公开(公告)号：US12233037B2

公开(公告)日：2025-02-25

申请号：US18062105

申请日：2022-12-06

Applicant: ALIOPHARM S.R.L. ,  Consiglio Nazionale delle Ricerche

Inventor： Gian Luigi Russo ,  Fabrizio Tarricone ,  Idolo Tedesco

IPC: A61K31/192 ,  A23L2/38 ,  A23L2/39 ,  A23L2/52 ,  A61K31/00 ,  A61K31/05 ,  A61K31/351 ,  A61K31/353 ,  A61K31/7034 ,  C12C1/16 ,  C12C1/18 ,  C12C5/02 ,  C12C7/04 ,  C12C7/20 ,  C12C12/04 ,  C12H1/22

Abstract: Method for the production of a polyphenolic composition from barley malt, including the fundamental steps of: grinding of the malt grains and splitting into two portions, 20% and 80%; mixing each of the two portions with water to obtain an A mixture and a B mixture, the A mixture being prepared with the 20% portion to obtain a mixture of the malt in water at a final concentration between 9.5% and 20%, the B mixture being prepared with the 80% portion to obtain a mixture of the malt in water at a final concentration between 33% and 60%; thermal cycle; separation of the liquid component from the solid component; boiling of the liquid component and the addition of hops; rapid cooling of the wort; storage; in which said thermal cycle consists of a first phase and a second phase, in which the first phase applies to the 20% portion (Mixture A) and the second phase during which Mixture B is added to Mixture A. The relative polyphenolic composition obtained according to this method is characterized by the fact that it can be in liquid, powder, dry, and lyophilized form, its use and relative beverage or beer according to the present method not obtained with fermentation methods.

公开(公告)号：US20250060306A1

公开(公告)日：2025-02-20

申请号：US18723954

申请日：2022-12-28

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  A.S.I. AGENZIA SPAZIALE ITALIANA

Inventor： Mario SICILIANI DE CUMIS ,  Simone BORRI ,  Mariaconcetta CANINO ,  Pablo CANCIO PASTOR ,  Paolo DE NATALE ,  Inaki LOPEZ GARCIA ,  Alberto RONCAGLIA

IPC: G01N21/17

Abstract: A photoacoustic sensor for spectroscopic gas detection includes a chamber to contain the gas; an excitation laser source that emits a modulated laser beam; a transducer, having a reflective portion, located inside the chamber; an interferometer having first and second arms and an output, the first arm ending in the transducer, and the second arm including an optical path changer element and an actuator connected to the optical path changer element to change the optical path defined by the second arm of the interferometer; a first polarizing beam splitter; a second laser source; a second polarizing beam splitter; a first detector; a second detector; an electronic circuit; and a feedback loop adapted to command the movements of the actuator in order to change and stabilize the optical path of the second arm, so that the difference signal is kept equal to a desired constant value during the gas concentration measurements.

公开(公告)号：US12064492B2

公开(公告)日：2024-08-20

申请号：US16096505

申请日：2017-05-03

Applicant: Consiglio Nazionale delle Ricerche ,  Plasma Diagnostics and Technologies S.r.l. ,  Universita degli Studi di Firenze

Inventor： Angela Zoppi ,  Mario Del Rosso ,  Anna Laurenzana ,  Gabriella Fibbi ,  Francesca Margheri ,  Anastasia Chilla' ,  Giancarlo Margheri

IPC: A61K9/00 ,  A61K33/242 ,  A61K35/28 ,  A61K41/00 ,  A61K47/69 ,  A61K49/00 ,  A61K51/12 ,  A61P35/00

CPC classification number: A61K51/1203 ,  A61K33/242 ,  A61K35/28 ,  A61K41/0052 ,  A61K47/6901 ,  A61K49/0065 ,  A61P35/00

Abstract: The present invention refers to cells from a subpopulation of progenitors of endothelial cells loaded with gold nanoparticles sensitive to excitation with infrared radiation with consequent release of thermal energy, to a composition having a plurality of these cells and to their use in the diagnosis and treatment of solid tumours thanks to the selective localization of the composition in the tumour mass, which can be thus identified easily for diagnostic purposes by marking the cells with appropriate marking agents, or treated by stimulation with pulsed laser beam up to the complete cauterization of the tumour mass for a targeted and highly effective therapeutic action.

公开(公告)号：US20240101623A1

公开(公告)日：2024-03-28

申请号：US18275151

申请日：2022-02-15

Applicant: Ospedale San Raffaele S.r.l. ,  Consiglio Nazionale Delle Ricerche

Inventor： Vania Broccoli ,  Alessandro Sessa

IPC: C07K14/47 ,  C12N9/10

CPC classification number: C07K14/4703 ,  C12N9/1007 ,  C12Y201/01037 ,  C07K2319/80

Abstract: An epigenetic silencer factor (ESF) comprising a transcription factor DNA-binding domain operably linked to at least one epigenetic effector domain, wherein the transcription factor is an oncogenic transcription factor or a cancer-associated transcription factor.

