公开(公告)号：US20230408216A1

公开(公告)日：2023-12-21

申请号：US18236912

申请日：2023-08-22

Applicant: Jesse QUINN

Inventor： Jesse QUINN

IPC: F41A3/42

CPC classification number: F41A3/42

Abstract: A system and method for operating a semi-automatic firearm as a single-shot firearm by installing a bolt with a bolt lock safety device, wherein the bolt lock safety device extends beyond the outer face of the bolt when engaged preventing the firearm from automatically reloading. The bolt lock safety device can be disengaged to allow pulling the charging handle back to cause the bolt to move rearward exposing the firearm chamber to reload a cartridge.

公开(公告)号：US20090023730A1

公开(公告)日：2009-01-22

申请号：US12036728

申请日：2008-02-25

Applicant: Avinash Phadke ,  Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

Inventor： Avinash Phadke ,  Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

IPC: A61K31/5377 ,  C07C69/00 ,  A61K31/216 ,  C07D213/02 ,  A61K31/44 ,  C07D295/00 ,  A61K31/5375 ,  C07D285/06 ,  A61K31/433 ,  C07D241/36 ,  A61K31/498 ,  C07D211/06 ,  A61K31/445 ,  C07D239/02 ,  A61K31/505 ,  C07D215/00 ,  A61K31/47 ,  C07D471/02 ,  A61P31/12 ,  A61K31/53 ,  C07D253/06 ,  A61K31/437 ,  C07D401/02 ,  A61K31/496 ,  C07D487/02 ,  A61K31/519 ,  C07D413/02

CPC classification number: C07D295/15 ,  C07C335/26 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/64 ,  C07D211/78 ,  C07D213/56 ,  C07D213/82 ,  C07D215/54 ,  C07D231/14 ,  C07D233/54 ,  C07D233/64 ,  C07D233/90 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D241/44 ,  C07D249/06 ,  C07D253/07 ,  C07D261/18 ,  C07D263/34 ,  C07D263/58 ,  C07D265/30 ,  C07D271/12 ,  C07D277/56 ,  C07D277/68 ,  C07D285/06 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/38 ,  C07D311/58 ,  C07D333/38 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D419/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents.The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

Abstract translation: 本发明提供式I的化合物和药学上可接受的盐，其中变量A1，A2，R1，R2，V，W，X，Y和Z在本文中定义。 某些本文所述的具有强抗病毒活性的式I化合物。 本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。 本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。 这些传染病包括病毒感染，特别是HCV感染。 本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。 治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

公开(公告)号：US07476686B2

公开(公告)日：2009-01-13

申请号：US11015300

申请日：2004-12-17

Applicant: Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Avinash Phadke ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

Inventor： Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Avinash Phadke ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

IPC: A61K31/44 ,  C07D213/46

CPC classification number: C07D209/48 ,  C07C335/26 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D207/12 ,  C07D207/16 ,  C07D207/34 ,  C07D207/416 ,  C07D209/42 ,  C07D211/14 ,  C07D211/62 ,  C07D211/70 ,  C07D211/86 ,  C07D213/64 ,  C07D213/65 ,  C07D213/81 ,  C07D215/06 ,  C07D215/48 ,  C07D217/04 ,  C07D231/14 ,  C07D233/42 ,  C07D233/90 ,  C07D239/26 ,  C07D241/24 ,  C07D241/44 ,  C07D249/06 ,  C07D257/04 ,  C07D261/18 ,  C07D263/34 ,  C07D263/57 ,  C07D271/08 ,  C07D271/12 ,  C07D277/56 ,  C07D277/66 ,  C07D277/68 ,  C07D285/06 ,  C07D295/135 ,  C07D295/15 ,  C07D307/52 ,  C07D307/68 ,  C07D307/85 ,  C07D311/24 ,  C07D311/66 ,  C07D317/66 ,  C07D319/20 ,  C07D333/20 ,  C07D333/34 ,  C07D333/38 ,  C07D333/70 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04

Abstract: The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

Abstract translation: 本发明提供式I的化合物和药学上可接受的盐，其中变量A1，A2，R1，R2，V，W，X，Y和Z在本文中定义。 某些本文所述的具有强抗病毒活性的式I化合物。 本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。 本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。 这些传染病包括病毒感染，特别是HCV感染。 本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。 治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

公开(公告)号：US07094807B2

公开(公告)日：2006-08-22

申请号：US10716175

申请日：2003-11-18

Applicant: Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Avinash Phadke ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

Inventor： Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Avinash Phadke ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

IPC: A61K31/17 ,  C07C335/02

CPC classification number: C07D209/48 ,  C07C335/26 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D207/12 ,  C07D207/16 ,  C07D207/34 ,  C07D207/416 ,  C07D209/42 ,  C07D211/14 ,  C07D211/62 ,  C07D211/70 ,  C07D211/86 ,  C07D213/64 ,  C07D213/65 ,  C07D213/81 ,  C07D215/06 ,  C07D215/48 ,  C07D217/04 ,  C07D231/14 ,  C07D233/42 ,  C07D233/90 ,  C07D239/26 ,  C07D241/24 ,  C07D241/44 ,  C07D249/06 ,  C07D257/04 ,  C07D261/18 ,  C07D263/34 ,  C07D263/57 ,  C07D271/08 ,  C07D271/12 ,  C07D277/56 ,  C07D277/66 ,  C07D277/68 ,  C07D285/06 ,  C07D295/135 ,  C07D295/15 ,  C07D307/52 ,  C07D307/68 ,  C07D307/85 ,  C07D311/24 ,  C07D311/66 ,  C07D317/66 ,  C07D319/20 ,  C07D333/20 ,  C07D333/34 ,  C07D333/38 ,  C07D333/70 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04

