公告)号：EP0937097A1

公开(公告)日：1999-08-25

申请号：EP97947374.0

申请日：1997-11-06

申请人： SEQUENOM, INC.

发明人： LOUGH, David, M. ,  KÖSTER, Hubert

IPC分类号： G01N37 ,  B01J19 ,  B01L3 ,  C07B61 ,  C07F9 ,  C07H21 ,  C07K17 ,  C12M1 ,  C12N15 ,  C12Q1 ,  G01N33 ,  C40B40 ,  C40B60 ,  G01N35

CPC分类号： B01L3/0255 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00387 ,  B01J2219/00468 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00504 ,  B01J2219/00511 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07B2200/11 ,  C07F9/2408 ,  C07F9/2429 ,  C07H21/00 ,  C12Q1/6834 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N35/1067 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/1037 ,  G01N2035/1069 ,  C12Q2563/131 ,  C12Q2523/319

摘要： Compositions containing at least one bead conjugated to a solid support and further conjugated to at least one macromolecule, such as a nucleic acid and methods for making the compositions are provided. The resulting surfaces formed from the beads linked to the solid support advantageously provide increased surface area for immobilization of biological particles or macromolecules, particularly nucleic acids compared to 'flat' surfaces. Furthermore, by selecting a bead with the desired functionality, an appropriate functionalization chemistry for immobilizing the selected macromolecule or biological support, which is different from the chemistry of the solid support, can be produced.

公开(公告)号：EP0923602A1

公开(公告)日：1999-06-23

申请号：EP97932497.0

申请日：1997-07-03

申请人： Zygam, Inc.

发明人： BLEIL, Jeffrey, D. ,  HEIN, Mich, B. ,  BOOKBINDER, Louis, H.

IPC分类号： G01N33 ,  A61K39 ,  A61P15 ,  C07K14 ,  C07K16 ,  C12N15 ,  C12P21

CPC分类号： C12N15/8258 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34

摘要： The invention relates generally to immunocontraceptive vaccine compositions comprising antigenic polypeptides having mammalian sp56 sperm protein antigenic determinants. The antigenic polypeptides can be synthetic polypeptides, fusion proteins and chimeric molecules. The vaccine is preferably administered to feral mammals in bait or feed formulations. Certain embodiments describe the use of species specific sequences of sp56. Also described are immunocontraceptive methods, antibodies immunoreactive with the sp56 antigenic determinants, and methods for screening for sperm fertility.