公开(公告)号：US20200299351A1

公开(公告)日：2020-09-24

申请号：US16743849

申请日：2020-01-15

Applicant: Berkeley Lights, Inc.

Inventor： Peter J. Beemiller ,  Alexander J. Mastroianni ,  Shao Ning Pei ,  Randall D. Lowe, JR. ,  Annamaria Mocciaro ,  Kevin D. Loutherback ,  Yelena Bronevetsky ,  Guido K. Stadler ,  Andrew W. McFarland ,  Kevin T. Chapman ,  Duane Smith ,  Natalie C. Marks ,  Amanda L. Goodsell

IPC: C07K14/725 ,  C07K16/28 ,  G01N33/50 ,  C07K14/74

Abstract: In biosciences and related fields, it can be useful to modify surfaces of apparatuses, devices, and materials that contact biomaterials such as biomolecules and biological micro-objects. Described herein are surface modifying and surface functionalizing reagents, preparation thereof, and methods for modifying surfaces to activate T Lymphocytes.

公开(公告)号：US20230313107A1

公开(公告)日：2023-10-05

申请号：US18147356

申请日：2022-12-28

Applicant: BERKELEY LIGHTS, INC.

Inventor： Andrew W. McFarland ,  Peter J. Beemiller ,  Guido K. Stadler ,  Alexander J. Mastroianni ,  Joshua J. Cardiel Rivera ,  Darcy K. Kelly-Greene ,  Jonathan Cloud Dragon Hubbard ,  Natalie C. Marks ,  Long Van Le ,  Ke-Chih Lin

IPC: C12M1/00 ,  C12M3/06 ,  C12M3/00 ,  C12M1/34 ,  C12N5/0783

CPC classification number: C12M29/10 ,  C12M23/16 ,  C12M23/40 ,  C12M23/42 ,  C12M41/12 ,  C12M41/36 ,  C12N5/0636 ,  B01L2300/0883

Abstract: Cartridge for manufacturing a population of cells suitable for formulation as a cellular therapeutic are disclosed herein, along with systems for operating the cartridges and performing methods to generate the population of cells suitable for formulation as a cellular therapeutic. The population of cells suitable for formulation as a cellular therapeutic can be T-cells, including CAR T-cells. The systems and methods can be largely automated.

公开(公告)号：US20220325240A1

公开(公告)日：2022-10-13

申请号：US17574459

申请日：2022-01-12

Applicant: Berkeley Lights, Inc.

Inventor： Andrew W. McFarland ,  Peter J. Beemiller ,  Guido K. Stadler ,  Alexander J. Mastroianni ,  Joshua J. Cardiel Rivera ,  Darcy K. Kelly-Greene ,  Jonathan Cloud Dragon Hubbard ,  Natalie C. Marks ,  Long Van Le ,  Ke-Chih Lin

IPC: C12N5/0783 ,  C12N15/62 ,  C12N15/86 ,  C12M3/00 ,  C12M1/42 ,  C12M1/00

Abstract: Cartridges for manufacturing a population of cells suitable for formulation as a cellular therapeutic are disclosed herein, along with systems and instruments for operating the cartridges and performing methods to generate the population of cells suitable for formulation as a cellular therapeutic. The population of cells suitable for formulation as a cellular therapeutic can be immunological cells, such as T lymphocytes, including endogenous T cells (ETCs), tumor infiltrating lymphocytes (TILs), CAR T-cells, TCR engineered T-cells, or otherwise engineered T-cells. The systems and methods can be largely automated.

公开(公告)号：US11365381B2

公开(公告)日：2022-06-21

申请号：US16920365

申请日：2020-07-02

Applicant: Berkeley Lights, Inc.

Inventor： Randall D. Lowe, Jr. ,  Kristin G. Beaumont ,  Aathavan Karunakaran ,  Natalie C. Marks ,  Jason M. McEwen ,  Mark P. White ,  J. Tanner Nevill ,  Gang F. Wang ,  Andrew W. McFarland ,  Daniele Malleo ,  Keith J. Breinlinger ,  Xiao Guan ,  Kevin T. Chapman

IPC: C12M3/00 ,  B01L3/00 ,  C12M3/06 ,  C12M1/00

Abstract: Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof. In some embodiments, culturing a single cell may produce a clonal population in the microfluidic device.