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34 条记录 (耗时 0.043 秒)

    5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES FOR THE SELECTIVE INHIBITION OF CHEMOKINE RECEPTORS
    8.
    发明申请
    5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES FOR THE SELECTIVE INHIBITION OF CHEMOKINE RECEPTORS 审中-公开
    5,7-取代的噻唑并[4,5-D]嘧啶，用于选择性抑制化合物受体

    公开(公告)号：US20110105537A1

    公开(公告)日：2011-05-05

    申请号：US13009384

    申请日：2011-01-19

    申请人： Rolf Johansson ,  Sofia Karlström ,  Annika Kers ,  Gunnar Nordvall ,  Tobias Rein ,  Can Slivo

    发明人： Rolf Johansson ,  Sofia Karlström ,  Annika Kers ,  Gunnar Nordvall ,  Tobias Rein ,  Can Slivo

    IPC分类号： A61K31/519 ,  C07D513/04 ,  A61P25/00 ,  A61P9/00 ,  A61P19/02 ,  A61P11/00 ,  A61P11/06

    CPC分类号： C07D513/04

    摘要： There are disclosed novel 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one derivatives of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.

    摘要翻译： 公开了式（I）的新的5,7-二取代[1,3]噻唑并[4,5-d]嘧啶-2（3H） - 酮衍生物，其中R 1，R 2，R 3，R 4和n如 说明书及其药学上可接受的盐以及其制备方法，包含它们的药物组合物及其在治疗中的用途。 式（I）化合物是CX3CR1受体拮抗剂，因此特别可用于治疗或预防神经变性疾病，脱髓鞘疾病，心血管和脑血管动脉粥样硬化疾病，外周动脉疾病，类风湿性关节炎，肺疾病如COPD，哮喘或 疼痛。

    5,7-DISUBSTITUTED[1.3]THIAZOLO[4,5-d]PYRIMIDIN-2(3H)-AMINE DERIVATIVES AND THEIR USE IN THERAPY
    9.
    发明申请
    5,7-DISUBSTITUTED[1.3]THIAZOLO[4,5-d]PYRIMIDIN-2(3H)-AMINE DERIVATIVES AND THEIR USE IN THERAPY 失效
    5,7-取代[1.3]噻唑并[4,5-d]吡啶-2（3H） - 胺衍生物及其在治疗中的用途

    公开(公告)号：US20100035899A1

    公开(公告)日：2010-02-11

    申请号：US12442831

    申请日：2007-09-27

    申请人： Rolf Johansson ,  Sofia Karlstrom ,  Annika Kers ,  Gunnar Nordvall ,  Tobias Rein ,  Can Slivo

    发明人： Rolf Johansson ,  Sofia Karlstrom ,  Annika Kers ,  Gunnar Nordvall ,  Tobias Rein ,  Can Slivo

    IPC分类号： A61K31/519 ,  C07D417/14 ,  A61P9/10 ,  A61P25/00

    CPC分类号： C07D513/04

    摘要： There are disclosed novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.

    摘要翻译： 公开了式（I）的新的5-取代的7-取代的7-氨基 - [1,3]噻唑并[4,5-d]嘧啶衍生物，其中R 1，R 2，R 3，R 4和n如说明书中所定义， 其可接受的盐及其制备方法，包含它们的药物组合物及其在治疗中的用途。 式（I）化合物是CX3CR1受体拮抗剂，因此特别可用于治疗或预防神经变性疾病，脱髓鞘疾病，心血管和脑血管动脉粥样硬化疾病，外周动脉疾病，类风湿性关节炎，肺疾病如COPD，哮喘或 疼痛。

    5,7-disubstituted[1.3]thiazolo [4,5-D] pyrimidin-2(3H)-amine derivatives and their use in therapy
    10.
    发明授权
    5,7-disubstituted[1.3]thiazolo [4,5-D] pyrimidin-2(3H)-amine derivatives and their use in therapy 失效
    5,7-二取代[1.3]噻唑并[4,5-D]嘧啶-2（3H） - 胺衍生物及其在治疗中的用途

    公开(公告)号：US08158785B2

    公开(公告)日：2012-04-17

    申请号：US12442831

    申请日：2007-09-27

    申请人： Rolf Johansson ,  Sofia Karlstrom ,  Annika Kers ,  Gunnar Nordvall ,  Tobias Rein ,  Can Slivo

    发明人： Rolf Johansson ,  Sofia Karlstrom ,  Annika Kers ,  Gunnar Nordvall ,  Tobias Rein ,  Can Slivo

    IPC分类号： A61K31/519 ,  A61P9/10 ,  A61P25/00 ,  C07D417/14

    CPC分类号： C07D513/04

    摘要： There are disclosed novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.

    摘要翻译： 公开了式（I）的新的5-取代的7-取代的7-氨基 - [1,3]噻唑并[4,5-d]嘧啶衍生物，其中R 1，R 2，R 3，R 4和n如说明书中所定义， 其可接受的盐及其制备方法，包含它们的药物组合物及其在治疗中的用途。 式（I）化合物是CX3CR1受体拮抗剂，因此特别可用于治疗或预防神经变性疾病，脱髓鞘疾病，心血管和脑血管动脉粥样硬化疾病，外周动脉疾病，类风湿性关节炎，肺疾病如COPD，哮喘或 疼痛。