公开(公告)号：US5694215A

公开(公告)日：1997-12-02

申请号：US610663

申请日：1996-03-04

申请人： David R. Carver

发明人： David R. Carver

IPC分类号： G01N21/05 ,  G01N27/447 ,  G01N30/74 ,  G01N1/10 ,  G01J3/00 ,  G01J3/42

CPC分类号： G01N27/44721 ,  G01N30/74 ,  G01N2021/0346 ,  G01N21/05

摘要： A sample cell assembly employs optics for focusing light though a sample cell, such as one used in electrophoresis. The optical array includes a first cylindrical lens having a central longitudinal axis in a common plane with the longitudinal axis of the sample cell. A second cylindrical lens has its central longitudinal axis oriented transversely to this common plane on another side of the sample cell from the first cylindrical lens. Preferably, a fiber optic beam splitter has a plurality of strands terminating in parallel second ends in the common plane so as to pass light at different longitudinally spaced locations through the sample cell cavity. Here, a plurality of second lenses receive the different light components to focus them respectively on different photodetectors each to create a sample data signal. Where a plurality of sample data signals are generated, processing electronics superimpose them to obtain an augmented signal of aggregate data. The invention further includes a method of measuring optical absorbance utilizing this technique and apparatus.

摘要翻译： 样品池组件采用光学器件用于通过样品池（例如用于电泳中的样品池）聚焦光。 光学阵列包括第一柱面透镜，其具有与样品池的纵向轴线在共同平面中的中心纵向轴线。 第二柱面透镜的中心纵向轴线与样品池的第一柱面透镜的另一侧横向于该共同平面定向。 优选地，光纤分束器具有在公共平面中平行的第二端终止的多根股线，以便使不同纵向间隔位置的光通过样品池腔。 这里，多个第二透镜接收不同的光分量，以将它们分别聚焦在不同的光电探测器上，以产生采样数据信号。 在产生多个采样数据信号的情况下，处理电子设备叠加它们以获得聚合数据的增强信号。 本发明还包括利用该技术和装置测量光吸收的方法。

公开(公告)号：US06530286B1

公开(公告)日：2003-03-11

申请号：US09568871

申请日：2000-05-09

申请人： David R. Carver ,  Thomas A. Tait

发明人： David R. Carver ,  Thomas A. Tait

IPC分类号： G01F1708

CPC分类号： G01F1/7086 ,  G01F1/7084

摘要： The present invention relates to methods and apparatus useful for detecting and measuring flow of a fluid along a flow path. In a method according to the invention, the temperature of a flowing fluid is altered at a selected location for a selected duration so as to generate a pulse in the fluid moving in a downstream direction along a flow path, and the fluid is monitored at a sensing region to detect the pulse passing therethrough. An apparatus according to the present invention may comprise a conduit, a sensor element disposed therein, an energy source proximate to the conduit, and a controller operative to generate an on signal and an off signal respectively operative to activate and deactivate the energy source. The present invention also relates to a liquid chromatography device having a fluid flow detecting and measuring apparatus according to the present invention.

摘要翻译： 本发明涉及用于检测和测量流体沿着流动路径的流动的方法和装置。 在根据本发明的方法中，流动流体的温度在所选择的位置处改变选定的持续时间，以便沿流动路径在下游方向上产生在流体中移动的脉冲，并且在 感测区域以检测穿过其中的脉冲。 根据本发明的装置可以包括导管，设置在其中的传感器元件，靠近导管的能量源，以及控制器，用于产生分别用于激活和去激活能量源的接通信号和断开信号。 本发明还涉及具有根据本发明的流体流动检测和测量装置的液相色谱装置。

公开(公告)号：US5699156A

公开(公告)日：1997-12-16

申请号：US344209

申请日：1994-11-23

申请人： David R. Carver

发明人： David R. Carver

IPC分类号： G01J3/02 ,  G01J3/06 ,  G01J3/14 ,  G01J3/10

CPC分类号： G01J3/06 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/14 ,  G01J2003/065

