公开(公告)号：EP1080435A1

公开(公告)日：2001-03-07

申请号：EP99955064.3

申请日：1999-10-19

Applicant: Symyx Technologies, Inc.

Inventor： LACY, Steven, D. ,  MCFARLAND, Eric, W. ,  SAFIR, Adam, L. ,  TURNER, Stephen, J. ,  VAN ERDEN, Lynn ,  WANG, Pei

IPC: G06F17/50

CPC classification number: C40B50/02 ,  B01J19/0046 ,  B01J2219/00477 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/007 ,  C40B60/14

Abstract: Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations representing arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of one or more components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.

公开(公告)号：EP1062033A1

公开(公告)日：2000-12-27

申请号：EP00905570.8

申请日：2000-01-06

Applicant: SYMYX TECHNOLOGIES

Inventor： TURNER, Howard, W. ,  VANERDEN, Lynn ,  DALES, Cameron, G. ,  SAFIR, Adam ,  NIELSEN, Ralph, B.

IPC: B01J19/00 ,  C07B61/00 ,  B01J31/16

CPC classification number: B01J19/26 ,  B01D15/08 ,  B01D15/26 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00344 ,  B01J2219/00351 ,  B01J2219/00452 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  C40B40/14 ,  C40B40/18 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/46 ,  G01N30/54 ,  G01N30/6052 ,  G01N30/88 ,  G01N33/44 ,  G01N35/085 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/885

Abstract: A method and system for researching and developing and/or optimizing new catalysts and polymers in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries.

公开(公告)号：EP1037872A1

公开(公告)日：2000-09-27

申请号：EP99954758.1

申请日：1999-10-05

Applicant: SYMYX TECHNOLOGIES

Inventor： GURAM, Anil, S. ,  LaPOINTE, Anne, Marie ,  TURNER, Howard, W. ,  UNO, Tetsuo

IPC: C07C217/84 ,  C07C217/92 ,  C07F7/18 ,  C07F15/04 ,  C08F4/80

CPC classification number: C07F15/045 ,  B01J31/1658 ,  B01J31/2243 ,  B01J31/24 ,  B01J2231/10 ,  B01J2531/847 ,  C07C217/84 ,  C07C217/92 ,  C08F10/00 ,  C08F4/7026 ,  C08F4/7014 ,  C08F4/027

Abstract: New ligands having a backbone comprised of NCCX can be combined with a metal or metal precursor compound or formed into a metal-ligand complex to catalyze a number of different chemical transformations, including polymerization.

公开(公告)号：EP1029238A1

公开(公告)日：2000-08-23

申请号：EP99946758.2

申请日：1999-09-03

Applicant: SYMYX TECHNOLOGIES

Inventor： DESROSIERS, Peter, J. ,  DUBE, Christopher, E. ,  ZHOU, Xiao, Ping

IPC: G01N31/02 ,  G01N33/00 ,  B01J19/00

CPC classification number: B01L3/5025 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10 ,  G01N33/0031 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/25875

Abstract: Methods and devices for rapidly analyzing groups of reactions aredisclosed. The method includes the steps of contacting a fluid sample from one of the reaction mixtures with a sorbent, trapping at least one component of the fluid sample on the sorbent, and detecting the at least one component of the fluid sample trapped on the sorbent. The contacting step, the trapping step, and the detecting step are carried out at least once for each of the reaction mixtures in rapid serial or parallel fashion. The present invention is useful for screening combinatorial libraries, especially libraries of catalysts made through parallel synthesis, but the disclosed methods and devices can be used to analyze a broad spectrum of chemical transformations.

公开(公告)号：EP1002573A3

公开(公告)日：2000-08-16

申请号：EP99203887.7

申请日：1995-10-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Symyx Technologies (US/US)

Inventor： Schultz, Peter G. ,  Xiang, Xiaodong ,  Goldwasser, Isy

IPC: B01J19/00 ,  C07B61/00 ,  B01J23/00 ,  C04B35/00 ,  C22C1/00

CPC classification number: C04B35/16 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00475 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B82Y25/00 ,  B82Y30/00 ,  C01G51/006 ,  C01G51/68 ,  C01P2002/34 ,  C01P2002/52 ,  C01P2002/72 ,  C01P2006/40 ,  C01P2006/42 ,  C04B35/01 ,  C04B35/4508 ,  C04B35/4521 ,  C04B35/4525 ,  C04B35/62218 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3262 ,  C04B2235/327 ,  C04B2235/3275 ,  C04B2235/3284 ,  C04B2235/3286 ,  C04B2235/3296 ,  C04B2235/3298 ,  C04B2235/3418 ,  C04B2235/3463 ,  C04B2235/656 ,  C04B2235/761 ,  C04B2235/762 ,  C04B2235/768 ,  C04B2235/96 ,  C23C14/042 ,  C23C14/087 ,  C23C16/042 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  C40B80/00 ,  G01R33/16 ,  H01F1/401 ,  H01F1/407 ,  H01F10/007 ,  H01F10/1933 ,  H01F41/18 ,  H01F41/34 ,  H01L43/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/31 ,  Y10T428/31645 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/255 ,  Y10T436/25875

Abstract: Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on a substrate and simultaneously reacting the components to form at least two materials. Materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic, organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties. Thus, the present invention provides for the parallel synthesis and analysis of novel material having useful properties

公开(公告)号：EP0992281A3

公开(公告)日：2000-08-16

申请号：EP99203888.5

申请日：1995-10-18

Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Symyx Technologies (US/US)

