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公开(公告)号：US08501957B2
公开(公告)日：2013-08-06
申请号：US12635206
申请日：2009-12-10
Applicant: Chih-Shiang Chang , Jih-Hwa Guh , Che-Ming Teng , Shiow-Lin Pan , Wei-Ling Chang , Ju-Fang Liu , Kai-Wei Chang , Sheng-Chu Kuo
Inventor： Chih-Shiang Chang , Jih-Hwa Guh , Che-Ming Teng , Shiow-Lin Pan , Wei-Ling Chang , Ju-Fang Liu , Kai-Wei Chang , Sheng-Chu Kuo
IPC: A61K31/4184 , C07D235/18
CPC classification number: A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D235/06 , C07D235/10 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04
Abstract: Benzimidazole compounds of formula (I): wherein R1, R2, R3, R4, R5, X, Y, Z1, and Z2 are defined herein. Also disclosed is a method for treating cancer with benzimidazole compounds.
Abstract translation: 式（I）的苯并咪唑化合物：其中R1，R2，R3，R4，R5，X，Y，Z1和Z2如本文所定义。 还公开了用苯并咪唑化合物治疗癌症的方法。
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公开(公告)号：US20100179147A1
公开(公告)日：2010-07-15
申请号：US12635206
申请日：2009-12-10
Applicant: Chih-Shiang Chang , Jih-Hwa Guh , Che-Ming Teng , Shiow-Lin Pan , Wei-Ling Chang , Ju-Fang Liu , Kai-Wei Chang , Sheng-Chu Kuo
Inventor： Chih-Shiang Chang , Jih-Hwa Guh , Che-Ming Teng , Shiow-Lin Pan , Wei-Ling Chang , Ju-Fang Liu , Kai-Wei Chang , Sheng-Chu Kuo
IPC: A61K31/5377 , C07D235/18 , A61K31/4184 , C07D403/10 , C07D413/10 , C07D409/04 , C07D401/04 , A61K31/4439 , C07D405/14 , A61K31/454 , A61K31/496 , C07D403/06 , A61P35/00
CPC classification number: A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D235/06 , C07D235/10 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04
Abstract: Benzimidazole compounds of formula (I): wherein R1, R2, R3, R4, R5, X, Y, Z1, and Z2 are defined herein. Also disclosed is a method for treating cancer with benzimidazole compounds.
Abstract translation: 式（I）的苯并咪唑化合物：其中R1，R2，R3，R4，R5，X，Y，Z1和Z2如本文所定义。 还公开了用苯并咪唑化合物治疗癌症的方法。
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公开(公告)号：US07501445B2
公开(公告)日：2009-03-10
申请号：US11590280
申请日：2006-10-30
Applicant: Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
Inventor： Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
IPC: A61K31/44 , A61K31/4166 , C07D401/04 , C07D233/02
CPC classification number: C07D233/32 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/12
Abstract: This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.
Abstract translation: 本发明涉及下式的化合物：其中R1，R2，A1，A2，X，Y，m，n，p，x和y如本文所定义，包含该化合物的药物组合物和该化合物在治疗 肠道病毒感染。
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公开(公告)号：US07259174B2
公开(公告)日：2007-08-21
申请号：US11134936
申请日：2005-05-23
Applicant: Jyh-Haur Chern , Shin-Ru Shih , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee
Inventor： Jyh-Haur Chern , Shin-Ru Shih , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee
IPC: A61K31/4402 , A61K31/4439 , C07D401/04
CPC classification number: C07D401/04
Abstract: Compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein. Also disclosed are pharmaceutical compositions each containing one or more of these compounds, and use thereof in treating enteroviral infection.
