公开(公告)号：US5505726A

公开(公告)日：1996-04-09

申请号：US215272

申请日：1994-03-21

Applicant: Peter M. Meserol

Inventor： Peter M. Meserol

IPC: A61F13/00 ,  A61F13/02 ,  A61K9/00 ,  A61M35/00 ,  A61M37/00 ,  A61N5/06

CPC classification number: A61M37/00 ,  A61F13/0213 ,  A61F13/0226 ,  A61K9/0009 ,  A61M35/00 ,  A61N5/062 ,  A61F2013/00365 ,  A61F2013/00676 ,  A61F2013/00846 ,  A61F2013/00902 ,  A61N2005/0645

Abstract: An article of manufacture for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin including the stratum corneum, transparent hydrogel for covering the dermal treatment site and containing hydration agent and photopharmaceutical, the transparent hydrogel couples the hydration agent to the stratum corneum to hydrate and soften the stratum corneum to enhance its optical transmissiveness to facilitate the transmission of light therethrough and to enhance its chemical transmissiveness to facilitate the transmission therethrough of the photopharmaceutical for treatment of the dermal lesion; and light delivery means are included for delivering light through the transparent hydrogel and the hydrated stratum corneum to photoactivate the photopharmaceutical to treat the dermal lesion.

Abstract translation: 一种用于光皮肤病变的光动力学治疗的制品，所述皮肤病变位于皮肤上的真皮处理部位，包括角质层，用于覆盖皮肤处理部位的透明水凝胶，并含有水化剂和光致药剂，透明水凝胶将水合剂与角质层 水合并软化角质层以增强其透光性，以促进光的透过，并增强其化学传导性，以促进用于治疗真皮病变的光致药物的透射; 并且包括用于通过透明水凝胶和水合角质层传递光的光输送装置以光敏化光药物以治疗真皮损伤。

公开(公告)号：US5029583A

公开(公告)日：1991-07-09

申请号：US431914

申请日：1989-11-06

Applicant: Peter M. Meserol ,  Thomas Palmieri

Inventor： Peter M. Meserol ,  Thomas Palmieri

IPC: A61B5/00 ,  A61B5/15 ,  G01N21/03 ,  G01N21/25 ,  G01N21/78

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150633 ,  A61B5/150702 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/15194 ,  G01N21/251 ,  G01N2021/0371 ,  G01N21/78 ,  G01N2201/122 ,  G01N2201/126

Abstract: An optical analyzer for determining an analyte in a fluid of interest such as a body fluid of interest satisfying the foregoing need and embodying the present invention may include a housing; combination optically transparent cuvette and lancet mounted removably in the housing, the cuvette may receive an optically transparent reagent test system for reacting with the body fluid to produce a change in at least one optical transmissive characteristic of the system indicative of the analyte; a cuvette carrier mounted slidably in the housing and for removably receiving the cuvette; a spring actuator mounted in the housing and connected to the cuvette carrier, the spring actuator may be compressed and released to advance the carrier and thereby advance the lancet into engagement with a portion of a body to produce the body fluid; depth control apparatus for controlling the depth of penetration of the lancet into the body portion; an electrooptical system mounted in the housing in optical engagement with the cuvette and for passing a light beam through the cuvette and the reagent system and for receiving the light beam modified by the change in optical transmissive characteristic of the system and for transmitting computation signals indicative of the analyte to a computer; a computer mounted in the housing for receiving the computation signals and for comparing the computation signals against predetermined data to produce display signals indicative of the analyte; a display mounted in the housing and for receiving the display signals and for providing a vehicle display indicative of the analyte; and control switches mounted in the housing and connected to the computer for controlling the operation of the computer.

