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29 条记录 (耗时 0.062 秒)

    Low NOx Fuel Injection for an Indurating Furnace
    1.
    发明申请
    Low NOx Fuel Injection for an Indurating Furnace 审中-公开
    用于惰性炉的低NOx燃料喷射

    公开(公告)号：US20130203003A1

    公开(公告)日：2013-08-08

    申请号：US13571424

    申请日：2012-08-10

    申请人： Bruce E. Cain ,  Thomas F. Robertson ,  Mark C. Hannum ,  Todd A. Miller ,  Joseph P. Brown

    发明人： Bruce E. Cain ,  Thomas F. Robertson ,  Mark C. Hannum ,  Todd A. Miller ,  Joseph P. Brown

    IPC分类号： C22B1/24 ,  F27B9/36 ,  F27B9/24

    CPC分类号： C22B1/2413 ,  F23C6/047 ,  F23D14/02 ,  F23D14/26 ,  F23D14/60 ,  F27B9/24 ,  F27B9/36

    摘要： A method delivers fuel gas to a furnace combustion chamber from a premix burner having a reaction zone with an outlet to the furnace combustion chamber. This includes the steps of injecting a premix of primary fuel gas and combustion air into the reaction zone, and combusting the premix to provide combustion products including vitiated combustion air in the reaction zone. Further steps include injecting staged fuel gas into the reaction zone separately from the premix, discharging the staged fuel gas and vitiated combustion air from the reaction zone through the outlet to the furnace combustion chamber, and combusting the staged fuel gas and vitiated combustion air in the furnace combustion chamber. This enables low NOx combustion in the furnace combustion chamber to be achieved as a result of interacting the staged fuel gas with the vitiated combustion air in the reaction zone.

    摘要翻译： 一种方法是将燃料气体从具有与出口到反应炉燃烧室的反应区的预混燃烧器送入炉燃烧室。 这包括将初级燃料气体和燃烧空气的预混合物注入反应区，并且将预混物燃烧以在反应区中提供包括残余燃烧空气的燃烧产物的步骤。 进一步的步骤包括将分级燃料气体与预混物分开注入反应区域，将分级燃料气体和残留燃烧空气从反应区通过出口排出到炉燃烧室，并将分级燃料气体和残余燃烧空气燃烧在 炉燃烧室。 这使得能够通过使分级燃料气体与反应区中的残留燃烧空气相互作用来实现炉燃烧室中的低NOx燃烧。

    Enhanced protective lens cover for an infrared thermometer
    2.
    发明授权
    Enhanced protective lens cover for an infrared thermometer 失效
    红外线温度计增强保护镜头盖

    公开(公告)号：US6022140A

    公开(公告)日：2000-02-08

    申请号：US933240

    申请日：1997-09-19

    申请人： Jacob Fraden ,  Joseph P. Brown ,  Robert P. Lackey ,  Randall R. Howe ,  Heinz Bultges ,  Wolfram Debus ,  Gunther Bautz ,  Helmut Franke

    发明人： Jacob Fraden ,  Joseph P. Brown ,  Robert P. Lackey ,  Randall R. Howe ,  Heinz Bultges ,  Wolfram Debus ,  Gunther Bautz ,  Helmut Franke

    IPC分类号： G01J5/02 ,  G01K1/08

    CPC分类号： G01J5/02 ,  G01J5/021

    摘要： A disposable cover for an infrared thermometer provides IR window isolation of handling and usage generated forces. The cover comprises a thin sidewall linked to the film window with a collar structure. The collar structure includes one or more characteristics that either isolate the film window from externally applied forces, or develops counter forces in a way that precludes film stretching and other transmission distorting effects. In a preferred embodiment, the probe includes retention ears and the cover includes a rim that cooperatively engages the retention ears. This combination of retention ears and an interlocking rim decreases movement of the cover along the probe axis. The cover of the present invention permits sanitary application of an infrared clinical thermometer without hindering reading accuracy or patient comfort.

    摘要翻译： 用于红外线温度计的一次性盖子可提供IR窗口隔离处理和使用量产生的力。 盖子包括一个薄壁的侧壁，与薄膜窗口相连，带有一个领子结构。 套环结构包括一个或多个特性，其将薄膜窗口与外部施加的力隔离，或以防止膜拉伸和其它传递失真效应的方式产生反作用力。 在优选实施例中，探针包括保持耳，并且盖包括与保持耳协作地接合的边缘。 保持耳和互锁边缘的这种组合减小了盖沿探针轴线的运动。 本发明的盖子可以卫生地应用红外线体温计而不会妨碍读取精度或病人的舒适度。

    Hybridoma CT43 producing a monoclonal antibody to a novel mucin epitope which correlates with the presence of colorectal cancer
    3.
    发明授权
    Hybridoma CT43 producing a monoclonal antibody to a novel mucin epitope which correlates with the presence of colorectal cancer 失效
    杂交瘤CT43产生与结肠直肠癌存在相关的新型粘蛋白表位的单克隆抗体

    公开(公告)号：US5459043A

    公开(公告)日：1995-10-17

    申请号：US985524

    申请日：1992-12-03

    申请人： Joseph P. Brown

    发明人： Joseph P. Brown

    IPC分类号： C07K16/00 ,  C07K14/00 ,  C07K16/30 ,  C07K19/00 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577

    CPC分类号： C07K16/3046 ,  Y10S436/813

    摘要： The present invention relates to a novel monoclonal antibody reactive with human colorectal mucin antigen. More particularly, the antibody of the invention is a murine monoclonal antibody, CT43, reactive with a novel antigenic determinant on much antigen highly correlated with human colorectal cancer. The antigenic determinant found by the CT43 has been characterized as neuraminidase and proteinase K resistant, periodate sensitive and unreactive with the glycoconjugates of Table 2. Methods are provided for the detection and quantitation of the CT43 antigenic determinant and its correlation with colorectal cancer. CT43, and CT66 specific for the sialylated Lewis a and Lewis a antigen have been deposited with the American Type Culture Collection, as accession numbers ATCC HB 10217 and ATCC HB 10218, deposited Sep. 6, 1989.