公开(公告)号：US20230291474A1

公开(公告)日：2023-09-14

申请号：US18040447

申请日：2021-08-03

Applicant: UNIVERSITÀ DEGLI STUDI DI PADOVA ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Gianluca RUFFATO ,  Filippo ROMANATO ,  Vincenzo GRILLO ,  Enzo ROTUNNO

IPC: H04B10/2581 ,  H04J14/04

CPC classification number: H04B10/2581 ,  H04J14/04

Abstract: It is disclosed a device for multipole phase division multiplexing and demultiplexing and a spatial division telecommunications system comprising the multiplexing and demultiplexing devices. The multipole phase demultiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a circular-sector transformation of a plurality of multipole phase electromagnetic beams. The multipole phase multiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a combination of |m | circular-sector transformations of a plurality of tilted electromagnetic beams.

公开(公告)号：US11744901B2

公开(公告)日：2023-09-05

申请号：US16478338

申请日：2018-01-29

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Piergiuseppe De Berardinis ,  Rossella Sartorius

IPC: A61K47/69 ,  A61P35/00 ,  A61K39/39 ,  C07K14/52 ,  C07K14/77 ,  C07K16/28 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K47/6901 ,  A61K39/39 ,  A61P35/00 ,  C07K14/521 ,  C07K14/77 ,  C07K16/2851 ,  C12N7/00 ,  A61K2039/55572 ,  A61K2039/585 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2319/33 ,  C07K2319/42 ,  C07K2319/735 ,  C07K2319/74 ,  C12N2795/14122 ,  C12N2795/14132 ,  C12N2795/14145

Abstract: The present invention relates to pharmaceutical compositions containing lipid-bacteriophage conjugates, wherein the bacteriophage:lipid ratio is in the range of 3:1 to 100:1 and wherein the lipid is an immunologically active lipid and the bacteriophage is a filamentous bacteriophage, and uses thereof. Preferably, the bacteriophage is engineered to stimulate an immune response and/or bind to a target cell.

公开(公告)号：US20230227832A1

公开(公告)日：2023-07-20

申请号：US18002213

申请日：2021-06-17

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Vittorio DE FRANCISCIS ,  Gerolama CONDORELLI ,  Silvia CATUOGNO ,  Carla Lucia ESPOSITO ,  Cristina QUINTAVALLE ,  Francesco INGENITO

IPC: C12N15/115 ,  C12N15/10 ,  C12Q1/6886

CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12Q1/6886 ,  C12N2310/16

Abstract: The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.

公开(公告)号：US20230167453A1

公开(公告)日：2023-06-01

申请号：US17995343

申请日：2021-04-01

Applicant: Board of Regents, The University of Texas System ,  Consiglio Nazionale delle Ricerche

Inventor： Anil K. SOOD ,  Paola AMERO ,  Gabriel LOPEZ-BERESTEIN ,  Vittorio DE FRANCISCIS

IPC: C12N15/115 ,  A61P35/00

CPC classification number: C12N15/115 ,  A61P35/00 ,  C12N2310/16 ,  C12N2310/322

Abstract: Provided herein are RNA aptamers targeting CD5L. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

公开(公告)号：US20230101466A1

公开(公告)日：2023-03-30

申请号：US18062105

申请日：2022-12-06

Applicant: ALIOPHARM S.R.L. ,  Consiglio Nazionale delle Ricerche

Inventor： Gian Luigi Russo ,  Fabrizio Tarricone ,  Idolo Tedesco

IPC: A61K31/192 ,  A23L2/39 ,  A23L2/52 ,  A61K31/353 ,  A61K31/7034 ,  C12C7/04 ,  C12C7/20 ,  C12C12/04 ,  C12H1/22 ,  C12C1/18 ,  C12C5/02 ,  C12C1/16

Abstract: Method for the production of a polyphenolic composition from barley malt, including the fundamental steps of: grinding of the malt grains and splitting into two portions, 20% and 80%; mixing each of the two portions with water to obtain an A mixture and a B mixture, the A mixture being prepared with the 20% portion to obtain a mixture of the malt in water at a final concentration between 9.5% and 20%, the B mixture being prepared with the 80% portion to obtain a mixture of the malt in water at a final concentration between 33% and 60%; thermal cycle; separation of the liquid component from the solid component; boiling of the liquid component and the addition of hops; rapid cooling of the wort; storage; in which said thermal cycle consists of a first phase and a second phase, in which the first phase applies to the 20% portion (Mixture A) and the second phase during which Mixture B is added to Mixture A. The relative polyphenolic composition obtained according to this method is characterized by the fact that it can be in liquid, powder, dry, and lyophilized form, its use and relative beverage or beer according to the present method not obtained with fermentation methods.

公开(公告)号：US11566070B2

公开(公告)日：2023-01-31

申请号：US16482455

申请日：2018-02-05

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Ileana Zucchi ,  Rolland Alvons Reinbold

IPC: C12N15/11 ,  C07K16/28 ,  C12N15/113 ,  G01N33/574

Abstract: The present invention relates to agents that modulate/regulate the activity of the protein TMEM230 for use in the therapeutic treatment of pathologies in which therapeutic regulation of angiogenesis is advisable or necessary.