公开(公告)号：US20250144172A1

公开(公告)日：2025-05-08

申请号：US19009000

申请日：2025-01-03

Applicant: The Texas A&M University System

Inventor： Richard H. Gomer ,  Darrell Pilling ,  Nehemiah Cox ,  Tejas R. Karhadkar

IPC: A61K38/17 ,  A61K9/00 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4192 ,  A61K31/495 ,  A61P11/00 ,  A61P19/04 ,  C07K16/40

Abstract: The present disclosure relates to anti-fibrotic sialidase-inhibitor compounds and methods of preventing or inhibiting fibrosis using such compounds. The present disclosure also relates to methods of controlling the formation of fibrocytes or their activity using such compounds. The compounds may include both antibodies as well as small molecules. The methods may involve administering the compounds to a patient with or at risk of developing fibrosis in a manner that inhibits at least one sialidase in the patient.

公开(公告)号：US12293856B2

公开(公告)日：2025-05-06

申请号：US17348418

申请日：2021-06-15

Applicant: The Texas A&M University System ,  FORMOSA PLASTICS CORPORATION

Inventor： Hung-Jue Sue ,  Chia-Ying Tsai ,  Kwang-Ming Chen ,  Kun-Pei Hsieh ,  Chao-Shun Chang ,  Ssu-Ping Huang

IPC: H01B1/22 ,  B22F1/054 ,  B22F1/07 ,  B22F1/102 ,  B22F9/24 ,  C08J3/20 ,  C08J3/205 ,  C08J3/215 ,  C08K3/08 ,  C08K7/06 ,  C08K9/04 ,  C09K5/14 ,  B22F1/107

Abstract: The present disclosure provides a copper nanowire composition. The copper nanowire composition includes copper nanowire having associated ligands with the structure HNR1R2, where R1 is hydrogen, alkyl group, or arylalkyl group, R2 is alkyl group or arylalkyl group, wherein the associated ligand has an amount of 100 wt % to 10000 wt % versus a weight of the copper nanowire.

公开(公告)号：US20250143196P1

公开(公告)日：2025-05-01

申请号：US18445578

申请日：2023-10-25

Applicant: The Texas A&M University System

Inventor： David BYRNE ,  Natalie ANDERSON

IPC: A01H6/74

Abstract: Disclosed is a new variety of Prunus persica named ‘Flat Delight Three’. This new variety, which requires approximately 350 chilling units of dormancy, is considered to be a peach tree of early season maturity, which produces subacid, white-fleshed flat (pantao) fruit that are firm, with the skin covered on 50-80% of its surface with a dark pink to dark maroon blush over a light yellow ground color, and suitable for both local and long-distance shipping.

公开(公告)号：US20250122266A1

公开(公告)日：2025-04-17

申请号：US18916086

申请日：2024-10-15

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Yubin ZHOU ,  Tianlu WANG

IPC: C07K14/71 ,  A61K47/65 ,  C07K14/47 ,  C07K16/10

Abstract: The present disclosure provides intrabody compositions comprising i) an intrabody and ii) one or more inserts. The disclosure also provides methods for activating and deactivating intracellular and extracellular interactions utilizing the compositions, for instance via chemical and/or light.

公开(公告)号：US12275975B2

公开(公告)日：2025-04-15

申请号：US18061840

申请日：2022-12-05

Applicant: The Texas A&M University System

Inventor： Shuhua Yuan ,  Shangxian Xie ,  Xin Wang

IPC: C12P19/02 ,  C12N1/21 ,  C12N9/02 ,  C12N9/04 ,  C12N9/08 ,  C12P7/06 ,  C12P7/14 ,  C12P7/625 ,  C12P7/6463

Abstract: The present invention provides methods and compositions for increasing lignin degradation to produce a biological product. Also provided are methods for increasing expression of laccase in a bacterial species to produce increased lignin degradation. Also provided are bacterial cells and commodities or commodity produces produced from such methods.

公开(公告)号：US12268393B2

公开(公告)日：2025-04-08

申请号：US17496328

申请日：2021-10-07

Applicant: Lawrence Livermore National Security, Inc. ,  The Texas A&M University System ,  Shape Memory Medical, Inc.

Inventor： Jason M. Ortega ,  William J. Benett ,  Ward Small ,  Thomas S. Wilson ,  Duncan J. Maitland ,  Jonathan Hartman

IPC: A61B17/12 ,  A61B17/00

Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.

公开(公告)号：US20250074907A1

公开(公告)日：2025-03-06

申请号：US18723200

申请日：2022-12-22

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： James SACCHETTINI ,  Arjun ACHARYA ,  Armando FLORES ,  Inna KRIEGER ,  Maloy PARAI ,  Nian ZHOU ,  Radha BAM ,  Pradeep Kumar JAISWAL ,  Su TANG ,  Xuelin BIAN ,  Zhe SHI

IPC: C07D471/04 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  C07D213/82 ,  C07D417/04 ,  C07D487/04 ,  C07D519/00

Abstract: Described herein are compounds, and methods for the treatment of coronavirus infection.

公开(公告)号：US20250051782A1

公开(公告)日：2025-02-13

申请号：US18893220

申请日：2024-09-23

Applicant: The Texas A&M University System

Inventor： Jiang Chang ,  Weijia Luo

IPC: C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C12Q1/6886 ,  G01N33/573

Abstract: Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.

公开(公告)号：US12220502B2

公开(公告)日：2025-02-11

申请号：US17847426

申请日：2022-06-23

Applicant: The Texas A&M University System

Inventor： Rachael Muschalek ,  Keith Hearon ,  Landon D. Nash ,  Duncan J. Maitland

IPC: A61L31/10 ,  A61L17/14 ,  A61L27/34 ,  A61L27/56 ,  A61L31/14

Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.

公开(公告)号：US12215023B2

公开(公告)日：2025-02-04

申请号：US17065471

申请日：2020-10-07

Applicant: The Texas A&M University System

Inventor： Arum Han ,  Jose A. Wippold ,  Adrian R. Guzman ,  Can Huang ,  Dimitra Stratis-Cullum

IPC: B81C1/00 ,  C08F2/48 ,  G03F7/00

Abstract: A microfluidic device includes a microfluidic channel formed in the microfluidic device and defined by a floor and a ceiling positioned vertically above the floor, wherein the microfluidic channel includes at least one fluid inlet configured to receive a fluid flow and at least one fluid outlet, and wherein at least one of the ceiling and the floor of the microfluidic channel is sloped relative to a horizontal plane.