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公开(公告)号：US12202906B2
公开(公告)日：2025-01-21
申请号：US17288234
申请日：2019-10-30
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Pavel Andreevich Iakovlev , Natalia Eugenievna Pestova , Arina Vitalevna Anikina , Anna Alexandrovna Trudovishnikova , Mariia Aleksandrovna Shchemeleva , Nina Grachyaevna Kharatian , Valery Vladimirovich Solovyev , Alexey Konstantinovich Misorin , Sergei Vasilyevich Diduk , Anna Vladimirovna Eroshova , Veronika Sergeevna Usatova , Elena Andreevna Krendeleva , Iakov Iurevich Ustiugov , Aleksei Aleksandrovich Aleksandrov , Iana Andreevna Smirnova , Svetlana Vladimirovna Koskova , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov
IPC: A61K39/395 , A61P35/02 , C07K16/28 , C12N15/63 , A61K39/00
Abstract: The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.
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公开(公告)号：US20240350663A1
公开(公告)日：2024-10-24
申请号：US18684886
申请日：2022-08-21
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Anna Nikolaevna STRELKOVA , Tatiana Evgenievna SHUGAEVA , Pavel Mikhailovich GERSHOVICH , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
IPC: A61K48/00 , C07K14/005 , C12N15/86
CPC classification number: A61K48/0041 , C07K14/005 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151
Abstract: The present application relates to the fields of gene therapy and molecular biology. More specifically, the present invention relates to an isolated modified capsid protein VP1 from adeno-associated virus serotype 9 (AAV9) comprising one or more amino acid substitutions compared to the wild-type AAV9 capsid protein VP1, which substitutions increase the efficiency of production (assembly) of the vector based on recombinant adeno-associated virus serotype 9 (rAAV9), to a capsid and a vector based on the above VP1, as well as to uses thereof.
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公开(公告)号：US11993647B2
公开(公告)日：2024-05-28
申请号：US16325528
申请日：2017-08-03
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Stanislav Rudolfovich Evdokimov , Andrei Borisovich Ulitin , Valery Vladimirovich Solovyev , Aleksei Aleksandrovich Aleksandrov , Yulia Sergeevna Chernykh , Timofey Aleksandrovich Nemankin , Anna Konstantinovna Vladimirova , Oleg Igorevich Smotrov , Tatiana Veniaminovna Chernovskaya , Aleksandr Aleksandrovich Moshchenko , Viktoriia Evgenevna Nalobina , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov
IPC: C07K16/24 , A61K9/00 , A61K9/19 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , C07K16/06 , C07K16/18 , C12N15/00 , C12N15/63
CPC classification number: C07K16/248 , A61K9/0073 , A61K9/19 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , C07K16/065 , C07K16/18 , C07K16/24 , C12N15/00 , C12N15/63
Abstract: The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be useful as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.
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公开(公告)号：US20240034764A1
公开(公告)日：2024-02-01
申请号：US18266001
申请日：2021-12-10
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Aleksey Vladimirovich KONONOV , Iuliia Viktorovna EVDOKIMOVSKAIA , Iana Andreevna SMIRNOVA , Stanislav Rudolfovich EVDOKIMOV , Elena Sergeevna KOLOSOVA , Sergei Andreevich AGEEV , Vladimir Sergeevich TSYMPILOV , Valery Vladimirovich SOLOVYEV , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
CPC classification number: C07K14/5428 , C12N15/63 , A61P35/00 , C07K16/2818 , C07K2319/30
Abstract: The present invention relates to the field of biotechnology and medicine, in particular to an immunocytokine for activating the human IL-10Rα receptor. The invention further relates to nucleic acids encoding said immunocytokine, expression vectors, host cells and methods for producing same, methods for producing the immunocytokine, pharmaceutical compositions comprising the above immunocytokine, pharmaceutical compositions comprising the above immunocytokine and other therapeutically active compounds, methods for treating an oncological disease and the uses of the immunocytokine or pharmaceutical compositions thereof for treating an oncological disease.