Abstract: The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

Abstract translation: 本发明提供式I的化合物和药学上可接受的盐，其中变量A 1，A 2，R 1，R 2， / SUB>，V，W，X，Y和Z在本文中定义。 某些本文所述的具有强抗病毒活性的式I化合物。 本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。 本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。 这些传染病包括病毒感染，特别是HCV感染。 本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。 治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

公开(公告)号：US20230083435A1

公开(公告)日：2023-03-16

申请号：US17473958

申请日：2021-09-13

Applicant: Jesse Quinn

Inventor： Jesse Quinn

IPC: F41A3/42

Abstract: A method for operating a semi-automatic firearm as a single-shot firearm comprising: installing a hole in the firearm, wherein the bolt comprises a bolt lock safety device, wherein the bolt lock safety device extends beyond a face of the bolt when engaged preventing the firearm from automatically reloading; when the bolt lock safety device is engaged, pulling a charging handle back to cause the bolt to move rearward exposing the firearm chamber to reload a cartridge, wherein the adjustable bolt lock is simultaneously rotated by the lock pivot pin to lay flush with the bolt forcing the bolt back into forward position; and upon release of the charging handle, automatically reengaging the adjustable bolt lock via a lock return spring causing the adjustable bolt lock to extend beyond the face of the bolt.

公开(公告)号：US07365068B2

公开(公告)日：2008-04-29

申请号：US11131013

申请日：2005-05-17

Applicant: Avinash Phadke ,  Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

Inventor： Avinash Phadke ,  Dawei Chen ,  Milind Deshpande ,  Andrew Thurkauf ,  Xiangzhu Wang ,  Yiping Shen ,  Cuixian Liu ,  Jesse Quinn ,  Junko Ohkanda ,  Shouming Li

IPC: A61K31/496 ,  A61K31/444 ,  A61K31/5377 ,  C07D211/78 ,  C07D401/02 ,  C07D401/06 ,  C07D413/02 ,  C07D413/06

CPC classification number: C07D295/15 ,  C07C335/26 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/64 ,  C07D211/78 ,  C07D213/56 ,  C07D213/82 ,  C07D215/54 ,  C07D231/14 ,  C07D233/54 ,  C07D233/64 ,  C07D233/90 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D241/44 ,  C07D249/06 ,  C07D253/07 ,  C07D261/18 ,  C07D263/34 ,  C07D263/58 ,  C07D265/30 ,  C07D271/12 ,  C07D277/56 ,  C07D277/68 ,  C07D285/06 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/38 ,  C07D311/58 ,  C07D333/38 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D419/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

Abstract translation: 本发明提供式I的化合物和药学上可接受的盐，其中变量A 1，A 2，R 1，R 2， / SUB>，V，W，X，Y和Z在本文中定义。 某些本文所述的具有强抗病毒活性的式I化合物。 本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。 本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。 这些传染病包括病毒感染，特别是HCV感染。 本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。 治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

公开(公告)号：US20070004711A1

公开(公告)日：2007-01-04

申请号：US11431155

申请日：2006-05-09

Applicant: Suoming Zhang ,  Avinash Phadke ,  Cuixian Liu ,  Xiangzhu Wang ,  Jesse Quinn ,  Dawei Chen ,  Venkat Gadhachanda ,  Shouming Li ,  Milind Deshpande

Inventor： Suoming Zhang ,  Avinash Phadke ,  Cuixian Liu ,  Xiangzhu Wang ,  Jesse Quinn ,  Dawei Chen ,  Venkat Gadhachanda ,  Shouming Li ,  Milind Deshpande

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/426

CPC classification number: C07D487/04 ,  C07D277/38 ,  C07D277/42 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention provides compounds, salts and hydrates of Formula I, wherein the variables Ar1, R2, R3, R4, r, q, and t are defined herein. Certain compounds of Formula I described herein possess potent antiviral activity. The invention also provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. Certain compounds described herein inhibit assembly of the HCV replication complex. The invention also provides pharmaceutical compositions containing one or more compounds of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

Abstract translation: 本发明提供式I的化合物，盐和水合物，其中变量Ar 1，R 2，R 3，R 3， 4，r，q和t在本文中定义。 某些本文所述的式I化合物具有有效的抗病毒活性。 本发明还提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。 本文所述的某些化合物抑制HCV复制复合物的组装。 本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 本发明还包括通过向这些患者施用一定量的有效降低疾病体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。 这些传染病包括病毒感染，特别是HCV感染。 本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。 治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

