公开(公告)号：US20070020746A1

公开(公告)日：2007-01-25

申请号：US10807556

申请日：2004-03-24

Applicant: Charles Kunsch ,  Gil Choi ,  Steven Barash ,  Patrick Dillon ,  Michael Fannon ,  Craig Rosen

Inventor： Charles Kunsch ,  Gil Choi ,  Steven Barash ,  Patrick Dillon ,  Michael Fannon ,  Craig Rosen

IPC: C07H21/02 ,  C07H21/04 ,  C12P21/04 ,  C12N1/20

CPC classification number: C12N15/1093 ,  A61K39/00 ,  C07K14/31 ,  C12N15/52

Abstract: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Abstract translation: 本发明提供金黄色葡萄球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。

公开(公告)号：US20050181439A1

公开(公告)日：2005-08-18

申请号：US11106649

申请日：2005-04-15

Applicant: Gil Choi ,  Charles Kunsch ,  Steven Barash ,  Patrick Dillon ,  Brian Dougherty ,  Michael Fannon ,  Craig Rosen

Inventor： Gil Choi ,  Charles Kunsch ,  Steven Barash ,  Patrick Dillon ,  Brian Dougherty ,  Michael Fannon ,  Craig Rosen

IPC: G01N33/53 ,  A01K67/027 ,  A61K38/00 ,  A61K39/00 ,  A61K39/09 ,  A61K48/00 ,  A61P31/04 ,  C07K14/315 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N5/18 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/569 ,  G06F17/30 ,  C07H21/04 ,  C07K14/31 ,  C12N15/74

CPC classification number: C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  C07K14/315

Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

Abstract translation: 本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。

公开(公告)号：US20050032168A1

公开(公告)日：2005-02-10

申请号：US10896972

申请日：2004-07-23

Applicant: Craig Rosen ,  George Komatsoulis ,  Kevin Baker ,  Charles Birse ,  Daniel Soppet ,  Henrik Olsen ,  Paul Moore ,  Ping Wei ,  Reinhard Ebner ,  D. Duan ,  Yanggu Shi ,  Gil Choi ,  Michele Fiscella ,  Jian Ni ,  Steven Ruben ,  Steven Barash

Inventor： Craig Rosen ,  George Komatsoulis ,  Kevin Baker ,  Charles Birse ,  Daniel Soppet ,  Henrik Olsen ,  Paul Moore ,  Ping Wei ,  Reinhard Ebner ,  D. Duan ,  Yanggu Shi ,  Gil Choi ,  Michele Fiscella ,  Jian Ni ,  Steven Ruben ,  Steven Barash

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/00 ,  A61K38/16 ,  A61K38/43 ,  A61K38/51 ,  A61K39/395 ,  A61K48/00 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P21/00 ,  A61P25/00 ,  A61P35/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/64 ,  C12N9/88 ,  C12N15/12 ,  C12N15/52 ,  C12N15/60 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/30 ,  C12N9/6424 ,  C12N2799/026 ,  C12Q1/6883 ,  G01N2500/00

Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070154986A1

公开(公告)日：2007-07-05

申请号：US11563552

申请日：2006-11-27

Applicant: Charles Kunsch ,  Gil Choi ,  Patrick Dillon ,  Craig Rosen ,  Steven Barash ,  Michael Fannon ,  Brian Dougherty

Inventor： Charles Kunsch ,  Gil Choi ,  Patrick Dillon ,  Craig Rosen ,  Steven Barash ,  Michael Fannon ,  Brian Dougherty

IPC: C12P21/06 ,  C12N1/21 ,  C12N15/74 ,  C07H21/04 ,  C07K14/315

CPC classification number: C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  C07K14/315

Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Abstract translation: 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。

公开(公告)号：US20060062789A1

公开(公告)日：2006-03-23

申请号：US11266444

申请日：2005-11-04

Applicant: Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

Inventor： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

IPC: C07K16/24 ,  A61K39/395 ,  G01N33/53

CPC classification number: C07K14/70575 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/564

Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

公开(公告)号：US20050255532A1

公开(公告)日：2005-11-17

申请号：US11054515

申请日：2005-02-10

Applicant: Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

Inventor： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

IPC: C07H21/04 ,  C07K16/28 ,  C07K16/30 ,  C12N5/06 ,  G01N33/50 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K16/2875 ,  A61K35/12 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5052 ,  G01N33/5091 ,  G01N33/564 ,  G01N33/574 ,  G01N33/68

Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated vith aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

Abstract translation: 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达相关的疾病或病症的方法和组合物，其包含抗体或其片段或变体，或免疫特异性结合B淋巴细胞刺激物的相关分子的B淋巴细胞刺激物的不适当功能。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。

公开(公告)号：US06593114B1

公开(公告)日：2003-07-15

申请号：US08956171

申请日：1997-10-20

Applicant: Charles A. Kunsch ,  Gil H. Choi ,  Steven Barash ,  Patrick J. Dillon ,  Michael R. Fannon ,  Craig A. Rosen

Inventor： Charles A. Kunsch ,  Gil H. Choi ,  Steven Barash ,  Patrick J. Dillon ,  Michael R. Fannon ,  Craig A. Rosen

IPC: C12N1564

CPC classification number: C07K14/31 ,  A61K39/00 ,  C12N15/1093 ,  C12N15/52

Abstract: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

Abstract translation: 本发明提供了金黄色葡萄球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。