Abstract translation: 用于确定感兴趣的流体（例如满足上述需要的体液的分析物）并体现本发明的光学分析仪可以包括壳体; 组合的光学透明比色杯和可拆卸地安装在壳体中的刺血针，反应杯可以接收光学透明的试剂测试系统，用于与体液反应以产生指示分析物的系统的至少一个光学透射特性的变化; 比色杯托架，其可滑动地安装在所述壳体中并用于可移除地接收所述比色皿; 安装在壳体中并连接到比色杯托架的弹簧致动器可以压缩和释放弹簧致动器以使托架前进，从而使刺血针与身体的一部分接合以产生体液; 深度控制装置，用于控制刺血针穿入体部的深度; 安装在壳体中的电光学系统与比色皿光学接合并使光束通过比色杯和试剂系统，并用于接收由系统的光学透射特性的改变而修改的光束，并且用于发射指示 分析物到计算机; 安装在壳体中用于接收计算信号并用于将计算信号与预定数据进行比较以产生指示分析物的显示信号的计算机; 安装在壳体中并用于接收显示信号并提供指示分析物的车辆显示器的显示器; 以及安装在壳体中并连接到计算机以控制计算机的操作的控制开关。

公开(公告)号：USRE28801E

公开(公告)日：1976-05-04

申请号：US568442

申请日：1975-04-16

Applicant: Jesse L. Acker ,  Peter M. Meserol

Inventor： Jesse L. Acker ,  Peter M. Meserol

IPC: C12M1/34 ,  G01N1/00 ,  G01N21/00 ,  G01N21/25 ,  G01N35/00 ,  H03K5/003 ,  H03K5/08 ,  H04L25/06

CPC classification number: G01N35/00594 ,  C12M41/36 ,  G01N1/00 ,  G01N21/00 ,  G01N21/253 ,  H03K5/003 ,  H03K5/084 ,  H04L25/062 ,  G01N35/00693

Abstract: The apparatus comprises a plurality of stationary cuvettes, a chamber for the fluid to be evaluated, means for placing the chamber in fluid communication with each of the cuvettes and for permitting the flow of fluid from the chamber into each of the cuvettes, a plurality of optical transmitting means in registration with each of the cuvettes for transmitting a beam of radiant energy through each of the cuvettes, and detector means for intercepting each of the beams of radiant energy and for measuring any optical changes in the radiant energy passing through the fluid in each of the cuvettes.The chamber for the fluid, the plurality of cuvettes and the fluid communication means are all housed within, preferably, a disposable, self-contained cartridge of unitary construction. The cartridge is mountable within a carriage that houses the transmitting and detector means of the apparatus. The chamber which forms the upper portion of the cartridge can be prefilled with bacterial suspension. Periodically, during the growth of the subject bacteria the suspensions are agitated by suitable means. Samples of antibiotics of varying potency are placed in the cuvettes. The cartridge is mounted in the carriage. On a signal from the detector means a portion of the suspension passes into each of the cuvettes to begin the antibiotic titer which is evaluated by means of the transmitting and detector means and associated electronic circuitry.

公开(公告)号：US4837160A

公开(公告)日：1989-06-06

申请号：US43876

申请日：1987-04-29

Applicant: Peter M. Meserol ,  Jesse Acker

Inventor： Peter M. Meserol ,  Jesse Acker

IPC: G01N33/487 ,  G01N33/543 ,  G01N33/80 ,  G01N35/00

CPC classification number: G01N33/80 ,  G01N33/54366 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/00495 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: A biological fluid assay system and method for the determination of immunoreactive characteristics of biological specimen and more particularly for the qualitative determination of immunological reactions. The apparatus includes a centrifuge rotor, a disposable belt mountable on the centrifuge rotor, and a plurality of light transmissive chambers as components of the removable belt, each of the chambers having a vertical apex and a horizontal radial apex for accepting a sample comprising a specimen and an appropriate reagent. An illumination system projects an image of the sample while a linear photosensitive array detects the image of the sample for measuring the vertical dimension of the sample and a microprocessor analyzes the vertical dimension of the sample. A sample is radially accelerated to compress the particulate portion of the sample or reagent into a compact mass in the extreme radial portion of the transparent chamber. The centrifugal force on the sample is balanced with the gravitational force acting on the compact mass by decelerating the rotor. The vertical dimension of the compact mass is measured while the sample is rotating. The vertical dimension of the compact mass is again measured after a delay to determine the presence of vertical streaming. The difference between the vertical dimension of the compact mass before streaming and the vertical dimension of the mass after streaming is completed, due to gravitational attraction, is determined.

