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公开(公告)号：US20110207721A1
公开(公告)日：2011-08-25
申请号：US13100618
申请日：2011-05-04
Applicant: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
Inventor： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC: A61K31/5517 , C07D487/04 , A61P3/10 , A61P25/28
CPC classification number: C07D471/06 , C07D487/06
Abstract: The present invention provides kinase inhibitors of Formula I.
Abstract translation: 本发明提供式I的激酶抑制剂。
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公开(公告)号：US20050090483A1
公开(公告)日：2005-04-28
申请号：US10506459
申请日：2003-03-04
Applicant: Thomas Engler , Timothy Burkholder , Joshua Clayton , Clive Diefenbacher , Kelly Furness , James Henry , Yihong Li , Sushant Malhotra , Angela Marquart , Johnathan McLean , David Mendel , Jon Reel
Inventor： Thomas Engler , Timothy Burkholder , Joshua Clayton , Clive Diefenbacher , Kelly Furness , James Henry , Yihong Li , Sushant Malhotra , Angela Marquart , Johnathan McLean , David Mendel , Jon Reel
IPC: A61K31/407 , A61K31/4355 , A61K31/4745 , A61K31/55 , A61K31/5513 , A61P3/10 , A61P25/08 , A61P25/28 , A61P43/00 , C07D471/06 , C07D487/06 , C07D498/06 , C07D519/00 , A61K31/551 , C07D487/14
CPC classification number: C07D471/06 , C07D487/06
Abstract: The present invention provides kinase inhibitors of Formula I.
Abstract translation: 本发明提供式I的激酶抑制剂。
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公开(公告)号：US08058425B2
公开(公告)日：2011-11-15
申请号：US13100618
申请日：2011-05-04
Applicant: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
Inventor： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC: A61P25/08 , A61K31/55 , C07D487/06
CPC classification number: C07D471/06 , C07D487/06
Abstract: The present invention provides kinase inhibitors of Formula I.
Abstract translation: 本发明提供式的激酶抑制剂。
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公开(公告)号：US08022065B2
公开(公告)日：2011-09-20
申请号：US12333775
申请日：2008-12-12
Applicant: Thomas Albert Engler , James Robert Henry , Sushant Malhotra , Jon Kevin Reel
Inventor： Thomas Albert Engler , James Robert Henry , Sushant Malhotra , Jon Kevin Reel
IPC: A61P25/28 , A61K31/55 , C07D487/06
CPC classification number: C07D471/06 , C07D487/06
Abstract: The present invention provides kinase inhibitors of Formula I.
Abstract translation: 本发明提供式I的激酶抑制剂。
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公开(公告)号：US07511056B2
公开(公告)日：2009-03-31
申请号：US11577094
申请日：2005-11-02
Applicant: Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
Inventor： Clive Gideon Diefenbacher , Thomas Albert Engler , Hong-Yu Li , Sushant Malhotra , Jason Scott Sawyer , Yan Wang
IPC: A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02 , C07D401/00
CPC classification number: C07D487/04 , C07D471/04 , C07D519/00
Abstract: The present invention is directed to inhibitors of TGF-β of Formula I:
Abstract translation: 本发明涉及式I的TGF-β抑制剂：
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Patent Agency Ranking
公开(公告)号：US07405305B2
公开(公告)日：2008-07-29
申请号：US10506029
申请日：2003-03-05
Applicant: Pamela Ann Albaugh , Jochen Ammenn , Timothy Paul Burkholder , Joshua Ryan Clayton , Scott Eugene Conner , Brian Eugene Cunningham , Thomas Albert Engler , Kelly Wayne Furness , James Robert Henry , Sushant Malhotra , Mark Joseph Tebbe , Guoxin Zhu , YiHong Li , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
Inventor： Pamela Ann Albaugh , Jochen Ammenn , Timothy Paul Burkholder , Joshua Ryan Clayton , Scott Eugene Conner , Brian Eugene Cunningham , Thomas Albert Engler , Kelly Wayne Furness , James Robert Henry , Sushant Malhotra , Mark Joseph Tebbe , Guoxin Zhu , YiHong Li , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC: C07D209/12 , C07D207/24 , C07D211/06
CPC classification number: C07D451/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/04
Abstract: The present invention provides kinase inhibitors of Formula (I)
Abstract translation: 本发明提供式（I）的激酶抑制剂，
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公开(公告)号：US07109229B2
公开(公告)日：2006-09-19
申请号：US10344245
申请日：2001-09-24
Applicant: Thomas Albert Engler , Kelly Wayne Furness , Sushant Malhotra , Stephen Lyle Briggs , Harold Burns Brooks , David K yes Clawson , Concepcion Sanchez-Martinez , Faming Zhang , Guoxin Zhu
Inventor： Thomas Albert Engler , Kelly Wayne Furness , Sushant Malhotra , Stephen Lyle Briggs , Harold Burns Brooks , David K yes Clawson , Concepcion Sanchez-Martinez , Faming Zhang , Guoxin Zhu
IPC: A61K31/40 , C07D481/00
CPC classification number: C07D403/14 , C07D487/14
Abstract: The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).
Abstract translation: 本文公开的化合物是式（I）的吲哚并唑，其是有效的CDK4抑制剂，并且可用于治疗包括癌症的细胞增殖性疾病。 式（I）。
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公开(公告)号：US20090105229A1
公开(公告)日：2009-04-23
申请号：US12333775
申请日：2008-12-12
Applicant: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
Inventor： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel
IPC: A61K31/5517 , C07D487/16
CPC classification number: C07D471/06 , C07D487/06
Abstract: The present invention provides kinase inhibitors of Formula I.
Abstract translation: 本发明提供式I的激酶抑制剂。
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公开(公告)号：US20050288321A1
公开(公告)日：2005-12-29
申请号：US10506029
申请日：2003-03-05
Applicant: Pamela Albaugh , Jochen Ammenn , Timothy Burkholder , Joshu Clayton , Scott Conner , Brian Cunningham , Thomas Engler , Kelly Furness , James Henry , Sushant Malhotra , Mark Joseph Tebbe
Inventor： Pamela Albaugh , Jochen Ammenn , Timothy Burkholder , Joshu Clayton , Scott Conner , Brian Cunningham , Thomas Engler , Kelly Furness , James Henry , Sushant Malhotra , Mark Joseph Tebbe
IPC: C07D491/052 , A61K31/404 , A61K31/405 , A61K31/4355 , A61K31/437 , A61K31/438 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/4741 , A61K31/4745 , A61K31/496 , A61K31/506 , A61P3/10 , A61P5/50 , A61P25/28 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D451/04 , C07D471/02 , C07D471/04 , C07D491/04 , C07D43/14
CPC classification number: C07D451/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/04
Abstract: The present invention provides kinase inhibitors of Formula (I).
Abstract translation: 本发明提供式（I）的激酶抑制剂。
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公开(公告)号：US20110294792A1
公开(公告)日：2011-12-01
申请号：US13206057
申请日：2011-08-09
Applicant: Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
Inventor： Thomas Albert Engler , Timothy Paul Burkholder , Joshua Ryan Clayton , Clive Gideon Diefenbacher , Kelly Wayne Furness , James Robert Henry , Yihong Li , Sushant Malhotra , Angela Lynn Marquart , Johnathan Alexander McLean , David Mendel , Jon Kevin Reel , Brian Raymond Berridge , Charles Edward Ruegg , John Morris Sullivan
IPC: A61K31/551 , A61P19/08 , C07D487/04
CPC classification number: C07D471/06 , C07D487/06
Abstract: The present invention provides kinase inhibitors of Formula I.
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