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12 条记录 (耗时 0.034 秒)

    Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation
    3.
    发明授权
    Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation 失效
    酰化苄基甘氨酸作为平滑肌细胞增殖的抑制剂

    公开(公告)号：US5773420A

    公开(公告)日：1998-06-30

    申请号：US531142

    申请日：1995-10-20

    申请人： Thomas T. Nguyen ,  John W. Ellingboe

    发明人： Thomas T. Nguyen ,  John W. Ellingboe

    IPC分类号： C07H15/203 ,  A61K31/70 ,  C07H17/00

    CPC分类号： C07H15/203

    摘要： This invention relates to acylated benzylglycosides and a method for their use as smooth muscle cell proliferation inhibitors and as therapeutic compositions for treating diseases and conditions which are characterize by excessive smooth muscle proliferation, such as restenosis. The acylated benzylglycosides of this invention are those of formula I, below: ##STR1## wherein X is ##STR2## R.sup.1 is H, alkyl having 1 to 6 carbon atoms, chloro, bromo, or alkoxy having 1 to 6 carbon atoms; R.sup.2 is H, an acyl group having 1 to 6 carbon atoms, phenylsulfonyl, or substituted phenylsulfonyl; and R.sup.3 is an acyl group having 1 to 8 carbon atoms, benzoyl, substituted benzoyl, alkylsulfonyl having 1 to 6 carbon atoms, phenylsulfonyl, or substituted phenylsulfonyl; R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are each, independently, an acyl group having 1 to 6 carbon atoms; and R.sup.10 and R.sup.11 are each, independently, an acyl group having 1 to 6 carbon atoms, or the R.sup.10 and R.sup.11 groups on the 4' and 6' positions of the maltose or the 4 and 6 positions of the glucose form an isopropylidene group; or pharmaceutically acceptable salts thereof. R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are each, independently, an acyl group having 1 to 6 carbon atoms; and R.sup.10 and R.sup.11 are each, independently, an acyl group having 1 to 6 carbon atoms, or the R.sup.10 and R.sup.11 groups on the 4' and 6' positions of the maltose or the 4 and 6 positions of the glucose form an isopropylidene group; or a pharmaceutically acceptable salt thereof a pharmaceutically acceptable agent.

    摘要翻译： 本发明涉及酰化苄基鹅糖苷及其作为平滑肌细胞增殖抑制剂和作为用于治疗以过度平滑肌增生为特征的疾病和病症如再狭窄的治疗组合物的方法。 本发明的酰化苄基鹅糖苷是下式I的化合物：其中X是R或R 1是H，具有1-6个碳原子的烷基，氯，溴或具有1-6个碳原子的烷氧基 碳原子 R2是H，具有1-6个碳原子的酰基，苯基磺酰基或取代的苯基磺酰基; 并且R 3是具有1至8个碳原子的酰基，苯甲酰基，取代的苯甲酰基，具有1至6个碳原子的烷基磺酰基，苯基磺酰基或取代的苯基磺酰基; R4，R5，R6，R7，R8和R9各自独立地为具有1至6个碳原子的酰基; R10和R11各自独立地为具有1至6个碳原子的酰基，或麦芽糖4'和6'位上的R 10和R 11基团或葡萄糖的4和6位形成异丙叉基; 或其药学上可接受的盐。 R4，R5，R6，R7，R8和R9各自独立地为具有1至6个碳原子的酰基; R10和R11各自独立地为具有1至6个碳原子的酰基，或麦芽糖4'和6'位上的R 10和R 11基团或葡萄糖的4和6位形成异丙叉基; 或其药学上可接受的盐是药学上可接受的试剂。

    Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
    4.
    发明授权
    Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation 失效
    聚阴离子苄基糖苷类作为平滑肌细胞增殖的抑制剂

    公开(公告)号：US5498775A

    公开(公告)日：1996-03-12

    申请号：US335278

    申请日：1994-11-07

    申请人： Sarah T. A. Novak ,  Richard M. Soll ,  John W. Ellingboe ,  Thomas T. Nguyen

    发明人： Sarah T. A. Novak ,  Richard M. Soll ,  John W. Ellingboe ,  Thomas T. Nguyen