Abstract translation: 一种用于测定生物标本免疫反应特性的生物流体测定系统和方法，更特别地用于定性测定免疫反应。 所述设备包括离心机转子，可安装在离心机转子上的一次性带，以及作为可移除带的部件的多个透光室，每个室具有垂直顶点和水平径向顶点，用于接收包含样品的样品 和适当的试剂。 照明系统投射样品的图像，而线性感光阵列检测样品的图像以测量样品的垂直尺寸，微处理器分析样品的垂直尺寸。 径向加速样品以将样品或试剂的颗粒部分压缩成透明室的极端径向部分中的致密块体。 样品上的离心力与通过减速转子作用在紧凑体上的重力相平衡。 在样品旋转时测量紧凑质量的垂直尺寸。 在延迟之后再次测量紧凑质量的垂直尺寸以确定垂直流动的存在。 确定流动前的紧凑质量的垂直尺寸与流动后的质量的垂直尺寸之间的差异，由于重力吸引而被确定。

公开(公告)号：US4400353A

公开(公告)日：1983-08-23

申请号：US97196

申请日：1979-11-26

Applicant: Peter M. Meserol ,  Jesse L. Acker

Inventor： Peter M. Meserol ,  Jesse L. Acker

IPC: G01N21/03 ,  G01N21/59 ,  G01N21/82 ,  G01N33/48 ,  G01N33/53 ,  G01N35/00 ,  G01N21/51 ,  G01N33/16

CPC classification number: G01N33/5302 ,  G01N21/5911 ,  G01N35/00029 ,  G01N2035/00099 ,  G01N21/03 ,  G01N21/82 ,  G01N33/48 ,  G01N33/53

Abstract: The method of this invention comprises introducing the fluid biological test specimen and the reagent (e.g., latex spheres) into a reaction zone in the image cell, evenly mixing and incubating the mixture thereby forming agglutinated particles. After transilluminating the reaction zone and imaging the light beams transmitted therethrough on the image sensor, the dark areas formed on the surface of the image sensor are measured, preferably electronically. This procedure is repeated for a reference specimen and the total dark imaged area is compared with the total dark area obtained for the unknown specimen for qualitative determination.In order to obtain the concentration of the immunoreactive component in the unknown specimen, the foregoing procedure is repeated for at least two specimens with known antibody concentrations, one of which may be a negative control. The concentration of the immunoreactive component of the unknown sample is then determined from the total dark imaged area thereof and the relationship between the total dark imaged areas of the known specimen and their respective concentrations.

Abstract translation: 本发明的方法包括将流体生物测试样本和试剂（例如胶乳球）引入图像池中的反应区，均匀混合并孵育混合物，从而形成凝集的颗粒。 在对反应区进行透光照射并在图像传感器上成像透过其的光束之后，优选以电子方式测量形成在图像传感器表面上的暗区域。 对于参考样品重复该过程，并将总暗区成像与未知样品获得的总暗区进行定性测定。 为了获得未知标本中免疫反应成分的浓度，对已知抗体浓度的至少两个样品重复上述步骤，其中一个可能是阴性对照。 然后从其全部暗成像区域确定未知样品的免疫反应性组分的浓度，以及已知样品的总暗成像区域与其相应浓度之间的关系。

公开(公告)号：US06231593B1

公开(公告)日：2001-05-15

申请号：US09000360

申请日：1998-07-24

Applicant: Peter M. Meserol

Inventor： Peter M. Meserol

IPC: A61N5067

CPC classification number: A61M35/00 ,  A61F13/00051 ,  A61F13/0213 ,  A61F2013/00365 ,  A61F2013/00676 ,  A61F2013/00846 ,  A61F2013/00902 ,  A61K9/0009 ,  A61M37/00 ,  A61N5/062 ,  A61N2005/0645