摘要： A spectrophotometer employs an array of optical elements to focus light from at least one, but preferably two light sources onto a fiber optic beam splitter that provides a pickup for a selected bandwidth of wavelengths of light in the spectral pattern. The spectral pattern can include wavelengths in the visible, near infrared and ultraviolet spectrum. To create the spectral pattern, two reflecting prisms having spherical surfaces are used, and the optical elements are arranged so that the two spectral bands from each prism are longitudinally aligned to create the spectral pattern. The prisms are on a motor driven pivot mount so that the spectral pattern may be swept across the pickup. The optical elements and the pickup are sized so that the selected bandwidth is less than twenty nanometers over the spectral pattern. The pickup is formed by a single row of the ends of fiber optic strands which are then collimated into two bundles to transmit a test component and a reference component of light. The sample cell is somewhat elongated, and a lens is interposed in the test component path before the sample cell, and this lens is sized to focus light axially through the sample cell without impinging on the sidewalls. Photodiode detectors, comparator circuitry and a controller are included.

摘要翻译： 分光光度计采用光学元件阵列将来自至少一个但优选两个光源的光聚焦到光纤分束器上，该光纤分束器为光谱图案中所选择的光波长的带宽提供拾取器。 光谱图可以包括可见光，近红外和紫外光谱中的波长。 为了产生光谱图案，使用具有球面的两个反射棱镜，并且光学元件被布置成使得来自每个棱镜的两个光谱带纵向对齐以产生光谱图案。 棱镜位于马达驱动的枢轴支架上，使得光谱图案可以扫过拾取器。 光学元件和拾取器的尺寸使得所选择的带宽在光谱图案上小于二十纳米。 拾取器由光纤束的一行端部形成，然后将其准直成两束，以传输测试部件和光的参考部件。 样品池稍微细长，并且在样品池之前的测试组件路径中插入透镜，并且该透镜的尺寸设计成可以将光轴轴向地聚焦通过样品池而不会侵入侧壁。 包括光电二极管检测器，比较器电路和控制器。

公开(公告)号：US5256801A

公开(公告)日：1993-10-26

申请号：US986852

申请日：1992-12-04

申请人： David R. Carver ,  Timothy R. Prout ,  Hernita A. Ewald ,  Donia L. Henderson

发明人： David R. Carver ,  Timothy R. Prout ,  Hernita A. Ewald ,  Donia L. Henderson

IPC分类号： C07D305/14

CPC分类号： C07D305/14

摘要： A process for the preparation of a compound of formula (I) ##STR1## comprising contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction solvent in the presence of a Lewis acid.

摘要翻译： 一种制备式（I）化合物的方法＆lt; IMAGE＆gt;包括在含有至少一种具有C-13位的酯键的紫杉烷化合物与至少一种硼氢化还原盐的反应溶剂中，在存在 的路易斯酸。

公开(公告)号：US20130109827A1

公开(公告)日：2013-05-02

申请号：US13599996

申请日：2012-08-30

申请人： David R. Carver ,  Sean W. Reynolds

发明人： David R. Carver ,  Sean W. Reynolds

IPC分类号： C07C2/02

CPC分类号： C07C2/02 ,  C07C2/76 ,  C07C2603/92 ,  C07C13/70

摘要： An improved process and method for the formation of stable intermediate cyclophanes. Embodiments describe a general method for the production of substituted and unsubstituted cyclophanes. The components include a pyrolysis reaction tube that may be electrically heated into which a flowing stream of nitrous oxide with xylene vapor in an optional inert carrier gas at atmospheric pressure. The exit gas is condensed resulting in the deposition of [2,2′]paracyclophane. Additionally a process and method whereby the reactive intermediates of the reaction described above can be directly deposited and polymerized at atmospheric pressures or thereabout is disclosed.

