Patent search ap:"Tritin Tran" Page 1

1.

发明授权
Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof 失效
Title translation: 取代的异喹啉-1,3（2H，4H） - 二酮，1-硫代，1,4-二氢-2H-异喹啉-3-酮和1,4-二羟基-3（2H） - 异喹诺酮及其使用方法

公开(公告)号：US07713994B2

公开(公告)日：2010-05-11

申请号：US11728897

申请日：2007-03-26

Applicant: Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Harold Birnberg , Middleton Brawner Floyd , Joshua Kaplan , Kristina M. Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Adufa Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Christian Mayer , Annette L. Banker , Marvin Reich

Inventor： Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Harold Birnberg , Middleton Brawner Floyd , Joshua Kaplan , Kristina M. Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Adufa Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Christian Mayer , Annette L. Banker , Marvin Reich

IPC: A61K31/47 , C07D217/08

CPC classification number: C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04

Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

Abstract translation: 本发明提供具有本文定义的G1，G2，G3，G4，A1，A2，Y1，Y2，L1，Z，e和f的结构的式（I）化合物或其药学上可接受的盐，可用于治疗或预防癌症。

2.

发明申请
Renin Inhibitors 审中-公开
Title translation: 肾素抑制剂

公开(公告)号：US20100280005A1

公开(公告)日：2010-11-04

申请号：US12450620

申请日：2008-04-04

Applicant: Jonh J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , John Gleason , Alexey V. Ishchenko , Brian Lawhorn , Gerard McGeehan , Jaclyn R. Patterson , Simon F. Semus , Robert D. Simpson , Suresh B. Singh , Colin Tice , Tritin Tran , Zhenrong Xu , Jing Yuan , Wei Zhao

Inventor： Jonh J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , John Gleason , Alexey V. Ishchenko , Brian Lawhorn , Gerard McGeehan , Jaclyn R. Patterson , Simon F. Semus , Robert D. Simpson , Suresh B. Singh , Colin Tice , Tritin Tran , Zhenrong Xu , Jing Yuan , Wei Zhao

IPC: A61K31/445 , C07D211/60 , C07D401/02 , C07D413/02 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/58 , A61P9/12

CPC classification number: C07D211/22 , C07D401/06

Abstract: Disclosed are compounds of Formula I, wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.

Abstract translation: 公开了式I的化合物，其中R，R 1，R 2，R 3，X，Y，A，Q，E和G如本文所定义。这些化合物与天冬氨酸蛋白酶结合以抑制其活性，并且可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。还公开了使用式I化合物在有需要的受试者中改善或治疗天冬氨酸蛋白酶相关病症的方法。

3.

发明申请
Renin Inhibitors 审中-公开
Title translation: 肾素抑制剂

公开(公告)号：US20100317697A1

公开(公告)日：2010-12-16

申请号：US12665217

申请日：2008-06-20

Applicant: John J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Qing Lu , Gerard McGeehan , Beth A. Knapp-Reid , Simon Semus , Robert D. Simpson , Suresh B. Singh , Lamont R. Terrell , Colin Tice , Tritin Tran , Zherong Xu , Jing Yuan , Wei Zhao , Yongdong Y. Zhao

Inventor： John J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Qing Lu , Gerard McGeehan , Beth A. Knapp-Reid , Simon Semus , Robert D. Simpson , Suresh B. Singh , Lamont R. Terrell , Colin Tice , Tritin Tran , Zherong Xu , Jing Yuan , Wei Zhao , Yongdong Y. Zhao

IPC: A61K31/445 , C07D211/06

CPC classification number: C07D211/22 , C07D265/30

Abstract: Disclosed are compounds having the formula (I): wherein the R1, R2, R3, X, Y, A, L, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.

Abstract translation: 公开了具有式（I）的化合物：其中R1，R2，R3，X，Y，A，L和G如本文所定义。这些化合物与天冬氨酸蛋白酶结合以抑制其活性，并且可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。还公开了使用式I化合物在有需要的受试者中改善或治疗天冬氨酸蛋白酶相关病症的方法。