公开(公告)号：US11545633B2

公开(公告)日：2023-01-03

申请号：US16980609

申请日：2019-03-13

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  Yuning Li ,  Jesse Quinn

Inventor： Jianping Lu ,  Afshin Dadvand ,  Mark Bortolus ,  Salima Alem ,  Ye Tao ,  Yuning Li ,  Jesse Quinn

IPC: H01L51/00 ,  C07D493/04 ,  H01L51/05 ,  H01L51/42

Abstract: The development of air-stable unipolar n-type semiconductors with good solubility in organic solvents at room temperature remains a critical issue in the field of organic electronics. Moreover, most of the existing semiconducting materials exhibit LUMO energy levels higher than −4.0 eV, making electron transport sensitive to both moisture and oxygen. Bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are disclosed herein. More specifically, bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof for use in organic electronics are disclosed. A process for the preparation of bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide and derivatives is also disclosed. The bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are characterized by high electron mobilities and are suitable for use as n-type semiconductors in organic electronics.

公开(公告)号：US20120108576A1

公开(公告)日：2012-05-03

申请号：US13307761

申请日：2011-11-30

Applicant: Suoming Zhang ,  Avinash Phadke ,  Cuixian Liu ,  Xiangzhu Wang ,  Jesse Quinn ,  Dawei Chen ,  Venkat Gadhachanda ,  Shouming Li ,  Milind Deshpande

Inventor： Suoming Zhang ,  Avinash Phadke ,  Cuixian Liu ,  Xiangzhu Wang ,  Jesse Quinn ,  Dawei Chen ,  Venkat Gadhachanda ,  Shouming Li ,  Milind Deshpande

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/498 ,  A61K31/501 ,  A61K31/496 ,  A61K31/497 ,  A61K31/519 ,  A61K31/506 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/429 ,  A61K31/426 ,  A61K31/427 ,  C07D239/02 ,  C07D513/14 ,  C07D471/04 ,  C07D417/04 ,  C07D513/04 ,  C07D417/14 ,  C07D277/38 ,  A61K31/538

CPC classification number: C07D487/04 ,  C07D277/38 ,  C07D277/42 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention provides compounds, salts and hydrates of Formula I, wherein the variables Ar1, R2, R3, R4, r, q, and t are defined herein. Certain compounds of Formula I described herein possess potent antiviral activity. The invention also provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. Certain compounds described herein inhibit assembly of the HCV replication complex. The invention also provides pharmaceutical compositions containing one or more compounds of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

Abstract translation: 本发明提供式I的化合物，盐和水合物，其中变量Ar1，R2，R3，R4，r，q和t在本文中定义。 某些本文所述的式I化合物具有有效的抗病毒活性。 本发明还提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。 本文所述的某些化合物抑制HCV复制复合物的组装。 本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 本发明还包括通过向这些患者施用一定量的有效降低疾病体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。 这些传染病包括病毒感染，特别是HCV感染。 本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。 治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

公开(公告)号：US07718671B2

公开(公告)日：2010-05-18

申请号：US10887227

申请日：2004-07-08

Applicant: Avinash Phadke ,  Jesse Quinn ,  Junko Ohkanda ,  Andrew Thurkauf ,  Yiping Shen ,  Cuixian Liu ,  Dawei Chen ,  Shouming Li ,  Xiangzhu Wang

Inventor： Avinash Phadke ,  Jesse Quinn ,  Junko Ohkanda ,  Andrew Thurkauf ,  Yiping Shen ,  Cuixian Liu ,  Dawei Chen ,  Shouming Li ,  Xiangzhu Wang

IPC: A61K31/47 ,  C07D217/02 ,  A61K31/445 ,  C07D211/32 ,  C07C335/00

CPC classification number: C07D211/64 ,  C07C335/12 ,  C07C335/14 ,  C07C335/16 ,  C07C335/18 ,  C07C335/20 ,  C07C335/22 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/44 ,  C07D211/14 ,  C07D211/62 ,  C07D215/06 ,  C07D217/04 ,  C07D295/135 ,  C07D317/66

Abstract: Substituted arylthiourea compounds of Formula I, and the pharmaceutically acceptable salts of such compounds, useful as antiviral agents, are provided herein. Certain substituted arylthioureas disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions containing one or more substituted arylthiourea compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents are provided herein. Such pharmaceutical compositions may contain a substituted arylthiourea as the only active agent or may contain a combination of a substituted arylthiourea derivative and one or more other pharmaceutically active agents. Methods of treating Hepatitis C viral infections in mammals are also provided herein.

Abstract translation: 本文提供了式I的取代的芳基硫脲化合物和可用作抗病毒剂的这类化合物的药学上可接受的盐。 本文公开的某些取代的芳基硫脲是有效和/或选择性的病毒复制抑制剂，特别是丙型肝炎病毒复制。 本文提供了含有一种或多种取代的芳基硫脲化合物和一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。 这样的药物组合物可以含有取代的芳基硫脲作为唯一的活性剂，或者可以含有取代的芳基硫脲衍生物和一种或多种其它药物活性剂的组合。 本文还提供了治疗哺乳动物中丙型肝炎病毒感染的方法。