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公开(公告)号：US11840531B2
公开(公告)日：2023-12-12
申请号：US17264670
申请日：2019-07-31
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Aleksei Leonidovich Mindich , Anna Jur'evna Chestnova , Mariia Andreevna Kasatkina , Andrei Ivanovich Alafinov , Aleksei Sergeevich Gavrilov , Anton Aleksandrovich Evdokimov , Liliana Vyacheslavovna Lenshmidt , Elena Aleksandrovna Maksimenko , Mariia Sergeevna Mishina , Sergei Aleksandrovich Silonov , Evgenii Jur'evich Smirnov , Pavel Andreevich Iakovlev , Dmitry Valentinovich Morozov
IPC: C07D471/04 , A61P35/00 , A61K31/4375
CPC classification number: C07D471/04 , A61K31/4375 , A61P35/00
Abstract: The present invention relates to novel compounds of formula I:
which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.-
Patent Agency Ranking
公开(公告)号：US20200291121A1
公开(公告)日：2020-09-17
申请号：US16753488
申请日：2018-10-02
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Ekaterina Vladimirovna SOFRONOVA , Aleksei Konstantinovich MISORIN , Aleksandr Nikolaevich DORONIN , Timofey Aleksandrovich NEMANKIN , Aleksandra Aleksandrovna SOZONOVA , Galina Stepanovna ZHIRIVSKAIA , Sergey Aleksandrovich LEGOTSKY , Anna Konstantinovna VLADIMIROVA , Alina Valerevna BELIASNIKOVA , Mariia Aleksandrovna SHCHEMELEVA , Pavel Andreevich IAKOVLEV , Valery Vladimirovich SOLOVYEV , Elena Andreevna KRENDELEVA , Natalia Evgenevna PESTOVA , Dmitry Valentinovich MOROZOV
Abstract: The present invention relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The invention also relates to DNA encoding said antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibodies.
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7.发明申请公开(公告)号：US20190194313A1
公开(公告)日：2019-06-27
申请号：US16325528
申请日：2017-08-03
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Stanislav Rudolfovich EVDOKIMOV , Andrei Borisovich ULITIN , Valery Vladimirovich SOLOVYEV , Aleksei Aleksandrovich ALEKSANDROV , Yulia Sergeevna CHERNYKH , Timofey Aleksandrovich NEMANKIN , Anna Konstantinovna VLADIMIROVA , Oleg Igorevich SMOTROV , Tatiana Veniaminovna CHERNOVSKAYA , Aleksandr Aleksandrovich MOSHCHENKO , Viktoriia Evgenevna NALOBINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV
CPC classification number: C07K16/248 , A61K9/0073 , A61K9/19 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , C07K16/065 , C07K16/18 , C07K16/24 , C12N15/00 , C12N15/63
Abstract: The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be useful as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.
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公开(公告)号：US20170081401A1
公开(公告)日：2017-03-23
申请号：US15254190
申请日：2016-09-01
Applicant: CLOSED JOINT STOCK COMPANY "BIOCAD"
Inventor： Andrey Borisovich ULITIN , Stanislav Rudolfovich EVDOKIMOV , Valeriy Vladimirovich SOLOVIEV , Yulia Sergeevna CHERNYH , Olga Vladimirovna GONCHAROVA , Dmitriy Valerievich KORZHAVIN , Tatyana Veniaminovna CHERNOVSKAYA , Roman Alexeevich IVANOV , Dmitriy Valentinovich MOROZOV
IPC: C07K16/24 , A61K45/06 , A61K39/395
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: The present invention relates to the field of medicine, and specifically to the field of monoclonal antibodies against human IL-17. More specifically, the invention relates to monoclonal antibodies/antagonists of IL-17A, which bind with high affinity to an IL-17 epitope, wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric, humanized or human antibodies or antigen-binding fragments thereof, and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies.
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公开(公告)号：US20240076691A1
公开(公告)日：2024-03-07
申请号：US18280338
申请日：2022-03-05
Inventor： Alexander Vladimirovich PROKOFYEV , Pavel Mikhailovich GERSHOVICH , Anna Nikolaevna STRELKOVA , Natalia Aleksandrovna SPIRINA , Tatiana Evgenievna SHUGAEVA , Dmitry Valentinovich MOROZOV
CPC classification number: C12N15/86 , A61K48/005 , A61P7/04 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12Y304/21022
Abstract: The present application relates to the fields of genetics, gene therapy, and molecular biology. More specifically, the present invention relates to an isolated codon-optimized nucleic acid that encodes the FIX (coagulation factor IX) protein, an expression cassette and a vector based thereon, as well as an AAV5 (adeno-associated virus serotype 5)-based recombinant virus for increasing the expression of the FIX gene in target cells, and use thereof.
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公开(公告)号：US11840567B2
公开(公告)日：2023-12-12
申请号：US16753587
申请日：2018-10-03
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Kirill Vladimirovich Solovyev , Andrei Borisovich Ulitin , Timofey Aleksandrovich Nemankin , Valery Vladimirovich Solovyev , Dmitry Valentinovich Morozov
IPC: C07K16/28
CPC classification number: C07K16/2803 , C07K16/2827 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid that codes for the given antibody or for the antigen-binding fragment thereof, to an expression vector, to a method of producing the antibody, and to a use of the aforementioned antibodies and compositions in cancer treatment.
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