Abstract: An apparatus for photodynamic therapy (PDT) includes a cover (22) shaped to engage skin tissue (12) and a fiber optic panel (31) housed within the cover (22). Hydrogel (26) is located within the cover (22) and is in intimate physical and optical contact with the fiber optic panel (31) for optically coupling light from the fiber optic panel (31) to the skin tissue (12). The hydrogel (26) engages the stratum corneum (14) and hydrates and softens the stratum corneum (14) to enhance its optical transmissiveness to facilitate the transmission of light therethrough and to enhance its chemical transmissiveness to facilitate the transmission therethrough of photopharmaceuticals (28, 54) for treatment of a dermal lesion 10.

Abstract translation: 一种用于光动力治疗（PDT）的装置包括形成为接合皮肤组织（12）的外壳（22）和容纳在盖（22）内的光纤面板）。 水凝胶（26）位于盖（22）内并与光纤面板（31）保持紧密的物理和光学接触，用于将来自光纤面板（31）的光光学耦合到皮肤组织（12）。 水凝胶（26）接合角质层（14）并水化并软化角质层（14）以增强其透光性，以促进光的透过，并增强其化学传导性，以促进光致药物（28， 54）用于治疗真皮病变10。

公开(公告)号：US5489279A

公开(公告)日：1996-02-06

申请号：US215274

申请日：1994-03-12

Applicant: Peter M. Meserol

Inventor： Peter M. Meserol

IPC: A61F13/00 ,  A61F13/02 ,  A61K9/00 ,  A61M35/00 ,  A61M37/00 ,  A61N5/06

CPC classification number: A61F13/02 ,  A61K9/0009 ,  A61M35/00 ,  A61M37/00 ,  A61N5/062 ,  A61F2013/00365 ,  A61F2013/00676 ,  A61F2013/00846 ,  A61F2013/00902 ,  A61N2005/0645

Abstract: Method of applying photodynamic therapy to dermal lesion located at a dermal treatment site in skin which includes the stratum corneum, including the steps of hydrating the stratum corneum at the dermal treatment site to enhance the chemical and optical transparency of the stratum corneum at the dermal treatment site and to enhance the passage therethrough of photopharmaceutical and light, introducing photopharmaceutical into the treatment site through the hydrated stratum corneum, and introducing light into the treatment site through the hydrated stratum corneum to photoactivate the photopharmaceutical to treat the dermal lesion.

Abstract translation: 将光动力学治疗应用于位于包括角质层在内的皮肤真皮处理部位的真皮病变的方法，包括在真皮处理部位水合角质层的步骤，以增强真皮处理时角质层的化学和光学透明度 并增强光学药物和光的通过，通过水合角质层将光致药物引入治疗部位，并通过水合角质层将光引入治疗部位以光敏化光致药物以治疗真皮病变。

公开(公告)号：US5304350A

公开(公告)日：1994-04-19

申请号：US821708

申请日：1992-01-16

Applicant: Peter M. Meserol

Inventor： Peter M. Meserol

IPC: G01N35/00 ,  G01N35/10 ,  B01L9/00

CPC classification number: G01N35/1002 ,  G01N35/00029 ,  Y10T436/112499

Abstract: Apparatus and method for depositing reagent only on a specimen contained in a cavity utilizing reagent deposition apparatus under the control of imaging apparatus providing an image of the specimen within the cavity; and an analytic implement including a pair of opposed and spaced apart transparent plates mounted in a frame and providing the cavity therebetween for receiving the specimen.

