公开(公告)号：US12275229B2

公开(公告)日：2025-04-15

申请号：US17910715

申请日：2021-03-12

Applicant: Amorepacific Corporation

Inventor： Jeong Eun Seo ,  Hyun Hyub Ko ,  Jin Young Myoung ,  Jong Hwa Park ,  Young Oh Lee ,  Young Kyung Kim ,  Seung Han Park ,  Won Seok Park ,  Sung Won Yi ,  Tae Ryong Lee ,  Byung Guen Chae

IPC: B32B9/04 ,  B32B27/18 ,  B32B27/28 ,  B32B27/30 ,  G01K7/18

Abstract: A sensor for measuring a temperature change amount. The sensor includes a first composite material layer including a polymer having a volume changing according to a temperature change amount; an electrode layer provided on one side of the first composite material layer and capable of representing the temperature change amount as a resistance change amount; and a second composite material layer at least partially provided on the upper side of the first composite material layer and containing polydimethylsiloxane (PDMS) and at least one of carbon nanotubes (CNT), boron nitride nanotubes (BNNT), and graphene or containing a thermoplastic polyurethane (TPU) so that the temperature change occurring on one side thereof is transferred to the other side thereof.

公开(公告)号：US10765623B2

公开(公告)日：2020-09-08

申请号：US15760908

申请日：2016-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sung Tae Kim ,  Yonghee Lee ,  Seung Hyun Shin ,  Hyun Gee Lee ,  Eun-Gyung Cho ,  Tae Ryong Lee

IPC: A61K8/00 ,  A61K8/18 ,  A61K9/00 ,  A01N63/00 ,  A01N65/00 ,  A61K51/00 ,  A61M36/14 ,  A61K8/99 ,  A61Q7/00 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61P17/14 ,  A61K8/14

Abstract: The present specification discloses a composition for preventing hair loss or promoting hair growth comprising, as an active ingredient, extracellular follicles derived from lactic acid bacteria, and a method for preparing the extracellular follicles derived from lactic acid bacteria. The composition has an effect of preventing and prohibiting hair from falling off from the scalp or becoming thin or tapered. In addition, the composition has an effect of implementing a hair growth function for generating new hair, or a function for promoting the hair growth, as well as a function of promoting a delay from an anagen to a catagen phase of a hair cycle and a function of growing the existing hair healthy.

公开(公告)号：US20210196619A1

公开(公告)日：2021-07-01

申请号：US17197526

申请日：2021-03-10

Applicant: Amorepacific Corporation

Inventor： Euidong Son ,  Hyungsu Kim ,  Jihyun Kim ,  Hyoung June Kim ,  Byeongbae Jeon ,  Ji Young Choi ,  Tae Ryong Lee

IPC: A61K8/9767 ,  A61K8/04 ,  A61K9/00 ,  A61K9/06 ,  A61K36/15 ,  A61Q19/08 ,  A61Q19/00 ,  A23L33/105

Abstract: One aspect of the present disclosure relates to a composition for enhancing the skin barrier containing Abies sibirica oil as an active ingredient, wherein Abies sibirica oil reacts with the fragrance receptor OR6M1 present in epidermal cells to enhance the skin barrier, restore the damaged skin barriers and enhance the skin moisturizing.

公开(公告)号：US11433110B2

公开(公告)日：2022-09-06

申请号：US16651880

申请日：2018-08-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June Kim ,  Tae Ryong Lee

IPC: A61K36/00 ,  A61K36/185 ,  A23L33/105 ,  A61K8/9789 ,  A61Q19/00

Abstract: Disclosed is a composition including a Hibiscus syriacus extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of at least one selected from the group consisting of IL-36G (NM_019618), PTGS2 (NM_000963), XDH (NM_000379) and S100A7 (NM_002963), which are all genes having the expression levels affected by fine dust in skin cells, is regulated to a normal level and for inhibiting an antibacterial peptide, wherein the expression of the antibacterial peptide S100A7 (NM_002963) is regulated to a normal level. By using the composition for treating fine dust-caused skin damage and the composition for inhibiting an antibacterial peptide, gene expression changed by fine dust can return to a normal level to treat skin cell damage and the increased expression of the antibacterial peptide due to various causes can return to normal level.

公开(公告)号：US11185488B2

公开(公告)日：2021-11-30

申请号：US16650575

申请日：2018-07-31

Applicant: AMOREPACIFIC CORPORATION

Inventor： Kyu Han Kim ,  Eui Dong Son ,  Jin Sup Shim ,  Tae Ryong Lee

IPC: A61K8/60 ,  A61K8/92 ,  A61Q19/00

Abstract: A skin external composition containing 1,2,3,4,6-penta-O-galloyl-β-D-glucose (hereinafter referred to as “PGG”) and its use to improve moisture balance of skin are disclosed. The skin external composition, due to containing PGG, stimulates the formation of filaggrin in keratinocytes, increases loricrin and involucrin expression, thereby stimulating the formation of a normal keratin layer, and as a result, can strengthen the skin barrier function to provide an excellent skin moisturization improving effect. Thus, the composition is effective in improving moisture balance of skin. A method for moisturizing the skin using the composition is also disclosed.

