利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

64 条记录 (耗时 0.023 秒)

    AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS
    8.
    发明公开
    AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS 失效
    AMINOVERBINDUNGEN UND ANGIOTENSIN IV REZEPTOR AGONISTEN

    公开(公告)号：EP0882699A1

    公开(公告)日：1998-12-09

    申请号：EP97933908.2

    申请日：1997-08-05

    申请人： TAISHO PHARMACEUTICAL CO. LTD ,  SAGAMI CHEMICAL RESEARCH CENTER

    发明人： KOBORI, Takeo ,  GODA, Kenichi ,  SUGIMOTO, Kikuo ,  OTA, Tomomi, Taisho Pharmaceutical Co., Ltd. ,  TOMISAWA, Kazuyuki, Taisho Pharmaceutical Co. Ltd.

    IPC分类号： C07C211/13 ,  C07C211/18 ,  C07C211/22 ,  C07C211/25 ,  C07C211/27 ,  C07C211/28 ,  C07C215/52 ,  C07K5/06 ,  C07K5/08 ,  A61K31/165 ,  A61K31/24

    CPC分类号： C07D213/40 ,  C07C237/20 ,  C07D215/12

    摘要： The present invention provides an amino compound represented by Formula:
    wherein X is CH 2 NH or CONH, Y is CH 2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R 4 )R 5 , CH 2 CH(R 4 )R 5 or an alkoxycarbonyl group, R 1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R 2 and R 3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R 4 and R 5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.

    摘要翻译： 本发明提供由式：表示的氨基化合物，其中X为CH 2 NH或CONH，Y为CH 2 NH或CONH，条件是X和Y不同时为CONH; Z是CH = C（R 4）R 5，CH 2 CH（R 4）R 5或烷氧基羰基，R 1是氢原子; 低级烷基，环烷基，环烷基取代的烷基，芳烷基或芳基，其各自为取代或未取代的，R 2和R 3各自独立地为低级烷基或 每个基团为取代或未取代的芳烷基，R 4和R 5各自独立地为氢原子; 其各自为取代或未取代的烷基，芳烷基，芳基或杂芳基，或其药学上可接受的盐; 包含式（1）的氨基化合物或其药学上可接受的盐的药物; 和含有与有效成分相同的血管紧张素IV受体激动剂，其特别可用作血管紧张素IV参与的各种疾病的治疗药物（拮抗剂或激动剂），例如加速肾血流量，脑血管舒张 ，抑制细胞增殖和高血症。