    摘要翻译： 本发明涉及与人结肠直肠粘蛋白抗原反应的新型单克隆抗体。 更具体地说，本发明的抗体是鼠类单克隆抗体CT43，与与人结肠直肠癌高度相关的许多抗原上的新抗原决定簇具有反应性。 CT43发现的抗原决定簇已经被表征为神经氨酸酶和蛋白酶K抗性，高碘酸盐敏感，并且与表2的糖缀合物无反应。提供了用于CT43抗原决定簇的检测和定量及其与结肠直肠癌的相关性的方法。 具有唾液酸化Lewis a和Lewis a抗原特异性的CT43和CT66已保藏于美国典型培养物保藏中心，保藏号为ATCC HB 10217和ATCC HB 10218，保藏于1989年9月6日。

    Unitary probe cover
    5.
    发明授权
    Unitary probe cover 失效
    单一探头盖

    公开(公告)号：US5088834A

    公开(公告)日：1992-02-18

    申请号：US752932

    申请日：1991-08-30

    申请人： Randall R. Howe ,  Joseph P. Brown

    发明人： Randall R. Howe ,  Joseph P. Brown

    IPC分类号： A61B1/00 ,  G01J5/02 ,  G01J5/04 ,  G01K1/08

    CPC分类号： G01J5/02 ,  A61B1/00142 ,  G01J5/021

    摘要： A unitary probe cover for an infrared radiation thermometer has a frustum-shaped sheath which fits over the thermometer probe. A base, which is engageable with the probe, is formed integrally with and around the periphery of the proximal end of the sheath to hold the sheath over the probe. The sheath is made of an infrared transparent material and is formed to have a thinner distal end portion terminating in a thin window which passes infrared radiation through the probe into the thermometer.

    摘要翻译： 用于红外辐射温度计的单一探针盖具有适合温度计探头的截头锥形护套。 与探针接合的基座与鞘的近端的周边整体地形成并围绕护套的近端周边形成，以将护套保持在探针上。 护套由红外线透明材料制成，并形成为具有较薄的远端部分终止于薄的窗口，其将红外辐射通过探头通入温度计。

    Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
    6.
    发明授权
    Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells 失效
    抗体 - 酶缀合物与用于向肿瘤细胞递送细胞毒性剂的前药组合

    公开(公告)号：US4975278A

    公开(公告)日：1990-12-04

    申请号：US211301

    申请日：1988-06-29

    申请人： Peter D. Senter ,  Mark G. Saulnier ,  Joseph P. Brown ,  David E. Kerr

    发明人： Peter D. Senter ,  Mark G. Saulnier ,  Joseph P. Brown ,  David E. Kerr

    IPC分类号： A61K47/48

    CPC分类号： B82Y5/00 ,  A61K47/48761

    摘要： This invention relates to a novel method for the delivery of cytotoxic drugs to tumor cells by the administration of a tumor-specific antibody-enzyme conjugate that binds to the tumor cells, and the additional administration of a prodrug that is converted at the tumor site, in the presence of the antibody-bound enzyme, to an active cytotoxic drug. According to preferred embodiments of this invention, antibody-enzyme conjugates containing the enzyme, alkaline phosphatase ("AP"), have been used in conjunction with the novel prodrug, etoposide-4'-phosphate or 7-(2'-aminoethyl phosphate)mitomycin or a combination thereof, to effect killing of tumor cells. According to another embodiment of the invention, an antibody-enzyme conjugate containing the enzyme, penicillin V amidase ("PVA"), has been used in conjunction with a novel prodrug, N-(p-hydroxyphenoxyacetyl)adriamycin to effect killing of tumor cells. Still another embodiment of the invention relates to the use of an antibody-enzyme conjugate containing the enzyme, cytosine deaminase ("CD"), in combination with the prodrug, 5-fluorocytosine, to effect killing of tumor cells. The method, antibody-enzyme conjugates, prodrugs, pharmaceutical compositions and combinations of this invention provide for enhanced selective killing of tumor cells and are thus useful in the treatment of cancers and other tumors.

    摘要翻译： 本发明涉及通过施用与肿瘤细胞结合的肿瘤特异性抗体 - 酶结合物向肿瘤细胞递送细胞毒性药物的新方法，以及额外施用在肿瘤部位转化的前体药物， 在抗体结合酶存在下，与活性细胞毒性药物接触。 根据本发明的优选实施方案，含有酶碱性磷酸酶（“AP”）的抗体 - 酶缀合物已经与新的前药，依托泊苷-4'-磷酸或7-（2'-氨基乙基磷酸酯）结合使用， 丝裂霉素或其组合，以杀死肿瘤细胞。 根据本发明的另一个实施方案，含有酶青霉素V酰胺酶（“PVA”）的抗体 - 酶结合物已经与新的前体药物N-（对羟基苯氧基乙酰基）阿霉素结合使用，以杀死肿瘤细胞 。 本发明的另一个实施方案涉及含有酶，胞嘧啶脱氨酶（“CD”）与前体药物5-氟胞嘧啶组合的抗体 - 酶偶联物用于杀死肿瘤细胞的用途。 本发明的方法，抗体 - 酶缀合物，前药，药物组合物和组合提供增强的肿瘤细胞的选择性杀伤，因此可用于治疗癌症和其它肿瘤。