公开(公告)号：US10967028B2

公开(公告)日：2021-04-06

申请号：US15902042

申请日：2018-02-22

Applicant: AMOREPACIFIC CORPORATION

Inventor： Pil Joon Park ,  Seung Hyun Shin ,  Hae Kwang Lee ,  Jon Hwan Lee ,  Tae Ryong Lee ,  Eun Gyung Cho

IPC: A61K36/539 ,  A61K36/282 ,  A61K8/97 ,  A61Q7/00 ,  A61K9/20 ,  A61K9/08 ,  A61K9/48 ,  A61K9/16 ,  A61K9/00 ,  A61K47/10

Abstract: Disclosed is a novel use of a composition comprising as an active ingredient an Artemisia umbelliformis extract. A composition according to the present description shows hair follicle cell proliferation or hair growth effect by means of comprising an Artemisia umbelliformis extract. Therefore, due to said effect, the Artemisia umbelliformis extract has hair loss prevention or hair growth stimulation effect.

公开(公告)号：US10533992B2

公开(公告)日：2020-01-14

申请号：US15559348

申请日：2015-03-19

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung June Kim ,  Min Sik Choi ,  Ji Yong Jung ,  Ju Yearl Park ,  Tae Ryong Lee ,  Dong Wook Shin ,  Eui Dong Son ,  Min Jung Chae

IPC: G01N33/52 ,  G01N33/53 ,  G01N33/68 ,  G01N33/50 ,  A61K8/27 ,  A61K8/29 ,  A61K33/30 ,  A61K33/00 ,  A61K33/24 ,  A61K8/37 ,  A61K8/49 ,  A61Q17/04

Abstract: Unlike a conventional method for evaluating a degree of ultraviolet protection through visual evaluation, the disclosed method for measuring a sunlight protection function can accurately and objectively measure and determine a degree of sunlight protection by measuring a change due to a material to be measured with respect to an expression amount of skin tissue antimicrobial peptides (AMPs) in skin cells, which decrease from exposure to sunlight, and/or a generation amount of S-nitrosylated protein. Additionally, the disclosed measurement method can determine whether blue/violet light of wavelengths of 400-500 nm, which induces the most skin damage among visible rays, is blocked and provide a more specified sunlight protection effect evaluation result. Moreover, by using the disclosed measurement method, a degree of sunlight protection can be indexed, and a sunlight protection composition for protecting normal skin from the blue/violet light can be provided.

公开(公告)号：US11583560B2

公开(公告)日：2023-02-21

申请号：US16759892

申请日：2018-10-05

Applicant: AMOREPACIFIC CORPORATION

Inventor： Eun-Gyung Cho ,  Wanil Kim ,  Tae Ryong Lee

IPC: A61K35/747 ,  A23L33/135 ,  A61K8/14 ,  A61K8/99

Abstract: The present specification discloses an immunomodulatory composition comprising lactobacillus-derived extracellular vesicles as an active ingredient. The lactobacillus may be Lactobacillus plantarum. The composition has the effects of inducing differentiation into M2-type macrophages and reducing expression of at least one member selected from the group consisting of CCR2, SOCS3 and HLA-DRα, which are M1-type macrophage differentiation markers.

公开(公告)号：US10344260B2

公开(公告)日：2019-07-09

申请号：US14346995

申请日：2012-09-27

Applicant: AMOREPACIFIC CORPORATION

Inventor： Eun Gyung Cho ,  Bum Ho Bin ,  Tae Ryong Lee ,  Ji Yeon Han ,  Hyun Jung Choi

IPC: C12N5/071

Abstract: The present invention relates to novel melanocytes and melanoblasts. In addition, the present invention relates to a novel method for producing melanocytes and melanoblasts. Specifically, provided is novel melanocytes of which gene expression, melanin content, and tyrosinase activity are different from those of conventional melanocytes. Even more specifically, provided is novel melanoblasts of which the gene expression, the melanin content the tyrosinase activity, and the protein expression are different from those of conventional melanocytes. Additionally, provided is a novel method for producing melanocytes or melanoblasts by culturing keratinocytes.

公开(公告)号：US12017974B2

公开(公告)日：2024-06-25

申请号：US17418940

申请日：2020-01-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yunghyup Joo ,  Jaeyoung Ko ,  Jaewon You ,  Yong Jin Kim ,  Tae Ryong Lee

IPC: C07C233/60 ,  A61K8/42 ,  A61K9/00 ,  A61Q19/02 ,  C07C231/02

CPC classification number: C07C233/60 ,  A61K8/42 ,  A61K9/0014 ,  A61Q19/02 ,  C07C231/02 ,  A61K2800/43

Abstract: The present specification relates to an adamantanecarboxylic acid benzyl amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, and a skin whitening composition comprising the same as an active ingredient. Specifically, the compound, according to the present specification, is a compound having a novel structure having adamantanecarboxylic acid bound to an amine compound, and exhibits a skin whitening effect by inhibiting the production of melanin, and thus may be used in various ways as a pharmaceutical composition, a cosmetic composition or a skin preparation for external use.