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    Azepane compound
    4.
    发明专利
    Azepane compound 审中-公开
    AZEPANE化合物

    公开(公告)号：JP2014159375A

    公开(公告)日：2014-09-04

    申请号：JP2011132896

    申请日：2011-06-15

    Applicant: Takeda Chem Ind Ltd ,  武田薬品工業株式会社

    Inventor： YAMADA MASAMI ,  ISHICHI YUJI

    IPC: C07D223/04 ,  A61K31/55 ,  A61P7/12 ,  A61P15/12 ,  A61P25/04 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D223/06 ,  C07D223/08

    CPC classification number: C07D223/04 ,  C07D223/06 ,  C07D223/08

    Abstract: PROBLEM TO BE SOLVED: To provide a compound having activities of inhibiting monoamine reuptake and to provide a prophylactic or therapeutic agent for depression, anxiety, attention deficit and hyperactivity disorder, climacteric disturbance, pain, abdominal pressure urinary incontinence and the like.SOLUTION: There is provided a compound represented by the following formula. There is provided a compound or a salt thereof represented by formula, where a ring A represents a benzene ring having a substituent or a 5 or 6-membered heteroaromatic ring which may have a substituent, a ring B represents, where a ring Bmay further have a substituent, Rrepresents a hydroxyl group, a cyano group, a carboxyl group which may be substituted, an amino group which may be substituted, a substituted Calkyl group, a Calkoxy group which may be substituted or a carbamoyl group which may be substituted, but a hydrogen atom bound to a nitrogen atom which is a constitution atom of the ring Bis not substituted.

    Abstract translation: 要解决的问题：提供具有抑制单胺再摄取活性的化合物，并提供抑郁，焦虑，注意力缺陷和多动障碍，更年期障碍，疼痛，腹压尿失禁等的预防或治疗剂。解决方案：有 提供由下式表示的化合物。 提供由式表示的化合物或其盐，其中环A表示具有取代基的苯环或可具有取代基的5或6元杂芳环，环B表示，其中环Bmay还具有 取代基，R表示羟基，氰基，可以被取代的羧基，可以被取代的氨基，取代的C烷基，可以被取代的Calkoxy基或可以被取代的氨基甲酰基，但是 与作为未被取代的环的构成原子的氮原子结合的氢原子。

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