摘要翻译： 一种用于形成稳定的中间环烷烃的改进方法和方法。 实施方案描述了制备取代和未取代的环戊烷的一般方法。 组分包括热电解反应管，该热解反应管可以在大气压下在任选的惰性载气中被电加热到二氧化碳气流中。 出口气体被冷凝，导致[2,2']对环磷烷的沉积。 另外，可以直接在大气压下沉积和聚合上述反应的反应中间体或其中的方法和方法。

公开(公告)号：US5969812A

公开(公告)日：1999-10-19

申请号：US545448

申请日：1995-10-18

申请人： David R. Carver

发明人： David R. Carver

IPC分类号： G01J3/02 ,  G01J3/06 ,  G01J3/28

CPC分类号： G01J3/02 ,  G01J3/0218 ,  G01J3/0243 ,  G01J3/06 ,  G01J2003/2866

摘要： A spectrophotometer measures optical absorption of light by a sample received in a sample cell. An array of optical elements disperses the light over a spectral pattern, and a fiber optic beam splitter splits light at a selected spectral band into a reference component and a test component. Detectors measure the intensity of the reference component and the test component after the test component passes through the sample. The fiber optic beam splitter includes a plurality of strands arranged with first ends terminating in a common circular area. Opposite ends of peripheral strands are collected into a first set that transmits the test component while the remaining strands for a second set that transmits the reference component. Preferably, there is a single, central, large strand surrounded by smaller strands. Two emitters are provided for light of two different types, such as visible and UV. The optical array forms a collimated beam having an inner core of one type of light and an outer shell of the other. Specially constructed optical elements then reflect and refract the collimated beam. A motor drives a mirror to scan the beam across an optical slit positioned in front of the beam splitter to select a desired spectral band.

摘要翻译： 分光光度计测量样品池中接收的样品的光吸收光。 光学元件的阵列将光分散在光谱图案上，并且光纤光束分束器将选定光谱带上的光分成参考部件和测试部件。 检测器在测试组件通过样品后测量参考组件和测试组件的强度。 光纤分束器包括多个绞合线，第一端部终止于共同的圆形区域。 外围股线的相对端被收集到第一组中，第一组传递测试组件，而第二组的另一组则传输参考组件。 优选地，存在由较小的股线包围的单个中央的大股。 提供两种发射器用于两种不同类型的光，例如可见光和UV。 光学阵列形成具有一种类型的光的内核和另一种类型的外壳的准直光束。 特别构造的光学元件然后反射并折射准直光束。 电动机驱动反射镜以横跨位于分束器前方的光学狭缝扫描光束以选择期望的光谱带。

公开(公告)号：US5549830A

公开(公告)日：1996-08-27

申请号：US203653

申请日：1994-02-28

申请人： David R. Carver ,  Timothy R. Prout ,  Christopher T. Workman ,  Charles L. Hughes

发明人： David R. Carver ,  Timothy R. Prout ,  Christopher T. Workman ,  Charles L. Hughes

IPC分类号： B01D61/02 ,  B01D61/14 ,  C07D305/14

CPC分类号： B01D61/025 ,  B01D61/022 ,  B01D61/145 ,  C07D305/14

摘要： A method of processing a feed liquid in the form of an extraction solution containing taxane solutes that is an extraction product of a biomass utilizes at least one semipermeable membrane to remove at least one taxane solute from the solvent by reverse osmosis. The feed liquid is placed in a first region on one side of the membrane and pressure is supplied to transport constitutes of the feed liquid across the membrane to a second region as a first permeate while retaining a first retentate in the first region. The taxane solute may be either retained or transported. Where the taxane solute is transported, the method can further include the use of a second semipermeable membrane of a pore size different from the first membrane and supplying a pressure to transport some of the first permeate across the second membrane as a second permeate while retaining a majority of the desired taxane solute as a second retentate. Here, the first membrane has a pore size which allows transport of the taxane solute while the second membrane has a pore size that retains the taxane solute. A variety of solvents and useable membranes is disclosed.