    IPC分类号： C07H15/18 ,  A61K31/70 ,  A61K31/7028 ,  A61P9/00 ,  A61P43/00 ,  C07H15/22 ,  C07H15/00

    CPC分类号： C07H15/22

    摘要： This invention relates to the use of polyanionic benzylglycosides as smooth muscle cell proliferation inhibitors and as therapeutic compositions for treating diseases and conditions which are characterized by excessive smooth muscle proliferation, such as restenosis. The compounds of this invention are those of formula I ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are, independently, H, SO.sub.3 M, or ##STR2## and each oligosaccharide group contains 1 to 3 sugar groups; M is lithium, sodium, potassium, or ammonium;n is 1 or 2;X is a halogen, lower alkyl having 1 to 6 carbon atoms, or lower alkoxy having 1 to 6 carbon atoms;Y is carbonyl or sulfonyl;Z is alkyl from 1 to 12 carbon atoms, ##STR3## and X is as defined above; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及聚阴离子苄基糖苷类作为平滑肌细胞增殖抑制剂的用途，以及用于治疗以过度平滑肌增生为特征的疾病和病症如再狭窄的治疗组合物。 本发明的化合物是式I的化合物，其中R 1，R 2，R 3和R 4各自独立地是H，SO 3 M或者每个寡糖基团含有1至3个糖基团 ; M是锂，钠，钾或铵; n为1或2; X是卤素，具有1至6个碳原子的低级烷基或具有1至6个碳原子的低级烷氧基; Y是羰基或磺酰基; Z是1至12个碳原子的烷基，X如上定义; 或其药学上可接受的盐。

    Planar lightwave circuit variable optical attenuator
    5.
    发明授权
    Planar lightwave circuit variable optical attenuator 有权
    平面光波电路可变光衰减器

    公开(公告)号：US07162108B2

    公开(公告)日：2007-01-09

    申请号：US11015223

    申请日：2004-12-17

    申请人： Anca L. Sala ,  Duncan W. Harwood ,  Barthelemy Fondeur ,  Anantharaman Vaidyanathan ,  Robert J. Brainard ,  Sanjay M. Thekdi ,  Thomas T. Nguyen ,  Ian Hutagalung

    发明人： Anca L. Sala ,  Duncan W. Harwood ,  Barthelemy Fondeur ,  Anantharaman Vaidyanathan ,  Robert J. Brainard ,  Sanjay M. Thekdi ,  Thomas T. Nguyen ,  Ian Hutagalung

    IPC分类号： G02F1/01 ,  G02F1/035 ,  G02F1/00 ,  G02B26/00 ,  G02B6/26 ,  G02B6/42

    CPC分类号： G02F1/0147 ,  G02B6/12007 ,  G02B6/266 ,  G02F1/21 ,  G02F2001/0113 ,  G02F2001/212 ,  G02F2203/06

    摘要： The invention relates to a variable optical attenuator constructed as a Mach Zehnder planar lightwave circuit, particularly including a channel waveguide support structure for heat isolation and stress relief to reduce polarization dependent loss (PDL) and power consumption in the device. Power reduction trenches comprise longitudinal segments having small stress relief pillars of cladding material left in between them in the etching process. The waveguides of the MZI are supported by a main pillar structure and integral stress relief pillars which remain after removal of the trenches. The waveguide is surrounded by air on three sides for improved heat isolation. The performance of the present invention shows substantial improvement in PDL and extinction ratio over the prior art continuous trench design, and also, to a smaller degree, over the case where power reduction trenches are not used at all. Segmented trenches appear to allow for the lowest stress on the two waveguide arms of all the cases including no trench and trenched devices.

    摘要翻译： 本发明涉及一种构成马赫曾德平面光波回路的可变光衰减器，特别是包括用于隔热和应力释放的通道波导支撑结构，以减少器件中的偏振相关损耗（PDL）和功耗。 功率减小沟槽包括在蚀刻工艺中在它们之间具有小的应力消除柱的包层材料的纵向段。 MZI的波导由主柱结构和消除沟槽后保留的积分应力消除柱支撑。 波导三面被空气包围，以改善热隔离。 与现有技术的连续沟槽设计相比，本发明的性能显示出PDL和消光比的显着改善，并且在更少的程度上，在完全不使用功率降低沟槽的情况下。 分段沟槽似乎允许在所有情况下的两个波导臂上的最小应力，包括没有沟槽和沟槽的器件。