Abstract translation: 用于在成像设备的控制下，在试样沉积装置的控制下，在试样沉积装置中沉积试剂的试样的沉积试剂的方法和装置， 以及分析器具，其包括安装在框架中的一对相对且间隔开的透明板，并在其间提供用于接收样本的空腔。

公开(公告)号：US4902629A

公开(公告)日：1990-02-20

申请号：US106573

申请日：1987-10-06

Applicant: Peter M. Meserol ,  Philip Bernstein ,  Rita C. Prodell ,  Thomas Palmieri

Inventor： Peter M. Meserol ,  Philip Bernstein ,  Rita C. Prodell ,  Thomas Palmieri

IPC: B01L3/00 ,  G01N33/53 ,  G01N33/543

CPC classification number: B01L3/502738 ,  G01N33/5302 ,  G01N33/54366 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/065 ,  Y10S435/805

Abstract: Apparatus for and process of facilitating reaction between analyte contained in a sample and test reagent system at least one of which sample and test reagent system is a liquid, wherein the liquid one of the sample and test reagent system is placed in a reservoir, the other of the analyte and test reagent system is placed in capillary means dimensioned for entry into the reservoir, the reservoir and capillary means being mounted for at least relative movement towards each other and entry of the capillary means into the reservoir to draw by capillary attraction the liquid one of the sample and test reagent system from the reservoir into the capillary means and to bring the analyte and test reagent system into contact in the capillary means and facilitate the reaction.

Abstract translation: 用于促进样品中包含的分析物和测试试剂系统之间的反应的装置，其中至少一个样品和测试试剂系统是液体，其中样品和测试试剂系统的液体被放置在储存器中，另一个 分析物和测试试剂系统被置于尺寸适于进入储存器的毛细管装置中，储存器和毛细管装置被安装成朝向彼此至少相对运动并且毛细管装置进入储存器以通过毛细管吸引液体 从储存器到毛细管装置的样品和试剂系统之一，并使分析物和试剂系统在毛细管装置中接触并促进反应。

公开(公告)号：US4666853A

公开(公告)日：1987-05-19

申请号：US512122

申请日：1983-07-08

Applicant: Peter M. Meserol ,  Jesse L. Acker ,  Janet G. Murnick ,  Dean Pappas

Inventor： Peter M. Meserol ,  Jesse L. Acker ,  Janet G. Murnick ,  Dean Pappas

IPC: C12M1/00 ,  C12M1/38 ,  C12M1/22 ,  G01N1/10 ,  G01N21/00

CPC classification number: C12M23/22 ,  C12M41/14 ,  C12M41/36 ,  Y10S435/809

Abstract: Self-sufficient incubation assembly for the in vitro cultivation of microorganisms such as bacteria and for being energized by a self-contained energy source, including a heater for heating means, such as a culture growth dish assembly or a cuvette, for receiving a culture growth medium seeded with microorganisms, to a physiological temperature to cultivate the microorganisms, and electrical circuitry which interconnects the heater with the energy source and which includes a temperature control element in intimate physical contact with the seeded culture growth receiving means to cause the temperature of the control element to be substantially the same as the temperature of the medium; the electrical circuit in operation produces heat and due to its intimate physical contact with the means for receiving the seeded culture growth medium supplements the heating of the medium by the heater and the supplementation reduces the total energy required to be supplied by the energy source to cultivate the microorganisms below that which would be required were the electrical circuitry not to be in intimate physical contact with the culture growth receiving means; and optical means are included to provide an external indication of the growth of the microorganisms within the interior of the assembly.

Abstract translation: 用于体外培养微生物如细菌并通过自给自足的能量源激活的自足孵育组件，包括用于加热装置的加热器，例如培养生长皿组件或比色皿，用于接受培养生长 培养微生物的培养基，培养微生物的生理温度和将加热器与能量源相互连接的电路，其包括与种子培养生长接收装置紧密物理接触的温度控制元件，以使控制温度 元素与介质的温度基本相同; 操作中的电路产生热量并且由于其与用于接收接种培养生长培养基的装置的亲密的物理接触补充了加热器对培养基的加热，并且补充物减少了由能源供应培养的总能量 要求的微生物是不与培养生长接收装置紧密物理接触的电路; 并且包括光学装置以提供组件内部的微生物生长的外部指示。