摘要翻译： 以包含作为生物质提取产物的紫杉烷溶质的提取溶液的形式的处理进料液的方法利用至少一种半透膜，通过反渗透从溶剂中除去至少一种紫杉烷溶质。 将进料液体放置在膜的一侧上的第一区域中，并且供应压力以将进料液体的组成物跨过膜输送到作为第一渗透物的第二区域，同时在第一区域保留第一滞留物。 紫杉烷溶质可以保留或运输。 当运输紫杉烷溶质时，该方法可以进一步包括使用不同于第一膜的孔径的第二半透膜，并提供压力以将一些第一渗透物作为第二渗透物输送穿过第二膜，同时保持 大部分所需的紫杉烷溶质作为第二滞留物。 这里，第一膜具有允许运输紫杉烷溶质的孔径，而第二膜具有保留紫杉烷溶质的孔径。 公开了各种溶剂和可用的膜。

公开(公告)号：US20100291160A1

公开(公告)日：2010-11-18

申请号：US12779017

申请日：2010-05-12

申请人： David R. Carver ,  Troy G. Fohrman ,  Sean William Reynolds

发明人： David R. Carver ,  Troy G. Fohrman ,  Sean William Reynolds

IPC分类号： A61K9/00 ,  A61K31/519 ,  A61K38/16 ,  A61K31/46 ,  A61K38/19 ,  A61K31/727 ,  A61K38/29 ,  A61K39/395 ,  A61K31/137 ,  A61P29/00 ,  A61P9/06 ,  A61P7/02 ,  A61P3/02 ,  A61P19/10 ,  A61P21/00 ,  A61P5/00 ,  A61P31/04 ,  A61P31/10 ,  A61P9/12 ,  A61P3/10 ,  A61P3/04 ,  A61P1/04 ,  A61P1/08 ,  A61P25/16 ,  A61P25/22

CPC分类号： A61K31/00 ,  A61K9/0014 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2086 ,  A61K9/209 ,  A61K38/1793 ,  A61K38/193 ,  A61K38/29 ,  A61K45/06 ,  A61K47/12 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22

摘要： Non-invasive drug delivery systems useful for the absorption of therapeutically active agents through the epithelial membrane are described. The non-invasive drug delivery system delivers a therapeutic active agent with an ionizable, or ionized, metal, transition metal or metal-containing vehicle. The non-invasive drug delivery system may also have a pH adjustable vehicle which facilitates the absorption of the therapeutic agents by altering the pH of the non-invasive drug delivery system at the site of administration. Also disclosed is a method for the pH “sweeping” of the administered therapeutic active agent to provide a consistent and reproducible absorption of the active agent. Certain formulations utilize low doses of active agents without altering the active agents from their current or previous form.

摘要翻译： 描述了可用于通过上皮膜吸收治疗活性剂的非侵入性药物递送系统。 非侵入性药物递送系统用可离子化或电离的金属，过渡金属或含金属的载体递送治疗活性剂。 非侵入性药物递送系统还可以具有pH调节载体，其通过改变施用部位的非侵入性药物递送系统的pH来促进治疗剂的吸收。 还公开了一种用于“施用”施用的治疗活性剂以提供活性剂一致和可再现的吸收的方法。 某些制剂使用低剂量的活性剂而不改变活性剂与其当前形式或先前形式。

