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    Thioxanthine derivatives and their use as inhibitors of MPO
    5.
    发明授权
    Thioxanthine derivatives and their use as inhibitors of MPO 失效
    硫代黄嘌呤衍生物及其作为MPO抑制剂的用途

    公开(公告)号：US08026244B2

    公开(公告)日：2011-09-27

    申请号：US12295306

    申请日：2007-04-12

    申请人： Anna-Karin Tiden ,  Jenny Viklund

    发明人： Anna-Karin Tiden ,  Jenny Viklund

    IPC分类号： C07D473/22 ,  A61K31/522 ,  A61P9/10 ,  A61P11/00 ,  A61P11/08 ,  A61P25/16 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12

    CPC分类号： C07D473/20 ,  C07D473/22

    摘要： There are disclosed novel compounds of Formula (I) wherein L, R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.

    摘要翻译： 公开了式（I）的新化合物，其中L，R 1，X和Y如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是MPO酶的抑制剂，因此特别可用于治疗或预防神经炎症性疾病，心脑血管动脉粥样硬化性疾病和外周动脉疾病和呼吸系统疾病。

    Thioxanthine Derivatives and Their Use as Inhibitors of MPO
    7.
    发明申请
    Thioxanthine Derivatives and Their Use as Inhibitors of MPO 审中-公开
    硫代黄嘌呤衍生物及其作为MPO抑制剂的用途

    公开(公告)号：US20090286813A1

    公开(公告)日：2009-11-19

    申请号：US12296347

    申请日：2007-04-12

    申请人： Donald Pivonka ,  Anna-Karin Tiden ,  Jenny Viklund

    发明人： Donald Pivonka ,  Anna-Karin Tiden ,  Jenny Viklund

    IPC分类号： A61K31/52 ,  C07D473/00 ,  A61P29/00 ,  A61P9/00 ,  A61P11/00

    CPC分类号： C07D473/20 ,  C07D473/22

    摘要： There are disclosed novel compounds of Formula (I) wherein R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.

    摘要翻译： 公开了式（I）的新化合物，其中R 1，X和Y如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是MPO酶的抑制剂，因此特别可用于治疗或预防神经炎症性疾病，心脑血管动脉粥样硬化性疾病和外周动脉疾病和呼吸系统疾病。