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公开(公告)号：US11021693B2
公开(公告)日：2021-06-01
申请号：US16524607
申请日：2019-07-29
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Xiao-Song Gong
IPC: C12N9/12
Abstract: Covalently-linked DNA polymerases are provided.
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公开(公告)号：US20180305739A1
公开(公告)日：2018-10-25
申请号：US16009894
申请日：2018-06-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng , Xiao-Song Gong , Yan Wang , Adam M. McCoy
IPC: C12Q1/6806 , C12Q1/686 , C12P19/34
CPC classification number: C12Q1/6806 , C12P19/34 , C12Q1/6853 , C12Q1/686 , C12Q2521/107 , C12Q2521/131 , C12Q2521/327 , C12Q2525/207 , C12Q2525/121
Abstract: Methods of detecting and amplifying short RNAs are provided.
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公开(公告)号：US12065645B2
公开(公告)日：2024-08-20
申请号：US18125661
申请日：2023-03-23
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song Gong , Yan Wang
IPC: C12N9/12 , C12N9/22 , C12N15/10 , C12Q1/686 , C12Q1/6844
CPC classification number: C12N15/1096 , C12N9/22 , C12Q1/686 , C12N2770/00022 , C12Q1/6844 , C12Q1/6844 , C12Q2521/107 , C12Q2521/327
Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
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4.发明授权公开(公告)号：US10787694B2
公开(公告)日：2020-09-29
申请号：US15977254
申请日：2018-05-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song Gong , John Sullivan , Rongdian Fu , Yan Wang , Evan H. Bursey , Man Cheng
Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.
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公开(公告)号：US10351840B2
公开(公告)日：2019-07-16
申请号：US15253648
申请日：2016-08-31
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jason Ma , Xiao-Song Gong
Abstract: Reverse transcriptase mixtures with improved storage stability are provided.
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Patent Agency Ranking
公开(公告)号：US20130203122A1
公开(公告)日：2013-08-08
申请号：US13681326
申请日：2012-11-19
Applicant: Bio Rad Laboratories, Inc.
Inventor： Xiao-Song Gong , Yan Wang
IPC: C12Q1/68
CPC classification number: C12Q1/686 , C07K14/195 , C12Q1/6844 , C12Q2527/127 , C12Q2527/125 , C12Q2521/307
Abstract: The present invention provides a method for amplifying a nucleic acid molecule. The method involves mixing an RNA template with a composition having a reverse transcriptase, a DNA polymerase and a RT inhibition reducer. The RT inhibition reducer can be Sso7d, Sac7d, Sac7e, Sso7e, AluI methylase, suramin, a phosphorothioate oligodeoxycytosine, a phosphorothioate oligodeoxyadenine, a phosphorothioate oligodeoxythymine or poly(rA)(dT). The mixing forms a mixture that is incubated under conditions sufficient to synthesize a DNA molecule complementary to all or a portion of the RNA template, thereby amplifying the nucleic acid molecule.
Abstract translation: 本发明提供了扩增核酸分子的方法。 该方法包括将RNA模板与具有逆转录酶，DNA聚合酶和RT抑制减少剂的组合物混合。 RT抑制减少剂可以是Sso7d，Sac7d，Sac7e，Sso7e，AluI甲基化酶，苏拉明，硫代磷酸寡脱氧胞嘧啶，硫代磷酸寡脱氧腺嘌呤，硫代磷酸酯寡脱氧胸苷或聚（rA）（dT）。 混合形成混合物，其在足以合成与所有或部分RNA模板互补的DNA分子的条件下孵育，从而扩增核酸分子。
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公开(公告)号：US11649453B2
公开(公告)日：2023-05-16
申请号：US17211595
申请日：2021-03-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song Gong , Yan Wang
IPC: C12N9/10 , C12N9/22 , C12N15/10 , C12Q1/686 , C12Q1/6844
CPC classification number: C12N15/1096 , C12N9/22 , C12Q1/686 , C12N2770/00022 , C12Q1/6844 , C12Q1/6844 , C12Q2521/107 , C12Q2521/327
Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
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公开(公告)号：US11021735B2
公开(公告)日：2021-06-01
申请号：US16009894
申请日：2018-06-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man Cheng , Xiao-Song Gong , Yan Wang , Adam M. McCoy
IPC: C12Q1/6806 , C12Q1/686 , C12P19/34 , C12Q1/6853 , C12N15/10
Abstract: Methods of detecting and amplifying short RNAs are provided.
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公开(公告)号：US10301675B2
公开(公告)日：2019-05-28
申请号：US14926461
申请日：2015-10-29
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song Gong , Yan Wang
IPC: C12Q1/686 , C12Q1/6844 , C07K14/195
Abstract: In one aspect, compositions and methods for reducing reverse transcriptase (RT) inhibition in RT-PCR are provided. In some embodiments, the RT inhibition reducer is a phosphorothioate oligodeoxycytosine (SdC), phosphorothioate oligodeoxyadenine (SdA), phosphorothioate oligodeoxythymine (SdT), or phosphorothioate oligodeoxyguanosine (SdG).
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公开(公告)号：US20170159032A1
公开(公告)日：2017-06-08
申请号：US15370646
申请日：2016-12-06
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Xiao-Song Gong
CPC classification number: C12N9/1252 , C07K2319/00 , C12N2740/13022 , C12Y207/07007
Abstract: Covalently-linked DNA polymerases are provided.
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