公开(公告)号：US20090090999A1

公开(公告)日：2009-04-09

申请号：US12245665

申请日：2008-10-03

申请人： David R. Carver

发明人： David R. Carver

IPC分类号： H01L27/06 ,  H01G4/04 ,  H02J7/00

CPC分类号： H02J7/00 ,  H01G4/04 ,  H01G4/08 ,  H01G4/38 ,  H02J7/345

摘要： A method is provided for making a high permittivity dielectric material for use in capacitors. Several high permittivity materials in an organic nonconductive media with enhanced properties and methods for making the same are disclosed. A general method for the formation of thin films of some particular dielectric material is disclosed, wherein the use of organic polymers, shellac, silicone oil, and/or zein formulations are utilized to produce low conductivity dielectric coatings. Additionally, a method whereby the formation of certain transition metal salts as salt or oxide matrices is demonstrated at low temperatures utilizing mild reducing agents. Further, a circuit structure and associated method of operation for the recovery and regeneration of the leakage current from the long-term storage capacitors is provided in order to enhance the manufacturing yield and utility performance of such devices.

摘要翻译： 提供了用于制造用于电容器的高介电常数介电材料的方法。 公开了具有增强性能的有机非导电介质中的几种高介电常数材料及其制备方法。 公开了形成一些特定电介质材料的薄膜的一般方法，其中使用有机聚合物，虫胶，硅油和/或玉米醇溶蛋白制剂来制备低电导率的电介质涂层。 此外，使用温和的还原剂在低温下证明形成某些过渡金属盐作为盐或氧化物基质的方法。 此外，提供了用于从长期存储电容器恢复和再生泄漏电流的电路结构和相关联的操作方法，以便提高这些装置的制造产量和效用。

公开(公告)号：US5281727A

公开(公告)日：1994-01-25

申请号：US982391

申请日：1992-11-27

申请人： David R. Carver ,  Timothy R. Prout ,  Christopher T. Workman ,  Donia L. Henderson ,  Charles L. Hughes

发明人： David R. Carver ,  Timothy R. Prout ,  Christopher T. Workman ,  Donia L. Henderson ,  Charles L. Hughes

IPC分类号： C07D305/14

CPC分类号： C07D305/14

摘要： The present invention is a method that uses an absorption column for the cleavage and recovery of taxanes, which are not normally detected as free taxanes. The method processes a first solution that contains standard detectable taxanes and other undetectable taxane compounds to generate a second solution that contains a higher percentage of detectable standard taxane then the first solution. The first step of this method is loading a column having a first opening and a second opening with an ion exchange media. The next step is placing the first solution in the first opening of the column so that the first solution passes through the ion exchange media in the column and flows to the second opening. Thus, the taxane compounds are converted to standard taxanes by an ion exchange reaction and the second solution is formed. Then the next step is collecting, from the second opening of the column, the second solution and recovering from the second solution a larger percentage of standard taxanes then was detectable in the first solution. The ion exchange media of the present solution is an ion exchange resin. The ion exchange resin can be a mixture of an anion exchange resin and a cation exchange resin. The anion exchange resin is in the OH-form. The cation exchange resin is in the H.sup.+ form. Preferably, the ion exchange resin is alumina.

摘要翻译： 本发明是使用吸收塔来分离和回收紫杉烷的方法，其通常不被视为游离紫杉烷。 该方法处理含有标准可检测的紫杉烷和其他不可检测的紫杉烷化合物的第一溶液以产生含有较高百分比的可检测标准紫杉烷的第二溶液，然后是第一溶液。 该方法的第一步是用离子交换介质装载具有第一开口和第二开口的柱。 下一步是将第一溶液置于塔的第一开口中，使得第一溶液通过塔中的离子交换介质并流到第二开口。 因此，紫杉烷化合物通过离子交换反应转化成标准紫杉烷并形成第二溶液。 然后，下一步是从第二个开口开始收集第二个溶液，然后从第二个溶液中回收，然后在第一个溶液中检测到较大百分比的标准紫杉烷。 本溶液的离子交换介质是离子交换树脂。 离子交换树脂可以是阴离子交换树脂和阳离子交换树脂的混合物。 阴离子交换树脂为OH型。 阳离子交换树脂为H +形式。 优选地，离子交换树脂是氧化铝。