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239 条记录 (耗时 0.047 秒)

    3-piperazinyl-1-piperidinyl-propane derivative and pharmaceutical compositions containing the same
    4.
    发明专利
    3-piperazinyl-1-piperidinyl-propane derivative and pharmaceutical compositions containing the same 有权
    含有它们的3-哌啶-1-基 - 哌啶衍生物和药物组合物

    公开(公告)号：JP2014108955A

    公开(公告)日：2014-06-12

    申请号：JP2012264935

    申请日：2012-12-04

    申请人： Aetas Pharma Co Ltd ,  株式会社アエタスファルマ ,  Noboru Kaneko ,  昇 金子

    发明人： KANEKO NOBORU

    IPC分类号： C07D211/66 ,  A61K31/496 ,  A61P13/00 ,  A61P13/10

    摘要： PROBLEM TO BE SOLVED: To provide compounds having pharmacological action useful for treating and preventing dysuria, and pharmaceutical compositions for treating and/or preventing dysuria using the same.SOLUTION: The present invention provides a 3-piperazinyl-1-piperidinyl-propane derivative represented by the specified general formula (I) or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing the same for treating and/or preventing dysuria.

    摘要翻译： 要解决的问题：提供具有用于治疗和预防排尿困难的药理学作用的化合物，以及用于治疗和/或预防排尿困难的药物组合物。解决方案：本发明提供了一种3-哌嗪基-1-哌啶基 - 丙烷衍生物 或其药学上可接受的盐，以及包含其用于治疗和/或预防排尿困难的药物组合物。

    Production method of N- phenyl -n- (4- piperidinyl) amide salt
    8.
    发明专利
    Production method of N- phenyl -n- (4- piperidinyl) amide salt 审中-公开

    公开(公告)号：JP2011526257A

    公开(公告)日：2011-10-06

    申请号：JP2011515118

    申请日：2008-07-03

    申请人： シラグ アーゲー

    发明人： ヴァイグル，ウルリヒ ,  フレーゲル，オリヴァー

    IPC分类号： C07D211/66 ,  A61K31/4468 ,  A61P25/02

    CPC分类号： C07D211/66

    摘要： The invention relates to a method for producing N-phenyl-N-(4-piperidinyl)amide salts, particularly pharmaceutically tolerable addition salts of the compound Remifentanil, in that a compound of the formula (III) is reacted with an acrylic acid alkyl ester of the formula CH2═CH—C(O)—OR: where independently of each other R denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl, R1 denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl; and HX denotes an inorganic or organic acid, wherein the components are optionally reacted in the presence of a catalyst, preferably at a higher temperature, thereby obtaining the salt of the compound of formula (I).