Abstract translation: 下式的化合物：其中R 1，R 2，A 1，A 2，X， Y，m，n，p，x和y如本文所定义。 还公开了各自含有这些化合物中的一种或多种的药物组合物及其在治疗肠道病毒感染中的用途。
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Patent Agency Ranking
5.发明授权公开(公告)号：US08440692B2
公开(公告)日：2013-05-14
申请号：US12448088
申请日：2007-12-07
Applicant: Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
Inventor： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
CPC classification number: C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
Abstract translation: 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠 盐。 初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。 还合成了一种新的中间体2-硒吩-4-喹诺酮和2-苯基-4-喹诺酮的λ/，λ/二烷基氨基烷基衍生物。 这些新型中间体显示出显着的抗癌活性。
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6.发明申请NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS 有权作为抗原剂的2-亚芳基-4-喹啉酮的新型疏水衍生物公开(公告)号：US20100168064A1
公开(公告)日：2010-07-01
申请号：US12448088
申请日：2007-12-07
Applicant: Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
Inventor： Sheng-Chu Kuo , Che-Ming Teng , Kuo-Hsiung Lee , Li-Jiau Huang , Li-Chen Chou , Chih-Shiang Chang , Chung-Ming Sun , Tian-Shung Wu , Shiow-Lin Pan , Tzong-Der Way , Jang-Chang Lee , Jing-Gung Chung , Jai-Sing Yang , Chien-Ting Chen , Ching-Che Huang , Shih-Ming Huang
IPC: A61K31/675 , C07F9/09 , A61K31/47 , A61P35/00 , A61P35/02 , C07D421/04 , C07D215/233
CPC classification number: C07F9/6561 , C07D215/233 , C07D421/04 , C07D491/056 , C07F9/60
Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
Abstract translation: 2-芳基-4-喹诺酮通过与焦磷酸四苄酯反应而形成磷酸盐，形成其二苄基磷酸酯，然后进行氢化，用H代替二苄基，然后与Amberlite IR-120（Na +形式）反应形成二钠 盐。 初步筛选结果表明，这些磷酸盐显示出显着的抗癌活性。 还合成2-苯基-4-喹诺酮的新型中间体2-硒吩-4-喹诺酮和Λ/，Λ/二烷基氨基烷基衍生物。 这些新型中间体显示出显着的抗癌活性。
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公开(公告)号：US07129359B2
公开(公告)日：2006-10-31
申请号：US10717786
申请日：2003-11-19
Applicant: Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
Inventor： Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
IPC: C07D401/04 , C07D233/02 , A61K31/44 , A61K31/4166
CPC classification number: C07D233/32 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/12
Abstract: This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.
Abstract translation: 本发明涉及下式的化合物：其中R 1，R 2，A 1，A 2， >，X，Y，m，n，p，x和y如本文所定义，包含该化合物的药物组合物和该化合物在治疗肠道病毒感染中的用途。
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公开(公告)号：US20050267164A1
公开(公告)日：2005-12-01
申请号：US11134936
申请日：2005-05-23
Applicant: Jyh-Haur Chern , Shin-Ru Shih , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee
Inventor： Jyh-Haur Chern , Shin-Ru Shih , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee
IPC: A61K31/4172 , A61K31/4439 , C07D43/02
CPC classification number: C07D401/04
Abstract: Compounds of the following formula: in which R1, R2, Al, A2, X, Y, m, n, p, x and y are as defined herein. Also disclosed are pharmaceutical compositions each containing one or more of these compounds, and use thereof in treating enteroviral infection.
Abstract translation: 下式的化合物：其中R 1，R 2，Al，A 2，X，Y，m，n，p， x和y如本文所定义。 还公开了各自含有这些化合物中的一种或多种的药物组合物及其在治疗肠道病毒感染中的用途。
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公开(公告)号：US20070049623A1
公开(公告)日：2007-03-01
申请号：US11590280
申请日：2006-10-30
Applicant: Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
Inventor： Jyh-Haur Chern , Shin-Ru Shih , Chiung-Tong Chen , Chih-Shiang Chang , Chung-Chi Lee , Yen-Chun Lee , Chia-Liang Tai
IPC: A61K31/4439 , C07D403/14 , C07D403/04
CPC classification number: C07D233/32 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/12
Abstract: This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.
Abstract translation: 本发明涉及下式的化合物：其中R 1，R 2，A 1，A 2， >，X，Y，m，n，p，x和y如本文所定义，包含该化合物的药物组合物和该化合物在治疗肠道病毒感染中的用途。
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