Inventor： Schultz, Peter ,  Xiang, Xiaodong ,  Goldwasser, Isy

IPC: B01J19/00 ,  G01N21/00 ,  G01N22/00

CPC classification number: C04B35/16 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00475 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B82Y25/00 ,  B82Y30/00 ,  C01G51/006 ,  C01G51/68 ,  C01P2002/34 ,  C01P2002/52 ,  C01P2002/72 ,  C01P2006/40 ,  C01P2006/42 ,  C04B35/01 ,  C04B35/4508 ,  C04B35/4521 ,  C04B35/4525 ,  C04B35/62218 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3262 ,  C04B2235/327 ,  C04B2235/3275 ,  C04B2235/3284 ,  C04B2235/3286 ,  C04B2235/3296 ,  C04B2235/3298 ,  C04B2235/3418 ,  C04B2235/3463 ,  C04B2235/656 ,  C04B2235/761 ,  C04B2235/762 ,  C04B2235/768 ,  C04B2235/96 ,  C23C14/042 ,  C23C14/087 ,  C23C16/042 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  C40B80/00 ,  G01R33/16 ,  H01F1/401 ,  H01F1/407 ,  H01F10/007 ,  H01F10/1933 ,  H01F41/18 ,  H01F41/34 ,  H01L43/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/31 ,  Y10T428/31645 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/255 ,  Y10T436/25875

Abstract: Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on a substrate and simultaneously reacting the components to form at least two materials. Materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic, organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties. Thus, the present invention provides for the parallel synthesis and analysis of novel material having useful properties

公开(公告)号：EP1001846A1

公开(公告)日：2000-05-24

申请号：EP99926131.6

申请日：1999-06-02

Applicant: SYMYX TECHNOLOGIES

Inventor： GUAN, Shenheng ,  VANERDEN, Lynn ,  HAUSHALTER, Robert C. ,  ZIIOU, Xiao Ping ,  WANG, Xuejun Jason ,  SRINIVASAN, Ravi

IPC: B01L3/02 ,  B01L3/00

CPC classification number: G01N31/10 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00394 ,  B01J2219/00409 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

公开(公告)号：EP0989988A1

公开(公告)日：2000-04-05

申请号：EP99917467.5

申请日：1999-04-14

Applicant: SYMYX TECHNOLOGIES

Inventor： GURAM, Anil

IPC: C07F9/50 ,  C07F15/00 ,  C07B61/00 ,  C07C209/10 ,  C07F9/655

CPC classification number: C07D295/023 ,  C07C209/10 ,  C07D295/073 ,  C07F9/5022 ,  C07F9/65515 ,  C07F15/0066 ,  C40B30/08 ,  C40B40/04 ,  C40B40/16 ,  C07C211/48

Abstract: A new ligand having a backbone comprised of PCCC, where the last carbon atom is sp3 hybridized can be combined with a metal or metal precursor compound or formed into a metal-ligand complex to catalyze a number of different chemical transformations, including C-N bond formation.

公开(公告)号：EP2206552A3

公开(公告)日：2011-03-09

申请号：EP09178577.4

申请日：2003-12-18

Applicant: Honda Giken Kogyo Kabushiki Kaisha ,  Symyx Technologies, Inc.

Inventor： Hagemeyer, Alfred ,  Brooks, Christopher; James ,  Carhart, Raymond, F. ,  Yaccato, Karin ,  Lesik, Andreas

IPC: B01J23/42 ,  B01J23/58 ,  B01J37/03 ,  B01J37/02 ,  B01J23/75 ,  B01J21/06 ,  C01B3/16 ,  B01J19/00

CPC classification number: B01J21/066 ,  B01J19/0046 ,  B01J21/06 ,  B01J23/42 ,  B01J23/58 ,  B01J23/75 ,  B01J23/894 ,  B01J23/8946 ,  B01J23/898 ,  B01J23/8986 ,  B01J23/8993 ,  B01J37/0201 ,  B01J37/0205 ,  B01J37/0244 ,  B01J37/031 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00745 ,  B01J2219/00747 ,  C01B3/16 ,  C01B2203/00 ,  C01B2203/0283 ,  C01B2203/1041 ,  C01B2203/1052 ,  C01B2203/107 ,  C01B2203/1082 ,  C40B30/08 ,  C40B40/18 ,  Y02P20/52

Abstract: A method of preparing a platinum-and sodium-containing catalyst comprising :
impregnating all non-platinum-and non-sodium-containing components of the catalyst composition onto a surface to form a first surface;
impregnating a platinum-containing solution to the first surface to form a platinum-containing surface;
calcining the platinum-containing surface to form a calcined platinum containing coating;
impregnating a sodium-containing solution to the calcined platinum-containing coating to form a second surface; and
drying the second surface.

公开(公告)号：EP1203394B1

公开(公告)日：2010-04-21

申请号：EP00942964.8

申请日：2000-06-19

Applicant: SYMYX TECHNOLOGIES ,  Agfa HealthCare NV

Inventor： DEVENNEY, Martin ,  REAVES, Casper ,  LEBLANS, Paul ,  STRUYE, Luc

IPC: H01J9/22 ,  G21K4/00 ,  C09K11/85

CPC classification number: G01N23/04 ,  A61B6/4216 ,  A61B6/502 ,  G01T1/2012 ,  G03B42/02 ,  G03B42/028